Contemporary treatment of APL.


:Acute promyelocytic leukemia (APL) is characterized by coagulopathy, leukopenic presentation and sensitivity to anthracyclines, all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). For the last 25 years, APL has been treated with a combination of ATRA and chemotherapy for induction followed by consolidation and maintenance therapy. This general treatment approach has resulted in cure rates of 80-90 %. ATO, originally approved in relapsed APL, has been incorporated into contemporary upfront treatment regimens with excellent response rates. Recent studies show that most patients with APL can be cured with ATRA and ATO alone, eliminating cytotoxic chemotherapy and resulting in superior outcomes compared to standard treatment. We will herein review historical treatment of APL, treatment considerations in specific patient populations, and therapeutic updates.


Curr Hematol Malig Rep


Cull EH,Altman JK




Has Abstract


2014-06-01 00:00:00












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    abstract::Myelodysplastic syndromes (MDS), or myelodysplasia, are a heterogeneous group of bone marrow disorders characterized by progressive cytopenias and a propensity to evolve into acute leukemia. The only curative strategy in the treatment of MDS is stem cell transplantation. The advent of hypomethylating agents and, more ...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章


    authors: Sirulnik LA,Stone RM

    更新日期:2008-01-01 00:00:00

  • The Next Generation of JAK Inhibitors: an Update on Fedratinib, Momelotonib, and Pacritinib.

    abstract:PURPOSE OF REVIEW:Ruxolitinib is the first FDA-approved JAK inhibitor for the treatment of myeloproliferative neoplasms and is an effective means of controlling symptom burden and improving splenomegaly. However, a majority of patients will develop disease progression with long-term use. Fedratinib, momelotinib, and pa...

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    authors: Patel AA,Odenike O

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  • Correction to: Strategies for Predicting Response to Checkpoint Inhibitors.

    abstract::The original version of this article unfortunately contained a mistake. The conflict of interest statement was incorrect. The corrected statement is given below. ...

    journal_title:Current hematologic malignancy reports

    pub_type: 已发布勘误


    authors: Zappasodi R,Wolchok JD,Merghoub T

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  • Leveraging Hypomethylating Agents for Better MDS Therapy.

    abstract:PURPOSE OF REVIEW:Myelodysplastic syndrome (MDS) is a clinically and molecularly heterogeneous disease, which primarily occurs in older adults. Although hypomethylating agents have survival benefit and are the current standard of care, many MDS patients will not garner a response from therapy. For those who do respond,...

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    pub_type: 杂志文章,评审


    authors: Bradley TJ,Watts JM,Swords RT

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  • The Future of Targeting FLT3 Activation in AML.

    abstract::Internal tandem duplications (ITD) and tyrosine-kinase domain (TKD) mutations of the FMS-like tyrosine-kinase 3 (FLT3) can be found in up to one third of patients with acute myeloid leukemia (AML) and confer a poor prognosis. First discovered 20 years ago, these mutations were identified as viable therapeutic targets,...

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    pub_type: 杂志文章,评审


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    更新日期:2017-06-01 00:00:00

  • The Effect of Psychosocial Interventions on Outcomes for Caregivers of Hematopoietic Cell Transplant Patients.

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  • Targets, Toxins, and T Cells--a Review of New Monoclonal Antibodies in the Treatment of Peripheral T Cell Lymphomas.

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    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


    authors: Hebb J,Kohrt H

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  • Assessing Quality of Care for the Myelodysplastic Syndromes.

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    pub_type: 杂志文章,评审


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  • Current Approaches to Transplantation for FLT3-ITD AML.

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  • Chronic myelomonocytic leukemia prognostic classification and management: evidence base and current practice.

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    pub_type: 杂志文章,评审


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    更新日期:2014-12-01 00:00:00

  • Artificial Intelligence in Hematology: Current Challenges and Opportunities.

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  • PET in T-Cell Lymphoma.

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  • Immunotherapy for Multiple Myeloma, Past, Present, and Future: Monoclonal Antibodies, Vaccines, and Cellular Therapies.

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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  • Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.

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    pub_type: 杂志文章,评审


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  • Antibody therapy for acute lymphoblastic leukemia.

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  • Updates on Circulating Tumor DNA Assessment in Lymphoma.

