Abstract：
PURPOSE:Loosening of implants occurs mainly for two reasons: bacterial infection of the implant or "aseptic loosening" presumably due to wear particles derived from the implant. To gain further insight into the pathomechanism, we analysed activation of the T cell response in these patients. METHODS:Activation of peripheral T lymphocytes was determined by cytofluorometry as down-regulation of CD28 and up-regulation of CD11b. In addition, tissue samples obtained during surgery were analysed by quantitative RT-PCR for gene expression of CD3, CD14 and cathepsin K, as markers for T cells, monocytes/macrophages or osteoclasts, respectively. RESULTS:Activated T lymphocytes were detected in patients with infection but not in patients with aseptic loosening. Gene expression of CD3 was significantly enhanced in tissues of patients with infection compared to those with aseptic loosening. Expression of CD14 and of cathepsin K did not differ between the two groups. CONCLUSION:Implant-associated infection and aseptic loosening are associated with a local inflammatory response, which eventually results in osteoclastogenesis and bone resorption. Systemic T cell activation, in contrast, occurs only in patients with implant-associated infection, and hence analysis of T cell activation markers could serve as a diagnostic tool to differentiate between the two entities.
journal_name
Int Orthopjournal_title
International orthopaedicsauthors
Dapunt U,Giese T,Prior B,Gaida MM,Hänsch GMdoi
10.1007/s00264-014-2310-5subject
Has Abstractpub_date
2014-06-01 00:00:00pages
1291-6issue
6eissn
0341-2695issn
1432-5195journal_volume
38pub_type
杂志文章abstract：PURPOSE:Heterotopic ossification is a common complication after total hip arthroplasty. Non-steroidal anti-inflammatory drugs (NSAIDs) are known to prevent heterotopic ossifications effectively, however gastrointestinal complaints are reported frequently. In this study, we investigated whether etoricoxib, a selective c...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-1781-0
更新日期：2013-04-01 00:00:00
abstract：:We reviewed a consecutive series of 19 patients with comminuted periprosthetic fractures, loosening of the femoral stem (Vancouver type B3) and significant loss of bone stock (Paprosky type III and IV). Sixteen porous-coated long stems and three Exeter stems, all with impaction grafting, were used. Large femoral onlay...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-002-0423-8
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:Percutaneous endoscopic discectomy is an effective minimally invasive spine surgery (MISS) for soft disc herniations. The objective of this review was to describe the current indications, surgical techniques, and clinical outcomes of endoscopic spine surgery. METHODS:A narrative review was performed with a foc...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-018-04283-w
更新日期：2019-04-01 00:00:00
abstract：:The purpose of this study was to evaluate concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Bone marrow was aspirated from iliac crests, concentrated on a conventional manual blood b...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-010-1048-y
更新日期：2011-06-01 00:00:00
abstract：:Twenty-eight arthrodeses of the wrist were carried out for various indications using an ulnar graft. The results were evaluated and it was found that the obliquely resected lower end of the ulna gave a longer graft for better fusion between the distal end of radius and the base of the 3rd metacarpal. There was no inst...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00180131
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:To assess histological changes and possible differences in the quadriceps of patients undergoing open repair of the tendon after spontaneous rupture, and subjects with no history of tendon pathology. MATERIALS:Biopsies were harvested from the quadriceps tendon of 46 patients (34 men, 12 women) who had reported...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-012-1637-z
更新日期：2012-11-01 00:00:00
abstract：:We evaluated the pre- and postoperative neurological state of 3 patients with lumbar intradural lipoma. Total resection of the lipoma in the cauda equina was impossible, and partial resection and expansive laminoplasty was carried out. Subsequent neural involvement may depend on the duration of symptoms rather than th...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640050147
更新日期：1997-01-01 00:00:00
abstract：PURPOSE:Intramedullary screw fixation is currently considered the gold standard treatment for Jones fractures in the athlete. Besides biological factors (i.e., poor vascularization), mechanical instability induced by the pull of the peroneus brevis tendon (PBT) contributes to deficient Jones fracture healing. This biom...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-020-04581-2
