Abstract:
:Erectile dysfunction (ED) is usually associated with cardiovascular disease and reduced endothelial function. The aim of the present study was to examine the effect of tadalafil and statin on the endothelial function of cavernous and brachial arteries in healthy men and in patients with ED. The cases included in the study were as follows: 150 men with ED complaints for at least 6 months, and 50 healthy volunteers without sexual problems. Patients were randomly divided into four groups of equal numbers. Group 1 received 20 mg of tadalafil on alternate days, Group 2 received 10 mg of statin a day, Group 3 received tadalafil on alternate days and 10 mg of statin a day, and the last group served as controls. Noninvasive evaluation of brachial artery flow-mediated dilatation (FMD) and percentage of increase in cavernosal arteries diameter (PICAD) was conducted via ultrasound at baseline and 4 weeks after administration of tadalafil or atorvastatin. Before drug administration, FMD and PICAD values did not significantly differ among the three treatment groups. After drug administration, FMD and PICAD values significantly increased in patients receiving tadalafil and tadalafil+statin (P < 0.001), but not in patients receiving only statin. These findings suggested that use of tadalafil alone and tadalafil combined with statin improved endothelial function of cavernous and brachial arteries.
journal_name
Andrologiajournal_title
Andrologiaauthors
Simsek A,Ozbek E,Oncu Mdoi
10.1111/and.12153subject
Has Abstractpub_date
2014-09-01 00:00:00pages
808-13issue
7eissn
0303-4569issn
1439-0272journal_volume
46pub_type
杂志文章相关文献
ANDROLOGIA文献大全abstract::Maturation arrest is a common cause of male infertility which has caused worldwide concern, and its pathophysiological process remains further elucidation. Our study aimed to identify genetic characteristics of maturation arrest by comparing gene expression between maturation arrest and normal samples using microarray...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13812
更新日期:2020-12-01 00:00:00
abstract::The human spongy urethras of individuals submitted to emasculation because of glans carcinoma have been studied by means of scanning electron microscopy. The luminal surface of the organ shows longitudinal folds and small glandular openings, surrounded by epithelial elements arranged in form of rosettes. Spermatozoa, ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1988.tb00676.x
更新日期:1988-03-01 00:00:00
abstract::According to numerous assisted reproductive medicine practitioners, semen with normal characteristics might not require further investigation. However, on the scale of the individual spermatozoon, it is well known that normal morphology does not guarantee optimal nuclear quality. Here, for 20 patients with normal sper...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12341
更新日期:2015-10-01 00:00:00
abstract::Polyorchidism is defined as the presence of more than 2 histologically proven testes. We report the case of a 20-year-old man with polyorchidism, presenting with right scrotal pain and right scrotal ovoid mass. Scrotal examination revealed two ovoid, mobile lumps with testicular sensation in the right side of the scro...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.2011.01205.x
更新日期:2012-05-01 00:00:00
abstract::The suggested concept of "bone as an endocrine organ" had shed the light on the role of osteocalcin, an osteoblast secreted hormone, in regulation of testosterone production. This study aimed to assess the association between the active undercarboxylated form of osteocalcin (ucOC) and semen parameters and hormonal lev...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12755
更新日期:2017-11-01 00:00:00
abstract::E prostaglandins are formed in seminal vesicles and can be oxygenated by (omega-1)-hydroxylation catalysed by cytochrome P450 to 19(R)-hydroxy metabolites. The latter are not further metabolized. Prostaglandin E1 (PGE1), PGE2, 19-hydroxy-PGE1 and 19-hydroxy-PGE2 were measured in seminal fluid of 95 men, who attended t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1995.tb01075.x
更新日期:1995-03-01 00:00:00
abstract::Erectile dysfunction could be an early sign of endothelial dysfunction and, therefore, of cardiovascular disease, with which it shares many risk factors. Among reversible risk factors, physical inactivity is one of the most important. Regular physical exercise has been shown to improve erectile function through differ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/and.13264
更新日期:2019-06-01 00:00:00
abstract::The effect of chronic chloroquine administration on prostaglandin E1 (PGE1) and human chorionic gonadotropin (hCG) stimulation of testosterone secretion by the rat Leydig cells was studied. Adult albino (Wistar strain) rats were injected with 4 mg/kg body weight of chloroquine phosphate every other day for 30 days. At...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1987.tb01900.x
更新日期:1987-09-01 00:00:00
abstract::Retraction: 'Aetiology and clinical profile of children with 46, XY differences of sex development at an Indian referral centre' by Vasundhera Chauhan, Rima Dada, Vandana Jain The above article, published online on 8 August 2016 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement b...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.12663
更新日期:2017-11-01 00:00:00
abstract::The manual of the World Health Organization defines leucocytospermia as the presence of >1 x 10(6) white blood cells per ml semen. Most authors consider leucocytospermia to be a consequence of inflammation due to bacterial infection. However, the efficacy of antibiotic therapy was not unequivocally demonstrated until ...
