A Tribute to the Philadelphia Lipid Group on the Occasion of Their Retirement.

abstract：:In human serum, polymorphism of apoA-II predominantly in HDL3 could be demonstrated. HDL3-apoA-II was composed of four isoproteins, each with a molecular weight of 8600 (reduced form) and identical immunological properties. The isoproteins are designated apoA-II-1 (pI 5.16), apoA-II-2 (pI 4.89) corresponding to the al...

journal_title：Journal of lipid research

authors： Schmitz G,Ilsemann K,Melnik B,Assmann G

更新日期：1983-08-01 00:00:00

abstract：:A reversed phase high performance liquid chromatographic (HPLC) method was developed for direct profiling and determination of adrenal cholesteryl ester composition. Cholesteryl adrenate and cholesteryl cervonate, which are not commercially available, were synthesized as markers. Lipid extracts of rat adrenal homogena...

journal_title：Journal of lipid research

authors： Cheng B,Kowal J

更新日期：1994-06-01 00:00:00

abstract：:The fatty acid transport protein (FATP) Fat1p in the yeast Saccharomyces cerevisiae functions in concert with acyl-coenzyme A synthetase (ACSL; either Faa1p or Faa4p) in vectorial acylation, which couples the transport of exogenous fatty acids with activation to CoA thioesters. To further define the role of Fat1p in t...

journal_title：Journal of lipid research

authors： Obermeyer T,Fraisl P,DiRusso CC,Black PN

更新日期：2007-11-01 00:00:00

abstract：:This study was undertaken to determine the mechanisms that regulate cholesterol synthesis in vivo and to quantitate the relative importance of the liver and extrahepatic tissues as sites for sterol synthesis. Rats were administered [3H]water intravenously and killed 1 hour later. The amount of [3H]water incorporated i...

journal_title：Journal of lipid research

authors： Jeske DJ,Dietschy JM

更新日期：1980-03-01 00:00:00

abstract：:It was postulated that specialized microdomains of the plasma membrane, consistent with caveolae, might play a role in cholesterol trafficking in intestinal cells. The existence, therefore, of caveolin and the role of detergent-resistant microdomains of the plasma membrane in cholesterol trafficking were investigated ...

journal_title：Journal of lipid research

authors： Field FJ,Born E,Murthy S,Mathur SN

更新日期：1998-10-01 00:00:00

abstract：:Rod outer segments (ROSs) are specialized light-sensitive organelles in vertebrate photoreceptor cells. Lipids in ROS are of considerable importance, not only in providing an adequate environment for efficient phototransduction, but also in originating the second messengers involved in signal transduction. ROSs have t...

journal_title：Journal of lipid research

authors： Giusto NM,Pasquaré SJ,Salvador GA,Ilincheta de Boschero MG

更新日期：2010-04-01 00:00:00

abstract：:Our previous studies have demonstrated the activity of oncostatin M (OM) in stimulating the transcription of the human LDL receptor (LDLR) gene in HepG2 cells through a sterol-independent regulatory mechanism. The current studies were designed to determine whether this in vitro property of OM could be recapitulated in...

journal_title：Journal of lipid research

authors： Kong W,Abidi P,Kraemer FB,Jiang JD,Liu J

更新日期：2005-06-01 00:00:00

abstract：:Imidazole catalyzed acylations of lysolipids by acyl-CoAs in water at room temperature and at a pH close to neutrality. In the presence of oleoyl-CoA and either lysophosphatidylcholine, 1-palmitoyl-sn-glycero-3-phosphocholine (LPC); lysophosphatidylglycerol, monoacyl-sn-glycero-3-phosphoglycerol; lysophosphatidyl acid...

journal_title：Journal of lipid research

authors： Testet E,Akermoun M,Shimoji M,Cassagne C,Bessoule JJ

更新日期：2002-07-01 00:00:00

abstract：:Lipid transfer inhibitor protein (LTIP) is a regulator of cholesteryl ester transfer protein (CETP) function. Factors affecting plasma LTIP levels are poorly understood. In humans, plasma LTIP is elevated in hypercholesterolemia. To define possible mechanisms by which hyperlipidemia modifies LTIP, we investigated the ...

journal_title：Journal of lipid research

authors： Izem L,Morton RE

更新日期：2009-04-01 00:00:00

abstract：:The pathogenesis of aortic valve stenosis (AS) is characterized by the accumulation of LDL-derived cholesterol in the diseased valves. Since LDL particles also contain plant sterols, we investigated whether plant sterols accumulate in aortic valve lesions. Serum samples were collected from 82 patients with severe AS a...

journal_title：Journal of lipid research

authors： Helske S,Miettinen T,Gylling H,Mäyränpää M,Lommi J,Turto H,Werkkala K,Kupari M,Kovanen PT

