Probability and magnitude of response to cardiac resynchronization therapy according to QRS duration and gender in nonischemic cardiomyopathy and LBBB.

Abstract:

BACKGROUND:QRS morphology and QRS duration (QRSd) determine cardiac resynchronization therapy (CRT) candidate selection but criteria require refinement. OBJECTIVE:To assess CRT effect according to QRSd, treated by dichotomization vs a continuous function, and modulation by gender. METHODS:Patients selected were those with New York Heart Association class III/IV heart failure and with left bundle branch block and nonischemic cardiomyopathy (to test "pure" CRT effect) with pre- and postimplant echocardiographic evaluations. Positive response was defined as increased left ventricular ejection fraction (LVEF) post-CRT. RESULTS:In 212 patients (LVEF 19% ± 7.1%; QRSd 160 ± 23 ms; 105 (49.5%) women), CRT increased LVEF to 30% ± 15% (P < .001) during a median follow-up of 2 years. Positive response occurred in 150 of 212 (71%) patients. Genders did not differ for QRSd, pharmacotherapy, and comorbidities, but response to CRT among women was greater: incidence 84% (88 of 105) in women vs 58% (62 of 107) in men (P < .001); increase in LVEF 15% ± 14% vs 7.2% ± 13%, respectively (P < .001). Overall, the response rate was 58% when QRSd <150 ms and 76% when QRSd ≥150 ms (P = .009). This probability differed between genders: 86% in women vs 36% in men (P < .001) when QRSd <150 ms and 83% vs 69%, respectively, when QRSd ≥150 ms (P = .05). Thus, female response rates remained high whether QRSd was <150 ms or ≥150 ms (86% vs 83%; P = .77) but differed in men (36% vs 69%; P < .001). With QRSd as a continuum, the CRT-response relationship was nonlinear and significantly different between genders. Female superiority at shorter QRSd inverted with prolongation >180 ms. CONCLUSION:The QRSd-CRT response relationship in patients with heart failure and with left bundle branch block and nonischemic cardiomyopathy is better described by a sex-specific continuous function and not by dichotomization by 150 ms, which excludes a large proportion of women with potentially favorable outcome.

journal_name

Heart Rhythm

journal_title

Heart rhythm

authors

Varma N,Manne M,Nguyen D,He J,Niebauer M,Tchou P

doi

10.1016/j.hrthm.2014.04.001

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1139-47

issue

7

eissn

1547-5271

issn

1556-3871

pii

S1547-5271(14)00392-0

journal_volume

11

pub_type

杂志文章
  • Ten-year ablation outcomes of patients with paroxysmal atrial fibrillation undergoing pulmonary vein isolation.

    abstract:BACKGROUND:Pulmonary vein isolation (PVI) is commonly performed in patients with drug-refractory symptomatic paroxysmal atrial fibrillation (PAF). However, the very long-term follow-up result is limited. OBJECTIVE:We aimed to investigate 10-year ablation outcomes in patients with PAF and long-term follow-up results af...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2019.03.028

    authors: Cheng WH,Lo LW,Lin YJ,Chang SL,Hu YF,Hung Y,Chung FP,Liao JN,Tuan TC,Chao TF,Tsai TY,Liu SH,Chen SA

    更新日期:2019-09-01 00:00:00

  • Balloon warming time is the strongest predictor of late pulmonary vein electrical reconnection following cryoballoon ablation for atrial fibrillation.

    abstract:BACKGROUND:Pulmonary vein isolation by cryoballoon ablation is an accepted method of treating atrial fibrillation. Little data exist regarding factors affecting late electrical reconnection of pulmonary veins following cryoballoon ablation. OBJECTIVE:To investigate factors determining pulmonary vein reconnection in pa...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2013.06.014

    authors: Ghosh J,Martin A,Keech AC,Chan KH,Gomes S,Singarayar S,McGuire MA

    更新日期:2013-09-01 00:00:00

  • Techniques for successful early retrieval of the Micra transcatheter pacing system: A worldwide experience.

    abstract:BACKGROUND:Experience with retrieval of the Micra transcatheter pacing system (TPS) is limited because of its relatively newer technology. Although abandonment of the TPS at end of life is recommended, certain situations such as endovascular infection or device embolization warrant retrieval. OBJECTIVE:The purpose of ...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2018.02.008

    authors: Afzal MR,Daoud EG,Cunnane R,Mulpuru SK,Koay A,Hussain A,Omar R,Wei KK,Amin A,Kidwell G,Patel N,Love C,Lloyd M,Sterliński M,Goldbarg S,Leal MA,Gabriels J,Patel A,Jadonath R,Grubman E,Crossley G,Pepper C,Lakkire