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    pub_type: 杂志文章,评审


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  • An immune dysregulation in MPN.

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    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


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  • Anti-CD19 Chimeric Antigen Receptor T Cell Therapies: Harnessing the Power of the Immune System to Fight Diffuse Large B Cell Lymphoma.

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  • Role of autologous stem cell transplantation in multiple myeloma.

    abstract::High-dose chemotherapy with autologous stem cell transplantation (ASCT) has been shown to improve survival in patients with multiple myeloma in randomized trials and is the standard of care for eligible patients. Recent randomized trials suggest a survival benefit with tandem ASCT, notably for patients failing to achi...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


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  • Update on antigen-specific immunotherapy of acute myeloid leukemia.

    abstract::Among the few drugs that have shown a benefit for patients with acute myeloid leukemia (AML) in randomized clinical trials over the last several decades is the CD33 antibody-drug conjugate, gemtuzumab ozogamicin (GO). Undoubtedly, this experience has highlighted the value of antigen-specific immunotherapy in AML. A wi...

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  • Outlook and Management of Patients with Myelodysplastic Syndromes Failed by Hypomethylating Agents.

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    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


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  • Infant acute lymphoblastic leukemia: Lessons learned and future directions.

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    journal_title:Current hematologic malignancy reports

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    authors: Pieters R

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  • Primary mediastinal large B-cell lymphoma.

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    authors: Dabrowska-Iwanicka A,Walewski JA

    更新日期:2014-09-01 00:00:00

  • Resistance to imatinib in chronic myelogenous leukemia: mechanisms and clinical implications.

    abstract::The introduction of imatinib represented a breakthrough in the treatment of chronic myelogenous leukemia (CML). However, about 20% of patients treated in early chronic-phase CML are off therapy after 6 years because of resistance or intolerance, and most patients taking imatinib remain BCR-ABL-positive at the molecula...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章


    authors: La Rosée P,Hochhaus A

    更新日期:2008-04-01 00:00:00

  • Rituximab maintenance versus radioimmunotherapy consolidation in follicular lymphoma: which, when, and for whom?

    abstract::Follicular lymphoma (FL), the most common indolent lymphoma, typically presents in advanced-stage disease. Currently available therapy does not generally result in a curative outcome, but survival in FL has improved since the introduction of anti-CD20 monoclonal antibody immunotherapy. The goals of treatment include p...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


    authors: Forstpointner R,Dreyling M

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  • Social Media and Hematopoietic Cell Transplantation: a Review of Online Resources and Communities.

    abstract:PURPOSE OF REVIEW:Social media has dramatically changed the access and exchange of information in healthcare and beyond. A variety of platforms and resources exist allowing blood and marrow transplant providers, researchers, and patients to interact. We review the adoption of social media by the transplantation communi...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


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    更新日期:2018-12-01 00:00:00

  • Recognizing unusual manifestations of Hodgkin lymphoma.

    abstract::Hodgkin lymphoma (HL) is a rare malignancy of the lymphatic system that is curable in at least 80 % of patients. Although patients usually present with painless lymphadenopathy, a variety of systemic and organ-specific syndromes may also exist in relation to HL. These syndromes may develop before, during, or after the...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


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    更新日期:2012-09-01 00:00:00

  • The GHSG Approach to Treating Hodgkin's Lymphoma.

    abstract::Hodgkin's lymphoma (HL) is a relatively rare disease accounting for 15 % of all lymphoma. This disease has developed from an incurable disease to the adult malignancy with the most favorable prognosis. With current therapeutic approaches consisting of polychemo- and small-field radiotherapy, up to 80 % of all patients...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


    authors: Bröckelmann PJ,Engert A

    更新日期:2015-09-01 00:00:00

  • Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: are we closer to knowing who needs it?

    abstract::Acute myeloid leukemia (AML) is a very heterogeneous disease. Prognosis is related not only to intrinsic characteristics such as cytogenetics and molecular markers, but also the patient's ability to tolerate therapy, and treatment response. Allogeneic stem cell transplantation (allo-HCT) has been traditionally indicat...

    journal_title:Current hematologic malignancy reports

    pub_type: 杂志文章,评审


    authors: Lekakis LJ,Cooper BW,de Lima MG

    更新日期:2014-06-01 00:00:00