Coordinated endothelial nitric oxide synthase activation by translocation and phosphorylation determines flow-induced nitric oxide production in resistance vessels.

abstract：:In response to stimuli, endothelial cells release arachidonic acid, a lipid precursor of various vasoactive substances. We have investigated the relationships between cytosolic Ca2+ movements and arachidonic acid release in human umbilical vein endothelial cells. Histamine, a receptor-dependent agonist, and thapsigarg...

journal_title：Journal of vascular research

authors： Millanvoye-Van Brussel E,David-Dufilho M,Pham TD,Iouzalen L,Aude Devynck M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND/AIMS:Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic a...

journal_title：Journal of vascular research

authors： Battson ML,Lee DM,Jarrell DK,Hou S,Ecton KE,Phan AB,Gentile CL

更新日期：2017-01-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:Insulin was reported to decrease Na(+)/H(+) exchange activity in murine vascular smooth muscle (VSM) tissue. In most other cells, insulin increases activity. We tested the effects of insulin on Na(+)/H(+) exchange activity in primary cultured canine VSM cells. Intracellular pH (pH(i)) was measured with 2',7'-bis(2-car...

journal_title：Journal of vascular research

authors： Kahn AM,Yang M

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to assess the rat pial microvessel alterations due to transient bilateral common carotid artery occlusion (BCCAO) and to investigate the mechanism of 10% hypertonic glycerol neuroprotection. Our suggestion was that 10% glycerol solution infusion could dilate pial arterioles through ni...

journal_title：Journal of vascular research

authors： Lapi D,Marchiafava PL,Colantuoni A

更新日期：2008-01-01 00:00:00

abstract：:The vascular endothelium is the source of a number of vasodilator and vasoconstrictor autacoids and is thus a key regulator of vascular homeostasis. We studied the effects of altering the balance between protein tyrosine kinase and phosphatase activity on Ca2+ signalling and phosphotyrosine levels in cultured human en...

journal_title：Journal of vascular research

authors： Fleming I,Bara AT,Busse R

更新日期：1996-05-01 00:00:00

abstract：:The influence of vascular endothelium on ouabain-induced contractions and sodium pump activity in aortic segments of Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) was analyzed. De-endothelialization increased and reduced ouabain-induced contractions in WKY and SHR segments, respectively. The effects of d...

journal_title：Journal of vascular research

authors： Ponte A,Marín J,Arribas S,González R,Barrús MT,Salaices M,Sánchez-Ferrer CF

更新日期：1996-03-01 00:00:00

abstract：:We examined the growth of the right common carotid artery of young rabbits after ligating the left common carotid artery at 3 weeks of age, a procedure that approximately doubled right carotid blood flows. Flow increased from 0.065 +/-0.003 to 0.096+/-0.009 ml/s within 1 h and, at 15 weeks of age, carotid blood flows ...

journal_title：Journal of vascular research

authors： Di Stefano I,Koopmans DR,Langille BL

更新日期：1998-01-01 00:00:00

abstract：:A radioligand binding assay and autoradiographic localisation of P2X-purinoceptors were carried out in several different blood vessels from rat, guinea-pig and rabbit by using [3H]alpha,beta-methylene ATP ([3H]alpha,beta-MeATP) as the radioligand. The radioligand binding assay on rabbit ear artery showed that the bind...

journal_title：Journal of vascular research

authors： Bo X,Burnstock G

更新日期：1993-03-01 00:00:00

abstract：:Mesenteric endothelial cell function and immunoreactivity for substance P and nitric oxide synthase (NOS) were examined in control rats and rats treated with capsaicin as neonates to destroy primary afferent nerves. Endothelial vasodilator function was examined pharmacologically in the methoxamine raised-tone isolated...

journal_title：Journal of vascular research

authors： Ralevic V,Dikranian K,Burnstock G

更新日期：1995-09-01 00:00:00

abstract：AIMS:We investigated the role of superoxide O(2)(-) during the initiation of vascular endothelial growth factor (VEGF)- and placental growth factor (PlGF)-mediated signal transduction in bone marrow-derived endothelial cells. METHODS:BMhTERT cells were treated with VEGF or PlGF in the presence or absence of antioxidan...

journal_title：Journal of vascular research

authors： Dhar-Mascareno M,Mascareno E,Golde DW

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Extracellular nucleotide release at the site of arterial injury mediates the proliferation and migration of vascular smooth muscle cells. Our aim was to investigate the role of the P2Y2 nucleotide receptor (P2Y2R) in neointimal hyperplasia. Approach and Results: Vascular injury was induced by the implantatio...

journal_title：Journal of vascular research

authors： Agca Y,Qian S,Agca C,Seye CI

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. METHODS AND RESULTS:After organ culture of the arteri...

journal_title：Journal of vascular research

authors： Zhang W,Zhang Y,Edvinsson L,Xu CB

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as a...

journal_title：Journal of vascular research

authors： Shiba T,Takahashi M,Matsumoto T,Hori Y

更新日期：2018-01-01 00:00:00

abstract：:This study utilised catecholamine fluorescence histochemistry, multiple-labelling immunohistochemistry and retrograde axonal transport to determine the distribution and neuropeptide content of sympathetic neurons innervating veins in the dorsal skin of the guinea pig pinna. There was a dense plexus of sympathetic axon...

journal_title：Journal of vascular research

authors： Morris JL

更新日期：1995-11-01 00:00:00

abstract：:The goal of this study was to determine the role of endothelium-derived relaxing factor (EDRF) in dilatation of cerebral arterioles in response to adenosine 5'-diphosphate (ADP). Using intravital microscopy, we measured the diameters of pial arterioles in vivo in rats during superfusion with ADP, acetylcholine and nit...