    更新日期:2018-06-01 00:00:00

  • Safety and efficacy of epicardial cryoablation in a canine model.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the safety and efficacy of cryoablation in a closed chest canine epicardial ablation model. BACKGROUND:Limitations of radiofrequency energy in the epicardial space warrants investigation of alternative energy sources. METHODS:A linear-tip catheter with a 3-cm freez...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2004.09.022

    authors: Lustgarten DL,Bell S,Hardin N,Calame J,Spector PS

    更新日期:2005-01-01 00:00:00

  • Atrial fibrillation occurring during head-up tilt testing: Once detected, atrial fibrillation should be monitored, regardless of how it is detected.

    abstract:BACKGROUND:Atrial fibrillation (AF) often progresses to more sustained forms and increases the risk of ischemic stroke or sinus node dysfunction. However, there have been no data on the clinical outcomes of patients who developed AF during head-up tilt testing (HUT). OBJECTIVE:The purpose of this study was to evaluate...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2018.11.030

    authors: Kim JH,Lee SH,Park SJ,Park KM,On YK,Kim JS

    更新日期:2019-04-01 00:00:00

  • Delayed QRS transition in the precordial leads of an electrocardiogram as a predictor of sudden cardiac death in the general population.

    abstract:BACKGROUND:QRS transition zone is related to the electrical axis of the heart in the horizontal plane and is easily determined from the precordial leads of a standard 12-lead ECG. However, whether delayed QRS transition, or clockwise rotation of the heart, carries prognostic implications and predicts sudden cardiac dea...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2014.08.014

    authors: Aro AL,Eranti A,Anttonen O,Kerola T,Rissanen HA,Knekt P,Porthan K,Tikkanen JT,Junttila MJ,Huikuri HV

    更新日期:2014-12-01 00:00:00

  • Defibrillator implantations for primary prevention in the United States: Inappropriate care or inadequate documentation: Insights from the National Cardiovascular Data ICD Registry.

    abstract:BACKGROUND:Prior studies have reported that more than 20% of implantable cardioverter-defibrillator (ICD) implantations in the United States do not adhere to trial-based criteria. OBJECTIVE:We sought to investigate the patient characteristics associated with not meeting the inclusion criteria of the clinical trials th...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.hrthm.2015.05.010

    authors: Kaiser DW,Tsai V,Heidenreich PA,Goldstein MK,Wang Y,Curtis J,Turakhia MP,National Cardiovascular Data Registry.

    更新日期:2015-10-01 00:00:00

  • Human KCNQ1 S140G mutation is associated with atrioventricular blocks.

    abstract:BACKGROUND:We recently reported that an S140G mutation in human KCNQ1, an alpha subunit of potassium channels, was involved in the pathogenesis of familial atrial fibrillation (AF), but it is not clear whether the mutation is associated with other cardiac arrhythmias. OBJECTIVE:The purpose of this study was to further...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2007.01.029

    authors: Yang Y,Liu Y,Dong X,Kuang Y,Lin J,Su X,Peng L,Jin Q,He Y,Liu B,Pan Z,Li L,Zhu Q,Lin X,Zhou Q,Pan Q,Eurlings PM,Fei J,Wang Z,Chen YH

    更新日期:2007-05-01 00:00:00

  • Comparison of longevity and clinical outcomes of implantable cardioverter-defibrillator leads among manufacturers.

    abstract:BACKGROUND:An early failure of the Biotronik Linox S/SD implantable cardioverter-defibrillator (ICD) lead has been reported. We have also experienced several cases with early failure of Linox leads. OBJECTIVE:Our aim was to assess the longevity of Linox S/SD (Biotronik, Berlin, Germany) compared with Sprint Fidelis (M...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2017.05.020

    authors: Kawada S,Nishii N,Morimoto Y,Miyoshi A,Tachibana M,Sugiyama H,Nakagawa K,Watanabe A,Morita H,Ito H

    更新日期:2017-10-01 00:00:00

  • Endocardial or epicardial ventricular tachycardia in nonischemic cardiomyopathy? The role of 12-lead ECG criteria in clinical practice.

    abstract:BACKGROUND:Specific 12-lead ECG criteria have been reported to predict an epicardial site of origin (SoO) of induced ventricular tachycardias (VTs) in left ventricular nonischemic cardiomyopathy. OBJECTIVE:The purpose of this study was to (1) determine the value of ECG criteria to predict an epicardial SoO of clinical...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2014.03.001

    authors: Piers SR,Silva Mde R,Kapel GF,Trines SA,Schalij MJ,Zeppenfeld K

    更新日期:2014-06-01 00:00:00

  • An alternative under-valve approach to ablate right-sided accessory pathways.

