Abstract:
:Administration of recombinant human erythropoietin (rHumanEPO) improves sporting performance and hence is frequently subject to abuse by athletes, although rHumanEPO is prohibited by the WADA. Approaches to detect rHumanEPO doping have improved significantly in recent years but remain imperfect. A new transcriptomic-based longitudinal screening approach is being developed that has the potential to improve the analytical performance of current detection methods. In particular, studies are being funded by WADA to identify a 'molecular signature' of rHumanEPO doping and preliminary results are promising. In the first systematic study to be conducted, the expression of hundreds of genes were found to be altered by rHumanEPO with numerous gene transcripts being differentially expressed after the first injection and further transcripts profoundly upregulated during and subsequently downregulated up to 4 weeks postadministration of the drug; with the same transcriptomic pattern observed in all participants. The identification of a blood 'molecular signature' of rHumanEPO administration is the strongest evidence to date that gene biomarkers have the potential to substantially improve the analytical performance of current antidoping methods such as the Athlete Biological Passport for rHumanEPO detection. Given the early promise of transcriptomics, research using an 'omics'-based approach involving genomics, transcriptomics, proteomics and metabolomics should be intensified in order to achieve improved detection of rHumanEPO and other doping substances and methods difficult to detect such a recombinant human growth hormone and blood transfusions.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Pitsiladis YP,Durussel J,Rabin Odoi
10.1136/bjsports-2014-093529subject
Has Abstractpub_date
2014-05-01 00:00:00pages
856-61issue
10eissn
0306-3674issn
1473-0480pii
bjsports-2014-093529journal_volume
48pub_type
杂志文章,评审abstract::Sedentary time is a modifiable determinant of poor health, and in older adults, reducing sedentary time may be an important first step in adopting and maintaining a more active lifestyle. The primary purpose of this consensus statement is to provide an integrated perspective on current knowledge and expert opinion per...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2016-097209
更新日期:2017-11-01 00:00:00
abstract::A case of bilateral stress fractures of the ulnae in a Kendo (Japanese fencing) player is reported; the mechanism of the fractures, particularly the difference in the site of fracture between the right and left ulna, is discussed. ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.32.4.340
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVES:To study factors associated with passive hip rotation range of motion (ROM) in former elite male athletes. METHODS:Athletes were interviewed about hip pain, disability, lifetime occupational loading, and athletic training. The passive hip rotation was measured with a Myrin inclinometer in 117 former elite m...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.34.1.44
更新日期:2000-02-01 00:00:00
abstract::Ankle sprain is a common sports injury and is often regarded as trivial by athletes and coaches. This epidemiological study was conducted among three categories of Hong Kong Chinese athletes: national teams, competitive athletes and recreational athletes. This study shows that as much as 73% of all athletes had recurr...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.28.2.112
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that stress reducing techniques such as meditation alter immune responses after strenous physical stress. METHODS:The hypothesis was tested by studying six meditating and six non-meditating male runners in a concurrent, controlled design. After a period of six months with meditation fo...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/bjsm.29.4.255
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:To compare injury rates among professional men's football teams that have a winter break in their league season schedule with corresponding rates in teams that do not. METHODS:56 football teams from 15 European countries were prospectively followed for seven seasons (2010/2011-2016/2017)-a total of 155 team-...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2018-099506
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:To investigate the prevalence of inguinal canal posterior wall deficiency (sports hernia) in professional Australian Rules footballers using an ultrasound technique and correlate the results with the clinical symptom of groin pain. METHODS:Thirty five professional Australian footballers with and without gro...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.32.2.134
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVES:To gain more insight into the mechanisms that underlie the development of interval endurance capacity in talented youth field hockey players in the 12-19 age band. METHODS:A total of 377 measurements were taken over three years. A longitudinal model for interval endurance capacity was developed using the mu...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.023044
更新日期:2006-04-01 00:00:00
abstract::The question of whether altitude training can enhance subsequent sea-level performance has been well investigated over many decades. However, research on this topic has focused on athletes from individual or endurance sports, with scant number of studies on team-sport athletes. Questions that need to be answered inclu...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092764
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To quantify and describe medically treated sport and active recreation injuries in a defined region of the Latrobe Valley from 7 November 1994 to 6 November 1995. METHOD:A geographic target area was defined, restricted to the six postcodes that fell wholly within the catchment area of the Latrobe Regional Ho...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.37.5.405
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND/AIM:To compare outcome of early mobilisation and plaster immobilisation in patients with a simple elbow dislocation. We hypothesised that early mobilisation would result in earlier functional recovery. METHODS:From August 2009 to September 2012, 100 adult patients with a simple elbow dislocation were enroll...
journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bjsports-2015-094704
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The relatively young sport of snowboarding exhibits high injury rates. The current efforts to characterise the injury pattern of snowboarders focus largely on the general snowboard population and upper extremity injuries, the most common injury site in snowboarders as a whole. METHODS:In an effort to descri...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-093019
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:As one of the purposes of anterior cruciate ligament reconstruction (ACLR) is to return athletes to their preinjury activity level, it is critical to understand variables influencing return to sport. Associations between return to sport and variables representing knee impairment, function and psychological s...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2012-091786
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To monitor the seasonal body composition alterations in 18 lightweight rowers (six females, 12 males) across a rowing season incorporating preseason, early competition, competition, and postseason. METHODS:Subject age was 23.1 (SD 4.5) years, height 170.8 (5.6) cm (female, 23.5 (3.5) years, 180.5 (2.7) cm (m...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.30.4.301
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVE:To describe the anthropometric and physical performance characteristics of a sample of senior A club rugby players and to highlight differences between the positional categories of the players within the forwards and backs. METHODS:94 senior A male rugby players were assessed on a number of anthropometric an...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.30.1.53
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Categorical grading and other measurable MRI parameters are frequently utilised for predicting the outcome of hamstring injuries. However, the reliability and smallest detectable difference (SDD) have not been previously evaluated. It therefore remains unclear if the variability in previously reported result...
journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/bjsports-2013-092564
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Technological limitations associated with oesophageal and rectal temperature probes have previously limited match play observations of body temperature. OBJECTIVE:To investigate the application of an intestinal pill system to measure core temperature during dynamic, field based, soccer matches. METHODS:Cor...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.021980
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:The current methods measuring sports activity after anterior cruciate ligament (ACL) injury are commonly restricted to the most knee-demanding sports, and do not consider participation in multiple sports. We therefore developed an online activity survey to prospectively record the monthly participation in al...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2012-092075
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:Examine the effectiveness of specific modes of exercise training in non-specific chronic low back pain (NSCLBP). DESIGN:Network meta-analysis (NMA). DATA SOURCES:MEDLINE, CINAHL, SPORTDiscus, EMBASE, CENTRAL. ELIGIBILITY CRITERIA:Exercise training randomised controlled/clinical trials in adults with NSCLBP...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2019-100886
更新日期:2020-11-01 00:00:00
abstract::The purpose of this investigation was to compare the effectiveness of using ratings of perceived exertion (RPE) with heart rate in the monitoring of exercise intensity during aerobic dance instruction. Thirty-eight students who enrolled in aerobic dance classes used heart rate to monitor exercise intensity while 38 ad...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.26.2.132
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVE:To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. ELIGIBILITY CRITERIA FOR SELECTING STUDIE...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析
doi:10.1136/bjsports-2018-100022
更新日期:2019-12-01 00:00:00
abstract::Team sports are increasingly popular, with millions of participants worldwide. Athletes engaged in these sports are required to repeatedly produce skilful actions and maximal or near-maximal efforts (eg, accelerations, changes in pace and direction, sprints, jumps and kicks), interspersed with brief recovery intervals...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092950
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Physical exercise is seen as a promising intervention to prevent or delay cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not conclusive. OBJECTIVES:To determine if physical exercise is effective in improving cognitive function in this population. DESIGN:Systemati...
journal_title:British journal of sports medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1136/bjsports-2016-096587
更新日期:2018-02-01 00:00:00
abstract::Promoting physical activity has become a priority because of its role in preventing childhood obesity and chronic disease. Ecological approaches that recognise the interaction between individuals and the settings in which they spend their time are currently at the forefront of public health action. Schools have been i...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2008.053447
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:A matched case-control study was carried out to evaluate biological risk indicators for recurrent non-specific low back pain in adolescents. METHODS:Adolescents with recurrent non-specific low back pain (symptomatic; n = 28; mean (SD) age 14.9 (0.7) years) and matched controls (asymptomatic; n = 28; age 14....
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.009951
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Improved oxygen uptake improves soccer performance as regards distance covered, involvements with the ball, and number of sprints. Large improvements in oxygen uptake have been shown using interval running. A similar physiological load arising from interval running could be obtained using the soccer ball in ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2004.012526
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The accurate measurement of physical activity is crucial to understanding the relationship between physical activity and disease prevention and treatment. OBJECTIVE:The primary purpose of this study was to investigate the validity and reliability of the activPAL physical activity monitor in measuring step n...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2006.027276
更新日期:2006-09-01 00:00:00
abstract:INTRODUCTION:The incidence of depression is high during the perinatal period. This mood disorder can have a significant impact on the mother, the child and the family. OBJECTIVE:To examine the effect of an exercise programme during pregnancy on the risk of perinatal depression. METHODS:Healthy women who were <16 week...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsports-2017-098926
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To assess the results of inferior capsular shift for multidirectional instability of the shoulder in athletes. METHODS:Multidirectional instability was surgically corrected in 53 shoulders in 47 athletes who engaged in contact sports. A history of major trauma was found in eight patients, the others having ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.36.4.290
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVE:In this study, the serum triglycerides and total serum cholesterol levels in patients with rotator cuff tear were determined. DESIGN:Frequency-matched case-control study. Setting University teaching hospital. PARTICIPANTS:240 individuals who were operated on at our institution were included in the study. 12...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.056440
更新日期:2010-10-01 00:00:00