Abstract:
INTRODUCTION:Resistance to chemotherapy poses a major problem in cancer patients. Although of multifactorial origin, some of the implicated mechanisms also interfere with (99m)Tc-MIBI uptake and retention in cancer cells. The aim of the current study was to investigate the prognostic value of baseline (99m)Tc-MIBI imaging in lymphoma. METHODS:(99m)Tc-MIBI SPECT was performed in 16 patients with Hodgkin lymphoma and 31 with non-Hodgkin lymphoma (NHL) before chemotherapy initiation. Early (20 minutes), late (120 minutes) tumor-to-background (T/B) ratios, and 2-hour (99m)Tc-MIBI washout were calculated. Follow-up data were obtained for a period of 45.5 ± 23.5 months. Study end points were response to first-line chemotherapy, lymphoma-related death (LRD), and time to disease progression. RESULTS:Of the scintigraphic indices examined, the late T/B ratio correlated best with study end points. A cutoff value of 1.8 determined by receiver operating characteristic analysis discriminated poor from good response and LRD from survival with an accuracy of 87% and 81%, respectively. Kaplan-Meier survivor functions separated by this cutoff differed significantly for both time to disease progression and LRD (P = 0.0001 and P = 0.0015). In the Cox proportional hazards model, the late T/B ratio proved to have an independent and incremental value over clinical prognostic factors (age, lymphoma type, Ann Arbor stage, lactate dehydrogenase levels) and, in NHL patients, over the international prognostic index. Patients with high international prognostic index score could be further stratified into different prognostic categories. CONCLUSION:The current study indicates that baseline (99m)Tc-MIBI SPECT can provide useful prognostic information in patients with lymphoma, particularly NHL, regarding therapy response and final outcome.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Spyridonidis TJ,Matsouka P,Symeonidis A,Savvopoulos C,Vassilakos PJ,Apostolopoulos DJdoi
10.1097/RLU.0b013e3182a755c8subject
Has Abstractpub_date
2013-11-01 00:00:00pages
847-54issue
11eissn
0363-9762issn
1536-0229journal_volume
38pub_type
杂志文章abstract::We describe a case of a 5-year-old boy with a history of intermittent melena underwent TcO4 scintigraphy. On dynamic images, no abnormal activity was noted. After voiding and also in the lateral view, the focus of activity was noted in the superior and anterior aspect of the urinary bladder, compatible with a Meckel's...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003016
更新日期:2020-06-01 00:00:00
abstract::We report the case of a 28-year-old woman presenting behavior disorders of subacute onset. She was referred in our institution for a suspicion of limbic encephalitis. F-FDG PET/CT did not show any mesiotemporal abnormality but depicted a decreased uptake of bilateral parietal and occipital lobes. This atypical pattern...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002098
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Investigate the ability of F-fluorothymidine (FLT) PET combined with CT at 6 weeks to predict treatment response at 12 weeks after treatment with pembrolizumab. METHODS:Five patients with unresectable stage IV melanoma were included in this single-institution pilot study. Patients underwent FLT-PET/CT (baselin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000002967
更新日期:2020-04-01 00:00:00
abstract::The neuroendocrine small cell carcinoma of the cervix is a rare malignancy that has a poor prognosis due to early lymphatic and hematogenous spread. We herein report a case of a 27- year-old woman who was referred for initial staging of a neuroendocrine small cell carcinoma with previous unremarkable structural imagin...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000001498
更新日期:2017-03-01 00:00:00
abstract::Patients with primary central nervous system lymphomas (PCNSLs) present with nonspecific clinical symptoms, which makes correct imaging evaluation essential for diagnostic and therapeutic management. In this work, we examined an 81-year-old man with recently discovered PCNSL using F-FDG PET/MRI, and we were able to di...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003067
更新日期:2020-07-01 00:00:00
abstract::Bone mineral content of the distal radius was determined in 106 patients by single photon absorptiometry using iodine-125 monochromatic source. The technique provided a reliable means to assess the degree of mineral loss in conditions such as osteoporosis, renal osteodystrophy in patients on chronic maintenance dialys...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198408000-00003
更新日期:1984-08-01 00:00:00
abstract::Tc-99m sestamibi imaging was performed in two patients with multiple myeloma. Focal areas of increased uptake in one patient and diffuse skeletal uptake in the second patient were found. Tc-99m sestamibi appears to identify bone marrow and osteolytic involvement in multiple myeloma. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199902000-00009
