The multidisciplinary management of giant cell tumor of bone.

Abstract:

:Giant cell tumor of bone is a locally aggressive lesion with a predilection for local recurrence, and in a small proportion of patients, metastatic disease can develop. Surgery is the mainstay of management for extremity-based lesions. For tumors located in challenging anatomical locations such as the sacrum and spine however, surgery may be associated with unacceptable functional morbidity. There are limited data regarding other treatment modalities such as radiation therapy, cytotoxic chemotherapy, interferon and bisphosphonates. Serial arterial embolization can be effective in some cases. Recent evidence has demonstrated denosumab to be a promising agent in the treatment of unresectable or metastatic disease.

authors

Ng VY,Davidson DJ,Kim EY,Pollack SM,Conrad Iii EU,Jones RL

doi

10.1586/14737140.2014.901891

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

783-90

issue

7

eissn

1473-7140

issn

1744-8328

journal_volume

14

pub_type

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