Atrial fibrillation and the risk of myocardial infarction.

Abstract:

IMPORTANCE:Myocardial infarction (MI) is an established risk factor for atrial fibrillation (AF). However, the extent to which AF is a risk factor for MI has not been investigated. OBJECTIVE:To examine the risk of incident MI associated with AF. DESIGN, SETTING, AND PARTICIPANTS:A prospective cohort of 23,928 participants residing in the continental United States and without coronary heart disease at baseline were enrolled from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort between 2003 and 2007, with follow-up through December 2009. MAIN OUTCOMES AND MEASURES:Expert-adjudicated total MI events (fatal and nonfatal). RESULTS:Over 6.9 years of follow-up (median 4.5 years), 648 incident MI events occurred. In a sociodemographic-adjusted model, AF was associated with about 2-fold increased risk of MI (hazard ratio [HR], 1.96 [95% CI, 1.52-2.52]). This association remained significant (HR, 1.70 [95% CI, 1.26-2.30]) after further adjustment for total cholesterol, high-density lipoprotein cholesterol, smoking status, systolic blood pressure, blood pressure-lowering drugs, body mass index, diabetes, warfarin use, aspirin use, statin use, history of stroke and vascular disease, estimated glomerular filtration rate, albumin to creatinine ratio, and C-reactive protein level. In subgroup analysis, the risk of MI associated with AF was significantly higher in women (HR, 2.16 [95% CI, 1.41-3.31]) than in men (HR, 1.39 [95% CI, 0.91-2.10]) and in blacks (HR, 2.53 [95% CI, 1.67-3.86]) than in whites (HR, 1.26 [95% CI, 0.83-1.93]); for interactions, P = .03 and P = .02, respectively. On the other hand, there were no significant differences in the risk of MI associated with AF in older (≥75 years) vs younger (<75 years) participants (HR, 2.00 [95% CI, 1.16-3.35] and HR, 1.60 [95% CI, 1.11-2.30], respectively); for interaction, P = .44. CONCLUSIONS AND RELEVANCE:AF is independently associated with an increased risk of incident MI, especially in women and blacks. These findings add to the growing concerns of the seriousness of AF as a public health burden: in addition to being a well-known risk factor for stroke, AF is also associated with increased risk of MI.

journal_name

JAMA Intern Med

journal_title

JAMA internal medicine

authors

Soliman EZ,Safford MM,Muntner P,Khodneva Y,Dawood FZ,Zakai NA,Thacker EL,Judd S,Howard VJ,Howard G,Herrington DM,Cushman M

doi

10.1001/jamainternmed.2013.11912

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

107-14

issue

1

eissn

2168-6106

issn

2168-6114

pii

1764008

journal_volume

174

pub_type

杂志文章
  • Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States.

    abstract:Importance:Lung cancer has become a leading cause of death among people living with human immunodeficiency virus (HIV) (PLWH). Over 40% of PLWH in the United States smoke cigarettes; HIV independently increases the risk of lung cancer. Objective:To project cumulative lung cancer mortality by smoking exposure among PLW...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2017.4349

    authors: Reddy KP,Kong CY,Hyle EP,Baggett TP,Huang M,Parker RA,Paltiel AD,Losina E,Weinstein MC,Freedberg KA,Walensky RP

    更新日期:2017-11-01 00:00:00

  • Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis.

    abstract:BACKGROUND:The benefit of blood transfusion in patients with myocardial infarction is controversial, and a possibility of harm exists. METHODS:A systematic search of studies published between January 1, 1966, and March 31, 2012, was conducted using MEDLINE, EMBASE, CINAHL, Scopus, Web of Science, and Cochrane Central ...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.1001/2013.jamainternmed.1001

    authors: Chatterjee S,Wetterslev J,Sharma A,Lichstein E,Mukherjee D

    更新日期:2013-01-28 00:00:00

  • Resource use and guideline concordance in evaluation of pulmonary nodules for cancer: too much and too little care.