更新日期：2020-07-01 00:00:00
abstract：:Five hundred and fifteen children with single segment non-physeal extremity fractures were retrospectively reviewed. The male to female ratio was 2.7:1. The average age of study group was 9.9+/-4.7 years; 273 fractures (53%) were on the left, 242 (47%) were on the right. A fall was the main cause of the injury in most...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640050388
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to compare the clinical outcomes of mobile-bearing unicompartmental knee arthroplasty (MB-UKA) and open-wedge high tibial osteotomy (OWHTO) for advanced isolated medial osteoarthritis (OA). METHODS:Patients with advanced medial compartment OA (Ahlbäck grade ≥ II) who underwent ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-018-3880-4
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:The aim of this study was to assess the anatomical results, functional results and the incidence of arthritis of a mixed intra- and extra-articular hamstring tendon based reconstruction for anterior instability of the knee. METHODS:This retrospective study consists of 100 knees in 99 patients (22 female and 77...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-1957-7
更新日期：2013-08-01 00:00:00
abstract：:The purpose of this study was to evaluate the outcome of subcoracoid pectoralis major transfer for the treatment of irreparable anterosuperior rotator cuff tears. This type of tear involves complete rupture of the subscapularis in combination with either the supraspinatus alone or the supraspinatus and infraspinatus. ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-009-0799-9
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:Controversy still surrounds the optimal treatment for patients with displaced intra-articular calcaneal fractures (DIACF). An up-to-date meta-analysis was performed to evaluate clinical effectiveness of surgical treatment for DIACF compared with nonsurgical treatment. METHODS:We systematically searched four el...
journal_title：International orthopaedics
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00264-012-1563-0
更新日期：2012-08-01 00:00:00
abstract：:Over 10 years, 842 consecutive autopsies on patients dying from a malignant neoplasm were evaluated microscopically to determine the incidence of spinal and skeletal metastases. Vertebral wedging, sclerosis and areas of osteolysis were defined as features of spinal metastases. The incidence was 30.6%, 65% of which aro...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00181116
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To evaluate the safety and efficacy of a novel technique of preconditioning autologous blood with gold particles (GOLDIC®) and injection in patients with moderate to severe knee osteoarthritis (KOA). METHODS:During this phase 2a, proof-of-concept (PoC) open label study, 83 consecutive patients that 64 patients...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-020-04870-w
更新日期：2021-02-01 00:00:00
abstract：:A woman aged 31 had an ameloblastoma of the inferior part of the maxilla treated by excision and a bone graft from the iliac crest. Nine years later she presented with a metastasis from the tumour at the donor site. Metastases from an ameloblastoma are rarely encountered. In this case there might have been contaminati...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00180180
更新日期：1994-02-01 00:00:00
abstract：PURPOSE:The rapidly growing and emerging nature of biologics have made indications for regenerative and reparative hip therapies ever changing, with at times only early-stage evidence for their use. The purpose of this study was to review and summarize the currently available data on the management of hip cartilage inj...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-020-04789-2
更新日期：2021-02-01 00:00:00
abstract：:The aim of this investigation was to examine the effect of short-term immobilization on subchondral cortical and trabecular bone tissue in the rat tibia and to determine whether there was any difference when the knee was immobilized in extension or flexion. Thirty-six male rats were used in this study, and in 18 the k...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00266984
更新日期：1988-01-01 00:00:00
abstract：PURPOSE:The aim of the present study was to compare the daily activity and functionality in a patient cohort 12 months after total hip arthroplasty (THA) using a direct anterior approach with a healthy non-operated control population. METHODS:Sixty-four patients who underwent THA and 59 healthy individuals (control) w...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-017-3541-z
