Abstract：
:Estimating the behavior of a network of neurons requires accurate models of the individual neurons along with accurate characterizations of the connections among them. Whereas for a single cell, measurements of the intracellular voltage are technically feasible and sufficient to characterize a useful model of its behavior, making sufficient numbers of simultaneous intracellular measurements to characterize even small networks is infeasible. This paper builds on prior work on single neurons to explore whether knowledge of the time of spiking of neurons in a network, once the nodes (neurons) have been characterized biophysically, can provide enough information to usefully constrain the functional architecture of the network: the existence of synaptic links among neurons and their strength. Using standardized voltage and synaptic gating variable waveforms associated with a spike, we demonstrate that the functional architecture of a small network of model neurons can be established.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Knowlton C,Meliza CD,Margoliash D,Abarbanel HDdoi
10.1007/s00422-014-0601-ysubject
Has Abstractpub_date
2014-06-01 00:00:00pages
261-73issue
3eissn
0340-1200issn
1432-0770journal_volume
108pub_type
杂志文章abstract：:An approach to solving nonlinear control problems is illustrated by means of a layered associative network composed of adaptive elements capable of reinforcement learning. The first layer adaptively develops a representation in terms of which the second layer can solve the problem linearly. The adaptive elements compr...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00319977
更新日期：1982-01-01 00:00:00
abstract：:This paper proposes multiport parallel and multidirectional intraconnected associative memories of outer product type with reduced interconnections. Some new reduced order memory architectures such as k-directional and k-port parallel memories are suggested. These architectures are, also, very suitable for implementat...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-009-0310-0
更新日期：2009-05-01 00:00:00
abstract：:Many neurons at the sensory periphery receive periodic input, and their activity exhibits entrainment to this input in the form of a preferred phase for firing. This article describes a modeling study of neurons which skip a random number of cycles of the stimulus between firings over a large range of input intensitie...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00198810
更新日期：1994-01-01 00:00:00
abstract：:This article introduces several fundamental concepts in information theory from the perspective of their origins in engineering. Understanding such concepts is important in neuroscience for two reasons. Simply applying formulae from information theory without understanding the assumptions behind their definitions can ...
journal_title：Biological cybernetics
pub_type： 杂志文章,评审
doi：10.1007/s00422-011-0451-9
更新日期：2011-07-01 00:00:00
abstract：:Explosive movements such as throwing, kicking, and jumping are characterized by high velocity and short movement time. Due to the fact that latencies of neural feedback loops are long in comparison to movement times, correction of deviations cannot be achieved on the basis of neural feedback. In other words, the contr...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00198959
更新日期：1993-01-01 00:00:00
abstract：:The evolutionary transition from water to land required new locomotor modes and corresponding adjustments of the spinal "central pattern generators" for locomotion. Salamanders resemble the first terrestrial tetrapods and represent a key animal for the study of these changes. Based on recent physiological data from sa...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-012-0538-y
更新日期：2013-10-01 00:00:00
abstract：:Neural field models have been successfully applied to model diverse brain mechanisms like visual attention, motor control, and memory. Most theoretical and modeling works have focused on the study of the dynamics of such systems under variations in neural connectivity, mainly symmetric connectivity among neurons. Howe...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-012-0544-0
更新日期：2013-04-01 00:00:00
abstract：:The superior colliculus (SC) integrates relevant sensory information (visual, auditory, somatosensory) from several cortical and subcortical structures, to program orientation responses to external events. However, this capacity is not present at birth, and it is acquired only through interactions with cross-modal eve...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-012-0511-9
更新日期：2012-12-01 00:00:00
abstract：:Small inhibitory neuronal circuits have long been identified as key neuronal motifs to generate and modulate the coexisting rhythms of various motor functions. Our paper highlights the role of a cellular switching mechanism to orchestrate such circuits. The cellular switch makes the circuits reconfigurable, robust, ad...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-018-0778-6
更新日期：2019-04-01 00:00:00
abstract：:The idea that a sparse representation is the computational principle of visual systems has been supported by Olshausen and Field [Nature (1996) 381: 607-609] and many other studies. On the other hand neurons in the inferotemporal cortex respond to moderately complex features called icon alphabets, and such neurons res...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s004220000149
更新日期：2000-08-01 00:00:00
abstract：:Response patterns recorded with 30 microelectrodes from area 17 of anaesthetized monkeys are analysed. A proportion of the patterns are used to define prototype response patterns. These in turn are used to recognize the stimulus from further non-averaged response patterns. In comparison, recognition by a feedforward '...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00194921
更新日期：1996-04-01 00:00:00
abstract：:Voltage-clamp of excitable membrane allows the measurement of membrane currents associated with electrical potential changes across the membrane. However, it has been impossible in practice to apply the conventional analog feedback voltage-clamp circuits to single electrode voltage clamping in central neurons. The rea...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00355690
更新日期：1985-01-01 00:00:00
abstract：:The trace version of classical conditioning is used as a prototypical hippocampal-dependent task to study the recoding sequence prediction theory of hippocampal function. This theory conjectures that the hippocampus is a random recoder of sequences and that, once formed, the neuronal codes are suitable for prediction....
