Role of interface coupling inhomogeneity in domain evolution in exchange bias.

abstract：:Toll-like receptor 9 (TLR9) is crucial to the host immune response against fungi, such as Candida albicans, Aspergillus fumigatus and Cryptococcus neoformans, but its importance in Cryptococcus gattii infection is unknown. Our study aimed to understand the role of TLR9 during the course of experimental C. gattii infec...

journal_title：Scientific reports

authors： da Silva-Junior EB,Firmino-Cruz L,Guimarães-de-Oliveira JC,De-Medeiros JVR,de Oliveira Nascimento D,Freire-de-Lima M,de Brito-Gitirana L,Morrot A,Previato JO,Mendonça-Previato L,Decote-Ricardo D,de Matos Guedes HL,Freire-de-Lima

更新日期：2021-01-14 00:00:00

abstract：:Organotypic, three-dimensional (3D) cancer models have enabled investigations of complex microtissues in increasingly realistic conditions. However, a drawback of these advanced models remains the poor biological relevance of cancer cell lines, while higher clinical significance would be obtainable with patient-derive...

journal_title：Scientific reports

authors： Ahonen I,Åkerfelt M,Toriseva M,Oswald E,Schüler J,Nees M

更新日期：2017-07-26 00:00:00

abstract：:An optical radon detection method is presented. Radon decay is directly measured by observing the secondary radiolumines cence light that alpha particles excite in air, and the selectivity of coincident photon detection is further enhanced with online pulse-shape analysis. The sensitivity of a demonstration device was...

journal_title：Scientific reports

authors： Sand J,Ihantola S,Peräjärvi K,Toivonen H,Toivonen J

更新日期：2016-02-12 00:00:00

abstract：:Serotonin (5-HT) is an important neurotransmitter and neuromodulator that controls a variety of sensory and motor functions through 5-HT receptors (5-HTRs). The 5-HT4R subfamily is linked to Gs proteins, which activate adenylyl cyclases (ACs), and is involved in many responses in peripheral organs. In this study, the ...

journal_title：Scientific reports

authors： Wang T,Yang Z,Zhou N,Sun L,Lv Z,Wu C

更新日期：2017-01-06 00:00:00

abstract：:In the epoch of the Anthropocene change, complexity, and uncertainty create a demand for new systems of water management and governance. One such management model that is rapidly gaining traction amongst both scholars and practitioners is the concept of water resilience. Although increasing attention has been paid to ...

journal_title：Scientific reports

authors： Baird J,Dale G,Farhad S

更新日期：2020-04-06 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a uniformly fatal condition of striated muscle wasting resulting in premature death from respiratory and/or cardiac failure. Symptomatic therapy has prolonged survival by limiting deaths resulting from respiratory insufficiency, but there is currently no effective therapy for most ...

journal_title：Scientific reports

authors： Fischer KD,Heitzman JA,Townsend D

更新日期：2019-08-23 00:00:00

abstract：:Intractable diseases such as cancer are associated with breakdown in multiple individual functions, which conspire to create unhealthy phenotype-combinations. An important challenge is to decipher how these functions are coordinated in health and disease. We approach this by drawing on dynamical systems theory. We pos...

journal_title：Scientific reports

authors： Deritei D,Aird WC,Ercsey-Ravasz M,Regan ER

更新日期：2016-03-16 00:00:00

abstract：:Our previous study suggested that microtubule network alteration affects the process of glycolysis in cardiomyocytes (CMs) via the regulation of hypoxia-inducible factor (HIF)-1α during the early stages of hypoxia. However, little is known regarding the underlying mechanisms of microtubule network alteration-induced c...

journal_title：Scientific reports

authors： Jiang X,Zhang D,Zhang H,Huang Y,Teng M

更新日期：2015-03-17 00:00:00

abstract：:The attenuated Sabin strains contained in the oral poliomyelitis vaccine are genetically unstable, and their circulation in poorly immunized populations can lead to the emergence of pathogenic circulating vaccine-derived polioviruses (cVDPVs). The recombinant nature of most cVDPV genomes and the preferential presence ...

journal_title：Scientific reports

authors： Bessaud M,Joffret ML,Blondel B,Delpeyroux F

更新日期：2016-12-13 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited therapeutic options. KCa3.1 ion channels play a critical role in TGFβ1-dependent pro-fibrotic responses in human lung myofibroblasts. We aimed to develop a human lung parenchymal model of fibrogenesis and test the efficacy of t...

