Abstract:
:Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Oxidative stress plays a large role in the pathogenesis of AMD. The present study was to evaluate the effects of Fructus lycii ethanol extract on AMD in mice and to investigate whether combination of lutein and zeaxanthin, two carotenoid pigments in Fructus lycii, could protect human retinal pigment epithelial ARPE-19 cells treated with hydrogen peroxide (H2O2) in vitro. We found that severe sediment beneath retinal pigment epithelium and thickened Bruch membrane occurred in AMD mice. However, Fructus lycii ethanol extract improved the histopathologic changes and decreased the thickness of Bruch membrane. Furthermore, the gene and protein expression of cathepsin B and cystatin C was upregulated in AMD mice but was eliminated by Fructus lycii ethanol extract. Investigations in vitro showed that ARPE-19 cell proliferation was suppressed by H2O2. However, lutein/zeaxanthin not only stimulated cell proliferation but also abrogated the enhanced expression of MMP-2 and TIMP-1 in H2O2-treated ARPE-19 cells. These data collectively suggested that Fructus lycii ethanol extract and its active components lutein/zeaxanthin had protective effects on AMD in vivo and in vitro, providing novel insights into the beneficial role of Fructus lycii for AMD therapy.
journal_name
J Ophthalmoljournal_title
Journal of ophthalmologyauthors
Xu X,Hang L,Huang B,Wei Y,Zheng S,Li Wdoi
10.1155/2013/862806subject
Has Abstractpub_date
2013-01-01 00:00:00pages
862806eissn
2090-004Xissn
2090-0058journal_volume
2013pub_type
杂志文章abstract::Purpose. To investigate the agreement between morphometric optic nerve head parameters assessed with the confocal laser ophthalmoscope HRT III and the stereoscopic fundus camera Kowa nonmyd WX3D retrospectively. Methods. Morphometric optic nerve head parameters of 40 eyes of 40 patients with primary open angle glaucom...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/4764857
更新日期:2016-01-01 00:00:00
abstract::Here we review evidence that loss of photoreceptors due to degenerative retinal disease causes an increase in the rate of spontaneous ganglion spike discharge. Information about persistent spike activity is important since it is expected to add noise to the communication between the eye and the brain and thus impact t...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/507037
更新日期:2011-01-01 00:00:00
abstract:Aim:The purpose of this study is to evaluate and compare the efficacy of 4 prostaglandin analogues (PGAs) and to determine the incidence of ocular surface disease in newly diagnosed, primary open-angle glaucoma (POAG) patients started on one of those 4 PGAs: bimatoprost (benzalkonium chloride, BAK, 0.3 mg/mL), latanopr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1319628
更新日期:2018-03-07 00:00:00
abstract::Retinitis pigmentosa (RP) represents a clinically and genetically heterogeneous disease characterized by progressive photoreceptor loss. In recent years, research has been rarely made in blood flow affected in RP. The specific mechanism of blood flow affected in RP is not completely clear. A number of studies indicate...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2018/3249064
更新日期:2018-02-25 00:00:00
abstract:Purpose:The aim of this study was to assess the effects of residual anterior lens epithelial cell (LEC) removal by anterior capsule polishing on the effective lens position (ELP) and axial position stability of the intraocular lens (IOL) after cataract surgery via postoperative measurement of the anterior chamber depth...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/9704892
更新日期:2018-08-19 00:00:00
abstract::Purpose. Ischemic central retinal vein occlusion (CRVO) eyes are at high risk of developing neovascular glaucoma (NVG). Our purpose is to investigate the effect of anti-VEGF therapy for macular edema after CRVO on the development of neovascular glaucoma (NVG) in ischemic CRVO eyes. Methods. This is a retrospective cas...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2014/317694
更新日期:2014-01-01 00:00:00
abstract::Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured fro...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/397495
更新日期:2015-01-01 00:00:00