    abstract:IMPORTANCE:Pulmonary nodules are common, and more will be found with implementation of lung cancer screening. How potentially malignant pulmonary nodules are evaluated may affect patient outcomes, health care costs, and effectiveness of lung cancer screening programs. Guidelines for evaluating pulmonary nodules for can...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2014.561

    authors: Wiener RS,Gould MK,Slatore CG,Fincke BG,Schwartz LM,Woloshin S

    更新日期:2014-06-01 00:00:00

  • Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review.

    abstract:Importance:After a drug receives regulatory approval, researchers often pursue small, underpowered trials, called exploratory trials, aimed at testing additional indications. If favorable early findings from exploratory trials are not promptly followed by confirmatory trials, then physicians, patients, and payers can b...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2018.5705

    authors: Federico CA,Wang T,Doussau A,Mogil JS,Fergusson D,Kimmelman J

    更新日期:2019-01-01 00:00:00

  • The Effect of Primary Care Provider Turnover on Patient Experience of Care and Ambulatory Quality of Care.

    abstract:IMPORTANCE:Primary care provider (PCP) turnover is common and can disrupt patient continuity of care. Little is known about the effect of PCP turnover on patient care experience and quality of care. OBJECTIVE:To measure the effect of PCP turnover on patient experiences of care and ambulatory care quality. DESIGN, SET...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2015.1853

    authors: Reddy A,Pollack CE,Asch DA,Canamucio A,Werner RM

    更新日期:2015-07-01 00:00:00

  • Optimizing Radiation Doses for Computed Tomography Across Institutions: Dose Auditing and Best Practices.

    abstract:Importance:Radiation doses for computed tomography (CT) vary substantially across institutions. Objective:To assess the impact of institutional-level audit and collaborative efforts to share best practices on CT radiation doses across 5 University of California (UC) medical centers. Design, Setting, and Participants:...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2017.0445

    authors: Demb J,Chu P,Nelson T,Hall D,Seibert A,Lamba R,Boone J,Krishnam M,Cagnon C,Bostani M,Gould R,Miglioretti D,Smith-Bindman R

    更新日期:2017-06-01 00:00:00

  • Effects of telephone-based peer support in patients with type 2 diabetes mellitus receiving integrated care: a randomized clinical trial.

    abstract:IMPORTANCE:In type 2 diabetes mellitus (T2DM), team management using protocols with regular feedback improves clinical outcomes, although suboptimal self-management and psychological distress remain significant challenges. OBJECTIVE:To investigate if frequent contacts through a telephone-based peer support program (Pe...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamainternmed.2014.655

    authors: Chan JC,Sui Y,Oldenburg B,Zhang Y,Chung HH,Goggins W,Au S,Brown N,Ozaki R,Wong RY,Ko GT,Fisher E,JADE and PEARL Project Team.

    更新日期:2014-06-01 00:00:00

  • Attending rounds in the current era: what is and is not happening.

    abstract:IMPORTANCE:General medicine rounds by attending physicians provide the foundation for patient care and education in teaching hospitals. However, the detailed activities of these rounds in the current era are not well characterized. OBJECTIVE:To describe the characteristics of attending rounds for internal medicine inp...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2013.6041

    authors: Stickrath C,Noble M,Prochazka A,Anderson M,Griffiths M,Manheim J,Sillau S,Aagaard E

    更新日期:2013-06-24 00:00:00

  • Implementation and Evaluation of a Large-Scale Teleretinal Diabetic Retinopathy Screening Program in the Los Angeles County Department of Health Services.

    abstract:Importance:Diabetic retinopathy (DR) is the leading cause of blindness in adults of working age in the United States. In the Los Angeles County safety net, a nonvertically integrated system serving underinsured and uninsured patients, the prevalence of DR is approximately 50%, and owing to limited specialty care resour...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2017.0204

    authors: Daskivich LP,Vasquez C,Martinez C Jr,Tseng CH,Mangione CM

    更新日期:2017-05-01 00:00:00

  • Acupuncture as Adjunctive Therapy for Chronic Stable Angina: A Randomized Clinical Trial.