    abstract:BACKGROUND:Right-sided accessory pathway (RAP) ablation is sometimes challenging. OBJECTIVE:Our study aimed to demonstrate an alternative ablation approach to RAPs under the tricuspid valve, especially when the conventional ablation attempts at the atrial side failed. METHODS:Twelve patients with RAPs were enrolled, ...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2018.07.022

    authors: Yang J,Yang G,Chen H,Ju W,Yang B,Zhang F,Jin Y,Cao J,Qian L,Chen M

    更新日期:2019-01-01 00:00:00

  • Adaptive cardiac resynchronization therapy is associated with decreased risk of incident atrial fibrillation compared to standard biventricular pacing: A real-world analysis of 37,450 patients followed by remote monitoring.

    abstract:BACKGROUND:The AdaptivCRT algorithm (aCRT) automatically adjusts atrioventricular delays each minute to achieve ventricular fusion through left ventricular (LV) or biventricular (BiV) pacing. aCRT is associated with superior clinical outcomes compared to standard BiV pacing, but the association of aCRT and subsequent a...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2019.05.012

    authors: Hsu JC,Birnie D,Stadler RW,Cerkvenik J,Feld GK,Birgersdotter-Green U

    更新日期:2019-07-01 00:00:00

  • Cardiac magnetic resonance imaging using wideband sequences in patients with nonconditional cardiac implanted electronic devices.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) has been performed safely in patients without MRI-conditional cardiac implantable electronic devices (CIEDs), but experience specifically with cardiac magnetic resonance imaging (CMR) is limited in this patient population. OBJECTIVE:Evaluate the safety of CMR in non-MRI-cond...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2017.10.003

    authors: Do DH,Eyvazian V,Bayoneta AJ,Hu P,Finn JP,Bradfield JS,Shivkumar K,Boyle NG

    更新日期:2018-02-01 00:00:00

  • Prolonged atrial refractoriness predicts the onset of atrial fibrillation: A 12-year follow-up study.

    abstract:BACKGROUND:Tissue refractoriness to conduction is a crucial electrophysiological factor in determining susceptibility to fibrillation. The relationship between atrial refractoriness and future onset of atrial fibrillation (AF) has not been well studied. OBJECTIVES:We investigated whether atrial effective refractory pe...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2016.03.037

    authors: Lee JM,Lee H,Janardhan AH,Park J,Joung B,Pak HN,Lee MH,Kim SS,Hwang HJ

    更新日期:2016-08-01 00:00:00

  • High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia.

    abstract:BACKGROUND:Atrioventricular nodal reentrant tachycardia (AVNRT) may coexist with Brugada syndrome (BrS). OBJECTIVES:The present study was designed to determine the prevalence of drug-induced type 1 Brugada ECG pattern (concealed BrS) in patients presenting with clinical spontaneous AVNRT and to investigate their elect...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2015.03.015

    authors: Hasdemir C,Payzin S,Kocabas U,Sahin H,Yildirim N,Alp A,Aydin M,Pfeiffer R,Burashnikov E,Wu Y,Antzelevitch C

    更新日期:2015-07-01 00:00:00

  • Color-coded three-dimensional entrainment mapping for analysis and treatment of atrial macroreentrant tachycardia.

    abstract:BACKGROUND:Mapping and ablation of atrial macroreentrant tachycardia focus on activation mapping with identification of the area of slow conduction. OBJECTIVE:The purpose of this study was to evaluate a new concept for analysis and treatment of macroreentrant tachycardia based on color-coded three-dimensional (3D) ent...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2008.12.013

    authors: Esato M,Hindricks G,Sommer P,Arya A,Gaspar T,Bode K,Bollmann A,Wetzel U,Hilbert S,Kircher S,Eitel C,Piorkowski C

    更新日期:2009-03-01 00:00:00

  • Long-term follow-up of patients with cardiac sarcoidosis and implantable cardioverter-defibrillators.

    abstract:BACKGROUND:Ventricular tachyarrhythmias are an important cause of morbidity and mortality in cardiac sarcoidosis. To date, the prevalence and incidence of ventricular tachycardia/ventricular fibrillation (VT/VF) in this population remain unknown. OBJECTIVES:To determine the prevalence and incidence of ventricular tach...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2012.02.010

    authors: Betensky BP,Tschabrunn CM,Zado ES,Goldberg LR,Marchlinski FE,Garcia FC,Cooper JM

