Analysis of the Pantoea ananatis pan-genome reveals factors underlying its ability to colonize and interact with plant, insect and vertebrate hosts.

abstract：BACKGROUND:Genomic inversion is one type of structural variations (SVs) and is known to play an important biological role. An established problem in sequence data analysis is calling inversions from high-throughput sequence data. It is more difficult to detect inversions because they are surrounded by duplication or ot...

journal_title：BMC genomics

authors： Wu Z,Wu Y,Gao J

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Haplotypes combine the effects of several single nucleotide polymorphisms (SNPs) with high linkage disequilibrium, which benefit the genome-wide association analysis (GWAS). In the haplotype association analysis, both haplotype alleles and blocks are tested. Haplotype alleles can be inferred with the same st...

journal_title：BMC genomics

authors： Chen H,Hao Z,Zhao Y,Yang R

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:LEF1/TCF transcription factors and their activator β-catenin are effectors of the canonical Wnt pathway. Although Wnt/β-catenin signaling has been implicated in neurodegenerative and psychiatric disorders, its possible role in the adult brain remains enigmatic. To address this issue, we sought to identify th...

journal_title：BMC genomics

authors： Wisniewska MB,Nagalski A,Dabrowski M,Misztal K,Kuznicki J

更新日期：2012-11-17 00:00:00

abstract：BACKGROUND:The NBS disease-related gene family coordinates the inherent immune system in plants in response to pathogen infections. Previous studies have identified NBS-encoding genes in Pyrus bretschneideri ('Dangshansuli', an Asian pear) and Pyrus communis ('Bartlett', a European pear) genomes, but the patterns of ge...

journal_title：BMC genomics

authors： Sun M,Zhang M,Singh J,Song B,Tang Z,Liu Y,Wang R,Qin M,Li J,Khan A,Wu J

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:The technological revolution in next-generation sequencing has brought unprecedented opportunities to study any organism of interest at the genomic or transcriptomic level. Transcriptome assembly is a crucial first step for studying the molecular basis of phenotypes of interest using RNA-Sequencing (RNA-Seq)...

journal_title：BMC genomics

authors： Huang X,Chen XG,Armbruster PA

更新日期：2016-07-27 00:00:00

abstract：BACKGROUND:Marek's disease (MD) is a lymphoproliferative disease in chickens caused by Marek's disease virus (MDV) and characterized by T cell lymphoma and infiltration of lymphoid cells into various organs such as liver, spleen, peripheral nerves and muscle. Resistance to MD and disease risk have long been thought to ...

journal_title：BMC genomics

authors： Yu Y,Luo J,Mitra A,Chang S,Tian F,Zhang H,Yuan P,Zhou H,Song J

更新日期：2011-10-12 00:00:00

abstract：BACKGROUND:Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabol...

journal_title：BMC genomics

authors： Fonknechten N,Chaussonnerie S,Tricot S,Lajus A,Andreesen JR,Perchat N,Pelletier E,Gouyvenoux M,Barbe V,Salanoubat M,Le Paslier D,Weissenbach J,Cohen GN,Kreimeyer A

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:The Transcription Factor (TF) p63 is a master regulator of epidermal development and differentiation as evident from the remarkable skin phenotype of p63 mouse knockouts. Furthermore, ectopic expression of p63 alone is sufficient to convert simple epithelium into stratified epithelial tissues in vivo and p63...

journal_title：BMC genomics

authors： Sethi I,Sinha S,Buck MJ

更新日期：2014-11-29 00:00:00

abstract：BACKGROUND:The transcriptome of the fruit pulp of the sweet orange variety Anliu (WT) and that of its red fleshed mutant Hong Anliu (MT) were compared to understand the dynamics and differential expression of genes expressed during fruit development and ripening. RESULTS:The transcriptomes of WT and MT were sampled at...

journal_title：BMC genomics

authors： Yu K,Xu Q,Da X,Guo F,Ding Y,Deng X

更新日期：2012-01-10 00:00:00

abstract：BACKGROUND:Simple sequence repeats (SSRs) are tandemly repeated sequence motifs common in genomic nucleotide sequence that often harbor significant variation in repeat number. Frequently used as molecular markers, SSRs are increasingly identified via in silico approaches. Two common classes of genomic resources that ca...

