Prevalence of rotavirus diarrhea among hospitalized under-five children.

Abstract:

OBJECTIVE:To estimate the prevalence of rotavirus diarrhea among hospitalized children less than 5 years of age in Kerala State and to determine the circulating strains of rotavirus in Kerala. DESIGN:Multicenter, cross-sectional study. SETTING:Eight representative hospitals in Kunnathunadu Thaluk, Ernakulam district, Kerala. PARTICIPANTS:Children in the age group under 5 years. METHODS:Hospitalized children admitted with acute diarrhea were examined and standardized case report form was used to collect demographic, clinical and health outcome. Stool specimens were collected and ELISA testing was done. ELISA rotavirus positive samples were tested by reverse transcription PCR for G and P typing (CMC Vellore). RESULTS:Among the 1827 children, 648 (35.9%) were positive for rotavirus by the Rotaclone ELISA test. The prevalence of rotavirus diarrhea in infants less than 6 months of age was 24.7%; 6- 11 months 31.9%; 12- 23 months 41.9%; 24- 35 months 46.9%; and 33.3% in 36- 59 months. Rotavirus infections were most common during the dry months from January through May. G1P[8] (49.7%) was the most common strain identified followed by G9P[8] (26.4%), G2P[4] (5.5%), G9P[4] (2.6%) and G12P[6] (1.3%). CONCLUSIONS:The prevalence of rotavirus diarrhea among hospitalized children less than 5 years is high in Ernakulam district, Kerala State.

journal_name

Indian Pediatr

journal_title

Indian pediatrics

authors

Mathew MA,Paulose A,Chitralekha S,Nair MK,Kang G,Kilgore P

doi

10.1007/s13312-014-0329-8

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

27-31

issue

1

eissn

0019-6061

issn

0974-7559

pii

S097475591300111

journal_volume

51

pub_type

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