    abstract:Importance:The effects of acupuncture as adjunctive treatment to antianginal therapies for patients with chronic stable angina are uncertain. Objective:To investigate the efficacy and safety of acupuncture as adjunctive therapy to antianginal therapies in reducing frequency of angina attacks in patients with chronic s...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2019.2407

    authors: Zhao L,Li D,Zheng H,Chang X,Cui J,Wang R,Shi J,Fan H,Li Y,Sun X,Zhang F,Wu X,Liang F

    更新日期:2019-07-29 00:00:00

  • Trends in Noninvasive and Invasive Mechanical Ventilation Among Medicare Beneficiaries at the End of Life.

    abstract:Importance:End-of-life care is costly, and decedents often experience overtreatment or low-quality care. Noninvasive ventilation (NIV) may be a palliative approach to avoid invasive mechanical ventilation (IMV) among select patients who are hospitalized at the end of life. Objective:To examine the trends in NIV and IM...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2020.5640

    authors: Sullivan DR,Kim H,Gozalo PL,Bunker J,Teno JM

    更新日期:2021-01-01 00:00:00

  • Trends in the use of percutaneous ventricular assist devices: analysis of national inpatient sample data, 2007 through 2012.

    abstract:IMPORTANCE:Percutaneous ventricular assist devices (PVADs) provide robust hemodynamic support compared with intra-aortic balloon pumps (IABPs), but clinical use patterns are unknown. OBJECTIVE:To examine contemporary patterns in PVAD use in the United States and compare them with use of IABPs. DESIGN, SETTING, AND PA...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2014.7856

    authors: Khera R,Cram P,Lu X,Vyas A,Gerke A,Rosenthal GE,Horwitz PA,Girotra S

    更新日期:2015-06-01 00:00:00

  • Device-guided breathing as treatment for hypertension in type 2 diabetes mellitus: a randomized, double-blind, sham-controlled trial.

    abstract:IMPORTANCE:Biofeedback with device-guided lowering of breathing frequency could be an alternate nonpharmacologic treatment option for hypertension. Evidence from trials with high methodologic quality is lacking. OBJECTIVE:To evaluate the effects of device-guided lowering of breathing frequency on blood pressure in pat...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamainternmed.2013.6883

    authors: Landman GW,Drion I,van Hateren KJ,van Dijk PR,Logtenberg SJ,Lambert J,Groenier KH,Bilo HJ,Kleefstra N

    更新日期:2013-07-22 00:00:00

  • Sodium Reduction in US Households' Packaged Food and Beverage Purchases, 2000 to 2014.

    abstract:Importance:Initiatives to reduce sodium in packaged foods have been launched in the United States, yet corresponding changes in the amount of sodium that US households obtain from packaged foods have not been evaluated, to our knowledge. Objective:To assess 15-year changes in the amount of sodium that US households ac...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2017.1407

    authors: Poti JM,Dunford EK,Popkin BM

    更新日期:2017-07-01 00:00:00

  • A Comparative Effectiveness Trial of Alternate Formats for Presenting Benefits and Harms Information for Low-Value Screening Services: A Randomized Clinical Trial.

    abstract:IMPORTANCE:Healthcare overuse, the delivery of low-value services, is increasingly recognized as a critical problem. However, little is known about the comparative effectiveness of alternate formats for presenting benefits and harms information to patients as a strategy to reduce overuse. OBJECTIVE:To examine the effe...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamainternmed.2015.7339

    authors: Sheridan SL,Sutkowi-Hemstreet A,Barclay C,Brewer NT,Dolor RJ,Gizlice Z,Lewis CL,Reuland DS,Golin CE,Kistler CE,Vu M,Harris R

    更新日期:2016-01-01 00:00:00

  • Use of Health Care Databases to Support Supplemental Indications of Approved Medications.

    abstract:Importance:Manufacturers of US Food and Drug Administration-approved prescription drugs often apply for additional indications based on randomized clinical trials. Real-world database analyses on a medication's use and outcomes in routine settings of care might help to inform decision making regarding such supplemental...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2017.3919

    authors: Fralick M,Kesselheim AS,Avorn J,Schneeweiss S

    更新日期:2018-01-01 00:00:00

  • Physicians' diagnostic accuracy, confidence, and resource requests: a vignette study.

