Abstract:
:It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may be intricately linked with the process of hypertrophy wherein there is not only a significant increase in myocardial O2 consumption but also important alterations in metabolic processes and in the local generation of O2-derived reactive species (ROS) that modulate and/or amplify cell signaling pathways. This article reviews our current knowledge of redox signaling pathways and their roles in cardiac hypertrophy. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".
journal_name
J Mol Cell Cardioljournal_title
Journal of molecular and cellular cardiologyauthors
Sag CM,Santos CX,Shah AMdoi
10.1016/j.yjmcc.2014.02.002subject
Has Abstractpub_date
2014-08-01 00:00:00pages
103-11eissn
0022-2828issn
1095-8584pii
S0022-2828(14)00042-Xjournal_volume
73pub_type
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