Methoxyflurane anesthesia augments the chronotropic and dromotropic effects of verapamil.

Abstract:

INTRODUCTION:Inhalation anesthetics have been shown to have electrical suppressant effects on excitable membranes such as the cardiac conduction system. Therefore, the anesthetized patient or laboratory animal may respond differently to cardiac drugs when compared with their conscious counterparts. The purpose of this study was to assess the effects of anesthesia with methoxyflurane (MF) on the dromotropic and chronotropic effects of verapamil (VER) in the rat. METHODS:A lead I ECG was measured using subcutaneous electrodes placed both axilli and over the xyphoid process in male Sprague-Dawley rats. Dromotropic effect was measured using the PR-interval which indicated the electrical spread across the atria to the AV-node and chronotropic effects were determined using RR-interval. A total of six animals were randomized to receive 10 mg/kg s.c. of verapamil in the presence or absence of general anesthesia containing methoxyflurane. In addition, PR-interval and RR-intervals were determined in the presence of only methoxyflurane and at rest without any drug exposure. The time for the ECG to normalize after exposure to methoxyflurane and/or verapamil was also determined. RESULTS:Exposure to verapamil alone resulted in a 5% prolongation in PR-interval and 6% prolongation in RR-interval. Methoxyflurane alone had a larger effect than verapamil demonstrating a 14.5% prolongation in PR-interval and a 12.3% in RR-interval which was statistically significant. The combination of MF + VER resulted in a synergistic prolongation in PR-interval to 28. 7% while the effect on RR-interval was additive with an increase to 17.6%. The time for the ECG to normalize after exposure to VER, MF and VER + MF was 37.5 15.1 min, 69.8 5.3 min, and 148.5 +/- 6.6 min respectively. CONCLUSION:General anesthesia with MF enhances the dromotropic and chronotropic effect of VER. This should be considered when MF-anesthesia is used in experimental procedure.

journal_name

J Pharm Pharm Sci

authors

Jamali F,Mayo PR

keywords:

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

30-5

issue

1

issn

1482-1826

journal_volume

2

pub_type

杂志文章
  • Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers.

    abstract:PURPOSE:To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. METHODS:An open-label, non-randomized, two-period, sequential clinical trial was conducted as follows: during Period...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 临床试验,杂志文章

    doi:10.18433/J3H03R

    authors: Todor I,Popa A,Neag M,Muntean D,Bocsan C,Buzoianu A,Vlase L,Gheldiu AM,Briciu C

    更新日期:2016-04-01 00:00:00

  • Discovery of chlorogenic acid-based peptidomimetics as a novel class of antifungals. A success story in rational drug design.

    abstract::Life-threatening fungal infections have increased dramatically in recent decades in immunocompromised patients. An estimated 40% of all deaths from hospital-acquired infections are due to infections caused by opportunistic fungi. The current treatment options are either causing serious toxicity, or becoming inactive a...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3h010

    authors: Daneshtalab M

    更新日期:2008-07-06 00:00:00

  • Effectiveness of academic detailing to optimize medication prescribing behaviour of family physicians.

    abstract:PURPOSE:To synthesize current knowledge about the effectiveness and the magnitude of the effect, of Academic Detailing (AD), as a stand-alone intervention, at modifying drug prescription behavior of Family Physicians (FPs) in primary care settings. METHODS:A search of MEDLINE, EMBASE, CENTRAL, and Web of Science datab...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3kk6c

    authors: Chhina HK,Bhole VM,Goldsmith C,Hall W,Kaczorowski J,Lacaille D

    更新日期:2013-01-01 00:00:00

  • Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery.

    abstract:PURPOSE:The present study was undertaken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of these polymers, three ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Reza MS,Quadir MA,Haider SS

    更新日期:2003-05-01 00:00:00

  • The effect of natural health products and traditional medicines on the activity of human hepatic microsomal-mediated metabolism of oseltamivir.

    abstract:PURPOSE:Oseltamivir is a prodrug that requires metabolic activation but there is little information on whether natural health products interact to prevent the biotransformation by the carboxylesterase. METHODS:HPLC-DAD-ESI-MSD and fluorometric assays were used to determine if 50-pooled mixed gender human liver microso...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3zp42

    authors: Liu R,Tam TW,Mao J,Saleem A,Krantis A,Arnason JT,Foster BC

    更新日期:2010-01-01 00:00:00

  • Alteration of pharmacokinetics of grepafloxacin in type 2 diabetic rats.

