A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement.

abstract：:In eukaryotes, many cell surface proteins are attached to the plasma membrane via a glycolipid glycosylphosphatidylinositol (GPI) anchor. GPI-anchored proteins (GPI-APs) receive the GPI anchor as a conserved posttranslational modification in the lumen of the endoplasmic reticulum (ER). After anchor attachment, the GPI...

journal_title：Journal of lipid research

authors： Muñiz M,Riezman H

更新日期：2016-03-01 00:00:00

abstract：:Expression of constitutively activated Akt in the mammary glands of transgenic mice results in a delay in post-lactational involution. We now report precocious lipid accumulation in the alveolar epithelium of mouse mammary tumor virus-myr-Akt transgenic mice accompanied by a lactation defect that results in a 50% decr...

journal_title：Journal of lipid research

authors： Schwertfeger KL,McManaman JL,Palmer CA,Neville MC,Anderson SM

更新日期：2003-06-01 00:00:00

abstract：:Agonist-induced lipolysis of adipose fat is robustly inhibited by insulin or by feedback inhibition by the long-chain fatty acids (LCFA) produced during lipolysis. However, the mode of action of LCFA in suppressing adipose lipolysis is not clear. β,β'-Tetramethyl hexadecanedioic acid (Mββ/ EDICA16) is a synthetic LCFA...

journal_title：Journal of lipid research

authors： Kalderon B,Azazmeh N,Azulay N,Vissler N,Valitsky M,Bar-Tana J

更新日期：2012-05-01 00:00:00

abstract：:Series of benzoolysis experiments with 1,2-dipalmitoyl glycerophosphocholine (GPC), 1-palmitoyl-2-lyso GPC, and 1-O-hexadecenyl-2-oleoyl GPC, as well as a few experiments with 1-oleoyl-2-acetyl GPC and 1-O-hexadecyl-2-acetyl GPC are reported. The results are used to present a consistent picture of the various dephosph...

journal_title：Journal of lipid research

authors： Gelsema WJ,van den Bosch H

更新日期：1997-08-01 00:00:00

abstract：:Ceramide-1-phosphate (C1P) is a novel bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). In this study, we evaluated the mechanism by which increased C1P during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing hCERK. Stable tran...

journal_title：Journal of lipid research

authors： Hinkovska-Galcheva V,Clark A,VanWay S,Huang JB,Hiraoka M,Abe A,Borofsky M,Kunkel RG,Shanley T,Shayman JA,Lanni F,Petty HR,Boxer LA

更新日期：2008-03-01 00:00:00

abstract：:Expression of bile salt export pump (BSEP) is regulated by the bile acid/farnesoid X receptor (FXR) signaling pathway. Two FXR isoforms, FXRα1 and FXRα2, are predominantly expressed in human liver. We previously showed that human BSEP was isoform-dependently regulated by FXR and diminished with altered expression of F...

journal_title：Journal of lipid research

authors： Song X,Chen Y,Valanejad L,Kaimal R,Yan B,Stoner M,Deng R

更新日期：2013-11-01 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has antiatherogenic and antidiabetic effects, but how it confers the atherogenic effects is not well known. To study the antiatherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low density lipoprotein (LDL) to attenuate LDL's atherogenicit...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-21 00:00:00

abstract：:The effect of 26-hydroxycholesterol and other intermediates in bile acid synthesis on HMG-CoA reductase activity was studied in Chinese hamster ovary (CHO) cell culture. Incubation of CHO cells for 5 hr in 0.25 microM 26-hydroxycholesterol caused a 40% inhibition of HMG-CoA reductase activity. All other intermediates ...

journal_title：Journal of lipid research

authors： Esterman AL,Baum H,Javitt NB,Darlington GJ

更新日期：1983-10-01 00:00:00

abstract：:Plasma levels of HDL cholesterol (HDL-C) have a strong inherited basis with heritability estimates of 40-60%. The well-established inverse relationship between plasma HDL-C levels and the risk of coronary artery disease (CAD) has led to an extensive search for genetic factors influencing HDL-C concentrations. Over the...

journal_title：Journal of lipid research

authors： Weissglas-Volkov D,Pajukanta P

更新日期：2010-08-01 00:00:00

abstract：:The effect of electron transport chain redox status on activity of the mitochondrial Ca(2+)-independent phospholipase A2 (iPLA2) has been examined. When oxidizing NAD-linked substrates, the enzyme is not active unless deenergization occurs. Uncoupler, rotenone, antimycin A, and cyanide are equally effective at upregul...

