Physiological and neurobiological bases of age-related hearing loss: biotherapeutic implications.

Abstract:

PURPOSE:The aim of this study was to highlight growing evidence of interactions between hormones and the structure and function of the auditory system. METHOD:Recent studies implicating sex hormones and other natural hormones in the modulation of hearing status in age-related hearing loss were reviewed. RESULTS:Progesterone, a sex hormone, has been shown to have negative effects on the hearing of older women and aging mice, whereas, in contrast, estrogen was found in some cases to have a positive influence. Aldosterone, used in studies of animal models of autoimmune hearing loss, slowed the progression of hearing loss. Follow-up studies in humans revealed that auditory measures varied as serum aldosterone levels shifted within the normal range, in otherwise healthy older subjects. This was true for simple as well as complex auditory tasks (i.e., sound spatial processing), suggesting benefits of aldosterone to postperipheral auditory processing as well. In addition, evidence suggests that this functional hearing improvement occurred in association with anatomical improvements to the stria vascularis--an important site of anatomical change in presbycusis. CONCLUSIONS:Audiology is now at the point where the search for biomedical interventions to modulate or prevent age-related hearing loss can move forward. Such interventions would require multidisciplinary collaborative initiatives by researchers in such areas as drug development, anatomy, auditory physiological and perceptual testing, and drug microdelivery systems.

journal_name

Am J Audiol

authors

Frisina RD,Frisina DR

doi

10.1044/1059-0889(2013/13-0003)

subject

Has Abstract

pub_date

2013-12-01 00:00:00

pages

299-302

issue

2

eissn

1059-0889

issn

1558-9137

pii

1059-0889_2013_13-0003

journal_volume

22

pub_type

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