abstract:Purpose:To analyze the results of three-year outcomes of combined epithelium-on cross-linking with femtosecond laser ICRS (cross-linking PLUS) for keratoconus management. Design:A retrospective multicenter clinical study. Methods:43 eyes of 38 patients were subjected to preoperative and postoperative UCVA, BCVA, refr...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/6907573
更新日期:2018-01-17 00:00:00
abstract::Purpose. To evaluate interobserver, intervisit, and interinstrument agreements for gonioscopy and Fourier domain anterior segment optical coherence tomography (FD ASOCT) for classifying open and narrow angle eyes. Methods. Eighty-six eyes with open or narrow anterior chamber angles were included. The superior angle wa...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/1727039
更新日期:2016-01-01 00:00:00
abstract:Objective:This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method:A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed w...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/3458356
更新日期:2017-01-01 00:00:00
abstract:Background:Chromatic contrast may affect stereopsis. Daltonism is a common color deficiency in which the colors red and green are incorrectly detected. The aim of this study was to evaluate the stereoacuity of color-defective individuals presented with color symbols that they see defectively. Methods:Ten students diag...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1926736
更新日期:2018-08-01 00:00:00
abstract::The leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4, also called GPR48) plays a key role in multiple developmental processes, and mice lacking Lgr4 display anterior segment dysgenesis leading to early-onset glaucomatous retinal ganglion cell loss as well as defective eyelid formation. This paper will...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2013/987494
更新日期:2013-01-01 00:00:00
abstract:Purpose:To present a new method of measuring ocular axial dimensions, termed OCT biometry (B-OCT). Design:Observational cross-sectional study and evaluation of new diagnostic technology. Methods:B-OCT was implemented in the spectral domain OCT device for posterior and anterior segment imaging (REVO NX, Optopol Techno...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9192456
更新日期:2019-08-14 00:00:00
abstract::Purpose. To evaluate functional and anatomical results of pars plana vitrectomy (PPV) in the retinal detachment (RD) followed by severe eye trauma. Methods. Retrospective analysis of medical records of forty-one consecutive patients treated with 23-gauge PPV due to traumatic RD. Age, gender, timing of PPV, visual acui...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/5084319
更新日期:2017-01-01 00:00:00
abstract::Purpose. To compare the mean corneal power (Km) and total astigmatism (Ka) estimated by three methods: simulated keratometry (simK), true net power (TNP), and total corneal refractive power (TCRP) before and after femtosecond laser small incision lenticule extraction (SMILE) surgery. Methods. A retrospective, cross-se...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2017/9659481
更新日期:2017-01-01 00:00:00
abstract:Purpose:To explore whether bandage lenses could be a safe and effective substitute for eye patch in the postoperative care for cataract surgery patients in terms of infection prevention, ocular impacts, and patient satisfaction. Methods:Patients who underwent cataract surgery were randomly divided into the eye patch g...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/1493967
更新日期:2018-05-15 00:00:00
abstract:Purpose:To evaluate early changes in visual function and visual quality parameters after Descemet membrane endothelial keratoplasty (DMEK) and to compare the outcomes with healthy controls. Methods:Thirteen patients who underwent DMEK and 14 controls were evaluated. All subjects underwent visual function evaluation, i...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/2012560
更新日期:2018-09-23 00:00:00
abstract::Individualized treatment regimens may reduce patient burden with satisfactory patient outcomes in neovascular age-related macular degeneration. Intravitreal anti-VEGF drugs are the current gold standard. Fixed monthly injections offer the best visual outcome but this regimen is not commonly followed outside clinical t...
