Acquired blue nevi in older individuals: retrospective case series from a Veterans Affairs population, 1991 to 2013.

abstract：Importance:Protective effects of UV-B radiation against nonmelanoma skin cancer (NMSC) are exerted via signaling mechanisms involving the vitamin D receptor (VDR). Recent studies have examined single-nucleotide polymorphisms (SNPs) in the VDR, resulting in contradictory findings as to whether these polymorphisms increa...

journal_title：JAMA dermatology

authors： Burns EM,Guroji P,Ahmad I,Nasr HM,Wang Y,Tamimi IA,Stiefel E,Abdelgawwad MS,Shaheen A,Muzaffar AF,Bush LM,Hurst CB,Griffin RL,Elmets CA,Yusuf N

更新日期：2017-10-01 00:00:00

abstract：Importance:Controversy persists regarding the appropriate management of incompletely excised, biopsy-proven, mild and moderate dysplastic nevi (DN). Objective:To determine long-term risk of associated melanoma in biopsied mild or moderate DN with positive histologic margins that were clinically observed vs reexcised w...

journal_title：JAMA dermatology

authors： Fleming NH,Egbert BM,Kim J,Swetter SM

更新日期：2016-12-01 00:00:00

abstract：Importance:Drug-induced hypersensitivity syndrome (DIHS), also known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, is a potentially life-threatening reaction to medications with a mortality rate up to 10%. Standard therapy involves the use of systemic corticosteroids with tapering doses ext...

journal_title：JAMA dermatology

authors： Kirchhof MG,Wong A,Dutz JP

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVES:To calculate sunbed use prevalence rates, to investigate the motivations for tanning, and to identify typical target groups for interventions to prevent skin cancer. DESIGN:Cross-sectional, representative, population-based study, primary analysis of the SUN-Study 2012 (Sunbed-Use: Needs for Action-Study). ...

journal_title：JAMA dermatology

authors： Schneider S,Diehl K,Bock C,Schlüter M,Breitbart EW,Volkmer B,Greinert R

更新日期：2013-01-01 00:00:00

abstract：IMPORTANCE:Topical corticosteroids are the current first-line therapy for vulvar lichen sclerosus (VLS). UV-A1 phototherapy may be a promising alternative treatment option, but controlled studies are lacking. OBJECTIVE:To compare the efficacy of high-potent topical corticosteroids with UV-A1 phototherapy in the treatm...

journal_title：JAMA dermatology

authors： Terras S,Gambichler T,Moritz RK,Stücker M,Kreuter A

更新日期：2014-06-01 00:00:00

abstract：Importance:Staged excision of lentigo maligna (LM) often requires multiple stages and can result in significant cosmetic morbidity. Imiquimod cream has been used off-label as monotherapy in the treatment of LM and may be used in the neoadjuvant setting prior to staged excision as a strategy to reduce the size of the su...

journal_title：JAMA dermatology

authors： Donigan JM,Hyde MA,Goldgar DE,Hadley ML,Bowling M,Bowen GM

更新日期：2018-08-01 00:00:00

abstract：IMPORTANCE:While monotherapy with biologic agents is effective for many patients with psoriasis, some patients require combination therapy. Evidence-based recommendations on combination therapy provide guidance for treating appropriately selected patients with psoriasis. OBJECTIVE:To make evidence-based, best-practice...

journal_title：JAMA dermatology

authors： Armstrong AW,Bagel J,Van Voorhees AS,Robertson AD,Yamauchi PS

更新日期：2015-04-01 00:00:00

abstract：IMPORTANCE:Lichen sclerosus (LS) is an uncommon chronic inflammatory disease that most commonly affects anogenital skin of postmenopausal women. It typically manifests as atrophic white plaques, which may be accompanied by purpura or fissuring. Rarely, LS has been observed to affect mucosal tissues in the mouth and the...

journal_title：JAMA dermatology

authors： Zendell K,Edwards L

更新日期：2013-10-01 00:00:00

abstract：Importance:Sun-protective behavior affects skin cancer prevention. Shade works by physically shielding skin from direct harmful UV rays; however, skin may still remain exposed to reflected and indirect UV rays. There is no current standard metric to evaluate shade for its effectiveness in sun protection, and there is i...

journal_title：JAMA dermatology

authors： Ou-Yang H,Jiang LI,Meyer K,Wang SQ,Farberg AS,Rigel DS

更新日期：2017-03-01 00:00:00

abstract：IMPORTANCE:Psoriasis and atopic dermatitis (AD) are inflammatory diseases thought to be mediated by helper T-cell subtypes 1 and 2 (TH1 and TH2), respectively. Although psoriasis and AD show histopathologic differences during chronic disease, they are difficult to distinguish histologically during erythrodermic exacerb...

