An integrative 'omics' solution to the detection of recombinant human erythropoietin and blood doping.

Abstract:

:Administration of recombinant human erythropoietin (rHumanEPO) improves sporting performance and hence is frequently subject to abuse by athletes, although rHumanEPO is prohibited by the WADA. Approaches to detect rHumanEPO doping have improved significantly in recent years but remain imperfect. A new transcriptomic-based longitudinal screening approach is being developed that has the potential to improve the analytical performance of current detection methods. In particular, studies are being funded by WADA to identify a 'molecular signature' of rHumanEPO doping and preliminary results are promising. In the first systematic study to be conducted, the expression of hundreds of genes were found to be altered by rHumanEPO with numerous gene transcripts being differentially expressed after the first injection and further transcripts profoundly upregulated during and subsequently downregulated up to 4 weeks postadministration of the drug; with the same transcriptomic pattern observed in all participants. The identification of a blood 'molecular signature' of rHumanEPO administration is the strongest evidence to date that gene biomarkers have the potential to substantially improve the analytical performance of current antidoping methods such as the Athlete Biological Passport for rHumanEPO detection. Given the early promise of transcriptomics, research using an 'omics'-based approach involving genomics, transcriptomics, proteomics and metabolomics should be intensified in order to achieve improved detection of rHumanEPO and other doping substances and methods difficult to detect such a recombinant human growth hormone and blood transfusions.

journal_name

Br J Sports Med

authors

Pitsiladis YP,Durussel J,Rabin O

doi

10.1136/bjsports-2014-093529

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

856-61

issue

10

eissn

0306-3674

issn

1473-0480

pii

bjsports-2014-093529

journal_volume

48

pub_type

杂志文章,评审
  • Sedentary time in older men and women: an international consensus statement and research priorities.

    abstract::Sedentary time is a modifiable determinant of poor health, and in older adults, reducing sedentary time may be an important first step in adopting and maintaining a more active lifestyle. The primary purpose of this consensus statement is to provide an integrated perspective on current knowledge and expert opinion per...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsports-2016-097209

    authors: Dogra S,Ashe MC,Biddle SJH,Brown WJ,Buman MP,Chastin S,Gardiner PA,Inoue S,Jefferis BJ,Oka K,Owen N,Sardinha LB,Skelton DA,Sugiyama T,Copeland JL

    更新日期:2017-11-01 00:00:00

  • Bilateral stress fractures of the ulnae in a Kendo (Japanese fencing) player.

    abstract::A case of bilateral stress fractures of the ulnae in a Kendo (Japanese fencing) player is reported; the mechanism of the fractures, particularly the difference in the site of fracture between the right and left ulna, is discussed. ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.32.4.340

    authors: Sujino T,Ohe T,Shinozuka M

    更新日期:1998-12-01 00:00:00

  • Factors associated with hip joint rotation in former elite athletes.

    abstract:OBJECTIVES:To study factors associated with passive hip rotation range of motion (ROM) in former elite male athletes. METHODS:Athletes were interviewed about hip pain, disability, lifetime occupational loading, and athletic training. The passive hip rotation was measured with a Myrin inclinometer in 117 former elite m...

    journal_title:British journal of sports medicine

    pub_type: 临床试验,杂志文章

    doi:10.1136/bjsm.34.1.44

    authors: Kettunen JA,Kujala UM,Räty H,Videman T,Sarna S,Impivaara O,Koskinen S

    更新日期:2000-02-01 00:00:00

  • An epidemiological survey on ankle sprain.

    abstract::Ankle sprain is a common sports injury and is often regarded as trivial by athletes and coaches. This epidemiological study was conducted among three categories of Hong Kong Chinese athletes: national teams, competitive athletes and recreational athletes. This study shows that as much as 73% of all athletes had recurr...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.28.2.112

    authors: Yeung MS,Chan KM,So CH,Yuan WY

    更新日期:1994-06-01 00:00:00

  • Meditation: a modulator of the immune response to physical stress? A brief report.

    abstract:OBJECTIVE:To test the hypothesis that stress reducing techniques such as meditation alter immune responses after strenous physical stress. METHODS:The hypothesis was tested by studying six meditating and six non-meditating male runners in a concurrent, controlled design. After a period of six months with meditation fo...

    journal_title:British journal of sports medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/bjsm.29.4.255

    authors: Solberg EE,Halvorsen R,Sundgot-Borgen J,Ingjer F,Holen A

    更新日期:1995-12-01 00:00:00

  • Elite football teams that do not have a winter break lose on average 303 player-days more per season to injuries than those teams that do: a comparison among 35 professional European teams.

