Ribosome profiling reveals features of normal and disease-associated mitochondrial translation.

abstract：:Type I CRISPR-Cas loci provide prokaryotes with a nucleic-acid-based adaptive immunity against foreign DNA. Immunity involves adaptation, the integration of ~30-bp DNA fragments, termed prespacers, into the CRISPR array as spacers, and interference, the targeted degradation of DNA containing a protospacer. Interferenc...

journal_title：Nature communications

authors： Shiriaeva AA,Savitskaya E,Datsenko KA,Vvedenskaya IO,Fedorova I,Morozova N,Metlitskaya A,Sabantsev A,Nickels BE,Severinov K,Semenova E

更新日期：2019-10-10 00:00:00

abstract：:Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC o...

journal_title：Nature communications

authors： Grassmann F,He W,Eriksson M,Gabrielson M,Hall P,Czene K

更新日期：2019-10-22 00:00:00

abstract：:Oriented assemblies of functional nanoparticles, with the aid of external physical and chemical driving forces, have been prepared on two-dimensional solid substrates. It is challengeable, however, to achieve three-dimensional assembly directly in solution, owing to thermal fluctuations and free diffusion. Here we des...

journal_title：Nature communications

authors： Kim K,Han HS,Choi I,Lee C,Hong S,Suh SH,Lee LP,Kang T

更新日期：2013-01-01 00:00:00

abstract：:Sodium-ion batteries are an alternative to lithium-ion batteries for large-scale applications. However, low capacity and poor rate capability of existing anodes are the main bottlenecks to future developments. Here we report a uniform coating of antimony sulphide (stibnite) on graphene, fabricated by a solution-based ...

journal_title：Nature communications

authors： Yu DY,Prikhodchenko PV,Mason CW,Batabyal SK,Gun J,Sladkevich S,Medvedev AG,Lev O

更新日期：2013-01-01 00:00:00

abstract：:Gut microbiota has been implicated in major diseases affecting the human population and has also been linked to triglycerides and high-density lipoprotein levels in the circulation. Recent development in metabolomics allows classifying the lipoprotein particles into more details. Here, we examine the impact of gut mic...

journal_title：Nature communications

authors： Vojinovic D,Radjabzadeh D,Kurilshikov A,Amin N,Wijmenga C,Franke L,Ikram MA,Uitterlinden AG,Zhernakova A,Fu J,Kraaij R,van Duijn CM

更新日期：2019-12-20 00:00:00

abstract：:The cycling of carbon between Earth's surface and interior governs the long-term habitability of the planet. But how carbon migrates in the deep Earth is not well understood. In particular, the potential role of hydrocarbon fluids in the deep carbon cycle has long been controversial. Here we show that immiscible isobu...

journal_title：Nature communications

authors： Huang F,Daniel I,Cardon H,Montagnac G,Sverjensky DA

更新日期：2017-06-12 00:00:00

abstract：:Classic, model-based theory of land-atmosphere interactions across the Sahel promote positive vegetation-rainfall feedbacks dominated by surface albedo mechanism. However, neither the proposed positive vegetation-rainfall feedback nor its underlying albedo mechanism has been convincingly demonstrated using observation...

journal_title：Nature communications

authors： Yu Y,Notaro M,Wang F,Mao J,Shi X,Wei Y

更新日期：2017-11-30 00:00:00

abstract：:Macrophages serve multiple functions including immune regulation, morphogenesis, tissue homeostasis and healing reactions. The current paradigm holds that mammary gland macrophages first arise postnatally during the prepubertal period from the bone marrow-derived monocytes. Here we delineate the origins of tissue-resi...

journal_title：Nature communications

authors： Jäppinen N,Félix I,Lokka E,Tyystjärvi S,Pynttäri A,Lahtela T,Gerke H,Elima K,Rantakari P,Salmi M

更新日期：2019-01-17 00:00:00

abstract：:Purely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over...

journal_title：Nature communications

authors： Zhang X,Du L,Zhao W,Zhao Z,Xiong Y,He X,Gao PF,Alam P,Wang C,Li Z,Leng J,Liu J,Zhou C,Lam JWY,Phillips DL,Zhang G,Tang BZ