    abstract:IMPORTANCE:Little is known about the relationship between physicians' diagnostic accuracy and their confidence in that accuracy. OBJECTIVE:To evaluate how physicians' diagnostic calibration, defined as the relationship between diagnostic accuracy and confidence in that accuracy, changes with evolution of the diagnosti...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2013.10081

    authors: Meyer AN,Payne VL,Meeks DW,Rao R,Singh H

    更新日期:2013-11-25 00:00:00

  • Use of cardiac biomarker testing in the emergency department.

    abstract:IMPORTANCE:Cardiac biomarker testing is not routinely indicated in the emergency department (ED) because of low utility and potential downstream harms from false-positive results. However, current rates of testing are unknown. OBJECTIVE:To determine the use of cardiac biomarker testing overall, as well as stratified b...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2014.5830

    authors: Makam AN,Nguyen OK

    更新日期:2015-01-01 00:00:00

  • Material need insecurities, control of diabetes mellitus, and use of health care resources: results of the Measuring Economic Insecurity in Diabetes study.

    abstract:IMPORTANCE:Increasing access to care may be insufficient to improve the health of patients with diabetes mellitus and unmet basic needs (hereinafter referred to as material need insecurities). How specific material need insecurities relate to clinical outcomes and the use of health care resources in a setting of near-u...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2014.6888

    authors: Berkowitz SA,Meigs JB,DeWalt D,Seligman HK,Barnard LS,Bright OJ,Schow M,Atlas SJ,Wexler DJ

    更新日期:2015-02-01 00:00:00

  • Evaluation of Medical Surveillance and Incidence of Post-September 11, 2001, Thyroid Cancer in World Trade Center-Exposed Firefighters and Emergency Medical Service Workers.

    abstract:Importance:Elevated incidence rates of thyroid cancer among World Trade Center (WTC)-exposed individuals may be associated with the identification of asymptomatic cancers during medical surveillance. Objective:To examine the association between WTC exposure and thyroid cancer among Fire Department of the City of New Y...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2020.0950

    authors: Colbeth HL,Genere N,Hall CB,Jaber N,Brito JP,El Kawkgi OM,Goldfarb DG,Webber MP,Schwartz TM,Prezant DJ,Zeig-Owens R

    更新日期:2020-06-01 00:00:00

  • Risk for Clinically Relevant Adverse Cardiac Events in Patients With Chest Pain at Hospital Admission.

    abstract:IMPORTANCE:Patients with potentially ischemic chest pain are commonly admitted to the hospital or observed after a negative evaluation in the emergency department (ED) owing to concern about adverse events. Previous studies have looked at 30-day mortality, but no current large studies have examined the most important i...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2015.1674

    authors: Weinstock MB,Weingart S,Orth F,VanFossen D,Kaide C,Anderson J,Newman DH

    更新日期:2015-07-01 00:00:00

  • Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial.

    abstract:Importance:Urinary stone disease is a common presentation in the emergency department, and α-adrenergic receptor blockers, such as tamsulosin, are commonly used to facilitate stone passage. Objective:To determine if tamsulosin promotes the passage of urinary stones within 28 days among emergency department patients. ...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamainternmed.2018.2259

    authors: Meltzer AC,Burrows PK,Wolfson AB,Hollander JE,Kurz M,Kirkali Z,Kusek JW,Mufarrij P,Jackman SV,Brown J

    更新日期:2018-08-01 00:00:00

  • Association Between Incretin-Based Drugs and the Risk of Acute Pancreatitis.

    abstract:Importance:The association between incretin-based drugs, such as dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide 1 (GLP-1) agonists, and acute pancreatitis is controversial. Objective:To determine whether the use of incretin-based drugs, compared with the use of 2 or more other oral antidiabetic dr...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2016.1522

    authors: Azoulay L,Filion KB,Platt RW,Dahl M,Dormuth CR,Clemens KK,Durand M,Hu N,Juurlink DN,Paterson JM,Targownik LE,Turin TC,Ernst P,and the Canadian Network for Observational Drug Effect Studies (CNODES) Investigators.,Suissa S,D