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-005-0568-9
更新日期：2005-06-01 00:00:00
abstract：:Mathematical or computational models of activity-dependent neural competition typically impose competition in anatomically fixed networks by the use of synaptic normalisation, for which there is very little experimental support. Recent experimental evidence, however, strongly implicates neurotrophic factors in neural ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s004220050311
更新日期：1996-12-01 00:00:00
abstract：:We have previously tried to explain perceptual inference and learning under a free-energy principle that pursues Helmholtz's agenda to understand the brain in terms of energy minimization. It is fairly easy to show that making inferences about the causes of sensory data can be cast as the minimization of a free-energy...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-010-0364-z
更新日期：2010-03-01 00:00:00
abstract：:It is shown that a convolution with certain reasonable receptive field (RF) profiles yields the exact partial derivatives of the retinal illuminance blurred to a specified degree. Arbitrary concatenations of such RF profiles yield again similar ones of higher order and for a greater degree of blurring. By replacing th...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00318371
更新日期：1987-01-01 00:00:00
abstract：:This work proposes a model of visual bottom-up attention for dynamic scene analysis. Our work adds motion saliency calculations to a neural network model with realistic temporal dynamics [(e.g., building motion salience on top of De Brecht and Saiki Neural Networks 19:1467-1474, (2006)]. The resulting network elicits ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-012-0542-2
更新日期：2013-04-01 00:00:00
abstract：:In motion-processing areas of the visual cortex in cats and monkeys, an anisotropic distribution of direction selectivities displays a preference for movements away from the fovea. This 'centrifugal bias' has been hypothetically linked to the processing of optic flow fields generated during forward locomotion. In this...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00201489
更新日期：1995-01-01 00:00:00
abstract：:This paper concerns the use of tracking studies to test a theoretical account of the information processing performed by the human CNS during control of movement. The theory provides a bridge between studies of reaction time and continuous tracking. It is proposed that the human CNS includes neuronal circuitry to comp...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00364156
更新日期：1988-01-01 00:00:00
abstract：:We discuss natural limitations on motor performance caused by the time delay required for feedback signals to propagate within the human body or mechanical control systems. By considering a very simple delayed linear servomechanism model, we show there exists a best possible speed-accuracy trade-off similar to Fitts' ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-008-0235-z
更新日期：2008-07-01 00:00:00
abstract：:A system of coupled bistable Hopf oscillators with an external periodic input source was used to model the ability of interacting neural populations to synchronize and desynchronize in response to variations of the input signal. We propose that, in biological systems, the settings of internal and external coupling str...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s004220050023
更新日期：2000-03-01 00:00:00
abstract：:A model calculation is presented simulating the coordinated interaction between the walking legs of a multi-legged animal. The neural network consists of separate modules with oscillatory capabilities. It has the ability to adjust the necessary parameters for producing a coordinated interaction between the modules in ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00200811
更新日期：1993-01-01 00:00:00
abstract：:Cognitive theory has decomposed human mental abilities into cognitive (sub) systems, and cognitive neuroscience succeeded in disclosing a host of relationships between cognitive systems and specific structures of the human brain. However, an explanation of why specific functions are located in specific brain loci had ...
journal_title：Biological cybernetics
pub_type： 杂志文章,评审
doi：10.1007/s00422-014-0603-9
更新日期：2014-10-01 00:00:00
abstract：:In the current research, the muscle equivalent linear damping coefficient which is introduced as the force-velocity relation in a muscle model and the corresponding time constant are investigated. In order to reach this goal, a 1D skeletal muscle model was used. Two characterizations of this model using a linear force...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-016-0680-z
更新日期：2016-02-01 00:00:00
abstract：:This paper studies the performance of single-layered neural networks. This study begins with the performance of single-layered neural networks trained using the outer-product rule. The outer-product rule is a suboptimal learning scheme, resulting under certain assumptions from optimal least-squares training of single-...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00203135
更新日期：1992-01-01 00:00:00
abstract：:Isolated and cultured neonatal cardiac myocytes contract spontaneously and cyclically, and have the properties of a non-linear oscillator. In this study, we have analyzed the relationship between the fluctuation of contraction rhythm of spontaneously beating cultured cardiac myocytes, and the coupling strength among t...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-001-0285-y
更新日期：2002-02-01 00:00:00
abstract：:We propose a model for the first stage of the cortical transformation of the visual image based on the principle that the cortex encodes the information with the minimum number of channels mathematically needed. We restrict our model to be consistent with the data on size adaptations, the known relationships of acuity...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00336972
更新日期：1982-01-01 00:00:00
abstract：:The behavior of the space-clamped Hodgkin-Huxley model has been studied using band-limited white noise (0-50 Hz) as the input membrane current and taking the output as a point process in time given by the peaks of the action potentials. The frequency response and coherence functions were measured by use of the Fourier...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00334462
更新日期：1984-01-01 00:00:00
abstract：:This paper continues the investigation of a three-loop representation of the segmental muscle stretch reflex system introduced in a preceding communication. Frequency response characteristics were computed for open-loop conditions, control and disturbance signal inputs under a variety of conditions: (i) "in parallel" ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/BF00326681
更新日期：1981-01-01 00:00:00
abstract：:Rapidly adapting (RA) currents expressed in dorsal root ganglia somatosensory neurons reduce their amplitude in response to prolonged and/or repeated mechanical stimulation. Both inactivation of mechanotransducer channels and adaptation of the force acting on the channels have been suggested to independently decrease ...
journal_title：Biological cybernetics
pub_type： 杂志文章
doi：10.1007/s00422-016-0693-7
更新日期：2016-12-01 00:00:00
