A mitocentric view of Parkinson's disease.

Abstract:

:Parkinson's disease (PD) is a common neurodegenerative disease, yet the underlying causative molecular mechanisms are ill defined. Numerous observations based on drug studies and mutations in genes that cause PD point to a complex set of rather subtle mitochondrial defects that may be causative. Indeed, intensive investigation of these genes in model organisms has revealed roles in the electron transport chain, mitochondrial protein homeostasis, mitophagy, and the fusion and fission of mitochondria. Here, we attempt to synthesize results from experimental studies in diverse systems to define the precise function of these PD genes, as well as their interplay with other genes that affect mitochondrial function. We propose that subtle mitochondrial defects in combination with other insults trigger the onset and progression of disease, in both familial and idiopathic PD.

journal_name

Annu Rev Neurosci

authors

Haelterman NA,Yoon WH,Sandoval H,Jaiswal M,Shulman JM,Bellen HJ

doi

10.1146/annurev-neuro-071013-014317

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

137-59

eissn

0147-006X

issn

1545-4126

journal_volume

37

pub_type

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