更新日期:1999-02-01 00:00:00
abstract::Pulmonary perfusion scintigraphy with Tc-99m MAA was performed on 182 patients, on whom either pneumonectomy or lobectomy was performed, because of primary nonsmall-cell lung carcinoma. Among them, 76 underwent pneumonectomy, and 106 underwent lobectomy. The mean value of the perfusion fraction (PF) of the affected lu...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199419120-00012
更新日期:1994-12-01 00:00:00
abstract::A 66-year-old woman had autopsy-proven miliary tuberculosis, with regional involvement of the meninges of the left Sylvian fissure. Radionuclide studies of the brain demonstrated the unusual findings of increased perfusion to the left hemisphere and linear increased activity corresponding to the left Sylvian fissure. ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197808000-00005
更新日期:1978-08-01 00:00:00
abstract::Burkitt lymphoma (BL) is a poorly differentiated non-Hodgkin B-cell lymphoma, more frequent in children than in adults. The extranodal debut of the disease is rare. We report a 43-year-old male patient with history of dyspnea. Burkitt lymphoma diagnosis was reached after biopsy of a pleural lesion. An initial staging ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000000885
更新日期:2015-09-01 00:00:00
abstract::Liver imaging was performed in two patients with traumatic right hemidiaphragmatic hernia. It has elucidated the cause of obliteration of the right hemidiaphragmatic shadow on the chest x-ray. These cases are illustrative of the usefulness of liver imaging in the diagnosis of traumatic right hemidiaphragmatic hernia a...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198501000-00008
更新日期:1985-01-01 00:00:00
abstract::A 38-year-old woman presented with nausea and abdominal distension 15 months after surgical resection of osteoclast-like giant cell tumor in the left lobe of the liver. An 18F-FDG PET/CT scan was performed to evaluate the recurrent tumor. The images demonstrated the recurrent malignancy in the liver. In addition, meta...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31826392c4
更新日期:2012-10-01 00:00:00
abstract::The purpose of this investigation was to determine the diagnostic value (validity) of technetium-99m-pyridoxylideneglutamate cholescintigraphy (99mTc-PGC) in patients with and without cholecystitis and to compare its validity to those of oral cholecystography (OC) and ultrasonography (US). 99mTc-PGC was applied to 50 ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-197804000-00007
更新日期:1978-04-01 00:00:00
abstract::A 52-year-old man with metastatic poorly differentiated bronchogenic carcinoma and serum calcium levels as high as 14.6 had intense Tc-99m MDP uptake found throughout the stomach wall on SPECT imaging. FDG uptake assessed by PET imaging was not elevated in the stomach, whereas multiple hyper-metabolic tumor foci could...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199509000-00002
更新日期:1995-09-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate retrospectively magnetic resonance imaging (MRI) and (18)F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) findings of hepatic epithelioid hemangioendothelioma (HEH). PATIENTS AND METHODS:MRI and FDG PET/CT findings were reviewed in 6 patie...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318266ceca
更新日期:2013-02-01 00:00:00
abstract::Regression in metastatic lesions as seen on a bone scan may be accompanied by increasing sclerosis radiographically. There are two possible causes for interval radiographic sclerosis: progressive osteoblastic tumor deposition or the healing process itself. The presence of active neoplasia can better be determined in s...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198203000-00001
更新日期:1982-03-01 00:00:00
abstract::A 28-year-old woman with a history of prior bilateral retinoblastoma presented with general fatigue, anemia, and a urinary bladder mass seen on abdominal ultrasound and CT. She was referred for a staging 18F-FDG PET/CT, which showed an intensely FDG-avid bladder mass that was biopsied to reveal a leiomyosarcoma, with ...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182523e33
更新日期:2013-05-01 00:00:00
abstract::In a patient with AIDS, marked uptake of Ga-67 in the stomach walls initially was regarded with a high degree of suspicion for gastric involvement. Results of subsequent intragastric tests, including biopsy and culture, proved negative. Caution should be exercised when considering further costly and/or invasive proced...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198602000-00015
更新日期:1986-02-01 00:00:00
abstract::The speed of Tc-99m DTPA/HMPAO radioaerosol clearance from the lungs that is represented as a slope from lungs to blood was measured in 23 male normal controls using commercial lung radioaerosol delivery units in the supine position in order to avoid the influences of gravity. The right lung was selected and three reg...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199507000-00016