更新日期：2018-02-01 00:00:00
abstract：:The Register for Orthopaedic Prosthetic Implantation (RIPO) has been prospectively collecting data on hip prostheses performed in all the orthopaedic units in the region Emilia-Romagna since January 2000. The register aims to determine the characteristics of patients, evaluate the effectiveness of prostheses, and allo...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-007-0465-z
更新日期：2009-04-01 00:00:00
abstract：PURPOSE:The disease activity score including 28 joints (DAS28), the simplified disease activity index and the clinical disease activity index (CDAI) were developed in order to provide a quantifiable measure of rheumatoid arthritis (RA) activity. Although inflamed hip joints greatly impact activities of daily living (AD...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-013-1900-y
更新日期：2013-07-01 00:00:00
abstract：:Between 1971 and 1987, we treated 26 patients with congenital absence of the radius which had produced a club hand; 37 hands were affected. Treatment before the age of 8 months was by gentle manipulation and serial plasters. If a functional position was not obtained, and in patients over 8 months, surgical reduction w...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00194186
更新日期：1993-01-01 00:00:00
abstract：:The healing of flexor tendons was studied in chickens using transmission electron microscopy. After resecting the flexor sheath between the proximal and distal pulleys in zone II, the profundus tendon was severed and sutured. Intermittent passive motion was carried out 35 times daily immediately afterwards. The chicke...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00189620
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:This prospective randomized trial is to determine the effectiveness of treating lumbar facet syndrome with oral diclofenac, methylprednisolone facet joint injection or both. METHODS:We enrolled lumbar facet syndrome patients treated at Srinagarind Hospital. Enrolled patients were randomly assigned to receive 1...
journal_title：International orthopaedics
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00264-016-3154-y
更新日期：2016-06-01 00:00:00
abstract：:The objective of this study was to select factors related to the prognosis and curative effect for posterolateral fusion (PLF) of lumbar low-grade isthmic spondylolisthesis (LGIS). Of 125 patients who accepted PLF treatment, 119 obtained solid union in this prospective study. Statistical analysis was used to evaluate ...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-008-0627-7
更新日期：2009-10-01 00:00:00
abstract：:This transtrochanteric approach to the hip maintains continuity between the greater trochanter and the vastus lateralis muscle, thereby preventing the gross displacement of the greater trochanter and preserving the branches of the lateral circumflex vessels to it. The procedure offers the advantages of easy exposure a...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/BF00265739
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:The aim of paper is to check how many preliminary reports (PR) reach a long-term publication (LT), and analyse differences in outcomes and complications between them. METHODS:A literature search was performed to identify shoulder preliminary or early reports. Fifty one papers fulfilled criteria and were c...
journal_title：International orthopaedics
pub_type： 杂志文章,评审
doi：10.1007/s00264-016-3228-x
更新日期：2017-05-01 00:00:00
abstract：:Between February 1996 and July 2000 eight patients (ages 35-74 years) with nine severely impacted humeral head fractures were operated on with the aim of preserving the humeral heads. Patients were treated surgically with open reduction, autologous bone grafting, and internal fixation with a screw-wiring technique. Th...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640100298
更新日期：2002-01-01 00:00:00
abstract：:We treated surgically 14 patients with symptomatic complete dislocation of the acromioclavicular joint. The surgical procedure included reconstruction of the coracoclavicular ligament using the coracoacromial ligament as substitute, reconstruction of the acromioclavicular ligament, and imbrications of the deltotrapezi...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s00264-003-0520-3
更新日期：2004-04-01 00:00:00
abstract：:In this study the authors present the results of 44 patients with 49 interfascicular nerve grafting procedures necessitated by gunshot wounds. The aim was to establish the effectiveness of microsurgical interfascicular nerve grafting for war injuries. The 49 interfascicular nerve grafting procedures were performed bet...
journal_title：International orthopaedics
pub_type： 杂志文章
doi：10.1007/s002640050036
更新日期：1996-01-01 00:00:00
