Redox regulation of cardiac hypertrophy.

Abstract:

:It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may be intricately linked with the process of hypertrophy wherein there is not only a significant increase in myocardial O2 consumption but also important alterations in metabolic processes and in the local generation of O2-derived reactive species (ROS) that modulate and/or amplify cell signaling pathways. This article reviews our current knowledge of redox signaling pathways and their roles in cardiac hypertrophy. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".

journal_name

J Mol Cell Cardiol

authors

Sag CM,Santos CX,Shah AM

doi

10.1016/j.yjmcc.2014.02.002

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

103-11

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(14)00042-X

journal_volume

73

pub_type

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