journal_title：JAMA dermatology

authors： Moy AP,Murali M,Kroshinsky D,Duncan LM,Nazarian RM

更新日期：2015-07-01 00:00:00

abstract：Importance:Incidence rates of skin cancer are increasing globally, and the correct classification of skin lesions (SLs) into benign and malignant tissue remains a continuous challenge. A collective intelligence approach to skin cancer detection may improve accuracy. Objective:To evaluate the performance of 2 well-know...

journal_title：JAMA dermatology

authors： Kurvers RH,Krause J,Argenziano G,Zalaudek I,Wolf M

更新日期：2015-12-01 00:00:00

abstract：Importance:Increased rates of autoimmune conditions have been reported in association with systemic lupus erythematosus (SLE). Little is known about coexisting autoimmune conditions in patients with cutaneous lupus erythematosus (CLE) without SLE. Objective:To determine the prevalence and risk factors of having coexis...

journal_title：JAMA dermatology

authors： Kunzler E,Hynan LS,Chong BF

更新日期：2018-06-01 00:00:00

abstract：Importance:Because moisturizer use is critical for the prevention and treatment of numerous dermatological conditions, patients frequently request product recommendations from dermatologists. Objective:To determine the product performance characteristics and ingredients of best-selling moisturizers. Design and Settin...

journal_title：JAMA dermatology

authors： Xu S,Kwa M,Lohman ME,Evers-Meltzer R,Silverberg JI

更新日期：2017-11-01 00:00:00

abstract：Importance:Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation-associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodie...

journal_title：JAMA dermatology

authors： Lepelletier C,Bengoufa D,Lyes Z,de Masson A,Chasset F,Jachiet M,Michonneau D,Robin M,Peffault de Latour R,Sicre de Fontbrune F,Tandjaoui-Lambiotte Y,Bensussan A,Rybojad M,Tazi A,Bagot M,Socié G,Bergeron A,Bouaziz JD

更新日期：2017-02-01 00:00:00

abstract：Importance:Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced disease severity in moderate to severe atopic dermatitis (AD) in 2 phase 3 monotherapy studies. Objective:To assess the efficacy and safety of 4 mg and 2 mg of baricitinib in combination with background topical corticosteroid...

journal_title：JAMA dermatology

authors： Reich K,Kabashima K,Peris K,Silverberg JI,Eichenfield LF,Bieber T,Kaszuba A,Kolodsick J,Yang FE,Gamalo M,Brinker DR,DeLozier AM,Janes JM,Nunes FP,Thyssen JP,Simpson EL

更新日期：2020-12-01 00:00:00

abstract：Importance:Although regression is commonly observed in cutaneous melanoma, it is uncertain whether it is associated with patient prognosis. Objective:To determine whether histologically confirmed regression was associated with better or worse survival in patients with primary cutaneous melanoma. Design, Setting, and ...

journal_title：JAMA dermatology

authors： El Sharouni MA,Aivazian K,Witkamp AJ,Sigurdsson V,van Gils CH,Scolyer RA,Thompson JF,van Diest PJ,Lo SN

更新日期：2020-12-23 00:00:00

abstract：Importance:Psoriasis is associated with an increased risk of cardiovascular diseases. Subclinical atherosclerosis in patients with psoriasis has not been compared with other conditions associated with increased cardiovascular risk and more rigorous cardiovascular disease screening, such as type 2 diabetes. Objective:T...

journal_title：JAMA dermatology

authors： Mansouri B,Kivelevitch D,Natarajan B,Joshi AA,Ryan C,Benjegerdes K,Schussler JM,Rader DJ,Reilly MP,Menter A,Mehta NN

更新日期：2016-11-01 00:00:00

abstract：Importance:Psoriasis of the scalp, palms and/or soles, and nails is challenging to treat. Objective:To evaluate the effect of guselkumab on psoriasis in specific body regions. Design, Setting, and Participants:VOYAGE 1 and VOYAGE 2 were, double-blind, placebo- and adalimumab-controlled studies of guselkumab conducted...

journal_title：JAMA dermatology

authors： Foley P,Gordon K,Griffiths CEM,Wasfi Y,Randazzo B,Song M,Li S,Shen YK,Blauvelt A

更新日期：2018-06-01 00:00:00

abstract：Importance:Psoriasis is a chronic inflammatory disease. The Mediterranean diet has been shown to reduce chronic inflammation and has a positive effect on the risk of metabolic syndrome and cardiovascular events. Thus, we hypothesized a positive effect on the onset and/or severity of psoriasis. Objective:To assess the ...

journal_title：JAMA dermatology

authors： Phan C,Touvier M,Kesse-Guyot E,Adjibade M,Hercberg S,Wolkenstein P,Chosidow O,Ezzedine K,Sbidian E

更新日期：2018-09-01 00:00:00

abstract：Importance:Population-level disease metrics are critical to guide the distribution of resources and implementation of public health initiatives. Internet search data reflect population interest in health topics and may be an alternative metric of disease characteristics when traditional sources are lacking, such as in ...