journal_title：Scientific reports

authors： Roach KM,Sutcliffe A,Matthews L,Elliott G,Newby C,Amrani Y,Bradding P

更新日期：2018-01-10 00:00:00

abstract：:As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are...

journal_title：Scientific reports

authors： Batista EMCC,Shultz J,Matos TTS,Fornari MR,Ferreira TM,Szpoganicz B,de Freitas RA,Mangrich AS

更新日期：2018-07-16 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) form the largest transcript class in the human transcriptome. These lncRNA are expressed not only in the cells, but they are also present in the cell-derived extracellular vesicles such as exosomes. The function of these lncRNAs in cancer biology is not entirely clear, but they appear to...

journal_title：Scientific reports

authors： Ahadi A,Brennan S,Kennedy PJ,Hutvagner G,Tran N

更新日期：2016-04-22 00:00:00

abstract：:Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodruse...

journal_title：Scientific reports

authors： Mishra Z,Ganegoda A,Selicha J,Wang Z,Sadda SR,Hu Z

更新日期：2020-06-12 00:00:00

abstract：:Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory...

journal_title：Scientific reports

authors： Kim E,Park S,Choi N,Lee J,Yoe J,Kim S,Jung HY,Kim KT,Kang H,Fryer JD,Zoghbi HY,Hwang D,Lee Y

更新日期：2015-02-05 00:00:00

abstract：:Constrained by the diffraction limit, a lens can only resolve features larger than half of the incident wavelength owing to the decaying nature of evanescent waves. Several novel devices have been proposed, for example, superlenses and hyperlenses to break this limit. In this work, we present a flat hyperlens composed...

journal_title：Scientific reports

authors： Tao CW,Yen TJ,Huang TY

更新日期：2020-03-24 00:00:00

abstract：:Accurate repair of DNA damage is crucial to ensure genome stability and cell survival of all organisms. Bile functions as a defensive barrier against intestinal colonization by pathogenic microbes. Campylobacter jejuni, a leading bacterial cause of foodborne illness, possess strategies to mitigate the toxic components...

journal_title：Scientific reports

authors： Gourley CR,Negretti NM,Konkel ME

更新日期：2017-10-31 00:00:00

abstract：:To increase the yield potential while limiting the environmental impact of N management practices is an important issue in rice cultivation. The large-grain rice cultivar Akita 63 showed higher N-use efficiency for grain production. To elucidate this, we analyzed yield characteristics of Akita 63 in comparison with th...

journal_title：Scientific reports

authors： Makino A,Kaneta Y,Obara M,Ishiyama K,Kanno K,Kondo E,Suzuki Y,Mae T

更新日期：2020-07-22 00:00:00

abstract：:Electrochemical nanosensors based on nanoporous gold leaf (NPGL) and molecularly imprinted polymer (MIP) are developed for pharmaceutical analysis by using metronidazole (MNZ) as a model analyte. NPGL, serving as the loading platform for MIP immobilization, possesses large accessible surface area with superb electric ...

journal_title：Scientific reports

authors： Li Y,Liu Y,Liu J,Liu J,Tang H,Cao C,Zhao D,Ding Y

更新日期：2015-01-09 00:00:00

abstract：:Evidence suggest that overexpression of hypoxia-inducible factor-1α (HIF-1α) is linked to multidrug resistance of epilepsy. Here we explored whether aberrant expression of HIF-1α is regulated by miRNAs. Genome-wide microRNA expression profiling was performed on temporal cortex resected from mesial temporal lobe epilep...

journal_title：Scientific reports

authors： Li Y,Huang C,Feng P,Jiang Y,Wang W,Zhou D,Chen L

更新日期：2016-08-24 00:00:00

abstract：:With the reduction of oil and gas reserves and the increase of mining difficulty in Northern China, the carbonate rocks in Southern North China Basin are becoming a significant exploration target for carbonate reservoirs. However, the development characteristics, formation stages, formation environments and mechanisms...

journal_title：Scientific reports

authors： Zhang H,Xu G,Liu M,Wang M

更新日期：2021-01-12 00:00:00

abstract：:In the last few years, significant changes in climate have had a disparate effect on biodiversity. The influences of these changes are random and unpredictable. The resurgence of insect pests, especially of medical and veterinary importance, often corresponds with climate changes. The Old World screwworm, Chrysomya be...