    更新日期:2016-10-01 00:00:00

  • Changes in Health Care Costs and Mortality Associated With Transitional Care Management Services After a Discharge Among Medicare Beneficiaries.

    abstract:Importance:Medicare adopted transitional care management (TCM) payment codes in 2013 to encourage clinicians to furnish TCM services after beneficiaries were discharged to the community from medical facilities. To bill for the 30-day service, a care team member must communicate with the beneficiary or the caregiver wit...

    journal_title:JAMA internal medicine

    pub_type: 社论

    doi:10.1001/jamainternmed.2018.2572

    authors: Bindman AB,Cox DF

    更新日期:2018-09-01 00:00:00

  • Effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on all-cause mortality, cardiovascular deaths, and cardiovascular events in patients with diabetes mellitus: a meta-analysis.

    abstract:IMPORTANCE:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) may have different effects on cardiovascular (CV) events in patients with diabetes mellitus (DM). OBJECTIVE:To conduct a meta-analysis to separately evaluate the effects of ACEIs and ARBs on all-cause mortality, CV ...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamainternmed.2014.348

    authors: Cheng J,Zhang W,Zhang X,Han F,Li X,He X,Li Q,Chen J

    更新日期:2014-05-01 00:00:00

  • Analysis of Physician Variation in Provision of Low-Value Services.

    abstract:Importance:Facing new financial incentives to reduce unnecessary spending, health care organizations may attempt to reduce wasteful care by influencing physician practices or selecting more cost-effective physicians. However, physicians' role in determining the use of low-value services has not been well described. Ob...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2018.5086

    authors: Schwartz AL,Jena AB,Zaslavsky AM,McWilliams JM

    更新日期:2019-01-01 00:00:00

  • Pharmaceutical Industry-Sponsored Meals and Physician Prescribing Patterns for Medicare Beneficiaries.

    abstract:IMPORTANCE:The association between industry payments to physicians and prescribing rates of the brand-name medications that are being promoted is controversial. In the United States, industry payment data and Medicare prescribing records recently became publicly available. OBJECTIVE:To study the association between ph...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2016.2765

    authors: DeJong C,Aguilar T,Tseng CW,Lin GA,Boscardin WJ,Dudley RA

    更新日期:2016-08-01 00:00:00

  • Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study.

    abstract:Importance:Approximately 1 million patients in the United States with type 2 diabetes mellitus and mild-to-moderate kidney disease do not receive guideline-directed therapy with metformin. This may reflect uncertainty regarding the risk of acidosis in patients with chronic kidney disease. Objective:To quantify the ass...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamainternmed.2018.0292

    authors: Lazarus B,Wu A,Shin JI,Sang Y,Alexander GC,Secora A,Inker LA,Coresh J,Chang AR,Grams ME

    更新日期:2018-07-01 00:00:00

  • Cardiovascular safety of inhaled long-acting bronchodilators in individuals with chronic obstructive pulmonary disease.

    abstract:IMPORTANCE:Chronic obstructive pulmonary disease (COPD) is a common and deadly disease. Long-acting inhaled β-agonists and anticholinergics, first-line medications for COPD, have been associated with increased risk of cardiovascular outcomes. When choosing between the medications, patients and physicians would benefit ...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2013.1016

    authors: Gershon A,Croxford R,Calzavara A,To T,Stanbrook MB,Upshur R,Stukel TA

    更新日期:2013-07-08 00:00:00

  • Influence of institutional culture and policies on do-not-resuscitate decision making at the end of life.

    abstract:IMPORTANCE:Controversy exists regarding whether the decision to pursue a do-not-resuscitate (DNR) order should be grounded in an ethic of patient autonomy or in the obligation to act in the patient's best interest (beneficence). OBJECTIVE:To explore how physicians' approaches to DNR decision making at the end of life ...

    journal_title:JAMA internal medicine

    pub_type: 杂志文章

    doi:10.1001/jamainternmed.2015.0295

    authors: Dzeng E,Colaianni A,Roland M,Chander G,Smith TJ,Kelly MP,Barclay S,Levine D

    更新日期:2015-05-01 00:00:00