Efficacy of Ethanol Extract of Fructus lycii and Its Constituents Lutein/Zeaxanthin in Protecting Retinal Pigment Epithelium Cells against Oxidative Stress: In Vivo and In Vitro Models of Age-Related Macular Degeneration.

Abstract:

:Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to investigate whether combination of lutein and zeaxanthin, two carotenoid pigments in Fructus lycii, could protect human retinal pigment epithelial ARPE-19 cells treated with hydrogen peroxide (H2O2) in vitro. We found that severe sediment beneath retinal pigment epithelium and thickened Bruch membrane occurred in AMD mice. However, Fructus lycii ethanol extract improved the histopathologic changes and decreased the thickness of Bruch membrane. Furthermore, the gene and protein expression of cathepsin B and cystatin C was upregulated in AMD mice but was eliminated by Fructus lycii ethanol extract. Investigations in vitro showed that ARPE-19 cell proliferation was suppressed by H2O2. However, lutein/zeaxanthin not only stimulated cell proliferation but also abrogated the enhanced expression of MMP-2 and TIMP-1 in H2O2-treated ARPE-19 cells. These data collectively suggested that Fructus lycii ethanol extract and its active components lutein/zeaxanthin had protective effects on AMD in vivo and in vitro, providing novel insights into the beneficial role of Fructus lycii for AMD therapy.

journal_name

J Ophthalmol

journal_title

Journal of ophthalmology

authors

Xu X,Hang L,Huang B,Wei Y,Zheng S,Li W

doi

10.1155/2013/862806

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

862806

eissn

2090-004X

issn

2090-0058

journal_volume

2013

pub_type

杂志文章
  • Morphometric Optic Nerve Head Analysis in Glaucoma Patients: A Comparison between the Simultaneous Nonmydriatic Stereoscopic Fundus Camera (Kowa Nonmyd WX3D) and the Heidelberg Scanning Laser Ophthalmoscope (HRT III).

    abstract::Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucom...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/4764857

    authors: Mariacher S,Hipp S,Wirthky R,Blumenstock G,Bartz-Schmidt KU,Ziemssen F,Schiefer U,Voykov B,Januschowski K

    更新日期:2016-01-01 00:00:00

  • Cellular origin of spontaneous ganglion cell spike activity in animal models of retinitis pigmentosa.

    abstract::Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact t...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2011/507037

    authors: Margolis DJ,Detwiler PB

    更新日期:2011-01-01 00:00:00

  • Comparison of Efficacy and Ocular Surface Disease Index Score between Bimatoprost, Latanoprost, Travoprost, and Tafluprost in Glaucoma Patients.

    abstract:Aim:The purpose of this study is to evaluate and compare the efficacy of 4 prostaglandin analogues (PGAs) and to determine the incidence of ocular surface disease in newly diagnosed, primary open-angle glaucoma (POAG) patients started on one of those 4 PGAs: bimatoprost (benzalkonium chloride, BAK, 0.3 mg/mL), latanopr...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/1319628

    authors: El Hajj Moussa WG,Farhat RG,Nehme JC,Sahyoun MA,Schakal AR,Jalkh AE,Abi Karam MP,Azar GG

    更新日期:2018-03-07 00:00:00

  • A Brief Review on the Pathological Role of Decreased Blood Flow Affected in Retinitis Pigmentosa.

    abstract::Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicate...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1155/2018/3249064

    authors: Yang YJ,Peng J,Ying D,Peng QH

    更新日期:2018-02-25 00:00:00

  • Effects of Residual Anterior Lens Epithelial Cell Removal on Axial Position of Intraocular Lens after Cataract Surgery.

    abstract:Purpose:The aim of this study was to assess the effects of residual anterior lens epithelial cell (LEC) removal by anterior capsule polishing on the effective lens position (ELP) and axial position stability of the intraocular lens (IOL) after cataract surgery via postoperative measurement of the anterior chamber depth...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/9704892

    authors: Bang SP,Yoo YS,Jun JH,Joo CK

    更新日期:2018-08-19 00:00:00

  • The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis.

    abstract::Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2014/317694

    authors: Ryu CL,Elfersy A,Desai U,Hessburg T,Edwards P,Gao H

    更新日期:2014-01-01 00:00:00

  • Local Relationship between Global-Flash Multifocal Electroretinogram Optic Nerve Head Components and Visual Field Defects in Patients with Glaucoma.

    abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/397495

    authors: Moon CH,Han J,Ohn YH,Park TK

    更新日期:2015-01-01 00:00:00

  • Three-Year Outcomes of Cross-Linking PLUS (Combined Cross-Linking with Femtosecond Laser Intracorneal Ring Segments Implantation) for Management of Keratoconus.

    abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/6907573

    authors: Saleem MIH,Ibrahim Elzembely HA,AboZaid MA,Elagouz M,Saeed AM,Mohammed OA,Kamel AG

    更新日期:2018-01-17 00:00:00

  • Agreement between Gonioscopic Examination and Swept Source Fourier Domain Anterior Segment Optical Coherence Tomography Imaging.

    abstract::Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/1727039

    authors: Rigi M,Bell NP,Lee DA,Baker LA,Chuang AZ,Nguyen D,Minnal VR,Feldman RM,Blieden LS

    更新日期:2016-01-01 00:00:00

  • Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study.

    abstract:Objective:This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method:A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed w...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/3458356

    authors: Wang J,Zhou H,Qin L,Peng C,Zhao J,Teng D,Lin D,Ai N,Xu Q,Wei S

    更新日期:2017-01-01 00:00:00

  • Stereoacuity of Black-White and Red-Green Patterns in Individuals with and without Color Deficiency.

    abstract:Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/1926736

    authors: Sun Y,Wu H,Qiu Y,Yue Z

    更新日期:2018-08-01 00:00:00

  • Lgr4 in ocular development and glaucoma.

    abstract::The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lacking Lgr4 display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation. This paper will...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2013/987494

    authors: Siwko S,Lai L,Weng J,Liu M

    更新日期:2013-01-01 00:00:00

  • OCT Biometry (B-OCT): A New Method for Measuring Ocular Axial Dimensions.

    abstract:Purpose:To present a new method of measuring ocular axial dimensions, termed OCT biometry (B-OCT). Design:Observational cross-sectional study and evaluation of new diagnostic technology. Methods:B-OCT was implemented in the spectral domain OCT device for posterior and anterior segment imaging (REVO NX, Optopol Techno...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2019/9192456

    authors: Sikorski BL,Suchon P

    更新日期:2019-08-14 00:00:00

  • Surgical Management of Traumatic Retinal Detachment with Primary Vitrectomy in Adult Patients.

    abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/5084319

    authors: Nowomiejska K,Choragiewicz T,Borowicz D,Brzozowska A,Moneta-Wielgos J,Maciejewski R,Jünemann AG,Rejdak R

    更新日期:2017-01-01 00:00:00

  • Comparison of Corneal Power and Astigmatism between Simulated Keratometry, True Net Power, and Total Corneal Refractive Power before and after SMILE Surgery.

    abstract::Purpose. To compare the mean corneal power (Km) and total astigmatism (Ka) estimated by three methods: simulated keratometry (simK), true net power (TNP), and total corneal refractive power (TCRP) before and after femtosecond laser small incision lenticule extraction (SMILE) surgery. Methods. A retrospective, cross-se...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2017/9659481

    authors: Qian Y,Liu Y,Zhou X,Naidu RK

    更新日期:2017-01-01 00:00:00

  • Bandage Lenses in the Postoperative Care for Cataract Surgery Patients: A Substitute for Eye Patch?

    abstract:Purpose:To explore whether bandage lenses could be a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients in terms of infection prevention, ocular impacts, and patient satisfaction. Methods:Patients who underwent cataract surgery were randomly divided into the eye patch g...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/1493967

    authors: Song H,Li Y,Zhang Y,Shi D,Li X

    更新日期:2018-05-15 00:00:00

  • Early Changes in Visual Quality and Corneal Structure after DMEK: Does DMEK Approach Optical Quality of a Healthy Cornea?

    abstract:Purpose:To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls. Methods:Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, i...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/2012560

    authors: Satue M,Idoipe M,Gavin A,Romero-Sanz M,Liarakos VS,Mateo A,Garcia-Martin E,Blasco-Martinez A,Sanchez-Perez A

    更新日期:2018-09-23 00:00:00

  • Individualized Therapy with Ranibizumab in Wet Age-Related Macular Degeneration.

    abstract::Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical t...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章,评审

    doi:10.1155/2015/412903

    authors: García-Layana A,Figueroa MS,Arias L,Araiz J,Ruiz-Moreno JM,García-Arumí J,Gómez-Ulla F,López-Gálvez MI,Cabrera-López F,García-Campos JM,Monés J,Cervera E,Armadá F,Gallego-Pinazo R