更新日期：2008-07-01 00:00:00

abstract：:Conventional ideas concerning the unidirectional movement of triacylglycerol from intestinal lumen to lymph with sn-2-monoacylglycerol being the major glyceride-glycerol precursor were challenged by our finding that steady state specific activities of radiolabeled triacylglycerol (glyceryl moiety) in the intestinal mu...

journal_title：Journal of lipid research

authors： Mansbach CM 2nd,Parthasarathy S

更新日期：1982-09-01 00:00:00

abstract：:Ceramides containing phytosphingosine as base and one of the fatty acids 16:0, 18:0, 20:0, 22:0, 23:0, and 24:0, were prepared by direct coupling in the presence of a mixed carbodiimide. The ceramides were analyzed as the 1,3,4-tri-O-trimethylsilyl ether derivatives by gas-liquid chromatography-mass spectrometry. Gas ...

journal_title：Journal of lipid research

authors： Hammarström S

更新日期：1970-05-01 00:00:00

abstract：:A three-step procedure has been developed for the separation of complex mixtures of sterol intermediates in cholesterol biosynthesis. The method has been applied to the separation of sterol intermediates formed from [14C]mevalonate by normal rat hepatocyte culture cells. In Step 1, a short gravity-flow silicic acid co...

journal_title：Journal of lipid research

authors： Hansbury E,Scallen TJ

更新日期：1980-09-01 00:00:00

abstract：:The storage of lipids in the form of triglycerides (TGs) and the de novo synthesis (lipogenesis) of fatty acids from nonlipid precursors [de novo lipogenesis (DNL)] are important functions of adipose tissue (AT) that influence whole-body metabolism. Yet, few studies have reported in vivo estimates of adipose lipid kin...

journal_title：Journal of lipid research

authors： White UA,Fitch MD,Beyl RA,Hellerstein MK,Ravussin E

更新日期：2018-09-01 00:00:00

abstract：:The mechanisms involved in the development of alcoholic liver disease (ALD) are not well established. We investigated the involvement of acyl-CoA: diacylglycerol acyltransferase 2 (DGAT2) upregulation in mediating hepatic fat accumulation induced by chronic alcohol consumption. Chronic alcohol feeding caused fatty liv...

journal_title：Journal of lipid research

authors： Wang Z,Yao T,Song Z

更新日期：2010-11-01 00:00:00

abstract：:Precipitation of cholesterol crystals from vesicles is an important step in the pathogenesis of cholesterol gallstones. Little is known, however, about the kinetics and the mechanisms involved in cholesterol crystallization. Therefore, the time course of cholesterol crystal precipitation and lipid exchange between ves...

journal_title：Journal of lipid research

authors： van de Heijning BJ,Stolk MF,van Erpecum KJ,Renooij W,Groen AK,vanBerge-Henegouwen GP

更新日期：1994-06-01 00:00:00

abstract：:3alpha-Hydroxy-5-cholanoic acid (lithocholic acid) and some unidentified acids (one of them perhaps 3-hydroxy-cholest-5-en-26-oic acid) have been detected in the brains of guinea pigs afflicted with experimental "allergic" encephalomyelitis. None of the acids could be identified in comparable amounts of brain tissue f...

journal_title：Journal of lipid research

authors： Naqvi SH,Herndon BL,Kelley MT,Bleisch V,Aexel RT,Nicholas HJ

更新日期：1969-01-01 00:00:00

abstract：:Pulmonary surfactant is a lipid:protein complex containing dipalmitoyl-phosphatidylcholine (DPPC) as the major component. Recent studies indicate adsorbed surfactant films consist of a surface monolayer and a monolayer-associated reservoir. It has been hypothesized that the monolayer and its functionally contiguous re...

journal_title：Journal of lipid research

authors： Yu SH,Possmayer F

更新日期：2003-03-01 00:00:00

abstract：:Biliary lipids (bile salts, phospholipids, cholesterol, plant sterols) were determined in 89 vertebrate species (cartilaginous and bony fish, reptiles, birds, and mammals), and individual phospholipid classes were measured in 35 species. All samples contained conjugated bile salts (C(27) bile alcohol sulfates and/or N...

journal_title：Journal of lipid research

authors： Moschetta A,Xu F,Hagey LR,van Berge-Henegouwen GP,van Erpecum KJ,Brouwers JF,Cohen JC,Bierman M,Hobbs HH,Steinbach JH,Hofmann AF

更新日期：2005-10-01 00:00:00

abstract：:The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis. Fibrate-statin combination therapy reduces ApoB levels and coronary events in the mixed dyslipidemia population. We sought to identify gene-gene ...