journal_title：Scientific reports

authors： Hosni EM,Nasser MG,Al-Ashaal SA,Rady MH,Kenawy MA

更新日期：2020-03-18 00:00:00

abstract：:Adherence to cardioprotective medications following myocardial infarction (MI) is commonly assessed using a binary threshold of 80%. We investigated the relationship between medication adherence as a continuous measure and outcomes in MI survivors using restricted cubic splines (RCS). We identified all patients aged ≥...

journal_title：Scientific reports

authors： Greenland M,Knuiman MW,Hung J,Nedkoff L,Arnet I,Rankin JM,Kilkenny MF,Sanfilippo FM

更新日期：2020-03-09 00:00:00

abstract：:Actinorhizal plants are ecologically and economically important. Symbiosis with nitrogen-fixing bacteria allows these woody dicotyledonous plants to colonise soils under nitrogen deficiency, water-stress or other extreme conditions. However, proteins involved in xerotolerance of symbiotic microorganisms have yet to be...

journal_title：Scientific reports

authors： Ghedira K,Harigua-Souiai E,Ben Hamda C,Fournier P,Pujic P,Guesmi S,Guizani I,Miotello G,Armengaud J,Normand P,Sghaier H

更新日期：2018-01-15 00:00:00

abstract：:One of the health hazards of PM2.5 exposure is to induce pulmonary inflammatory responses. In our previous study, we demonstrated that exposing both the immortalized and primary human bronchial epithelial cells to PM2.5 results in a significant upregulation of VEGF production, a typical signaling event to trigger chro...

journal_title：Scientific reports

authors： Xu H,Xu X,Wang H,Qimuge A,Liu S,Chen Y,Zhang C,Hu M,Song L

更新日期：2019-11-12 00:00:00

abstract：:Adipose tissue plays a major role in regulating whole-body insulin sensitivity and energy metabolism. To accommodate surplus energy, the tissue rapidly expands by increasing adipose cell size (hypertrophy) and cell number (hyperplasia). Previous studies have shown that enlarged, hypertrophic adipocytes are less respon...

journal_title：Scientific reports

authors： Hansson B,Morén B,Fryklund C,Vliex L,Wasserstrom S,Albinsson S,Berger K,Stenkula KG

更新日期：2019-09-10 00:00:00

abstract：:Kaposiform hemangioendothelioma (KHE) is a relatively rare vascular tumor with an aggressive and infiltrating nature. Previous studies have revealed an exclusive relationship between KHE and Kasabach-Merritt Phenomenon (KMP), which is associated with high morbidity and mortality. No universally accepted treatment moda...

journal_title：Scientific reports

authors： Wu HW,Wang X,Zhang L,Zhao HG,Wang YA,Su LX,Fan XD,Zheng JW

更新日期：2016-10-31 00:00:00

abstract：:Complex interactions occur between tumor and host immune system at each site in the metastatic setting, the outcome of which can determine behavior ranging from dormancy to rapid growth. An additional layer of complexity arises from the understanding that cytotoxic T cells can traffic through the host circulatory syst...

journal_title：Scientific reports

authors： Walker R,Poleszczuk J,Pilon-Thomas S,Kim S,Anderson AARA,Czerniecki BJ,Harrison LB,Moros EG,Enderling H

更新日期：2018-06-21 00:00:00

abstract：:The role of marginal populations for the long-term maintenance of species' genetic diversity and evolutionary potential is particularly timely in view of the range shifts caused by climate change. The Centre-Periphery hypothesis predicts that marginal populations should bear reduced genetic diversity and have low evol...

journal_title：Scientific reports

authors： Ciborowski K,Jordan WC,Garcia de Leaniz C,Consuegra S

更新日期：2017-02-10 00:00:00

abstract：:An impairment of cardiac function is a key feature of the cardiovascular failure associated with sepsis. Although there is some evidence that suppression of sarcoplasmic reticulum Ca2+-ATP-ase (SERCA2) contributes to septic cardiomyopathy, it is not known whether prevention of the down-regulation of SERCA2 improves ou...

journal_title：Scientific reports

authors： Martin L,Horst K,Chiazza F,Oggero S,Collino M,Brandenburg K,Hildebrand F,Marx G,Thiemermann C,Schuerholz T

更新日期：2016-11-17 00:00:00

abstract：:Leaf functional traits have attracted the attention of ecologists for several decades, but few studies have systematically assessed leaf morphological traits (termed "economic traits"), stomatal (termed "hydraulic"), and anatomical traits of entire forest communities, thus it is unclear whether their relationships are...

journal_title：Scientific reports

authors： Liu C,Li Y,Xu L,Chen Z,He N

更新日期：2019-04-09 00:00:00