更新日期：2019-11-14 00:00:00

abstract：:Thousands of tons of isotopic mixtures are processed annually for heavy-water production and tritium decontamination. The existing technologies remain extremely energy intensive and require large capital investments. New approaches are needed to reduce the industry's footprint. Recently, micrometre-size crystals of gr...

journal_title：Nature communications

authors： Lozada-Hidalgo M,Zhang S,Hu S,Esfandiar A,Grigorieva IV,Geim AK

更新日期：2017-05-09 00:00:00

abstract：:MADS-domain transcription factors have been shown to act as key repressors or activators of the transition to flowering and as master regulators of reproductive organ identities. Despite their important roles in plant development, the origin of several MADS-box subfamilies has remained enigmatic so far. Here we demons...

journal_title：Nature communications

authors： Ruelens P,de Maagd RA,Proost S,Theißen G,Geuten K,Kaufmann K

更新日期：2013-01-01 00:00:00

abstract：:The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

journal_title：Nature communications

authors： Aberg J

更新日期：2013-01-01 00:00:00

abstract：:Materials with switchable absorption properties have been widely used for smart window applications to reduce energy consumption and enhance occupant comfort in buildings. In this work, we combine the benefits of smart windows with energy conversion by producing a photovoltaic device with a switchable absorber layer t...

journal_title：Nature communications

authors： Wheeler LM,Moore DT,Ihly R,Stanton NJ,Miller EM,Tenent RC,Blackburn JL,Neale NR

更新日期：2017-11-23 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00

abstract：:Plasma accelerators driven by particle beams are a very promising future accelerator technology as they can sustain high accelerating fields over long distances with high energy efficiency. They rely on the excitation of a plasma wave in the wake of a drive beam. To generate the plasma, a neutral gas can be field-ioni...

journal_title：Nature communications

authors： Corde S,Adli E,Allen JM,An W,Clarke CI,Clausse B,Clayton CE,Delahaye JP,Frederico J,Gessner S,Green SZ,Hogan MJ,Joshi C,Litos M,Lu W,Marsh KA,Mori WB,Vafaei-Najafabadi N,Walz D,Yakimenko V

更新日期：2016-06-17 00:00:00

abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...

journal_title：Nature communications

authors： Wang H,D'Souza C,Lim XY,Kostenko L,Pediongco TJ,Eckle SBG,Meehan BS,Shi M,Wang N,Li S,Liu L,Mak JYW,Fairlie DP,Iwakura Y,Gunnersen JM,Stent AW,Godfrey DI,Rossjohn J,Westall GP,Kjer-Nielsen L,Strugnell RA,McClusk

更新日期：2018-08-22 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one o...

journal_title：Nature communications

authors： Mondal T,Subhash S,Vaid R,Enroth S,Uday S,Reinius B,Mitra S,Mohammed A,James AR,Hoberg E,Moustakas A,Gyllensten U,Jones SJ,Gustafsson CM,Sims AH,Westerlund F,Gorab E,Kanduri C

更新日期：2015-07-24 00:00:00

abstract：:The world is entering a new era of the COVID-19 pandemic in which there is an increasing call for reliable antibody testing. To support decision making on the deployment of serology for either population screening or diagnostics, we present a detailed comparison of serological COVID-19 assays. We show that among the s...

journal_title：Nature communications

authors： GeurtsvanKessel CH,Okba NMA,Igloi Z,Bogers S,Embregts CWE,Laksono BM,Leijten L,Rokx C,Rijnders B,Rahamat-Langendoen J,van den Akker JPC,van Kampen JJA,van der Eijk AA,van Binnendijk RS,Haagmans B,Koopmans M

更新日期：2020-07-06 00:00:00

abstract：:Over the last century the North Anatolian Fault Zone in Turkey has produced a remarkable sequence of large earthquakes. These events have now left an earthquake gap south of Istanbul and beneath the Marmara Sea, a gap that has not been filled for 250 years. Here we investigate the nature of the eastern end of this gap...

journal_title：Nature communications

authors： Bohnhoff M,Bulut F,Dresen G,Malin PE,Eken T,Aktar M

更新日期：2013-01-01 00:00:00

abstract：:In nature, plant tendrils can produce two fundamental motion modes, bending and chiral twisting (helical curling) distortions, under the stimuli of sunlight, humidity, wetting or other atmospheric conditions. To date, many artificial plant-like mechanical machines have been developed. Although some previously reported...