journal_title：BMC genomics

authors： Ellison CK,Shaw KL

更新日期：2010-07-12 00:00:00

abstract：BACKGROUND:Obtaining reliable and reproducible two-color microarray gene expression data is critically important for understanding the biological significance of perturbations made on a cellular system. Microarray design, RNA preparation and labeling, hybridization conditions and data acquisition and analysis are varia...

journal_title：BMC genomics

authors： Novoradovskaya N,Whitfield ML,Basehore LS,Novoradovsky A,Pesich R,Usary J,Karaca M,Wong WK,Aprelikova O,Fero M,Perou CM,Botstein D,Braman J

更新日期：2004-03-09 00:00:00

abstract：BACKGROUND:Pantoea spp. are frequently isolated from a wide range of ecological niches and have various biological roles, as plant epi- or endophytes, biocontrol agents, plant-growth promoters or as pathogens of both plant and animal hosts. This suggests that members of this genus have undergone extensive genotypic div...

journal_title：BMC genomics

authors： De Maayer P,Chan WY,Blom J,Venter SN,Duffy B,Smits TH,Coutinho TA

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Vinyl chloride is a widespread groundwater pollutant and Group 1 carcinogen. A previous comparative genomic analysis revealed that the vinyl chloride reductase operon, vcrABC, of Dehalococcoides sp. strain VS is embedded in a horizontally-acquired genomic island that integrated at the single-copy tmRNA gene,...

journal_title：BMC genomics

authors： McMurdie PJ,Hug LA,Edwards EA,Holmes S,Spormann AM

更新日期：2011-06-02 00:00:00

abstract：BACKGROUND:Next generation sequencing (NGS) has become a universal practice in modern molecular biology. As the throughput of sequencing experiments increases, the preparation of conventional multiplexed libraries becomes more labor intensive. Conventional library preparation typically requires quality control (QC) tes...

journal_title：BMC genomics

authors： Chiniquy J,Garber ME,Mukhopadhyay A,Hillson NJ

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Relationships between an organism and its environment can be fundamental in the understanding how populations change over time and species arise. Local ecological conditions can shape variation at multiple levels, among these are the evolutionary history and trajectories of coding genes. This study examines ...

journal_title：BMC genomics

authors： Allan CW,Matzkin LM

更新日期：2019-10-12 00:00:00

abstract：BACKGROUND:Genetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenotype. Several approaches have been used to fill this gap, including those that at...

journal_title：BMC genomics

authors： Harrison BR,Wang L,Gajda E,Hoffman EV,Chung BY,Pletcher SD,Raftery D,Promislow DEL

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate. The EPSPS genes of allohexaploid wheat (Triticum aestivum, AABBDD) have not been well characterized. Herein, the three homoeologous cop...

journal_title：BMC genomics

authors： Aramrak A,Kidwell KK,Steber CM,Burke IC

更新日期：2015-10-23 00:00:00

abstract：BACKGROUND:Whole exome sequencing studies identify hundreds to thousands of rare protein coding variants of ambiguous significance for human health. Computational tools are needed to accelerate the identification of specific variants and genes that contribute to human disease. RESULTS:We have developed the Variant Eff...

journal_title：BMC genomics

authors： Carter H,Douville C,Stenson PD,Cooper DN,Karchin R

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The WRKY gene family is one of the most important families in higher plants. As transcription factors, they actively respond to biotic and abiotic stress and are also involved in plant development. Chinese jujube (Ziziphus jujuba Mill.) is the largest type of dried fruit tree in China in terms of production,...

journal_title：BMC genomics

authors： Xue C,Li H,Liu Z,Wang L,Zhao Y,Wei X,Fang H,Liu M,Zhao J

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:Salmonella enterica is a significant foodborne pathogen, which can be transmitted via several distinct routes, and reports on acquisition of antimicrobial resistance (AMR) are increasing. To better understand the association between human Salmonella clinical isolates and the potential environmental/animal re...