    更新日期:2012-06-01 00:00:00

  • Prevalence, characteristics, and prognosis role of type 1 ST elevation in the peripheral ECG leads in patients with Brugada syndrome.

    abstract:BACKGROUND:Despite isolated reports of Brugada syndrome (BrS) in the inferior or lateral leads, the prevalence and prognostic value of ST elevation in the peripheral electrocardiographic (ECG) leads in patients with BrS remain poorly known. OBJECTIVE:To study the prevalence, characteristics, and prognostic value of ty...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.hrthm.2013.03.001

    authors: Rollin A,Sacher F,Gourraud JB,Pasquié JL,Raczka F,Duparc A,Mondoly P,Cardin C,Delay M,Chatel S,Derval N,Denis A,Sadron M,Davy JM,Hocini M,Jaïs P,Jesel L,Haïssaguerre M,Probst V,Maury P

    更新日期:2013-07-01 00:00:00

  • Digital music players cause interference with interrogation telemetry for pacemakers and implantable cardioverter-defibrillators without affecting device function.

    abstract:BACKGROUND:Concern exists regarding the potential electromagnetic interaction between pacemakers, implantable cardioverter-defibrillators (ICDs) and digital music players (DMPs). A preliminary study reported interference in 50% of patients whose devices were interrogated near Apple iPods. OBJECTIVE:Given the high prev...

    journal_title:Heart rhythm

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.hrthm.2008.02.033

    authors: Webster G,Jordao L,Martuscello M,Mahajan T,Alexander ME,Cecchin F,Triedman JK,Walsh EP,Berul CI

    更新日期:2008-04-01 00:00:00

  • Atrial flutter and atrial fibrillation ablation - sequential or combined? A cost-benefit and risk analysis of primary prevention pulmonary vein ablation.

    abstract:BACKGROUND:Recent studies have tested the hypothesis that preventive pulmonary vein isolation (PVI) at time of atrial flutter ablation in patients who have not had atrial fibrillation (AF) will reduce future incidence of AF. OBJECTIVE:To model relative procedural costs, risks, and benefits of sequential versus combine...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2016.02.018

    authors: Gula LJ,Skanes AC,Klein GJ,Jenkyn KB,Redfearn DP,Manlucu J,Roberts JD,Yee R,Tang AS,Leong-Sit P

    更新日期:2016-07-01 00:00:00

  • Prospective, multicenter validation of a clinical risk score for left atrial arrhythmogenic substrate based on voltage analysis: DR-FLASH score.

    abstract:BACKGROUND:Left atrial (LA) low-voltage areas (LVAs) are frequently observed in patients with atrial fibrillation (AF) and may predict AF recurrence after catheter ablation. OBJECTIVE:The aim of this study was to develop and validate a clinical tool to identify LVAs that are associated with AF recurrence after pulmona...

    journal_title:Heart rhythm

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.hrthm.2015.07.003

    authors: Kosiuk J,Dinov B,Kornej J,Acou WJ,Schönbauer R,Fiedler L,Buchta P,Myrda K,Gąsior M,Poloński L,Kircher S,Arya A,Sommer P,Bollmann A,Hindricks G,Rolf S

    更新日期:2015-11-01 00:00:00

  • Utility of high-resolution electroanatomic mapping of the left ventricle using a multispline basket catheter in a swine model of chronic myocardial infarction.

    abstract:BACKGROUND:Standard electroanatomic mapping systems use a single catheter to perform left ventricular substrate mapping. A new mapping system uses a 64-electrode mini-basket catheter to perform rapid automated acquisition of chamber geometry, voltage, and activation. OBJECTIVE:The aim of this study was to compare the ...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2014.08.036

    authors: Tanaka Y,Genet M,Chuan Lee L,Martin AJ,Sievers R,Gerstenfeld EP

    更新日期:2015-01-01 00:00:00

  • Arrhythmogenicity of weight-loss supplements marketed on the Internet.

    abstract:BACKGROUND:We examined nonprescription weight-loss supplements marketed on the Internet for ingredients with potential arrhythmogenic and life-threatening cardiac adverse effects. OBJECTIVE:We aimed to define the risks of life-threatening cardiac adverse effects that are associated with weight-loss supplements markete...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2009.02.021

    authors: Nazeri A,Massumi A,Wilson JM,Frank CM,Bensler M,Cheng J,Saeed M,Rasekh A,Razavi M