journal_title:Andrologia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1439-0272.2003.00580.x
更新日期:2003-08-01 00:00:00
abstract::The present study was conducted to evaluate in vitro and in vivo antiproliferative potential of the Cameroonian propolis and to elucidate its underlying mechanism. In vitro, ethanol-extracted propolis (EEP) was tested on cell growth, cell proliferation, cell cycle, cell death mechanism and cell migration. The cell cyc...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13698
更新日期:2020-10-01 00:00:00
abstract::Chlamydia trachomatis infection is one of the most common sexually transmitted diseases. Its effect on male fertility, however, is still controversial. In this study, 284 male partners of infertile couples consulting the Center of Studies in Reproductive Biology (CEBRE) were analyzed. The incidence of C. trachomatis i...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1046/j.1439-0272.2002.00472.x
更新日期:2002-06-01 00:00:00
abstract::The total amount of humoral sperm antibody protein is determined following its isolation by affinity-chromatography on spermatozoa. Serum proteins are eluted by Sorensen phosphate buffer. Antibodies attached to spermatozoa suspended in Sephadex G 75 columns resist elution by Sorensen buffer. They can be quantitatively...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1975.tb01236.x
更新日期:1975-01-01 00:00:00
abstract::Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a multifactorial problem affecting men of all ages and demographics. Currently, there is a relative dearth of epidemiological information on CPPS. It is clear that patients with CPPS have a dismal quality of life and many have benefited only minimally from ...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1046/j.1439-0272.2003.00584.x
更新日期:2003-10-01 00:00:00
abstract::The inactivation of ornithine decarboxylase, a polyamine biosynthetic enzyme, by alpha-difluoromethylornithine (alpha-DFMO) was studied in patients with chronic non-suppurative prostatitis. Partial clinical response and remission of gross hematospermia were observed after 18 g/day alpha-DFMO, when administered orally ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1981.tb00014.x
更新日期:1981-03-01 00:00:00
abstract::An estrogen binding protein has been demonstrated in the cytosol of the epididymis and caudal lobe of prostate of immature rhesus monkey. Scatchard plot analyses were linear, suggesting a single class of high affinity binding sites for the synthetic estrogen, R-2858 (Moxestrol) with a Kd of 5.88 X 10(-10) mol/l and a ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1985.tb01016.x
更新日期:1985-07-01 00:00:00
abstract::The aim of this study was to find discriminatory parameters, based on sperm characteristics on the day of ovum pickup, that can help guide the decision to perform either intracytoplasmic sperm injection (ICSI) or in vitro fertilisation (IVF). We evaluated 112 cycles fertilised with both regular and ICSI insemination d...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.2010.01107.x
更新日期:2012-04-01 00:00:00
abstract::The aim of the study was to investigate whether the promoter methylation of XRCC1 and ERCC2 genes is associated with sperm DNA fragmentation and chromatin condensation in idiopathic oligoasthenoteratozoospermic men. This study involved 77 infertile men with idiopathic oligoasthenoteratozoospermia and 51 normozoospermi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13925
更新日期:2020-12-23 00:00:00
abstract::The effects of incubation with caffeine at final concentration of 0.5 and 5.0 mM for 30 min at ambient temperature were examined in three normal semen samples and three from asthenozoospermic men. A 50 frames/s microcinematographic analysis of the sperm motility was performed and two characteristic parameters of the t...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1982.tb02295.x
更新日期:1982-09-01 00:00:00
abstract::A histochemical study has been made of the localization and changes of lipids, carbohydrates, ATPase and 5'-nucleotidase in fresh and fixed frozen sections of testicular and epididymal components in the normal and alpha-chlorohydrin-treated rats. After treatment with a single low dose of alpha-chlorohydrin, the phosph...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1978.tb03032.x