更新日期:1995-07-01 00:00:00
abstract::Presence of enlarged spleen using CT with absence of splenic visualization in Ga-67 citrate images in a patient with chronic myelogenous leukemia and splenomegaly after splenic irradiation was observed. Since Howell-Jolly bodies had not been identified in the peripheral circulation, the finding of splenic nonvisualiza...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198503000-00012
更新日期:1985-03-01 00:00:00
abstract::Low back pain with radiation to lower limbs is due to nerve root impingement or involvement in most cases. F-FDG PET/CT has shown sacral nerve root involvement in several peripheral nerve pathologies, including neurolymphomatosis, peripheral nerve sheath tumor, and plexopathies. We present 2 cases of a low back pain w...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0000000000003021
更新日期:2020-06-01 00:00:00
abstract::Sodium fluoride (NaF) is a bone-seeking positron-emitting tracer with high sensitivity and specificity for detection of osseous lesions, particularly osteolytic lesions. We believe that NaF positron emission tomography (PET)/computed tomography (CT) scans can provide a more thorough and conclusive evaluation of bone d...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e31824c81ee
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:To evaluate the findings and usefulness of Ga-67 scanning in recent cases of tuberculosis (TB). MATERIALS AND METHODS:The authors reviewed chest x-ray films and Ga-67 citrate scans of 52 patients with culture-confirmed infection caused by Mycobacterium tuberculosis treated after 1988. RESULTS:Ga-67 scans were...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199707000-00005
更新日期:1997-07-01 00:00:00
abstract::The authors report atypical findings of discordant bone scans and radiography seen in a patient with transient osteoporosis of the hip (TOH). Presented in the case of a 60-year-old man who had spontaneous onset of left hip pain which worsened for 2 months with weight-bearing on the affected side. Initial and follow-up...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
doi:10.1097/00003072-199803000-00006
更新日期:1998-03-01 00:00:00
abstract::Chronic myelomonocytic leukemia (CMML) is a rare hematologic malignancy characterized by the accumulation of monocytes in the blood and bone marrow, dysplastic hematopoiesis, and potential leukemic involvement of organs. We report a case of leukemic involvement of cervical lymph nodes detected by 18F-FDG PET/CT. A 53-...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e3182a77c99
更新日期:2014-09-01 00:00:00
abstract::Radionuclide angiography (RNA) and cholescintigraphy were performed prospectively in 300 patients with suspected acute cholecystitis (AC). Of 79 patients with positive RNA, 63 had AC (80%). Positive RNA was seen in 23 of 26 cases with gangrenous AC (88%) while 12 of the 26 had a positive "rim" sign (46%). All 12 patie...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198912000-00001
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVE:Fibrosing alveolitis is a prominent feature of systemic sclerosis (SSc), and accounts for much of the morbidity and mortality of this disease. Sensitive techniques for the detection and monitoring of fibrosing alveolitis could target patients for early therapeutic intervention. The objective of this small pil...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199801000-00007
更新日期:1998-01-01 00:00:00
abstract::Intravenous injection of Tc-99m-labeled radionuclides permits angioscintigraphic and blood pool visualization of both supra- and infradiaphragmatic organs. By adding this procedure to routine bone scans an improvement in the diagnostic yield of incidentally observed renal abnormalities was achieved. Several illustrati...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198003000-00002
更新日期:1980-03-01 00:00:00
abstract::A case that demonstrates the relationship between malignancy and pulmonary throboembolic disease is presented. Pulmonary embolism, which was diagnosed on a ventilation-perfusion lung scan, initiated a search for the etiology of this condition. Normal examination of the deep venous system of the legs prompted further i...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199011000-00016
更新日期:1990-11-01 00:00:00
abstract::The authors report a case in which a radionuclide hepatobiliary image was falsely indicative of cystic duct obstruction in a patient with an indwelling cholecystostomy tube and an externalized gallbladder-duodenal stent. Cystic duct patency was demonstrated radiographically shortly before and after the radionuclide st...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-198903000-00001
更新日期:1989-03-01 00:00:00