当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Extra-atrial expression of the gene for atrial natriuretic factor.

Extra-atrial expression of the gene for atrial natriuretic factor.

Abstract：

:Atrial natriuretic factor (ANF) is a group of peptides, originally isolated from the cardiac atria, that have a number of important effects on blood pressure, renal function, and salt balance. In the current study, expression of the ANF gene in certain extra-atrial tissues of the rat has been examined by radioimmunoassay of extracted ANF protein and by blot-hybridization, nuclease S1 analysis, and primer-extension analysis of the ANF mRNA. ANF peptides and mRNA were detected in cardiac ventricles, lung, and pituitary gland at levels generally less than or equal to 1% those of cardiac atria. The ANF transcripts in extra-atrial tissue appear to be very similar to those synthesized in the atria. They are polyadenylylated, are equivalent in overall length (950-1050 nucleotides), and have identical 5' termini. A secondary transcription start site mapping approximately 80 base pairs upstream from the primary start site is employed in atria and to a lesser extent in other tissues. The ANF transcript is present throughout the cardiac ventricles from apex to base and in the septum as well as the ventricular free walls. The transcript is more prevalent in the left ventricle and interventricular septum than in the right ventricle. Immunocytochemistry using various anti-rat ANF antibodies localized ANF immunoreactivity to the atrial myocytes; the ventricular myocytes, particularly along the endothelial surface of the ventricular chamber; perialveolar cells in the lung; and the gonadotropin-producing cells of the pituitary. The data indicate that the capacity for ANF gene expression extends beyond atrial tissue, albeit at much reduced levels, and may suggest alternative, perhaps paraendocrine, functions for the peptide in these tissues.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Gardner DG,Deschepper CF,Ganong WF,Hane S,Fiddes J,Baxter JD,Lewicki J

doi

10.1073/pnas.83.18.6697

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

6697-701

issue

18

eissn

0027-8424

issn

1091-6490

journal_volume

83

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors up-regulate transforming growth factor-beta signaling in cultured heart cells via inhibition of geranylgeranylation of RhoA GTPase.

    abstract：:Transforming growth factor-beta (TGFbeta) signaling has been shown to play a role in cardiac development as well as in the pathogenesis of cardiovascular disease. Prior studies have suggested a relationship between cholesterol metabolism and TGFbeta signaling. Here we demonstrate that induction of the cholesterol meta...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.20.11525

    authors： Park HJ,Galper JB

    更新日期：1999-09-28 00:00:00

  • Complex formation between stage-specific oocyte factors and a Xenopus mRNA localization element.

    abstract：:It is a long-standing proposal that localization of maternal factors in eggs can provide the basis for pattern formation in the early embryo. The localized information can be stored as RNA, one example being Vg1 RNA, which is localized exclusively to the vegetal hemisphere of Xenopus oocytes and eggs. Localization of ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.25.14608

    authors： Mowry KL

    更新日期：1996-12-10 00:00:00

  • Lazaroids improve the survival of grafted rat embryonic dopamine neurons.

    abstract：:In rodent models of Parkinson disease in which transplants of dissociated rodent and human embryonic mesencephalic tissue, rich in dopamine neurons, have been studied, only 5-20% of the dopamine neurons survive the implantation procedure. We have investigated the effects of inhibiting free radical generation with two ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.26.12408

    authors： Nakao N,Frodl EM,Duan WM,Widner H,Brundin P

    更新日期：1994-12-20 00:00:00

  • Enzymatic characteristics of the c-Raf-1 protein kinase.

    abstract：:The c-Raf-1 protein kinase plays a central role in the mitogenic response of cells to growth factors, cytokines, and many oncogenes. Despite the critical importance of this enzyme, very little is known of its biochemical properties or mechanisms of regulation. In these experiments, we used the only candidate physiolog...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.4.1270

    authors： Force T,Bonventre JV,Heidecker G,Rapp U,Avruch J,Kyriakis JM

    更新日期：1994-02-15 00:00:00

  • Aging and the encoding of changes in events: The role of neural activity pattern reinstatement.

