Abstract:
:Salivary cortisol and alpha-amylase are known to have distinctive diurnal profiles. However, little is known about systematic changes in these biomarkers across the adult lifespan. In a study of 185 participants (aged 20-81 years), time-stamped salivary cortisol and alpha-amylase were collected 7 times/day over 10 days. Samples were taken upon waking, 30 min later, and then approximately every 3 h until 9 pm. Multilevel models showed that older age was associated with increased daily cortisol secretion as indicated by greater area under the curve, attenuated wake-evening slopes, and more pronounced cortisol awakening responses. Further, older age was related to greater daily alpha-amylase output and attenuated wake-evening slopes. No age differences were observed regarding the alpha-amylase awakening response. Our findings may contribute to a better understanding of age-related differences in functioning of stress-related systems.
journal_name
Psychoneuroendocrinologyjournal_title
Psychoneuroendocrinologyauthors
Nater UM,Hoppmann CA,Scott SBdoi
10.1016/j.psyneuen.2013.09.008subject
Has Abstractpub_date
2013-12-01 00:00:00pages
3167-71issue
12eissn
0306-4530issn
1873-3360pii
S0306-4530(13)00327-2journal_volume
38pub_type
杂志文章abstract::Cocaine stimulates the release of adrenocorticotropin hormone (ACTH) and cortisol in both clinical and preclinical studies, but the temporal sequence of cocaine-induced changes in other hormones and affective states is unclear. The purpose of this study was to analyze the pattern and temporal concordance of cocaine-in...
journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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doi:10.1016/j.psyneuen.2008.09.006
更新日期:2009-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2013.05.009
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journal_title:Psychoneuroendocrinology
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更新日期:2017-04-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 临床试验,杂志文章
doi:10.1016/j.psyneuen.2009.07.006
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:1983-01-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2005.09.003
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pub_type: 杂志文章
doi:10.1016/j.psyneuen.2019.03.006
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psyneuen.2014.02.016
更新日期:2014-06-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2011.07.021
更新日期:2012-05-01 00:00:00
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journal_title:Psychoneuroendocrinology
pub_type: 杂志文章
doi:10.1016/j.psyneuen.2016.09.011
更新日期:2016-12-01 00:00:00