journal_title：Nature communications

authors： Wang M,Lin BP,Yang H

更新日期：2016-12-22 00:00:00

abstract：:A Weyl semimetal possesses spin-polarized band-crossings, called Weyl nodes, connected by topological surface arcs. The low-energy excitations near the crossing points behave the same as massless Weyl fermions, leading to exotic properties like chiral anomaly. To have the transport properties dominated by Weyl fermion...

journal_title：Nature communications

authors： Xu N,Weng HM,Lv BQ,Matt CE,Park J,Bisti F,Strocov VN,Gawryluk D,Pomjakushina E,Conder K,Plumb NC,Radovic M,Autès G,Yazyev OV,Fang Z,Dai X,Qian T,Mesot J,Ding H,Shi M

更新日期：2016-03-17 00:00:00

abstract：:Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The...

journal_title：Nature communications

authors： Torres JP,Lin Z,Winter JM,Krug PJ,Schmidt EW

更新日期：2020-06-08 00:00:00

abstract：:The vimentin network displays remarkable plasticity to support basic cellular functions and reorganizes during cell division. Here, we show that in several cell types vimentin filaments redistribute to the cell cortex during mitosis, forming a robust framework interwoven with cortical actin and affecting its organizat...

journal_title：Nature communications

authors： Duarte S,Viedma-Poyatos Á,Navarro-Carrasco E,Martínez AE,Pajares MA,Pérez-Sala D

更新日期：2019-09-13 00:00:00

abstract：:In addition to acting as a cellular energy source, ATP can also act as a damage-associated molecular pattern in both animals and plants. Stomata are leaf pores that control gas exchange and, therefore, impact critical functions such as photosynthesis, drought tolerance, and also are the preferred entry point for patho...

journal_title：Nature communications

authors： Chen D,Cao Y,Li H,Kim D,Ahsan N,Thelen J,Stacey G

更新日期：2017-12-22 00:00:00

abstract：:The discovery of superconductivity at 260 K in hydrogen-rich compounds like LaH10 re-invigorated the quest for room temperature superconductivity. Here, we report the temperature dependence of the upper critical fields μ0Hc2(T) of superconducting H3S under a record-high combination of applied pressures up to 160 GPa a...

journal_title：Nature communications

authors： Mozaffari S,Sun D,Minkov VS,Drozdov AP,Knyazev D,Betts JB,Einaga M,Shimizu K,Eremets MI,Balicas L,Balakirev FF

更新日期：2019-06-07 00:00:00

abstract：:Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...

journal_title：Nature communications

authors： Galenkamp NS,Soskine M,Hermans J,Wloka C,Maglia G

更新日期：2018-10-05 00:00:00

abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

journal_title：Nature communications

authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

更新日期：2018-04-18 00:00:00

abstract：:Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. He...

journal_title：Nature communications

authors： Sultana N,Zhang L,Yan J,Chen J,Cai W,Razzaque S,Jeong D,Sheng W,Bu L,Xu M,Huang GY,Hajjar RJ,Zhou B,Moon A,Cai CL

更新日期：2015-10-30 00:00:00

abstract：:A key challenge in the field of molecular spintronics, and for the design of single-molecule magnet-based devices in particular, is the understanding and control of the molecular coupling at the electrode interfaces. It was demonstrated for the field of molecular electronics that the characterization of the molecule-m...

journal_title：Nature communications

authors： Schwöbel J,Fu Y,Brede J,Dilullo A,Hoffmann G,Klyatskaya S,Ruben M,Wiesendanger R

更新日期：2012-07-17 00:00:00

abstract：:Maize rough dwarf disease (MRDD), caused by various species of the genus Fijivirus, threatens maize production worldwide. We previously identified a quantitative locus qMrdd1 conferring recessive resistance to one causal species, rice black-streaked dwarf virus (RBSDV). Here, we show that Rab GDP dissociation inhibito...

journal_title：Nature communications

authors： Liu Q,Deng S,Liu B,Tao Y,Ai H,Liu J,Zhang Y,Zhao Y,Xu M

更新日期：2020-01-24 00:00:00