    abstract:OBJECTIVE:To compare injury rates among professional men's football teams that have a winter break in their league season schedule with corresponding rates in teams that do not. METHODS:56 football teams from 15 European countries were prospectively followed for seven seasons (2010/2011-2016/2017)-a total of 155 team-...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsports-2018-099506

    authors: Ekstrand J,Spreco A,Davison M

    更新日期:2019-10-01 00:00:00

  • Groin pain associated with ultrasound finding of inguinal canal posterior wall deficiency in Australian Rules footballers.

    abstract:OBJECTIVES:To investigate the prevalence of inguinal canal posterior wall deficiency (sports hernia) in professional Australian Rules footballers using an ultrasound technique and correlate the results with the clinical symptom of groin pain. METHODS:Thirty five professional Australian footballers with and without gro...

    journal_title:British journal of sports medicine

    pub_type: 临床试验,杂志文章

    doi:10.1136/bjsm.32.2.134

    authors: Orchard JW,Read JW,Neophyton J,Garlick D

    更新日期:1998-06-01 00:00:00

  • Development of the interval endurance capacity in elite and sub-elite youth field hockey players.

    abstract:OBJECTIVES:To gain more insight into the mechanisms that underlie the development of interval endurance capacity in talented youth field hockey players in the 12-19 age band. METHODS:A total of 377 measurements were taken over three years. A longitudinal model for interval endurance capacity was developed using the mu...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2005.023044

    authors: Elferink-Gemser MT,Visscher C,van Duijn MA,Lemmink KA

    更新日期:2006-04-01 00:00:00

  • Yin and yang, or peas in a pod? Individual-sport versus team-sport athletes and altitude training.

    abstract::The question of whether altitude training can enhance subsequent sea-level performance has been well investigated over many decades. However, research on this topic has focused on athletes from individual or endurance sports, with scant number of studies on team-sport athletes. Questions that need to be answered inclu...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1136/bjsports-2013-092764

    authors: Aughey RJ,Buchheit M,Garvican-Lewis LA,Roach GD,Sargent C,Billaut F,Varley MC,Bourdon PC,Gore CJ

    更新日期:2013-12-01 00:00:00

  • Epidemiology of medically treated sport and active recreation injuries in the Latrobe Valley, Victoria, Australia.

    abstract:OBJECTIVE:To quantify and describe medically treated sport and active recreation injuries in a defined region of the Latrobe Valley from 7 November 1994 to 6 November 1995. METHOD:A geographic target area was defined, restricted to the six postcodes that fell wholly within the catchment area of the Latrobe Regional Ho...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.37.5.405

    authors: Cassell EP,Finch CF,Stathakis VZ

    更新日期:2003-01-01 00:00:00

  • Early mobilisation versus plaster immobilisation of simple elbow dislocations: results of the FuncSiE multicentre randomised clinical trial.

    abstract:BACKGROUND/AIM:To compare outcome of early mobilisation and plaster immobilisation in patients with a simple elbow dislocation. We hypothesised that early mobilisation would result in earlier functional recovery. METHODS:From August 2009 to September 2012, 100 adult patients with a simple elbow dislocation were enroll...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bjsports-2015-094704

    authors: Iordens GI,Van Lieshout EM,Schep NW,De Haan J,Tuinebreijer WE,Eygendaal D,Van Beeck E,Patka P,Verhofstad MH,Den Hartog D,FuncSiE Trial Investigators.

    更新日期:2017-03-01 00:00:00

  • Injuries in elite and recreational snowboarders.

    abstract:BACKGROUND:The relatively young sport of snowboarding exhibits high injury rates. The current efforts to characterise the injury pattern of snowboarders focus largely on the general snowboard population and upper extremity injuries, the most common injury site in snowboarders as a whole. METHODS:In an effort to descri...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1136/bjsports-2013-093019

    authors: Wijdicks CA,Rosenbach BS,Flanagan TR,Bower GE,Newman KE,Clanton TO,Engebretsen L,Laprade RF,Hackett TR

    更新日期:2014-01-01 00:00:00

  • Variables associated with return to sport following anterior cruciate ligament reconstruction: a systematic review.

    abstract:BACKGROUND:As one of the purposes of anterior cruciate ligament reconstruction (ACLR) is to return athletes to their preinjury activity level, it is critical to understand variables influencing return to sport. Associations between return to sport and variables representing knee impairment, function and psychological s...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1136/bjsports-2012-091786

    authors: Czuppon S,Racette BA,Klein SE,Harris-Hayes M

    更新日期:2014-03-01 00:00:00

  • Seasonal variations in the body composition of lightweight rowers.

