Abstract:
:Genome-wide association study (GWAS) analysis identified three new susceptibility loci for PACG. In this study, we aimed to investigate whether these three loci in PLEKHA7, COL11A1, and PCMTD1-ST18 are associated with PAC and ocular biometric characteristics, such as axial length (AL), anterior chamber depth (ACD), and diopter of spherical power (DS). The study was a part of the Jiangsu Eye Study. The samples were collected from 232 PAC subjects and 306 controls from a population-based prevalence survey conducted in Funing County of Jiangsu, China. The single nucleotide polymorphisms (SNPs) of rs11024102 in PLEKHA7, rs3753841 in COL11A1, and rs1015213 in PCMTD1-ST18 were genotyped by TaqMan-MGB probe using the RT-PCR system. None of the three polymorphisms showed differences in the distribution of genotypes and allele frequencies between the PAC group and the control group. No significant association was determined between the 3 SNPs and AL, ACD, or DS of PAC subjects. We concluded that even though PLEKHA7 rs11024102, COL11A1 rs3753841, and PCMTD1-ST18 rs1015213 are associated with PACG, those sequence variations are not associated with PAC in a Han Chinese population. Our results also did not support a significant role for these three SNPs in ocular biometry such as AL, ACD, and DS.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Shi H,Zhu R,Hu N,Shi J,Zhang J,Jiang L,Jiang H,Guan Hdoi
10.1155/2013/641596subject
Has Abstractpub_date
2013-01-01 00:00:00pages
641596eissn
2090-004Xissn
2090-0058journal_volume
2013pub_type
杂志文章abstract::Purpose. To investigate the association of birth parameters with refractive status in different age groups of Caucasian children. Materials and Methods. This cross-sectional study included 564 eyes of 282 children aged 4 to 17 years. All children underwent complete ophthalmologic examination. The children were divided...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/635682
更新日期:2015-01-01 00:00:00
abstract::Purpose. To evaluate the ability of spectral-domain optical coherence tomography to detect subtle amounts of retinal fluid when the choroidal neovascularization is detected as inactive via time-domain optical coherence tomography and clinical examination in neovascular age-related macular degeneration (nAMD) patients....
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/786107
更新日期:2013-01-01 00:00:00
abstract:Objective:This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method:A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/3458356
更新日期:2017-01-01 00:00:00
abstract::This paper demonstrates multiple benefits of intravitreal bevacizumab (IVB) on diabetic retinopathy (DR) including diabetic macular edema (DME) and proliferative diabetic retinopathy (PDR) at 24 months of followup. This is a retrospective multicenter interventional comparative case series of intravitreal injections of...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/584238
更新日期:2011-01-01 00:00:00
abstract:Purpose:To compare the outcomes of Ex-PRESS glaucoma filtration device and transscleral cyclophotocoagulation (TSCP) in the management of neovascular glaucoma (NVG). Patients and Methods. A total of 30 eyes (12 express shunts and 18 TSCP) of 28 patients were included. The eyes had NVG with intraocular pressure (IOP) mo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/3781249
更新日期:2020-05-17 00:00:00
abstract::Purpose. To evaluate the relationship between the macular ganglion cell complex (mGCC) thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectral-domain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning las...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/914250
更新日期:2011-01-01 00:00:00
abstract::Purpose. To report a comparative prospective long-term functional analysis after Riboflavin UV A corneal cross-linking (CXL) in three different age groups of patients affected by progressive keratoconus (KC). Methods. Functional analysis comprised paediatric patients (≤18 years) included 152 eyes (29.5%); intermediate...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/608041
更新日期:2011-01-01 00:00:00
abstract::The ocular surface-a continuous epithelial surface with regional specializations including the surface and glandular epithelia of the cornea, conjunctiva, and lacrimal and meibomian glands connected by the overlying tear film-plays a central role in vision. Molecular and cellular events involved in embryonic developme...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/103947
更新日期:2013-01-01 00:00:00
abstract::Purpose. To examine the clinical implications of change in choroidal neovascularization (CNV) size on indocyanine green (ICG) angiography in subjects with idiopathic CNV undergoing bevacizumab therapy. Methods. The charts of subjects with an idiopathic CNV treated by a modified PRN regimen with intravitreal bevacizuma...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/642624
更新日期:2015-01-01 00:00:00
abstract::Aim. To assess the effects of mydriatics commonly used in clinical practice on choroidal thickness and anterior chamber change. Methods. This was a prospective, randomized, controlled, double-blinded study including a single eye of the participants. The subjects were assigned into 4 groups to receive tropicamide 1%, p...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/981274
更新日期:2015-01-01 00:00:00
abstract::This study is for identifying systemic factors correlating with intraocular levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in diabetic retinopathy. Forty-two consecutive patients undergoing pars plana vitrectomy (PPV) for PDR were included in this cross-sectional study. The aqueous humor ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/4831967
更新日期:2019-07-17 00:00:00
abstract::Current data permit only speculations regarding sex differences in the prevalence of infectious uveitis between women and men because uveitis case surveys do not uniformly report gender data. Differences in prevalence that are reported in the literature could relate to simple differences in the number of women and men...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2014/683246
更新日期:2014-01-01 00:00:00
abstract:Purpose:One of the most difficult refractory glaucomas is the neovascular type (NVG), and its association with dense cataract adds to this difficulty. This study aimed to provide results of the triple surgical procedure for such conditions. Methods:12 eyes of 12 patients with NVG and dense cataract were included in th...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/1251203
更新日期:2020-06-21 00:00:00
abstract:Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1926736
更新日期:2018-08-01 00:00:00
abstract::Purpose. To investigate the effect of cigarette smoking on the ocular tear film. Methods. Thirty healthy young male cigarette smokers (20-38 years old) and 30 healthy age matched nonsmokers were enrolled in the study. McMonnies questionnaire, slit lamp, and PRT test were used to screen the subjects. Tear samples were ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/8154315
更新日期:2016-01-01 00:00:00
abstract::Purpose. To describe the SD-OCT findings in patients with diffuse unilateral subacute neuroretinitis (DUSN) and evaluate CRT and RNFL thickness. Methods. Patients with clinical diagnosis of DUSN who were submitted to SD-OCT were included in the study. Complete ophthalmologic examination and SD-OCT were performed. Cirr...