    abstract:PURPOSE:Patients with type 2 diabetes are generally treated with various pharmacological compounds and are exposed to a high risk of drug-drug interactions. However, alterations of pharmacokinetics in a type 2 diabetes model have been obscure. The present study was undertaken to investigate the effects of type 2 diabet...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3mc70

    authors: Watanabe M,Kobayashi M,Ogura J,Takahashi N,Yamaguchi H,Iseki K

    更新日期:2014-01-01 00:00:00

  • Fluorescence detection of Zabofloxacin, a novel fluoroquinolone antibiotic, in plasma, bile, and urine by HPLC: the first oral and intravenous applications in a pharmacokinetic study in rats.

    abstract:PURPOSE:To develop an HPLC method using fluorescence detection for the pharmacokinetic evaluation of levels of zabofloxacin, a novel broad spectrum fluoroquinolone antibiotic, in the plasma, bile and urine of rats. METHODS:A simple reversed-phase HPLC method using a C18 column with fluorescence detection was developed...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3j592

    authors: Jin HE,Kang IH,Shim CK

    更新日期:2011-01-01 00:00:00

  • Multitarget Therapy: An Effective and Safe Therapeutic Regimen for Lupus Nephritis.

    abstract:INTRODUCTION:We evaluated the effectiveness and safety of various multitarget therapies for inducing remission in lupus nephritis patients. METHODS:Randomized controlled trials (RCT) were identified and extracted from the Embase, PubMed, Chinese Biomedical Literature Database (CBM), and the Cochrane Library until Oct ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,随机对照试验

    doi:10.18433/jpps30526

    authors: Zhou T,Zhang X,Lin W,Lin S

    更新日期:2019-01-01 00:00:00

  • A Combined Computer-Aided Approach to Drive the Identification of Potential Epitopes in Protein Therapeutics.

    abstract:BACKGROUND:The identification of fragment sequences, or motifs, within a therapeutic protein that may elicit an immune response when processed by T-cells can be provided by computer-aided approaches. Immunogenicity is a significant problem associated with protein therapeutics and should be investigated in the early sta...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps29800

    authors: Galvão da Silva BAV,Chudzinski-Tavassi AM,Pasqualoto KFM

    更新日期:2018-01-01 00:00:00

  • Beta Adrenoceptor Polymorphism and Clinical Response to Sertraline in Major Depressive Patients.

    abstract:PURPOSE:The adrenoceptor family, as one of the main contributors in regulating the noradrenergic system, has been studied in involvement of depression and its treatment. A functional polymorphism of G1165C on beta adrenoceptor (βAR) enhances post receptor signalling and is assumed to be involved in pharmacotherapy of d...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3W31F

    authors: Firouzabadi N,Raeesi R,Zomorrodian K,Bahramali E,Yavarian I

    更新日期:2017-01-01 00:00:00

  • In Vitro ADME, Preclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of RBx14255, a Novel Ketolide with Pharmacodynamics Against Multidrug-Resistant Bacterial Pathogens.

    abstract:PURPOSE:The preclinical pharmacokinetic and pharmacodynamic properties of a potent fluoroketolide RBx14255 against Streptococcus pneumoniae and Haemophilus influenzae was compared with telithromycin and human clinical dose was predicted for preclinical development. METHODS:The in vitro pharmacokinetic characterization...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps30942

    authors: Chaira T,Barman T,Samuel Raj V

    更新日期:2020-01-01 00:00:00

  • miR-484: A Possible Indicator of Drug-Induced Pulmonary Fibrosis.

    abstract:BACKGROUND:Drug-induced lung injury leads to serious lung diseases, such as pulmonary fibrosis. We demonstrated in an alveolar epithelial cell line A549/ABCA3 that certain microRNAs were associated with bleomycin induced epithelial-mesenchymal transition (EMT) which is closely related to pulmonary fibrosis. In this stu...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps31448

    authors: Konaka T,Kawami M,Yamamoto A,Yumoto R,Takano M

    更新日期:2020-01-01 00:00:00

  • Different storing and processing conditions of human lymphocytes do not alter P-glycoprotein rhodamine 123 efflux.

    abstract::P-glycoprotein (Pgp), a protein codified by Multi Drug Resistance (MDR1) gene, has a detoxifying function and might influence the toxicity and pharmacokinetics and pharmacodynamics of drugs. Sampling strategies to improve Pgp studies could be useful to optimize the sensitivity and the reproducibility of efflux assays....