journal_title：Journal of lipid research

authors： Rauckhorst AJ,Broekemeier KM,Pfeiffer DR

更新日期：2014-05-01 00:00:00

abstract：:MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for a total of 21 infusions, and effects on lipids, (apo)lipoproteins, and ex-vivo cholesterol efflux capacity were monitor...

journal_title：Journal of lipid research

authors： Kempen HJ,Gomaraschi M,Bellibas SE,Plassmann S,Zerler B,Collins HL,Adelman SJ,Calabresi L,Wijngaard PL

更新日期：2013-09-01 00:00:00

abstract：:PAF-dependent transacetylase (TA) modifies the functions of platelet-activating factor (PAF), a potent inflammatory lipid, either by transferring the acetyl group from PAF to lysophospholipids (TAL activity), or to sphingosine (TAS activity) or by hydrolyzing PAF (acetylhydrolase activity). In stimulated endothelial c...

journal_title：Journal of lipid research

authors： Balestrieri ML,Castaldo D,Balestrieri C,Quagliuolo L,Giovane A,Servillo L

更新日期：2003-02-01 00:00:00

abstract：:Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the ...

journal_title：Journal of lipid research

authors： Bahn YJ,Lee KP,Lee SM,Choi JY,Seo YS,Kwon KS

更新日期：2015-02-01 00:00:00

abstract：:A simple, rapid, and sensitive bioluminescence method for measuring primary bile acids has been developed and validated. The method is based on enzymatic dehydrogenation of bile acids using a bacterial 7 alpha-hydroxysteroid dehydrogenase that is co-immobilized on Sepharose 4B beads with NADH:FMN oxidoreductase and a ...

journal_title：Journal of lipid research

authors： Roda A,Kricka LJ,DeLuca M,Hofmann AF

更新日期：1982-12-01 00:00:00

abstract：:The activity of phospholipase A on phosphatidyl choline and phosphatidal choline spread as monolayers on phosphate buffers containing snake venom (Crotalus atrox or Naja naja) was studied by measuring the fall of surface potential as a function of time, pH, film pressure, temperature, and concentrations of phosphate a...

journal_title：Journal of lipid research

authors： Colacicco G,Rapport MM

更新日期：1966-03-01 00:00:00

abstract：:Sphingolipids (SLs) have been implicated in numerous important cellular biologies; however, their study has been hindered by the complexities of SL metabolism. Furthermore, enzymes of SL metabolism represent a dynamic and interconnected network in which one metabolite can be transformed into other bioactive SLs throug...

journal_title：Journal of lipid research

authors： Snider JM,Trayssac M,Clarke CJ,Schwartz N,Snider AJ,Obeid LM,Luberto C,Hannun YA

更新日期：2019-04-01 00:00:00

abstract：:As microsomal triglyceride transfer protein (MTP) is required for the assembly and secretion of apoB-containing lipoproteins by intestinal epithelial cells, the characterization and regulation of MTP in human intestinal cells, CaCo-2, was studied. CaCo-2 cells express MTP mRNA of 4.2 kb and a 97 kDa subunit of MTP pro...

journal_title：Journal of lipid research

authors： Mathur SN,Born E,Murthy S,Field FJ

更新日期：1997-01-01 00:00:00

abstract：:Niemann-Pick type C1 disease (NPC1) is an autosomal recessive lysosomal storage disorder characterized by neonatal jaundice, hepatosplenomegaly, and progressive neurodegeneration. The present study provides the lipid profiles, mutations, and corresponding associations with the biochemical phenotype obtained from NPC1 ...

journal_title：Journal of lipid research

authors： Garver WS,Jelinek D,Meaney FJ,Flynn J,Pettit KM,Shepherd G,Heidenreich RA,Vockley CM,Castro G,Francis GA

更新日期：2010-02-01 00:00:00

abstract：:14C-labeled oleic acid and (3)H-labeled monoether in a bile salt solution were perfused through three types of plastic tubing. Large proportions of lipid were lost to the walls of silicone rubber and polyvinyl chloride tubes. The major portion of the lipid lost was recoverable only when chloroform-methanol was perfuse...

journal_title：Journal of lipid research

authors： Lee KY

更新日期：1971-09-01 00:00:00

abstract：:Diseases such as obesity, diabetes, and atherosclerosis result from multiple genetic and environmental factors, and importantly, interactions between genetic and environmental factors. Identifying susceptibility genes for these diseases using genetic and genomic technologies is accelerating, and the expectation over t...

journal_title：Journal of lipid research

authors： Schadt EE,Lum PY

更新日期：2006-12-01 00:00:00

abstract：:Egg triglycerides chromatographed on silicic acid are eluted in a skew curve in which fatty acid composition varies. The triglycerides were cleaved by sodium methoxide in chloroform-methanol at 0 degrees C to yield diglycerides (11.3%) and monoglycerides (17.5% of original triglycerides) after 3 min. Complete cleavage...