    abstract:OBJECTIVE:To monitor the seasonal body composition alterations in 18 lightweight rowers (six females, 12 males) across a rowing season incorporating preseason, early competition, competition, and postseason. METHODS:Subject age was 23.1 (SD 4.5) years, height 170.8 (5.6) cm (female, 23.5 (3.5) years, 180.5 (2.7) cm (m...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.30.4.301

    authors: Morris FL,Payne WR

    更新日期:1996-12-01 00:00:00

  • The New Zealand rugby injury and performance project. IV. Anthropometric and physical performance comparisons between positional categories of senior A rugby players.

    abstract:OBJECTIVE:To describe the anthropometric and physical performance characteristics of a sample of senior A club rugby players and to highlight differences between the positional categories of the players within the forwards and backs. METHODS:94 senior A male rugby players were assessed on a number of anthropometric an...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.30.1.53

    authors: Quarrie KL,Handcock P,Toomey MJ,Waller AE

    更新日期:1996-03-01 00:00:00

  • Excellent reliability for MRI grading and prognostic parameters in acute hamstring injuries.

    abstract:BACKGROUND:Categorical grading and other measurable MRI parameters are frequently utilised for predicting the outcome of hamstring injuries. However, the reliability and smallest detectable difference (SDD) have not been previously evaluated. It therefore remains unclear if the variability in previously reported result...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/bjsports-2013-092564

    authors: Hamilton B,Whiteley R,Almusa E,Roger B,Geertsema C,Tol JL

    更新日期:2014-09-01 00:00:00

  • Thermoregulatory observations in soccer match play: professional and recreational level applications using an intestinal pill system to measure core temperature.

    abstract:BACKGROUND:Technological limitations associated with oesophageal and rectal temperature probes have previously limited match play observations of body temperature. OBJECTIVE:To investigate the application of an intestinal pill system to measure core temperature during dynamic, field based, soccer matches. METHODS:Cor...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2005.021980

    authors: Edwards AM,Clark NA

    更新日期:2006-02-01 00:00:00

  • Online registration of monthly sports participation after anterior cruciate ligament injury: a reliability and validity study.

    abstract:BACKGROUND:The current methods measuring sports activity after anterior cruciate ligament (ACL) injury are commonly restricted to the most knee-demanding sports, and do not consider participation in multiple sports. We therefore developed an online activity survey to prospectively record the monthly participation in al...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsports-2012-092075

    authors: Grindem H,Eitzen I,Snyder-Mackler L,Risberg MA

    更新日期:2014-05-01 00:00:00

  • Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis.

    abstract:OBJECTIVE:Examine the effectiveness of specific modes of exercise training in non-specific chronic low back pain (NSCLBP). DESIGN:Network meta-analysis (NMA). DATA SOURCES:MEDLINE, CINAHL, SPORTDiscus, EMBASE, CENTRAL. ELIGIBILITY CRITERIA:Exercise training randomised controlled/clinical trials in adults with NSCLBP...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bjsports-2019-100886

    authors: Owen PJ,Miller CT,Mundell NL,Verswijveren SJJM,Tagliaferri SD,Brisby H,Bowe SJ,Belavy DL

    更新日期:2020-11-01 00:00:00

  • Efficacy of perceptual versus heart rate monitoring in the development of endurance.

    abstract::The purpose of this investigation was to compare the effectiveness of using ratings of perceived exertion (RPE) with heart rate in the monitoring of exercise intensity during aerobic dance instruction. Thirty-eight students who enrolled in aerobic dance classes used heart rate to monitor exercise intensity while 38 ad...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.26.2.132

    authors: Koltyn KF,Morgan WP

    更新日期:1992-06-01 00:00:00

  • Knee osteoarthritis risk is increased 4-6 fold after knee injury - a systematic review and meta-analysis.

    abstract:OBJECTIVE:To estimate knee osteoarthritis (OA) risk following anterior cruciate ligament (ACL), meniscus or combined ACL and meniscus injury. DESIGN:Systematic review and meta-analysis. DATA SOURCES:MEDLINE, Embase, SPORTDiscus, CINAHL and Web of Science until November 2018. ELIGIBILITY CRITERIA FOR SELECTING STUDIE...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析

    doi:10.1136/bjsports-2018-100022

    authors: Poulsen E,Goncalves GH,Bricca A,Roos EM,Thorlund JB,Juhl CB

    更新日期:2019-12-01 00:00:00

  • Determinants of team-sport performance: implications for altitude training by team-sport athletes.