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j34g69

    authors: Chiva-Blanch G,Giménez-Bonafe P,Llaudó I,Torras J,Cruzado JM,Petriz J,Castaño E,Franquesa Ml,Herrero-Fresneda I,Tortosa A,Rama I,Bestard O,Grinyó JM,Lloberas N

    更新日期:2009-01-01 00:00:00

  • A simple and efficient method for radiolabeling of preformed liposomes.

    abstract::A simple and efficient method for radiolabeling preformed liposomes was developed using hepatobiliary imaging agent (99m)Tc-diisopropyl iminodiacetic acid ((99m)Tc-DISIDA). Chloroform extraction of (99m)Tc-DISIDA from aqueous solutions results in 80% radioactivity in the organic phase due to its lipophilic properties....

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Suresh M,Cao Y

    更新日期:1998-01-01 00:00:00

  • Structural equation modeling of qualification of pharmacists to improve subjected quality of life in cancer patients.

    abstract:PURPOSE:To establish structural equation model (SEM) of subjected quality of life (QOL) in cancer patients taking into account qualification of pharmacists. METHOD:The SEM model was constructed from correlation matrix of the scores of answers of questions to both patients and pharmacists. Data were collected from 15 c...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Yamamura S,Takehira R,Kawada K,Katayama S,Nishizawa K,Hirano M,Momose Y

    更新日期:2005-10-04 00:00:00

  • Inhibition of human liver cytochrome P450 by star fruit juice.

    abstract:PURPOSE:To examine the inhibitory effects of star fruit (Averrhoa carambola) juice towards seven major cytochrome P450 (CYP) isoforms and NADPH-cytochrome P450 reductase (CPR). METHODS:The inhibitory effects of star fruit juice (0.5 to 5%, v/v) against the activities of seven CYP isoforms including CYP1A2, CYP2A6, CYP...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j30593

    authors: Zhang JW,Liu Y,Cheng J,Li W,Ma H,Liu HT,Sun J,Wang LM,He YQ,Wang Y,Wang ZT,Yang L

    更新日期:2007-01-01 00:00:00

  • Cannabis and the Gastrointestinal Tract.

    abstract::Cannabis has been used for its medicinal purposes since ancient times. Its consumption leads to the activation of Cannabis receptors CB1 and CB2 that, through specific mechanisms can lead to modulation and progression of inflammation or repair. The novel findings are linked to the medical use of Cannabis in gastrointe...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/jpps31242

    authors: Cohen L,Neuman MG

    更新日期:2020-01-01 00:00:00

  • A topical w/o/w multiple emulsions prepared with Tetronic 908 as a hydrophilic surfactant: formulation, characterization and release study.

    abstract:PURPOSE:The aim of this work was to prepare the stable water/oil/water multiple emulsions (MEs), to investigate the usage of poloxamine 908, to observe the influence of surfactant percentage on the properties of MEs. METHOD:MEs were prepared by liquid paraffin, cetyl dimethicone copolyol and poloxamine 908 by a two-st...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Tirnaksiz F,Kalsin O

    更新日期:2005-08-11 00:00:00

  • Application of 12S rRNA gene for the identification of animal-derived drugs.

    abstract::PURPOSE. Animal-derived drugs are the major source of biological products and traditional medicine, but they are often difficult to identify, causing confusion in the clinical application. Among these medicinal animals, a number of animal species are endangered, leading to the destruction of biodiversity. The identifi...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3n017

    authors: Luo J,Yan D,Zhang D,Han Y,Dong X,Yang Y,Deng K,Xiao X

    更新日期:2011-01-01 00:00:00

  • Hantzsch-Type dihydropyridines and Biginelli-type tetra-hydropyrimidines: a review of their chemotherapeutic activities.

    abstract::Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. This is mainly due to the convenient methods that exist for their synthesis and the diverse pharmacologic properties that these scaffolds prese...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3q01v

    authors: Sepehri S,Sanchez HP,Fassihi A

    更新日期:2015-01-01 00:00:00

  • Phytoestrogens Modulate Breast Cancer Resistance Protein Expression and Function at the Blood-Cerebrospinal Fluid Barrier.

    abstract:PURPOSE:Breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter expressed at the blood cerebrospinal fluid barrier (BCSFB), and influences distribution of drugs into the central nervous systems (CNS). Current inhibitors have failed clinically due to neurotoxicity. Novel approaches are needed to ident...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3p31k

    authors: Kaur M,Badhan RK

    更新日期:2015-01-01 00:00:00

  • Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells.

    abstract:PURPOSE:To investigate the effect of clofibrate on inducing liver fatty acid binding protein (FABP1) following a high-fat load in a hepatocyte cell culture model. METHODS:Rat hepatoma cells (CRL-1548) were treated with a fatty acid (FA) mixture consisting of oleate:palmitate (2:1) in the presence of 3% albumin. Cells ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3TS70

    authors: Chen Y,Li W,Wang G,Burczynski FJ

    更新日期:2017-01-01 00:00:00

  • Clearance Concepts: Fundamentals and Application to Pharmacokinetic Behavior of Drugs.