journal_title:Journal of ophthalmology
pub_type:
doi:10.1155/2011/285296
更新日期:2011-01-01 00:00:00
abstract:Aims:To determine the accuracy and repeatability of new software to automatically quantify GA areas associated to age-related macular degeneration (AMD) by swept-source optical coherence tomography (SS-OCT). Settings and Design. Tertiary referral hospital in Spain. Cross-sectional and noninterventional. Methods and Mat...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/8204641
更新日期:2020-08-05 00:00:00
abstract:PURPOSE:To investigate the detailed distribution of corneal epithelial thickness in single sectors and its correlated characteristics in myopic eyes. METHODS:SD-OCT was used to measure the corneal epithelial thickness distribution profile. Differences of corneal epithelial thickness between different parameters and so...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1018321
更新日期:2017-01-01 00:00:00
abstract:Purpose:To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls. Methods:Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, i...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2012560
更新日期:2018-09-23 00:00:00
abstract:PURPOSE:To investigate neovascular age-related macular degeneration (AMD) in patients aged ≥90 years from several perspectives for a comprehensive overview: prevalence, presenting characteristics, treatment adherence, reasons for discontinuation, and efficacy of antivascular endothelial growth factor (VEGF) treatment c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/7194927
更新日期:2017-01-01 00:00:00
abstract::Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materia...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/6354025
更新日期:2017-01-01 00:00:00
abstract:Purpose:To examine the current knowledge about the age-related processes in the anterior segment of the eye at a biological, clinical, and molecular level. Methods:We reviewed the available published literature that addresses the aging process of the anterior segment of the eye and its associated molecular and physiol...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2017/1295132
更新日期:2017-01-01 00:00:00
abstract:Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/2670153
更新日期:2020-07-25 00:00:00
abstract::Purpose. To evaluate the relationship between self-reported vision-related quality of life (VRQL) and visual field (VF) loss in people from glaucoma clinics. Methods. A postal survey using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) was administered to people with a range of VF loss identifie...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/1621640
更新日期:2017-01-01 00:00:00
abstract::Purpose. To assess the different check sizes of pattern visual evoked potential (PVEP) in diabetic patients without retinopathy according to HbA1c levels and diabetes duration. Methods. Fifty-eight eligible patients with type 2 diabetes mellitus and 26 age- and sex-matched healthy controls were included in the study. ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/8597629
更新日期:2017-01-01 00:00:00
abstract::Purpose. To evaluate the relationship between internal carotid artery (ICA) stenosis and subfoveal choroidal thickness (SFCT) in the elderly population. Methods. A total of 42 eyes of 21 patients with more than 70% ICA stenosis (Group 1) on one side and less than 70% stenosis (Group 2) on the other side were recruited...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5296048
更新日期:2016-01-01 00:00:00
abstract::Early diagnosis and positive outcomes of retinoblastoma in childhood have been positively correlated with the economic wealth of high-income countries (HICs) worldwide. Adequate curability and survival rates, adherence to treatment, presence of poor prognostic initial clinical signs, and metastatic disease at diagnosi...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2020/1953602
更新日期:2020-08-10 00:00:00
abstract::Quantitative measurement of the orbital soft tissue volume plays a very important role in the study of orbital diseases. The purpose of this study is to establish a computed tomography- (CT-) based three-dimensional (3D) reconstruction model and measure the orbital soft tissue volume in Chinese adults. We collected da...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9721085
更新日期:2019-07-02 00:00:00
abstract:Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7263564
更新日期:2018-04-17 00:00:00
abstract::The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lacking Lgr4 display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation. This paper will...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/987494
更新日期:2013-01-01 00:00:00