Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid.

Abstract:

:We have determined the genetic basis of minocycline resistance in a strain of Streptococcus infantis isolated from a healthy human oral cavity. We demonstrate that tet(S), identical to tet(S) found on the enterococcal conjugative transposon Tn6000, is responsible for the observed resistance. The gene is located on a small, low copy number plasmid and is flanked by IS1216 elements. The tet(S) gene is capable of excising from the plasmid together with one of the IS1216 elements. The plasmid contains a putative toxin/antitoxin system related to relBE. Deletion of the toxin, relE, did not result in plasmid instability but did increase the fitness of the mutant compared to the wild-type strain.

journal_name

FEMS Microbiol Lett

authors

Ciric L,Brouwer MS,Mullany P,Roberts AP

doi

10.1111/1574-6968.12410

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

106-15

issue

2

eissn

0378-1097

issn

1574-6968

journal_volume

353

pub_type

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