更新日期:1978-07-01 00:00:00
abstract::The aim of this study was to evaluate the production of artefacts during preparation and observation of human sperm for ultrastructural morphology and analyse the possible reasons of causing these artefacts. Under the scanning electron microscopy, damaged sperm heads (crack or/and rupture), necks (head-neck or head-mi...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13043
更新日期:2018-09-01 00:00:00
abstract::In order to detect abnormalities in the size of the penis, firstly, the penis length must be measured correctly. Controversies about the best technique on to be used to measure the length of the penis still persist. The hypothesis of this study is to show that penile length in children is longer than measured under no...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13864
更新日期:2020-12-01 00:00:00
abstract::In fertile men, the majority of epididymal spermatozoa acquire the potential to fertilize (assessed with sperm function assays) on passage into the corpus and cauda regions of the epididymis. Although secretions of the epididymal epithelium are clearly important for sperm maturation and survival, their role in this pr...
journal_title:Andrologia
pub_type: 杂志文章,评审
doi:10.1111/j.1439-0272.1998.tb01165.x
更新日期:1998-08-01 00:00:00
abstract::The incretory testicular function was tested in 21 patient with varicocele aged 19 to 39 years. In one group baseline testosterone was measured, while a second group received a single injection of 5000 IU HCG. Testosterone was studied in peripheral plasma in the spermatic vein and in testicular tissue. Baseline values...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1983.tb00179.x
更新日期:1983-11-01 00:00:00
abstract::The male component that is necessary for successful reproduction depends on a large variety of biological processes working in concert. The sperm-egg interaction occurs through complementary molecules and is an obligatory process for successful fertilization. However, this complex phenomenon and its molecular mechanis...
journal_title:Andrologia
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::Several drugs have been used to stimulate human sperm motility, including 3-deoxy-adenosine, caffeine, and pentoxifylline. Pentoxifylline is an inhibitor of the phosphodiesterase and may stimulate sperm motility by increasing the intracellular levels of cAMP. In this study we have evaluated the effect of pentoxifyllin...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1993.tb02743.x
更新日期:1993-11-01 00:00:00
abstract::Various nuclear sperm alterations are reported in patients with syndromic teratozoospermia; however, this has not been clearly identified yet in total polymorphic teratozoospermia. The aim of this study was to analyse sperm aneuploidy, DNA integrity and chromatin packaging in 45 infertile patients with total polymorph...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13252
更新日期:2019-06-01 00:00:00
abstract::Ran-binding protein 3 (RanBP3) is a Ran-interacting protein, which participates in the Ran GTPase system in cancer cell biology. However, the expression pattern and physiological role of RanBP3 remain largely unknown. In this study, we found that RanBP3 was expressed in human testes and localised to spermatogonium and...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13446
更新日期:2020-03-01 00:00:00
abstract::CAG trinucleotide repeats are coded for the polyglutamine tract in the N-terminal of the androgen receptor (AR) gene which varies in normal individuals from 6 to 36 residues. In this study, we inspected the impact of the CAG repeats on the spermatogenic defects by measuring the size of AR-CAG repeats length in a cohor...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/and.13728
更新日期:2020-10-01 00:00:00
abstract::Angiotensin converting enzyme (EC 3.4.15.1) from bovine seminal plasma was shown to exist in two distinct forms. A lower molecular weight form of the enzyme having higher activity was purified to homogeneity. Final recovery of the enzyme was 18.37%. The apparent molecular weight of the enzyme was estimated to be 1.99 ...
journal_title:Andrologia
pub_type: 杂志文章
doi:10.1111/j.1439-0272.1991.tb02569.x
更新日期:1991-07-01 00:00:00