Abstract:
:Human brain tissue is complex and multi-component in nature. It consists of an anisotropic hyperelastic solid material composed of tissue cells and blood vessel walls. Brain tissue is permeated by two viscous pore liquids, the interstitial fluid and the blood. Both liquids are mobile within the tissue and exhibit a significant anisotropic perfusion behaviour. To model this complex aggregate, the well-founded Theory of Porous Media, a continuum-mechanical approach for the description of multi-component aggregates, is used. To include microscopic information, the model is enhanced by tissue characteristics obtained from medical imaging techniques. Moreover, the model is applied to invasive drug-delivery strategies, i.e. the direct extra-vascular infusion of therapeutic agents. For this purpose, the overall interstitial fluid is treated as a real two-component mixture of a liquid solvent and a dissolved therapeutic solute. Finally, the continuum-mechanical model results in a set of strongly coupled partial differential equations which are spatially discretised using mixed finite elements and solved in a monolithic manner with an implicit Euler time-integration scheme. Numerical examples demonstrate the applicability of the presented model.
journal_name
Comput Methods Biomech Biomed Enginauthors
Ehlers W,Wagner Adoi
10.1080/10255842.2013.853754subject
Has Abstractpub_date
2015-01-01 00:00:00pages
861-79issue
8eissn
1025-5842issn
1476-8259journal_volume
18pub_type
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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journal_title:Computer methods in biomechanics and biomedical engineering
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