Epigenetic regulation by heritable RNA.

Abstract:

:Genomic concepts are based on the assumption that phenotypes arise from the expression of genetic variants. However, the presence of non-Mendelian inheritance patterns provides a direct challenge to this view and suggests an important role for alternative mechanisms of gene regulation and inheritance. Over the past few years, a highly complex and diverse network of noncoding RNAs has been discovered. Research in animal models has shown that RNAs can be inherited and that RNA methyltransferases can be important for the transmission and expression of modified phenotypes in the next generation. We discuss possible mechanisms of RNA-mediated inheritance and the role of these mechanisms for human health and disease.

journal_name

PLoS Genet

journal_title

PLoS genetics

authors

Liebers R,Rassoulzadegan M,Lyko F

doi

10.1371/journal.pgen.1004296

subject

Has Abstract

pub_date

2014-04-17 00:00:00

pages

e1004296

issue

4

eissn

1553-7390

issn

1553-7404

pii

PGENETICS-D-13-03210

journal_volume

10

pub_type

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