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Naturally occurring antimicrobial peptide OH-CATH30 selectively regulates the innate immune response to protect against sepsis.

Abstract：

:Sepsis, which is a systemic inflammatory response that follows a bacterial infection, has a high mortality rate and limited therapeutic options. Here we show that the antimicrobial peptide OH-CATH30, which naturally occurs in snake, selectively regulates the innate immune response to protect mice from lethal sepsis. The administration of OH-CATH30 significantly improves the survival rate of mice infected by antibiotic-susceptible and -resistant pathogens, including Escherichia coli , Pseudomonas aeruginosa , and Staphylococcus aureus . OH-CATH30 selectively up-regulates the production of chemokines and cytokines without harmful immune response. Recruitment of monocytes, macrophages, and neutrophils to the infection site is pivotal to the protective capacity of OH-CATH30. Furthermore, the alternative activation of the innate immune response by OH-CATH30 depends on p38 mitogen-activated protein kinase signaling. Taken together, our study demonstrates that OH-CATH30, a naturally occurring antimicrobial peptide, selectively stimulates the innate immune response to protect against sepsis.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Li SA,Xiang Y,Wang YJ,Liu J,Lee WH,Zhang Y

doi

10.1021/jm401134n

subject

Has Abstract

pub_date

2013-11-27 00:00:00

pages

9136-45

issue

22

eissn

0022-2623

issn

1520-4804

journal_volume

56

pub_type

杂志文章

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