journal_title：JAMA dermatology

authors： Wehner MR,Nead KT,Linos E

更新日期：2017-09-01 00:00:00

abstract：IMPORTANCE:Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), occurs in elderly patients and has been considered as a lymphoma with a poor prognosis, with estimated 5-year specific survival rates of approximately 50%. The hypothesis of an improvement in prognosis over time has not been studied. OB...

journal_title：JAMA dermatology

authors： Grange F,Joly P,Barbe C,Bagot M,Dalle S,Ingen-Housz-Oro S,Maubec E,D'Incan M,Ram-Wolff C,Dalac S,Templier I,Esteve E,Quereux G,Machet L,Leduc M,Dereure O,Laroche L,Saiag P,Vergier B,Beylot-Barry M

更新日期：2014-05-01 00:00:00

abstract：Importance:Advanced practice professionals (APPs) such as nurse practitioners and physician assistants independently perform a large number and variety of dermatologic procedures, but little is known about how the number and scope of these procedures have changed over time. Objective:To examine the trends in scope and...

journal_title：JAMA dermatology

authors： Zhang M,Zippin J,Kaffenberger B

更新日期：2018-09-01 00:00:00

abstract：Importance:Pubic hair grooming is a common practice that can lead to injury and morbidity. Objective:To identify demographic and behavioral risk factors associated with pubic hair grooming-related injuries to characterize individuals with high risk of injury and develop recommendations for safe grooming practices. De...

journal_title：JAMA dermatology

authors： Truesdale MD,Osterberg EC,Gaither TW,Awad MA,Elmer-DeWitt MA,Sutcliffe S,Allen I,Breyer BN

更新日期：2017-11-01 00:00:00

abstract：Importance:There is ongoing controversy about the adverse events of finasteride, a drug used in the management of alopecia and benign prostatic hyperplasia (BPH). In 2012, reports started emerging on men who had used finasteride and either attempted or completed suicide. Objective:To investigate the association of sui...

journal_title：JAMA dermatology

authors： Nguyen DD,Marchese M,Cone EB,Paciotti M,Basaria S,Bhojani N,Trinh QD

更新日期：2021-01-01 00:00:00

abstract：IMPORTANCE:Nevi are among the strongest risk factors for melanoma. However, little is known about the association of many total nevi (TN) or atypical nevi (AN) with tumor thickness. OBJECTIVES:To examine the association between age and the number of TN and AN and to explore whether there was a relationship between TN ...

journal_title：JAMA dermatology

authors： Geller AC,Mayer JE,Sober AJ,Miller DR,Argenziano G,Johnson TM,Swetter SM

更新日期：2016-04-01 00:00:00

abstract：IMPORTANCE:Mobile smartphones are rapidly emerging as an effective means of communicating with many Americans. Using mobile applications (apps), they can access remote databases, track time and location, and integrate user input to provide tailored health information. OBJECTIVE:A smartphone mobile app providing person...

journal_title：JAMA dermatology

authors： Buller DB,Berwick M,Lantz K,Buller MK,Shane J,Kane I,Liu X

更新日期：2015-05-01 00:00:00

abstract：IMPORTANCE:Recently, a group of melanocytic tumors with loss of BAP1 expression has been described. The lesions may occur sporadically or as part of a familial cancer syndrome. They have distinct histopathologic features characterized by a nevus like silhouette and cytologic composition of large epithelioid melanocytes...

journal_title：JAMA dermatology

authors： Busam KJ,Wanna M,Wiesner T

更新日期：2013-03-01 00:00:00

abstract：IMPORTANCE:Ustekinumab is a human monoclonal antibody that binds to the shared p40 subunit of interleukin (IL) 12 and IL-23. It is approved in the United States for adults (>18 years) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy. In 1 phase 2 trial of ustekinumab for ...

journal_title：JAMA dermatology

authors： Stamell EF,Kutner A,Viola K,Cohen SR

更新日期：2013-12-01 00:00:00

abstract：IMPORTANCE:Approximately 10% to 25% of patients treated with BRAF inhibitors develop cutaneous squamous cell carcinoma (SCC), but the mechanism responsible has not yet been determined. We report what we believe to be the first case in which Merkel cell polyomavirus (MCPyV) and human papillomavirus subtype 17 (HPV-17) w...

journal_title：JAMA dermatology

authors： Falchook GS,Rady P,Hymes S,Nguyen HP,Tyring SK,Prieto VG,Hong DS,Kurzrock R

更新日期：2013-03-01 00:00:00

abstract：Importance:Melanoma treatment has been revolutionized with the development of immune-based therapies that offer durable clinical responses in a subset of patients. Clinical outcomes after treatment by immunotherapy can be influenced by the host's immune system. The immune system is modified with age by age-related immu...

journal_title：JAMA dermatology

authors： Perier-Muzet M,Gatt E,Péron J,Falandry C,Amini-Adlé M,Thomas L,Dalle S,Boespflug A

更新日期：2018-01-01 00:00:00