    abstract：:When encountering unexpected event changes, memories of relevant past experiences must be updated to form new representations. Current models of memory updating propose that people must first generate memory-based predictions to detect and register that features of the environment have changed, then encode the new eve...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1918063117

    authors： Stawarczyk D,Wahlheim CN,Etzel JA,Snyder AZ,Zacks JM

    更新日期：2020-11-24 00:00:00

  • Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

    abstract：:A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide sequence of the gene reveals the existence of 11 exons interrupted by 10 small introns (76-427 base pairs). Putative regulatory sequences have bee...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.85.9.3024

    authors： Millán JL,Manes T

    更新日期：1988-05-01 00:00:00

  • Mineral dust photochemistry induces nucleation events in the presence of SO2.

    abstract：:Large quantities of mineral dust particles are frequently ejected into the atmosphere through the action of wind. The surface of dust particles acts as a sink for many gases, such as sulfur dioxide. It is well known that under most conditions, sulfur dioxide reacts on dust particle surfaces, leading to the production ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1212297109

    authors： Dupart Y,King SM,Nekat B,Nowak A,Wiedensohler A,Herrmann H,David G,Thomas B,Miffre A,Rairoux P,D'Anna B,George C

    更新日期：2012-12-18 00:00:00

  • Postischemic PKC activation rescues retrograde and anterograde long-term memory.

    abstract：:Therapeutics for cerebral ischemia/hypoxia, which often results in ischemic stroke in humans, are a global unmet medical need. Here, we report that bryostatin-1, a highly potent protein kinase C (PKC) activator, interrupts pathophysiological molecular cascades and apoptosis triggered by cerebral ischemia/hypoxia, enha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0907842106

    authors： Sun MK,Hongpaisan J,Alkon DL

    更新日期：2009-08-25 00:00:00

  • Most invasive species largely conserve their climatic niche.

    abstract：:The ecological niche is a key concept for elucidating patterns of species distributions and developing strategies for conserving biodiversity. However, recent times are seeing a widespread debate whether species niches are conserved across space and time (niche conservatism hypothesis). Biological invasions represent ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2004289117

    authors： Liu C,Wolter C,Xian W,Jeschke JM

    更新日期：2020-09-22 00:00:00

  • Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death.

    abstract：:Neutrophil spontaneous death plays essential roles in neutrophil homeostasis and resolution of inflammation, whereas the underlying molecular mechanisms are still ill-defined. Neutrophils die because of programmed cell death or apoptosis. However, treatment with inhibitor of caspases, which are responsible for the maj...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0605722103

    authors： Zhu D,Hattori H,Jo H,Jia Y,Subramanian KK,Loison F,You J,Le Y,Honczarenko M,Silberstein L,Luo HR

    更新日期：2006-10-03 00:00:00

  • Crystal structure of a DNA decamer showing a novel pseudo four-way helix-helix junction.

    abstract：:The crystal structure of the decanucleotide d(CGCAATTGCG)2 has been solved by a combination of molecular replacement and heavy-atom procedures and has been refined to an R factor of 20.2% at 2.7 A. It is not a fully base-paired duplex but has a central core of eight Watson-Crick base pairs flanked by unpaired terminal...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.23.10767

    authors： Spink N,Nunn CM,Vojtechovsky J,Berman HM,Neidle S

    更新日期：1995-11-07 00:00:00

  • Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines.

    abstract：:Mast cells (MCs) are potent inflammatory cells that are distributed throughout mucosal barrier tissues and respond rapidly to pathogenic stimuli. During helminth infections, MCs play an important role as late-stage effectors. However, it is currently unknown whether MCs contribute to the early innate events that deter...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1112268109

    authors： Hepworth MR,Daniłowicz-Luebert E,Rausch S,Metz M,Klotz C,Maurer M,Hartmann S

    更新日期：2012-04-24 00:00:00

  • Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.

    abstract：:Previous studies have identified nuclear matrix attachment regions (MARs) that are closely associated with transcriptional enhancers in the IgH, Igkappa, and T cell receptor (TCR) beta loci, but have yielded conflicting information regarding their functional significance. In this report, a combination of in vitro and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.21.11970

    authors： Zhong XP,Carabaña J,Krangel MS

    更新日期：1999-10-12 00:00:00

  • Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.

