Abstract:
:The use of atypical antipsychotic agents has rapidly increased in the United States and worldwide in the last decade. Nonetheless, many health care practitioners do not appreciate the significance of the cardiovascular side effects that may be associated with their use and the means to minimize them. Thus, atypical antipsychotic medications can cause cardiovascular side effects such as arrhythmias and deviations in blood pressure. In rare cases, they may also cause congestive heart failure, myocarditis, and sudden death. Patients with schizophrenia have a higher risk of cardiovascular mortality than healthy individuals, possibly because of excessive smoking, the underlying disorder itself, or a combination of both factors. Increased awareness of these potential complications can allow pharmacists and physicians to better manage and monitor high risk patients. Accurate assessments are very important to avoid medications from being given to patients inappropriately. Additionally, monitoring patients regularly via blood draws and checking blood pressure, heart rate, and electrocardiogram can help catch any clinical problems and prevent further complications. Finally, patient and family-member education, which pharmacists in particular can play key roles in, is central for the management and prevention of side effects, which is known to reflect positively on morbidity and mortality in these patients.
journal_name
Cardiol Res Practjournal_title
Cardiology research and practiceauthors
Khasawneh FT,Shankar GSdoi
10.1155/2014/273060subject
Has Abstractpub_date
2014-01-01 00:00:00pages
273060eissn
2090-8016issn
2090-0597journal_volume
2014pub_type
杂志文章,评审abstract:Background:Australian guidelines advocate primary percutaneous coronary intervention (PPCI) as the reperfusion strategy of choice for ST elevation myocardial infarction (STEMI) in patients in whom it can be performed within 90 minutes of first medical contact; otherwise, fibrinolytic therapy is preferred. In a large he...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2018/2951860
更新日期:2018-05-21 00:00:00
abstract::Background. Endothelial function is impaired in chronic heart failure (CHF). Statins upregulate endothelial NO synthase (eNOS) and improve endothelial function. Recent studies demonstrated that HDL stimulates NO production due to eNOS phosphorylation at Ser(1177), dephosphorylation at Thr(495), and diminished phosphor...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2016/4826102
更新日期:2016-01-01 00:00:00
abstract::Myocardial edema is one of the most common complications of coronary artery bypass grafting (CABG) that is linearly related to many coronary artery diseases. Myocardial edema can cause several consequences including systolic dysfunction, diastolic dysfunction, arrhythmia, and cardiac tissue fibrosis that can increase ...
journal_title:Cardiology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/3979630
更新日期:2020-05-20 00:00:00
abstract::Aims. Dysregulated expression of the endothelial nitric oxide synthase (eNOS) is observed in aortic aneurysms associated with bicuspid aortic valve (BAV). We determined eNOS protein levels in various areas in ascending aortic aneurysms. Methods and Results. Aneurysmal specimens were collected from 19 patients, 14 with...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2012/165957
更新日期:2012-01-01 00:00:00
abstract::Objective. To identify modifiable neighborhood factors and quantify their effect on the rate of revascularization among acute myocardial infarction (AMI) patients. Method. Using the New York City hospital discharge records during 1998-2002, we employed a hierarchical regression model that integrates patient-level risk...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2011/348527
更新日期:2011-01-01 00:00:00
abstract::Background. Currently there are no reliable predictors of response to cardiac resynchronization therapy (CRT) before implantation. We compared pre-CRT left ventricular (LV) dyssynchrony by tissue Doppler imaging (TDI) and regional volumetric analysis by 3-dimensional transthoracic echocardiography (3DTTE) in predictin...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2011/568918
更新日期:2010-12-22 00:00:00
abstract::Background. Right ventricular pacing (RVP) has been associated with adverse outcomes, including heart failure and death. Minimizing RVP has been proposed as a therapeutic goal for a variety of pacing devices and indications. Objective. Quantify survival according to frequency of RVP in veterans with pacemakers. Method...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2010/310768
