Abstract:
:Estimating the behavior of a network of neurons requires accurate models of the individual neurons along with accurate characterizations of the connections among them. Whereas for a single cell, measurements of the intracellular voltage are technically feasible and sufficient to characterize a useful model of its behavior, making sufficient numbers of simultaneous intracellular measurements to characterize even small networks is infeasible. This paper builds on prior work on single neurons to explore whether knowledge of the time of spiking of neurons in a network, once the nodes (neurons) have been characterized biophysically, can provide enough information to usefully constrain the functional architecture of the network: the existence of synaptic links among neurons and their strength. Using standardized voltage and synaptic gating variable waveforms associated with a spike, we demonstrate that the functional architecture of a small network of model neurons can be established.
journal_name
Biol Cybernjournal_title
Biological cyberneticsauthors
Knowlton C,Meliza CD,Margoliash D,Abarbanel HDdoi
10.1007/s00422-014-0601-ysubject
Has Abstractpub_date
2014-06-01 00:00:00pages
261-73issue
3eissn
0340-1200issn
1432-0770journal_volume
108pub_type
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