journal_title：BMC genomics

authors： Pornsukarom S,van Vliet AHM,Thakur S

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:Genomes store information for building and maintaining organisms. Complete sequencing of many genomes provides the opportunity to study and compare global information properties of those genomes. RESULTS:We have analyzed aspects of the information content of Homo sapiens, Mus musculus, Drosophila melanogast...

journal_title：BMC genomics

authors： Liu Z,Venkatesh SS,Maley CC

更新日期：2008-10-30 00:00:00

abstract：BACKGROUND:Recent molecular studies have revealed considerably more diversity in the phylum Chlamydiae than was previously thought. Evidence is growing that many of these novel chlamydiae may be important pathogens in humans and animals. A significant barrier to characterising these novel chlamydiae is the requirement ...

journal_title：BMC genomics

authors： Taylor-Brown A,Bachmann NL,Borel N,Polkinghorne A

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Meloidogyne chitwoodi commonly known as Columbia root-knot nematode or CRKN is one of the most devastating pests of potato in the Pacific Northwest of the United States of America. In addition to the roots, it infects potato tubers causing internal as well as external defects, thereby reducing the market val...

journal_title：BMC genomics

authors： Bali S,Vining K,Gleason C,Majtahedi H,Brown CR,Sathuvalli V

更新日期：2019-11-28 00:00:00

abstract：BACKGROUND:Microarray data analysts commonly filter out genes based on a number of ad hoc criteria prior to any high-level statistical analysis. Such ad hoc approaches could lead to conflicting conclusions with no clear guidance as to which method is most likely to be reproducible. Furthermore, the number of tests perf...

journal_title：BMC genomics

authors： Hu P,Beyene J,Greenwood CM

更新日期：2006-02-22 00:00:00

abstract：BACKGROUND:Nicotiana attenuata (coyote tobacco) is an ecological model for studying plant-environment interactions and plant gene function under real-world conditions. During the last decade, large amounts of genomic, transcriptomic and metabolomic data have been generated with this plant which has provided new insight...

journal_title：BMC genomics

authors： Brockmöller T,Ling Z,Li D,Gaquerel E,Baldwin IT,Xu S

更新日期：2017-01-13 00:00:00

abstract：BACKGROUND:Increased focus surrounds identifying patients with advanced non-small cell lung cancer (NSCLC) who will benefit from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). EGFR mutation, gene copy number, coexpression of ErbB proteins and ligands, and epithelial to mesenchy...

journal_title：BMC genomics

authors： Balko JM,Potti A,Saunders C,Stromberg A,Haura EB,Black EP

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:Modifications of RNA bases have been found in some mRNAs and non-coding RNAs including rRNAs, tRNAs, and snRNAs, where modified bases are important for RNA function. Little is known about RNA base modifications in Arabidopsis thaliana. RESULTS:In the current work, we carried out a bioinformatics analysis of...

journal_title：BMC genomics

authors： Iida K,Jin H,Zhu JK

更新日期：2009-04-09 00:00:00

abstract：BACKGROUND:Identification and classification of highly similar microbial strains is a challenging issue in microbiology, ecology and evolutionary biology. Among various available approaches, gene content analysis is also at the core of microbial taxonomy. However, no threshold has been determined for grouping microorgn...

journal_title：BMC genomics

authors： Tu Q,Lin L

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Lateral gene transfer (LGT) is an important evolutionary process in microbial evolution. In sewage treatment plants, LGT of antibiotic resistance and xenobiotic degradation-related proteins has been suggested, but the role of LGT outside these processes is unknown. Microbial communities involved in Enhanced ...

journal_title：BMC genomics

authors： Wong DH,Beiko RG

更新日期：2015-07-16 00:00:00

abstract：BACKGROUND:In higher eukaryotes, small RNAs play a role in regulating gene expression. Overexpression (OE) lines of Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) were shown to grow faster and exhibit higher ATP and sugar contents. Leaf microarray studies showed that many genes involved in microRNAs (miRNAs) a...

journal_title：BMC genomics

authors： Liang C,Liu X,Sun Y,Yiu SM,Lim BL

更新日期：2014-02-10 00:00:00