    更新日期:2009-05-01 00:00:00

  • Targeted nonviral gene-based inhibition of Gα(i/o)-mediated vagal signaling in the posterior left atrium decreases vagal-induced atrial fibrillation.

    abstract:BACKGROUND:Pharmacologic and ablative therapies for atrial fibrillation (AF) have suboptimal efficacy. Newer gene-based approaches that target specific mechanisms underlying AF are likely to be more efficacious in treating AF. Parasympathetic signaling appears to be an important contributor to AF substrate. OBJECTIVE:...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2011.06.018

    authors: Aistrup GL,Cokic I,Ng J,Gordon D,Koduri H,Browne S,Arapi D,Segon Y,Goldstein J,Angulo A,Wasserstrom JA,Goldberger JJ,Kadish AH,Arora R

    更新日期:2011-11-01 00:00:00

  • Epicardial but not endocardial premature stimulation initiates ventricular tachyarrhythmia in canine in vitro model of long QT syndrome.

    abstract:OBJECTIVES:To explore the mechanism, we tested the hypothesis that premature epicardial stimulation transiently increased the dispersion of repolarization leading to VT. BACKGROUND:Premature stimulation initiated ventricular tachycardia (VT) when applied to the epicardium but not to the endocardium in a canine model o...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2004.07.019

    authors: Ueda N,Zipes DP,Wu J

    更新日期:2004-12-01 00:00:00

  • Outcomes of long-standing persistent atrial fibrillation ablation: a systematic review.

    abstract:BACKGROUND:Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes. OBJECTIVE:The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ...

    journal_title:Heart rhythm

    pub_type: 杂志文章,评审

    doi:10.1016/j.hrthm.2010.01.017

    authors: Brooks AG,Stiles MK,Laborderie J,Lau DH,Kuklik P,Shipp NJ,Hsu LF,Sanders P

    更新日期:2010-06-01 00:00:00

  • History and clinical significance of early repolarization syndrome.

    abstract::The early repolarization (ER) pattern has historically been regarded as a benign ECG variant. However, in recent years this view has been challenged based on multiple reports linking the ER pattern with an increased risk of sudden cardiac death. The mechanistic basis of ventricular arrhythmogenesis in ER syndrome is p...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2014.09.048

    authors: Mahida S,Derval N,Sacher F,Berte B,Yamashita S,Hooks DA,Denis A,Lim H,Amraoui S,Aljefairi N,Hocini M,Jais P,Haissaguerre M

    更新日期:2015-01-01 00:00:00

  • A novel algorithm increases the delivery of effective cardiac resynchronization therapy during atrial fibrillation: The CRTee randomized crossover trial.

    abstract:BACKGROUND:Cardiac resynchronization therapy (CRT) requires a high percentage of ventricular pacing (%Vp) to maximize its clinical benefits. Atrial fibrillation (AF) has been shown to reduce %Vp in CRT due to competition with irregular intrinsic atrioventricular (AV) conduction. We report the results of a prospective r...

    journal_title:Heart rhythm

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.hrthm.2017.10.026

    authors: Plummer CJ,Frank CM,Bári Z,Al Hebaishi YS,Klepfer RN,Stadler RW,Ghosh S,Liu S,Mittal S

    更新日期:2018-03-01 00:00:00

  • Caring for the pregnant woman with an inherited arrhythmia syndrome.

    abstract::Pregnancy is a period of increased cardiovascular risk in a woman's life. In the setting of an inherited arrhythmia syndrome (IAS), cardiologists and obstetricians may be unfamiliar with cardiovascular optimization and risk stratification in pregnancy. Historically, there were little data addressing the safety of preg...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2019.08.004

    authors: Roston TM,van der Werf C,Cheung CC,Grewal J,Davies B,Wilde AAM,Krahn AD

    更新日期:2020-02-01 00:00:00

  • Small-conductance calcium-activated potassium current modulates the ventricular escape rhythm in normal rabbit hearts.

    abstract:BACKGROUND:The apamin-sensitive small-conductance calcium-activated K (SK) current IKAS modulates automaticity of the sinus node. IKAS blockade by apamin causes sinus bradycardia. OBJECTIVE:The purpose of this study was to test the hypothesis that IKAS modulates ventricular automaticity. METHODS:We tested the effects...

    journal_title:Heart rhythm

    pub_type: 杂志文章

    doi:10.1016/j.hrthm.2018.10.033

    authors: Wan J,Chen M,Wang Z,Everett TH 4th,Rubart-von der Lohe M,Shen C,Qu Z,Weiss JN,Boyden PA,Chen PS

    更新日期:2019-04-01 00:00:00