journal_title：Journal of lipid research

authors： Marinetti GV

更新日期：1966-11-01 00:00:00

abstract：:An enzyme-coupled, colorimetric method for the assay of acyl-CoA synthetase is described. Acyl-CoA formed from fatty acid and CoA by acyl-CoA synthetase was dehydrogenated by acyl-CoA oxidase. Hydrogen peroxide produced was then converted into formaldehyde in the presence of methanol by catalase. The formaldehyde reac...

journal_title：Journal of lipid research

authors： Ichihara K,Shibasaki Y

更新日期：1991-10-01 00:00:00

abstract：:Nine even-numbered saturated (C4 to C20) and two unsaturated (C18:1, C18:2) cholesterol alkyl ethers were studied by differential scanning calorimetry, polarizing microscopy, and X-ray powder diffraction. Seven of the nine saturated ethers examined melt into stable liquid crystal mesophases. Mesophase transition tempe...

journal_title：Journal of lipid research

authors： Deckelbaum RJ,Halperin G,Atkinson D

更新日期：1983-05-01 00:00:00

abstract：:Purified liver plasma membranes were prepared from rats fed a high-fat, carbohydrate-free diet or a high-glucose, fat-free diet. Membranes from rats fed the high-fat diet bound significantly less 125I-labeled concanavalin A (Con A) than did those from rats fed the fat-free diets. The magnitude of the binding differenc...

journal_title：Journal of lipid research

authors： Henriquez DS,Tepperman HM,Tepperman J

更新日期：1979-07-01 00:00:00

abstract：:Human monocyte-derived macrophages secrete lipoprotein lipase (LPL) in culture. The regulation of human macrophage LPL production is poorly understood. Since bacterial lipopolysaccharide (LPS) alters production of several macrophage secretory products, its effect on human monocyte-derived macrophage LPL was tested. LP...

journal_title：Journal of lipid research

authors： White JR,Chait A,Klebanoff SJ,Deeb S,Brunzell JD

更新日期：1988-10-01 00:00:00

abstract：:Serum amyloid A (SAA) is an acute phase reactant that can become the predominant apolipoprotein of high density lipoprotein (HDL) during severe inflammatory states. However, the function of SAA is unknown. To study the ability of SAA to form HDL in the absence of apolipoprotein A-I, we expressed the mouse SAA pI 6.15 ...

journal_title：Journal of lipid research

authors： Webb NR,de Beer MC,van der Westhuyzen DR,Kindy MS,Banka CL,Tsukamoto K,Rader DL,de Beer FC

更新日期：1997-08-01 00:00:00

abstract：:4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar excess of apoA-I. Physiologic concentrations ( approximately 35 microM) of human apoA-I did not inhibit the production of LDL-induced monocyte chemotactic activity...

journal_title：Journal of lipid research

authors： Van Lenten BJ,Wagner AC,Jung CL,Ruchala P,Waring AJ,Lehrer RI,Watson AD,Hama S,Navab M,Anantharamaiah GM,Fogelman AM

更新日期：2008-11-01 00:00:00

abstract：:In hepatocytes, vitamin E is secreted via the efflux pathway and is believed to associate with apolipoprotein B (apoB)-lipoproteins extracellularly. The molecular mechanisms involved in the uptake, intracellular trafficking, and secretion of dietary vitamin E by the intestinal cells are unknown. We observed that low c...

journal_title：Journal of lipid research

authors： Anwar K,Kayden HJ,Hussain MM

更新日期：2006-06-01 00:00:00

abstract：:Hepatic steatosis is one of the most common liver disorders in the general population. The main cause of hepatic steatosis is nonalcoholic fatty liver disease (NAFLD), representing the hepatic component of the metabolic syndrome, which is characterized by type 2 diabetes, obesity, and dyslipidemia. Insulin resistance ...

journal_title：Journal of lipid research

authors： Hooper AJ,Adams LA,Burnett JR

更新日期：2011-04-01 00:00:00

abstract：:In this study we employed a capillary gas-liquid chromatographic-mass spectrometric (GLC-MS) method to measure the plasma concentrations of 3-hydroxybutyrate (3-OHB) and 3-hydroxyisobutyrate (3-OHIB) in overnight fasted diabetic subjects and in normal subjects. Plasma contents of 3-hydroxybutyrate measured in this fas...

journal_title：Journal of lipid research

authors： Avogaro A,Bier DM

更新日期：1989-11-01 00:00:00