Abstract:
OBJECTIVES:To compare maturity of placentas from women with hypertensive disorders with those from normotensive pregnancies and to determine the relationship between placental maturity (PM) and the diagnosis of small-for-gestational-age (SGA) in the newborns. MATERIALS AND METHODS:We examined placental stained specimens from women with normotensive pregnancies (n = 100), diagnosis of gestational hypertension (n = 38), mild (n = 10), or severe preeclampsia (n = 34) in an optical microscope. Placental Maturity Index (PMI) was calculated as the number of vasculo-syncytial membranes (VSM) in 1 mm(2) divided by VSM thickness (µm). Hypermaturity was defined as >90th percentile of the PMI from placentas of normotensive pregnancies. Newborns were classified as SGA, adequate-for-gestational-age (AGA) or large-for-gestational-age (<10th, 10-90th, and >90th percentile from weight for gestational age reference tables, respectively). RESULTS:PMI in preeclamptic women (taking together mild and severe preeclampsia, PMI = 43.4 ± 1.6) was significantly higher than in normotensive women (PMI = 36 ± 2, p = 0.045). Hypermaturity was more frequent (p < 0.05) in placentas from women with preeclampsia than in those from normotensive women only in preterm pregnancies (<37 weeks), but not in those at term (p = 0.41). The frequency of hypermaturity in placentas from women with gestational hypertension was not statistically different than in normotensive women. Hypermaturity was also more frequent in placentas from SGA (OR = 2.63, p < 0.05) than in AGA newborns. CONCLUSION:The PMI was increased in preeclampsia, but not in gestational hypertension. Placental hypermaturity was also associated with the diagnosis of SGA in newborns. PM might have a role in the relationship between maternal factors and SGA.
journal_name
Hypertens Pregnancyjournal_title
Hypertension in pregnancyauthors
Ruiz-Quiñonez G,Reza-López SA,Chávez-Corral DV,Sánchez-Ramírez B,Leal-Berumen I,Levario-Carrillo Mdoi
10.3109/10641955.2013.842583subject
Has Abstractpub_date
2014-05-01 00:00:00pages
132-44issue
2eissn
1064-1955issn
1525-6065journal_volume
33pub_type
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journal_title:Hypertension in pregnancy
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章,随机对照试验
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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journal_title:Hypertension in pregnancy
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更新日期:2014-08-01 00:00:00
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journal_title:Hypertension in pregnancy
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更新日期:2002-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2012.704108
更新日期:2013-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:Hypertension in pregnancy
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更新日期:2011-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Hypertension in pregnancy
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更新日期:2010-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
doi:10.3109/10641955.2014.913615
更新日期:2015-11-01 00:00:00
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journal_title:Hypertension in pregnancy
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更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1081/PRG-120002906
更新日期:2002-01-01 00:00:00
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journal_title:Hypertension in pregnancy
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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更新日期:2020-05-01 00:00:00