    abstract::Team sports are increasingly popular, with millions of participants worldwide. Athletes engaged in these sports are required to repeatedly produce skilful actions and maximal or near-maximal efforts (eg, accelerations, changes in pace and direction, sprints, jumps and kicks), interspersed with brief recovery intervals...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1136/bjsports-2013-092950

    authors: Bishop DJ,Girard O

    更新日期:2013-12-01 00:00:00

  • Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis.

    abstract:BACKGROUND:Physical exercise is seen as a promising intervention to prevent or delay cognitive decline in individuals aged 50 years and older, yet the evidence from reviews is not conclusive. OBJECTIVES:To determine if physical exercise is effective in improving cognitive function in this population. DESIGN:Systemati...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/bjsports-2016-096587

    authors: Northey JM,Cherbuin N,Pumpa KL,Smee DJ,Rattray B

    更新日期:2018-02-01 00:00:00

  • Prevention in the first place: schools a setting for action on physical inactivity.

    abstract::Promoting physical activity has become a priority because of its role in preventing childhood obesity and chronic disease. Ecological approaches that recognise the interaction between individuals and the settings in which they spend their time are currently at the forefront of public health action. Schools have been i...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,评审

    doi:10.1136/bjsm.2008.053447

    authors: Naylor PJ,McKay HA

    更新日期:2009-01-01 00:00:00

  • Biological risk indicators for recurrent non-specific low back pain in adolescents.

    abstract:OBJECTIVES:A matched case-control study was carried out to evaluate biological risk indicators for recurrent non-specific low back pain in adolescents. METHODS:Adolescents with recurrent non-specific low back pain (symptomatic; n = 28; mean (SD) age 14.9 (0.7) years) and matched controls (asymptomatic; n = 28; age 14....

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2003.009951

    authors: Jones MA,Stratton G,Reilly T,Unnithan VB

    更新日期:2005-03-01 00:00:00

  • Physiological adaptations to soccer specific endurance training in professional youth soccer players.

    abstract:BACKGROUND:Improved oxygen uptake improves soccer performance as regards distance covered, involvements with the ball, and number of sprints. Large improvements in oxygen uptake have been shown using interval running. A similar physiological load arising from interval running could be obtained using the soccer ball in ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2004.012526

    authors: McMillan K,Helgerud J,Macdonald R,Hoff J

    更新日期:2005-05-01 00:00:00

  • The validity and reliability of a novel activity monitor as a measure of walking.

    abstract:BACKGROUND:The accurate measurement of physical activity is crucial to understanding the relationship between physical activity and disease prevention and treatment. OBJECTIVE:The primary purpose of this study was to investigate the validity and reliability of the activPAL physical activity monitor in measuring step n...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2006.027276

    authors: Ryan CG,Grant PM,Tigbe WW,Granat MH

    更新日期:2006-09-01 00:00:00

  • Physical exercise programme during pregnancy decreases perinatal depression risk: a randomised controlled trial.

    abstract:INTRODUCTION:The incidence of depression is high during the perinatal period. This mood disorder can have a significant impact on the mother, the child and the family. OBJECTIVE:To examine the effect of an exercise programme during pregnancy on the risk of perinatal depression. METHODS:Healthy women who were <16 week...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/bjsports-2017-098926

    authors: Vargas-Terrones M,Barakat R,Santacruz B,Fernandez-Buhigas I,Mottola MF

    更新日期:2019-03-01 00:00:00

  • Inferior capsular shift operation for multidirectional instability of the shoulder in players of contact sports.

    abstract:OBJECTIVES:To assess the results of inferior capsular shift for multidirectional instability of the shoulder in athletes. METHODS:Multidirectional instability was surgically corrected in 53 shoulders in 47 athletes who engaged in contact sports. A history of major trauma was found in eight patients, the others having ...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.36.4.290

    authors: Choi CH,Ogilvie-Harris DJ

    更新日期:2002-08-01 00:00:00

  • Triglycerides and total serum cholesterol in rotator cuff tears: do they matter?

    abstract:OBJECTIVE:In this study, the serum triglycerides and total serum cholesterol levels in patients with rotator cuff tear were determined. DESIGN:Frequency-matched case-control study. Setting University teaching hospital. PARTICIPANTS:240 individuals who were operated on at our institution were included in the study. 12...

    journal_title:British journal of sports medicine

    pub_type: 杂志文章

    doi:10.1136/bjsm.2008.056440

    authors: Longo UG,Franceschi F,Spiezia F,Forriol F,Maffulli N,Denaro V

    更新日期:2010-10-01 00:00:00