    abstract::Clearance concepts were introduced into the pharmacokinetics discipline in the 1970s and since then have played a major role in characterization of the pharmacokinetic behavior of drugs. These concepts are based on the relationship between organ extraction ratio or clearance and physiologic parameters such as the orga...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/jpps29896

    authors: Mehvar R

    更新日期:2018-01-01 00:00:00

  • Evidence for non-linear pharmacokinetics of oxytocin in anesthetizetized rat.

    abstract:PURPOSE:Because oxytocin (OT) is potentially useful in cardiovascular therapy but has hormonal roles on the cardiovascular and renal systems, we characterized its pharmacokinetic (PK) properties as a function of dose. METHODS:A single intravenous bolus of OT was given at doses of 200, 300, 500, 1000, 3000, 5000 and 10...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3pk5x

    authors: Morin V,Del Castillo JR,Authier S,Ybarra N,Otis C,Gauvin D,Gutkowska J,Troncy E

    更新日期:2008-01-01 00:00:00

  • Fluorescent fatty acid transfer from bovine serum albumin to phospholipid vesicles: collision or diffusion mediated uptake.

    abstract:PURPOSE:The extent of palmitate uptake by hepatocytes is dependent upon the surface charge of the extracellular binding protein. Specifically, hepatocyte uptake is greater when palmitate is bound to cationic binding proteins than when it is bound to anionic proteins. To further understand the role of protein surface ch...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3bc8w

    authors: Elmadhoun BM,Swairjo MA,Burczynski FJ

    更新日期:2012-01-01 00:00:00

  • Strategies for the discovery and development of anti-diabetic drugs from the natural products of traditional medicines.

    abstract::This review discusses issues largely from the biological point of view about the targeted approaches for the use of natural products for the discovery of anti-diabetic drugs in collaboration with medicinal chemists and computer-aided drug design. A major thrust of this review reflects the collaborative research of fou...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,评审

    doi:10.18433/j3t60g

    authors: Chan SM,Ye JM

    更新日期:2013-01-01 00:00:00

  • Effect of acidic ternary compounds on the formation of miconazole/cyclodextrin inclusion complexes by means of supercritical carbon dioxide.

    abstract:PURPOSE:The aim of the study is to evaluate the effect of different acidic compounds on the inclusion of miconazole (MICO) in several cyclodextrins (CDs) using supercritical carbon dioxide (SCCO(2) ) processing. METHODS:Physical mixtures were processed by SCCO(2) at 30 MPa, 125 degrees C during 60 minutes in a static ...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:

    authors: Barillaro V,Bertholet P,Henry de Hassonville S,Ziemon E,Evrard B,Delattre L,Piel G

    更新日期:2004-11-30 00:00:00

  • Enhanced lactone stability of CZ48 in blood correlates to its lack of toxicity in mice.

    abstract:PURPOSE:The aim of this study was to correlate the relationship between the pharmacokinetic behaviors and the toxicity of a new investigational anticancer agent CZ48, a C20-propionate ester of camptothecin (CPT) in mice. METHODS:In this study, the safety and pharmacokinetics of oral doses of CZ48 were compared with th...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/j3b604

    authors: Liu X,Wang Y,Cao Z,Zhan M,Vardeman D,Giovanella B

    更新日期:2013-01-01 00:00:00

  • Effects of one year treatment of sibutramine on insulin resistance parameters in type 2 diabetic patients.

    abstract:PURPOSE:Comparison of the effects of one year treatment with sibutramine compared to placebo on insulin resistance parameters, body weight, glycemic control, and lipid profile, in type 2 diabetic patients. METHODS:Two hundred and forty-six patients with uncontrolled type 2 diabetes mellitus in therapy with different o...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.18433/j3388p

    authors: Derosa G,Maffioli P,Ferrari I,Palumbo I,Randazzo S,D'Angelo A,Cicero AF

    更新日期:2010-01-01 00:00:00

  • Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction Studies?

    abstract::Purpose - The CEIBA cocktail consisting of caffeine (CAF), omeprazole (OZ), dextromethorphan (DM) and losartan (LOS) was previously proposed for the clinical phenotyping of five major human cytochrome P450 (CYP) isoenzymes. This work aimed to assess the usefulness of CEIBA cocktail to study non-clinical drug interacti...

    journal_title:Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    pub_type: 杂志文章

    doi:10.18433/J3D313

    authors: Magalhães P,De Andrés F,Falcão A,LLerena A,Alves G

    更新日期:2016-01-01 00:00:00