    abstract：:Neovascular diseases of the retina include age-related macular degeneration and diabetic retinopathy, and together they comprise the leading causes of adult-onset blindness in developed countries. Current surgical, pharmaceutical, and laser therapies for age-related macular degeneration (AMD) rarely result in improved...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.122247299

    authors： Raisler BJ,Berns KI,Grant MB,Beliaev D,Hauswirth WW

    更新日期：2002-06-25 00:00:00

  • Antigen induces chronic idiotype suppression.

    abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.82.12.4217

    authors： Tokuhisa T,Rajewsky K

    更新日期：1985-06-01 00:00:00

  • DNA modification of a maize transposable element correlates with loss of activity.

    abstract：:An unstable allele of the bronze 2 (bz2) locus was isolated from a Robertson's Mutator Zea mays line containing a family of active transposable Mu elements. This mutation is somatically unstable, resulting in numerous revertant purple sectors on a bronze kernel. By following the variegated kernel phenotype through two...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.83.6.1767

    authors： Chandler VL,Walbot V

    更新日期：1986-03-01 00:00:00

  • Amygdala damage eliminates monetary loss aversion.

    abstract：:Losses are a possibility in many risky decisions, and organisms have evolved mechanisms to evaluate and avoid them. Laboratory and field evidence suggests that people often avoid risks with losses even when they might earn a substantially larger gain, a behavioral preference termed "loss aversion." The cautionary brak...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0910230107

    authors： De Martino B,Camerer CF,Adolphs R

    更新日期：2010-02-23 00:00:00

  • Nerve growth factor: activation of the classical complement pathway by specific substitution for component C1-.

    abstract：:The interaction of homogeneous preparations of mouse submandibular gland nerve growth factor (NGF) with the classical complement pathway was studied. NGF was found to be capable of carrying out the enzyme activities of the first component (C1-) of the classical complement pathway (i.e., the cleavage of zymogen C4 and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.79.8.2519

    authors： Boyle MD,Young M

    更新日期：1982-04-01 00:00:00

  • Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety.

    abstract：:It was recently demonstrated that amyloid beta (Abeta) peptide vaccination was effective in reducing the Abeta burden in Alzheimer model mice. However, the clinical trial was halted because of the development of meningoencephalitis in some patients. To overcome this problem, anti-Abeta antibody therapy and other types...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0600966103

    authors： Okura Y,Miyakoshi A,Kohyama K,Park IK,Staufenbiel M,Matsumoto Y

    更新日期：2006-06-20 00:00:00

  • Monitoring food preference in Drosophila by oligonucleotide tagging.

    abstract：:Drosophila melanogaster is a powerful model organism for dissecting the neurogenetic basis of appetitive and aversive behaviors. However, some methods used to assay food preference require or cause starvation. This can be problematic for fly ethanol research because it can be difficult to dissociate caloric preference...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1716880115

    authors： Park A,Tran T,Atkinson NS

    更新日期：2018-09-04 00:00:00

  • Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.

    abstract：:STAT1 is an essential transcription factor for macrophage activation by IFN-gamma and requires phosphorylation of the C-terminal Ser727 for transcriptional activity. In macrophages, Ser727 phosphorylation in response to bacterial lipopolysaccharide (LPS), UV irradiation, or TNF-alpha occurred through a signaling path ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.24.13956

    authors： Kovarik P,Stoiber D,Eyers PA,Menghini R,Neininger A,Gaestel M,Cohen P,Decker T

    更新日期：1999-11-23 00:00:00

  • Dynamic updating of hippocampal object representations reflects new conceptual knowledge.

    abstract：:Concepts organize the relationship among individual stimuli or events by highlighting shared features. Often, new goals require updating conceptual knowledge to reflect relationships based on different goal-relevant features. Here, our aim is to determine how hippocampal (HPC) object representations are organized and ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1614048113

    authors： Mack ML,Love BC,Preston AR

    更新日期：2016-11-15 00:00:00

  • Imaging breast cancer using hyperpolarized carbon-13 MRI.