更新日期:2010-01-01 00:00:00
abstract::Incidence of sudden cardiac death (SCD) in end-stage renal disease (ESRD) remains high. Limited data is available about whether implantable cardioverter-defibrillators (ICDs) can prevent arrhythmic death in patients with chronic kidney disease (CKD). The purpose of this retrospective study was to determine the impact ...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2010/989261
更新日期:2010-08-03 00:00:00
abstract::Background. Neurohormonal systems play an important role in chronic heart failure (CHF). Due to interindividual heterogeneity in the benefits of therapy, it may be hypothesized that polymorphisms of neurohormonal systems may affect left ventricular (LV) remodelling and systolic function. We aimed to assess whether gen...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2011/798658
更新日期:2011-01-05 00:00:00
abstract::GLP-1 is a new type of antidiabetic agent that possesses many beneficial effects. Although its cardiovascular actions have been widely examined, little is known about GLP-1's effects on the rat coronary artery (RCA) or about the mechanisms underpinning these effects. Here, we report that GLP-1 inhibits depolarization-...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2019/1968785
更新日期:2019-10-23 00:00:00
abstract:Purpose:Ivabradine has emerged as a new antiarrhythmic agent that could compete with the traditional ones, such as beta-blockers. This experimental study aims to ascertain whether ivabradine directly interferes with the myocardial contractility in an in vitro environment. Methods:Myocardial tissues from the right atri...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2019/7512318
更新日期:2019-10-30 00:00:00
abstract::Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2019/7395239
更新日期:2019-12-23 00:00:00
abstract:Objective:Coronary revascularization in chronic total occlusion (CTO) is associated with improved clinical outcomes. The choice of the coronary stent is crucial in maintaining long-term vessel patency after CTO revascularization. We investigated the efficacy and safety of polymer-free ultrathin strut sirolimus-probucol...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2018/8053168
更新日期:2018-03-01 00:00:00
abstract::This paper reviews the current evidence regarding long-chained marine omega-3 polyunsaturated fatty acids (PUFAs) and cardiovascular disease (CVD), their possible mechanisms of action, and results of clinical trials. Also, primary and secondary prevention trials as studies on antiarrhythmic effects and meta-analyses a...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2012/303456
更新日期:2012-01-01 00:00:00
abstract::Metabolic syndrome (MetS) is a clinical syndrome that consists of visceral obesity, dyslipidemia, hypertension, and impaired insulin sensitivity. Although individual components of MetS have been implicated in the development of chronic kidney disease (CKD), few studies have examined the effect of combinations of the c...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2011/963517
更新日期:2010-10-07 00:00:00
abstract::Aneurysms of saphenous vein grafts are rare but can result in complications such as myocardial infarction or death. Percutaneous treatment has included a variety of approaches, including covered stents. Long aneurysms in saphenous vein grafts pose an additional challenge due to the lack of coronary covered stents with...
journal_title:Cardiology research and practice
pub_type:
doi:10.4061/2009/981292
更新日期:2009-01-01 00:00:00
abstract::Pathophysiology of heart failure has been considered to be a damaged state of systolic function of the heart followed by a state of low cardiac output that is, systolic heart failure. Even if systolic function is preserved, left ventricular filling in diastole can be impeded and resulted in elevation of filling pressu...
journal_title:Cardiology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2013/824135
更新日期:2013-01-01 00:00:00
abstract::Giant cell myocarditis is an aggressive form of this condition that is typically progressive and unresponsive to usual medical treatment. Here, we describe a 34-year-old patient presenting with incessant ventricular arrhythmias with hemodynamic compromise who required prolonged support in intensive care with an intra-...