journal_title：Journal of vascular research

authors： Mayhan WG

更新日期：1992-09-01 00:00:00

abstract：:The release of cytokines and chemokines from activated immune-competent cells plays a crucial role in determining the pathology of the atherogenic progress. We investigated the effect of bacterial lipopolysaccharide (LPS) on cytokine/chemokine expression in carotid lesions and normal renal arteries. The lesions or ren...

journal_title：Journal of vascular research

authors： Jatta K,Wågsäter D,Norgren L,Stenberg B,Sirsjö A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND/AIMS:Laser Doppler flowmetry (LDF) was used to determine the influence of acute myocardial infarction (AMI) and of successful reperfusion treatment on basal skin blood flow and its oscillatory components. METHODS:Skin LDF was performed on all extremities in 58 patients 4-9 days after AMI (Killip class I), a...

journal_title：Journal of vascular research

authors： Azman-Juvan K,Bernjak A,Urbancic-Rovan V,Stefanovska A,Stajer D

更新日期：2008-01-01 00:00:00

abstract：:In this study we aimed to investigate whether the therapeutic efficacy of anisodamine in the treatment of bacteraemic shock could--at least in part--be brought about by its direct interference with the lipopolysaccharide (LPS)-induced activation of endothelial cells. Thus, we investigated the effect of anisodamine on ...

journal_title：Journal of vascular research

authors： Ruan QR,Zhang WJ,Hufnagl P,Kaun C,Binder BR,Wojta J

更新日期：2001-01-01 00:00:00

abstract：:Previous studies have demonstrated endothelial and smooth muscle hyperplasia occur during arterial luminal expansion associated with elevation of arterial wall shear rates. The current study investigated whether remodeling induced by elevated wall shear would ultimately result in a vessel with intimal and medial cell ...

journal_title：Journal of vascular research

authors： Fath SW,Burkhart HM,Miller SC,Dalsing MC,Unthank JL

更新日期：1998-07-01 00:00:00

abstract：:Peripheral vascular resistance is increased in essential hypertension. This involves structural changes of resistance arteries and stiffening of the arterial wall, including remodeling of the extracellular matrix. We hypothesized that biopsies of the human parietal pericardium, obtained during coronary artery bypass g...

journal_title：Journal of vascular research

authors： Bloksgaard M,Leurgans TM,Nissen I,Jensen PS,Hansen ML,Brewer JR,Bagatolli LA,Marcussen N,Irmukhamedov A,Rasmussen LM,De Mey JG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth...

journal_title：Journal of vascular research

authors： Su SH,Wu CH,Chiu YL,Chang SJ,Lo HH,Liao KH,Tsai CF,Tsai TN,Lin CH,Cheng SM,Cheng CC,Wang HW

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Vasomotion consists in cyclic oscillations of the arterial diameter induced by the synchronized activity of the smooth muscle cells. So far, contradictory results have emerged in the literature about the role of the endothelium in the onset and maintenance of vasomotion. Here our aim is to understan...

journal_title：Journal of vascular research

authors： Seppey D,Sauser R,Koenigsberger M,Bény JL,Meister JJ

更新日期：2008-01-01 00:00:00

abstract：AIMS:Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent g...

journal_title：Journal of vascular research

authors： Taavitsainen J,Tarvainen S,Kuivanen A,Mangiardi EK,Guelcher M,Martin J,Mathur A,Hytönen JP,Ylä-Herttuala S

更新日期：2020-01-01 00:00:00

abstract：:Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, ...

journal_title：Journal of vascular research

authors： Busch A,Holm A,Wagner N,Ergün S,Rosenfeld M,Otto C,Baur J,Kellersmann R,Lorenz U

更新日期：2016-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a principal stimulator of angiogenesis. However, the downstream targets of VEGF in endothelial cells (ECs) are not entirely clarified. Survey of downstream targets of VEGF in human ECs identified a number of genes, including Down syndrome candidate region 1 (DSCR1). Here, w...

journal_title：Journal of vascular research

authors： Iizuka M,Abe M,Shiiba K,Sasaki I,Sato Y

更新日期：2004-07-01 00:00:00

abstract：:Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation w...

journal_title：Journal of vascular research

authors： Jiang F,Jones GT,Husband AJ,Dusting GJ

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIMS:The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS:Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior d...

journal_title：Journal of vascular research

authors： Horstick G,Bierbach B,Abegunewardene N,Both S,Kuhn S,Manefeld D,Reinecke HJ,Vosseler M,Helisch A,Becker D,Lauterbach M,Kempski O,Lehr HA

更新日期：2009-01-01 00:00:00

abstract：:In segments of rabbit basilar artery (BA) platelet-activating factor (PAF) initiated a concentration-dependent transitory contraction which was unaffected by indomethacin or nordihydroguaiaretic acid (NDGA). N omega-nitro-L-arginine (NLA) did not change the magnitude of PAF-induced contraction, but in the presence of ...

journal_title：Journal of vascular research

authors： Akopov SE,Sercombe R,Seylaz J

更新日期：1995-01-01 00:00:00

abstract：AIM:Vascular remodeling following injury substantially accounts for restenosis and adverse clinical outcomes. In this study, we investigated the role of the giant scaffold protein Ahnak1 in vascular healing after endothelial denudation of the murine femoral artery. METHODS:The spatiotemporal expression pattern of Ahna...

journal_title：Journal of vascular research

authors： Haase N,Rüder C,Haase H,Kamann S,Kouno M,Morano I,Dechend R,Zohlnhöfer D,Haase T

更新日期：2017-01-01 00:00:00