    更新日期:2015-01-01 00:00:00

  • Visual Performance after Bilateral Implantation of a Four-Haptic Diffractive Toric Multifocal Intraocular Lens in High Myopes.

    abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2016/5320105

    authors: Chang JS,Chan VK,Ng JC,Law AK

    更新日期:2016-01-01 00:00:00

  • Clinical Features of Acute Anterior Uveitis with Complicated Course in a Slovenian Patient Population.

    abstract:Purpose:To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27- AAU in the population of Slovenian patients. Methods:Retrospective study of hospitalized patients with AAU in the last 39 mo...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2020/6079146

    authors: Vergot K,Pockar S,Umek L,Vidovic Valentincic N

    更新日期:2020-09-19 00:00:00

  • Changing Trends in Eye-Related Complaints Presenting to the Emergency Department in Beirut, Lebanon, over 15 Years.

    abstract:Objective:To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods:Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and b...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/4739865

    authors: Salti HI,Mehanna CJ,Abiad B,Ghazi N,Raad S,Barikian A,Haddad R,Ashkar A,Harmouche E,Zaghrini E,Mufarrij A

    更新日期:2018-03-13 00:00:00

  • Novel Technique of Pneumatic Posterior Capsulorhexis for Treatment and Prevention of Posterior Capsular Opacification.

    abstract:Purpose:To evaluate a new technique of posterior capsulorhexis using air support to treat primary posterior capsular opacification (PCO) during cataract extraction surgery or to prevent postoperative PCO. Setting:(1) Ophthalmology department, Faculty of Medicine, Minia University, 61519, El-Minia, Egypt. (2) Security ...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2019/3174709

    authors: Eid AM,Abd-Elhamid Mehany Elwan S,Sabry AM,Moharram HM,Bakhsh AM

    更新日期:2019-12-21 00:00:00

  • Assessing Errors Inherent in OCT-Derived Macular Thickness Maps.

    abstract::SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness m...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2011/692574

    authors: Odell D,Dubis AM,Lever JF,Stepien KE,Carroll J

    更新日期:2011-01-01 00:00:00

  • Unfolded Protein Response Pathways Correlatively Modulate Endoplasmic Reticulum Stress Responses in Rat Retinal Müller Cells.

    abstract:Background:Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR). This study was to investigate the underlying mechanisms through which the 3 main unfolded protein response (UPR) pathways regulate ERS and...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2019/9028483

    authors: Wu S,Zhu X,Guo B,Zheng T,Ren J,Zeng W,Chen X,Ke M

    更新日期:2019-02-24 00:00:00

  • Correlation of Myopia with Physical Exercise and Sleep Habits among Suburban Adolescents.

    abstract:Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2020/2670153

    authors: Qu Y,Yu J,Xia W,Cai H

    更新日期:2020-07-25 00:00:00

  • Characteristics of Facial Asymmetry in Congenital Superior Oblique Palsy according to Trochlear Nerve Absence.

    abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2020/9476749

    authors: Yang HK,Jung S,WhangBo TK,Hwang JM

    更新日期:2020-12-17 00:00:00

  • Group Analysis of Q Values Calculated with Tangential Radius of Curvature from Human Anterior Corneal Surface.

    abstract:Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2018/7263564

    authors: Xia Z,Lin C,Huang X,Ying J,Shi M,Zheng S

    更新日期:2018-04-17 00:00:00

  • Dry Eye Disease following Refractive Surgery: A 12-Month Follow-Up of SMILE versus FS-LASIK in High Myopia.

    abstract::Purpose. To compare dry eye disease following SMILE versus FS-LASIK. Design. Prospective, nonrandomised, observational study. Patients. 90 patients undergoing refractive surgery for myopia were included. 47 eyes underwent SMILE and 43 eyes underwent FS-LASIK. Methods. Evaluation of dry eye disease was conducted preope...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/132417

    authors: Wang B,Naidu RK,Chu R,Dai J,Qu X,Zhou H

    更新日期:2015-01-01 00:00:00

  • Complications of corneal collagen cross-linking.

    abstract::Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2011/869015

    authors: Dhawan S,Rao K,Natrajan S

    更新日期:2011-01-01 00:00:00

  • A Comparison of Clinical Features between Community-Associated and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus Keratitis.

    abstract::Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...

    journal_title:Journal of ophthalmology

    pub_type: 杂志文章

    doi:10.1155/2015/923941

    authors: Hsiao CH,Ong SJ,Chuang CC,Ma DH,Huang YC

    更新日期:2015-01-01 00:00:00