Abstract:
:Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance patterns provides a direct challenge to this view and suggests an important role for alternative mechanisms of gene regulation and inheritance. Over the past few years, a highly complex and diverse network of noncoding RNAs has been discovered. Research in animal models has shown that RNAs can be inherited and that RNA methyltransferases can be important for the transmission and expression of modified phenotypes in the next generation. We discuss possible mechanisms of RNA-mediated inheritance and the role of these mechanisms for human health and disease.
journal_name
PLoS Genetjournal_title
PLoS geneticsauthors
Liebers R,Rassoulzadegan M,Lyko Fdoi
10.1371/journal.pgen.1004296subject
Has Abstractpub_date
2014-04-17 00:00:00pages
e1004296issue
4eissn
1553-7390issn
1553-7404pii
PGENETICS-D-13-03210journal_volume
10pub_type
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