journal_title:Journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1155/2015/412903
更新日期:2015-01-01 00:00:00
abstract::Background. The vision with diffractive toric multifocal intraocular lenses after cataract surgery in long eyes has not been studied previously. Objectives. To report visual performance after bilateral implantation of a diffractive toric multifocal intraocular lens in high myopes. Methods. Prospective, observational c...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2016/5320105
更新日期:2016-01-01 00:00:00
abstract:Purpose:To report on patients who needed hospitalization due to acute anterior uveitis (AAU) and within this group to compare clinical features and outcomes of treatment of HLA-B27+ and HLA-B27- AAU in the population of Slovenian patients. Methods:Retrospective study of hospitalized patients with AAU in the last 39 mo...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/6079146
更新日期:2020-09-19 00:00:00
abstract:Objective:To report the 15-year trend in ophthalmic presentations to the emergency department (ED) at the only medical center in Lebanon that provides 24-hour ophthalmologic care. Methods:Retrospective review of 1967 patients presenting to the ED with eye-related complaints between September 1997 and August 1998 and b...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/4739865
更新日期:2018-03-13 00:00:00
abstract:Purpose:To evaluate a new technique of posterior capsulorhexis using air support to treat primary posterior capsular opacification (PCO) during cataract extraction surgery or to prevent postoperative PCO. Setting:(1) Ophthalmology department, Faculty of Medicine, Minia University, 61519, El-Minia, Egypt. (2) Security ...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/3174709
更新日期:2019-12-21 00:00:00
abstract::SD-OCT has become an essential tool for evaluating macular pathology; however several aspects of data collection and analysis affect the accuracy of retinal thickness measurements. Here we evaluated sampling density, scan centering, and axial length compensation as factors affecting the accuracy of macular thickness m...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/692574
更新日期:2011-01-01 00:00:00
abstract:Background:Endoplasmic reticulum stress (ERS) in the retinal Müller cells is a key factor contributing to the retinal inflammation and vascular leakage in diabetic retinopathy (DR). This study was to investigate the underlying mechanisms through which the 3 main unfolded protein response (UPR) pathways regulate ERS and...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2019/9028483
更新日期:2019-02-24 00:00:00
abstract:Purpose:To analyse the correlation of myopia with physical exercise and sleep habits to explore the possible risk or protective factors of juvenile myopia. Methods:This study was a retrospective cross-sectional study. A total of 1831 students aged 11-18 years from five schools in Qingpu completed questionnaires from 2...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/2670153
更新日期:2020-07-25 00:00:00
abstract:Methods:A total of 287 consecutive patients diagnosed with congenital SOP and 82 control subjects were included. Congenital SOP patients were grouped according to the presence (present group) or absence (absent group) of the trochlear nerve using thin-section high-resolution MRI of cranial nerves. We developed a comput...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2020/9476749
更新日期:2020-12-17 00:00:00
abstract:Objective:To calculate the Q values from the human anterior corneal surface with the tangential radius of curvature and analyze its distribution characteristics in different age and refractive status groups. Methods:Tangential power maps of the anterior cornea from Orbscan II were acquired for 201 subjects' right eyes...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2018/7263564
更新日期:2018-04-17 00:00:00
abstract::Purpose. To compare dry eye disease following SMILE versus FS-LASIK. Design. Prospective, nonrandomised, observational study. Patients. 90 patients undergoing refractive surgery for myopia were included. 47 eyes underwent SMILE and 43 eyes underwent FS-LASIK. Methods. Evaluation of dry eye disease was conducted preope...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/132417
更新日期:2015-01-01 00:00:00
abstract::Cross-linking of corneal collagen (CXL) is a promising approach for the treatment of keratoconus and secondary ectasia. Several long-term and short-term complications of CXL have been studied and documented. The possibility of a secondary infection after the procedure exists because the patient is subjected to epithel...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2011/869015
更新日期:2011-01-01 00:00:00
abstract::Purpose. To compare the clinical features of community-associated (CA) and healthcare-associated (HA) methicillin-resistant Staphylococcus aureus (MRSA) keratitis. Methods. Patients presenting with culture-proven MRSA keratitis between January 1, 2006, and December 31, 2010, at Chang Gung Memorial Hospital, Taiwan, we...
journal_title:Journal of ophthalmology
pub_type: 杂志文章
doi:10.1155/2015/923941
更新日期:2015-01-01 00:00:00