    abstract：:Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenous tumor lactate pool. Treatment-naïve breast cancer patients were recruite...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1913841117

    authors： Gallagher FA,Woitek R,McLean MA,Gill AB,Manzano Garcia R,Provenzano E,Riemer F,Kaggie J,Chhabra A,Ursprung S,Grist JT,Daniels CJ,Zaccagna F,Laurent MC,Locke M,Hilborne S,Frary A,Torheim T,Boursnell C,Schiller A,Pa

    更新日期：2020-01-28 00:00:00

  • Binding of bisubstrate analog promotes large structural changes in the unregulated catalytic trimer of aspartate transcarbamoylase: implications for allosteric regulation.

    abstract：:A central problem in understanding enzyme regulation is to define the conformational states that account for allosteric changes in catalytic activity. For Escherichia coli aspartate transcarbamoylase (ATCase; EC) the active, relaxed (R state) holoenzyme is generally assumed to be represented by the crystal structure o...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.090087197

    authors： Endrizzi JA,Beernink PT,Alber T,Schachman HK

    更新日期：2000-05-09 00:00:00

  • SOX2-LIN28/let-7 pathway regulates proliferation and neurogenesis in neural precursors.

    abstract：:The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood. Using human embryonic stem cell...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1220176110

    authors： Cimadamore F,Amador-Arjona A,Chen C,Huang CT,Terskikh AV

    更新日期：2013-08-06 00:00:00

  • Sex difference in the near-24-hour intrinsic period of the human circadian timing system.

    abstract：:The circadian rhythms of melatonin and body temperature are set to an earlier hour in women than in men, even when the women and men maintain nearly identical and consistent bedtimes and wake times. Moreover, women tend to wake up earlier than men and exhibit a greater preference for morning activities than men. Altho...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1010666108

    authors： Duffy JF,Cain SW,Chang AM,Phillips AJ,Münch MY,Gronfier C,Wyatt JK,Dijk DJ,Wright KP Jr,Czeisler CA

    更新日期：2011-09-13 00:00:00

  • Association of yeast SIN1 with the tetratrico peptide repeats of CDC23.

    abstract：:The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family of genes. In addition, sin1 mutants are defective in proper mitotic chromosome segregation. In an effort to understand the basis for these phenotypes, we employed the yeast two-hybrid system...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.93.16.8274

    authors： Shpungin S,Liberzon A,Bangio H,Yona E,Katcoff DJ

    更新日期：1996-08-06 00:00:00

  • Transgenic cotton and sterile insect releases synergize eradication of pink bollworm a century after it invaded the United States.

    abstract：:Invasive organisms pose a global threat and are exceptionally difficult to eradicate after they become abundant in their new habitats. We report a successful multitactic strategy for combating the pink bollworm (Pectinophora gossypiella), one of the world's most invasive pests. A coordinated program in the southwester...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.2019115118

    authors： Tabashnik BE,Liesner LR,Ellsworth PC,Unnithan GC,Fabrick JA,Naranjo SE,Li X,Dennehy TJ,Antilla L,Staten RT,Carrière Y

    更新日期：2021-01-05 00:00:00

  • Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis.

    abstract：:The protein defective in hereditary hemochromatosis, called HFE, is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). Its association with beta2M was previously shown to be necessary for its stability, normal intracellular processing, and cell surface expression in transfected COS ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.042701499

    authors： Waheed A,Grubb JH,Zhou XY,Tomatsu S,Fleming RE,Costaldi ME,Britton RS,Bacon BR,Sly WS

    更新日期：2002-03-05 00:00:00

  • Monopoles and fractional vortices in chiral superconductors.

    abstract：:I discuss two exotic objects that must be experimentally identified in chiral superfluids and superconductors. These are (i) the vortex with a fractional quantum number (N = 1/2 in chiral superfluids, and N = 1/2 and N = 1/4 in chiral superconductors), which plays the part of the Alice string in relativistic theories ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.97.6.2431

    authors： Volovik GE

    更新日期：2000-03-14 00:00:00