journal_title:Cardiology research and practice
pub_type:
doi:10.4061/2011/925104
更新日期:2011-04-27 00:00:00
abstract::Background. Disparities in acute myocardial infarction (AMI) care for women and minorities have been extensively reported in United States but with limited information on Hispanics. Methods. Medical records of 287 (62%) Hispanic and 176 (38%) non-Hispanic white (NHW) patients and 245 women (53%) admitted with suspecte...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2013/975393
更新日期:2013-01-01 00:00:00
abstract:Introduction:The natural course of atrial fibrillation (AF) is not well defined. We aimed to investigate the change in AF burden over time and its associated risk factors among AF patients. Methods:Fifty-four participants with recently documented paroxysmal or persistent AF were enrolled. Main exclusion criteria were ...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2020/9583409
更新日期:2020-04-17 00:00:00
abstract::Background. Although 80% of the burden of cardiovascular disease (CVD) is in developing countries, the 2010 global burden of disease (GBD) estimates have been cited to support a premise that sub-Saharan Africa (SSA) is exempt from the CVD epidemic sweeping across developing countries. The widely publicized perspective...
journal_title:Cardiology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2015/921021
更新日期:2015-01-01 00:00:00
abstract:Aim:The slow coronary flow (SCF) phenomenon was characterized by delayed perfusion of epicardial arteries, and no obvious coronary artery lesion in coronary angiography. The prognosis of patients with slow coronary flow was poor. However, there is lack of rapid, simple, and accurate method for SCF diagnosis. This study...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2020/7361434
更新日期:2020-01-25 00:00:00
abstract:Objective:Donepezil, a widely used cholinesterase inhibitor for treating Alzheimer's disease, has been reported to induce bradyarrhythmias and torsade de pointes. In this study, we aimed at determining electrocardiogram changes of donepezil administration in elderly patients with ischemic heart disease, who tend to suf...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2018/9141320
更新日期:2018-04-23 00:00:00
abstract::Recent European Society of Cardiology and American Heart Association/American College of Cardiology Guidelines did not recommend biomarker-guided therapy in the management of heart failure (HF) patients. Combination of echo- and B-type natriuretic peptide (BNP) may be an alternative approach in guiding ambulatory HF m...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3139861
更新日期:2018-09-30 00:00:00
abstract::Coronary heart disease is a major cause of death and disability in developed countries. Stent implantation has become an efficacious treatment for a culprit lesion vessel of the coronary artery. However, 10%-20% restenosis is still an important complication that restricts the clinical safety and efficacy of drug-eluti...
journal_title:Cardiology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2020/8104939
更新日期:2020-10-25 00:00:00
abstract::Background. Literature regarding the influence of age/sex on mortality trends for acute myocardial infarction (AMI) hospitalizations is limited to hospitals participating in voluntary AMI registries. Objective. Evaluate the impact of age and sex on in-hospital AMI mortality using a nationally representative hospital s...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.4061/2010/752765
更新日期:2010-12-28 00:00:00
abstract::Current therapies for arrhythmia using ion channel blockade, catheter ablation, or an implantable cardioverter defibrillator have limitations, and it is important to search for new antiarrhythmic therapeutic targets. Both atrial fibrillation and heart failure, a condition with increased arrhythmic risk, are associated...
journal_title:Cardiology research and practice
pub_type: 杂志文章,评审
doi:10.1155/2016/9656078
更新日期:2016-01-01 00:00:00
abstract:Objective:The objective of this study was to investigate the impact of left atrial (LA) size for the ablation of atrial fibrillation (AF) using remote magnetic navigation (RMN). Methods:A total of 165 patients with AF who underwent catheter ablation using RMN were included. The patients were divided into two groups ba...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2018/3096261
更新日期:2018-12-05 00:00:00
abstract::A 16-year-old boy affected by Sotos syndrome was referred to our clinic for cardiac evaluation in order to play noncompetitive sport. Physical examination was negative for major cardiac abnormalities and rest electrocardiogram detected only minor repolarization anomalies. Transthoracic echocardiography showed left ven...
journal_title:Cardiology research and practice
pub_type:
doi:10.4061/2011/824095
更新日期:2011-01-01 00:00:00
abstract::Significant strides have been made in the durability, portability, and safety of mechanical circulatory support devices (MCS). Although transplant is considered the standard treatment for advanced heart failure, limits in organ availability leave a much larger pool of recipients in need versus donors. MCS is used as b...
journal_title:Cardiology research and practice
pub_type: 杂志文章
doi:10.1155/2012/524961
更新日期:2012-01-01 00:00:00