journal_title：Journal of lipid research

authors： Ma L,Ballantyne CM,Belmont JW,Keinan A,Brautbar A

更新日期：2012-11-01 00:00:00

abstract：:Ethanolamine phosphotransferase (EPT)1, also known as selenoprotein 1 (SELENOI), is an enzyme that transfers phosphoethanolamine from cytidine diphosphate-ethanolamine to lipid acceptors to produce ethanolamine glycerophospholipids, such as diacyl-linked phosphatidylethanolamine (PE) and ether-linked plasmalogen [1-al...

journal_title：Journal of lipid research

authors： Horibata Y,Elpeleg O,Eran A,Hirabayashi Y,Savitzki D,Tal G,Mandel H,Sugimoto H

更新日期：2018-06-01 00:00:00

abstract：:Previous studies have indicated that a G to A substitution at position -76 in the gene encoding apolipoprotein A-I (apoA-I) confers increased plasma high density lipoprotein cholesterol (HDL-C). Increased HDL-C may be a direct consequence of the A allele, or may reflect the action of a locus in linkage disequilibrium ...

journal_title：Journal of lipid research

authors： Barre DE,Guerra R,Verstraete R,Wang Z,Grundy SM,Cohen JC

更新日期：1994-07-01 00:00:00

abstract：:There is unequivocal evidence of an inverse association between plasma high-density lipoprotein (HDL) cholesterol concentrations and the risk of cardiovascular disease, a finding that has led to the hypothesis that HDL protects from atherosclerosis. This review details the experimental evidence for this "HDL hypothesi...

journal_title：Journal of lipid research

authors： Vergeer M,Holleboom AG,Kastelein JJ,Kuivenhoven JA

更新日期：2010-08-01 00:00:00

abstract：:The recent insight that inflammation contributes to the development of atherosclerosis and type 2 diabetes mellitus constitutes a major breakthrough in understanding the mechanisms underlying these conditions. In addition, it opens the way for new therapeutic approaches that might eventually decrease the prevalence of...

journal_title：Journal of lipid research

authors： Popa C,Netea MG,van Riel PL,van der Meer JW,Stalenhoef AF

更新日期：2007-04-01 00:00:00

abstract：:The resistin gene is expressed in adipocytes and encodes a protein proposed to link obesity and type 2 diabetes. Increased plasma FFA is associated with insulin resistance. We examined the effect of separate FFAs on the expression of resistin mRNA in cultured murine 3T3-L1 adipocytes. The FFAs tested did not increase ...

journal_title：Journal of lipid research

authors： Haugen F,Zahid N,Dalen KT,Hollung K,Nebb HI,Drevon CA

更新日期：2005-01-01 00:00:00

abstract：:Expression of constitutively activated Akt in the mammary glands of transgenic mice results in a delay in post-lactational involution. We now report precocious lipid accumulation in the alveolar epithelium of mouse mammary tumor virus-myr-Akt transgenic mice accompanied by a lactation defect that results in a 50% decr...

journal_title：Journal of lipid research

authors： Schwertfeger KL,McManaman JL,Palmer CA,Neville MC,Anderson SM

更新日期：2003-06-01 00:00:00

abstract：:Despite a complete lack of microsomal triglyceride transfer protein (MTP), L35 rat hepatoma cells secrete triglyceride-containing lipoproteins, albeit at a rate 25% of that of parental FAO hepatoma cells, which express high levels of MTP. The inability to express MTP was associated with a complete block in the secreti...

journal_title：Journal of lipid research

authors： Hui TY,Olivier LM,Kang S,Davis RA

更新日期：2002-05-01 00:00:00

abstract：:In an effort to explore the feasibility of converting a lipase into an esterase by modifying the lid region, we designed and characterized two novel Rhizopus chinensis lipase variants by lid swapping. The substrate specificity of an R. chinensis lipase was successfully modified toward water-soluble substrates, that is...

journal_title：Journal of lipid research

authors： Yu XW,Zhu SS,Xiao R,Xu Y

更新日期：2014-06-01 00:00:00

abstract：:Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents. Using the knowledge gained from the development of PFTIs for the treatment of cancer, researc...

journal_title：Journal of lipid research

authors： Eastman RT,Buckner FS,Yokoyama K,Gelb MH,Van Voorhis WC

更新日期：2006-02-01 00:00:00

abstract：:Decreased HDL-cholesterol (HDL-C) and familial combined hyperlipidemia (FCHL) are the two most common familial dyslipidemias predisposing to premature coronary heart disease (CHD). These dyslipidemias share many phenotypic features, suggesting a partially overlapping molecular pathogenesis. This was supported by our p...

journal_title：Journal of lipid research

authors： Lilja HE,Suviolahti E,Soro-Paavonen A,Hiekkalinna T,Day A,Lange K,Sobel E,Taskinen MR,Peltonen L,Perola M,Pajukanta P

更新日期：2004-10-01 00:00:00