Abstract:
STUDY DESIGN:A prospective molecular mechanism of macrophages infiltration in experimental disc herniation. OBJECTIVE:To investigate the mechanisms of macrophages infiltration into the dorsal root ganglion (DRG) in a rat model of disc herniation. SUMMARY OF BACKGROUND DATA:Macrophages infiltrate the DRG after application of nucleus pulposus (NP) on the DRG, and may play an important role in radiculopathy. However, the mechanisms of macrophages infiltration after NP application remain poorly understood. METHODS:After experimental disc herniation in this study, we investigated changes in the expression of ED1 (a marker of macrophages) and vascular cell adhesion molecule-1 (VCAM-1) in DRG using immunofluorescence. We also investigated the expression of ED1 and VCAM-1 in DRG by treatment with tumor necrosis factor-α (TNF-α) inhibitor at the time of surgery. RESULTS:We found a massive ED1-positive macrophages infiltrated the DRG, and VCAM-1-like immunoreactivity vessels became evident after NP application. Furthermore, both macrophage infiltration and VCAM-1 expression were prevented by treatment with TNF-α inhibitor at the time of surgery. CONCLUSION:These findings indicated that macrophages infiltration into the DRG was TNF-α-dependent, and might be partly mediated by VCAM-1 in the early stage of experimental lumbar disc herination. Taken together, this study provides important preliminary data suggesting that TNF-α plays an important role in the macrophage infiltration. LEVEL OF EVIDENCE:N/A.
journal_name
Spine (Phila Pa 1976)journal_title
Spineauthors
You C,Zhu K,Liu X,Xi C,Zhang Z,Xu G,Yan Jdoi
10.1097/BRS.0b013e3182a84701subject
Has Abstractpub_date
2013-11-01 00:00:00pages
2003-7issue
23eissn
0362-2436issn
1528-1159journal_volume
38pub_type
杂志文章相关文献
SPINE文献大全abstract::A retrospective review of the treatment of chronic back and extremity pain is presented. Laminectomy is most effective for pain secondary to direct compression of the neural elements. Treatment of pseudoradicular pain requires identification of the source of pain input. Facet rhizotomy is specific for pain arising fro...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197903000-00009
更新日期:1979-03-01 00:00:00
abstract:STUDY DESIGN:In vivo animal study. OBJECTIVES:To describe a new porcine disc degeneration model, and to analyze disc remodeling and degeneration after nucleotomy with special view to the different nucleus pulposus (NP) cell types. SUMMARY OF BACKGROUND DATA:Thus far, predominantly smaller animals were used for disc d...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b723c9
更新日期:2009-12-01 00:00:00
abstract::This report describes the intraoperative use of a somatosensory cortical evoked potential system to monitor spinal cord function during 300 orthopedic surgical procedures. This system requires sophisticated equipment and the establishment of normative data but has performed well with no false negatives noted. The most...
journal_title:Spine
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract::This article presents the content and the application criteria of a questionnaire intended for the study of spinal disorders in workers and the results of an investigation, carried out via this questionnaire, in a group of 1205 male workers not exposed to occupational risks for the spine either currently or in the pas...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199307000-00006
更新日期:1993-07-01 00:00:00
abstract:STUDY DESIGN:Retrospective radiographic and clinical study. OBJECTIVE:To examine the long-term outcome of selective thoracic fusion (STF) performed for lumbar "C" modifier curves in adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA:The efficacy of STF in lumbar "C" false double major curves is controversial...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181e5e36e
更新日期:2010-11-15 00:00:00
abstract:STUDY DESIGN:Trunk sway occurring during clinical stance and gait tasks was compared between a group of subjects with a chronic whiplash injury, resulting from an automobile collision, and a normal collective. OBJECTIVES:To examine if population specific trunk sway patterns for stance and gait could be identified for ...
journal_title:Spine
pub_type: 临床试验,杂志文章
doi:10.1097/01.BRS.0000083170.34304.A3
更新日期:2003-08-01 00:00:00
abstract:STUDY DESIGN:Animal experimental study. OBJECTIVE:The aim of this study was to investigate the optimal time of hydrogel injection for regenerating intervertebral disc degeneration (IDD) based on T1ρ magnetic resonance imaging (MRI). SUMMARY OF BACKGROUND DATA:Currently, different approaches are being pursued to regen...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003667
更新日期:2020-11-15 00:00:00
abstract:STUDY DESIGN:Report of the use of one segmental artery from the left renal artery as inflow source for reconstructing a spine with recalcitrant osteomyelitis. OBJECTIVE:To describe one difficult case of spinal osteomyelitis and our reconstruction procedure. SUMMARY OF BACKGROUND DATA:The use of a vascularized fibular...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181ecbfa1
更新日期:2010-12-01 00:00:00
abstract:STUDY DESIGN:Literature-based review. OBJECTIVE:To review the published data on occupant kinematic and neuromuscular responses during low-speed impacts and analyze how these data inform our understanding of whiplash injury. SUMMARY OF BACKGROUND DATA:A stereotypical kinematic and neuromuscular response has been obser...
journal_title:Spine
pub_type: 杂志文章,评审
doi:10.1097/BRS.0b013e3182387d71
更新日期:2011-12-01 00:00:00
abstract:STUDY DESIGN:Prospective imaging study. OBJECTIVE:To clarify the frequency of positional vertebral artery (VA) occlusion using duplex ultrasonography in patients with rheumatoid arthritis (RA). SUMMARY OF BACKGROUND DATA:Some patients with upper cervical RA develop thromboembolic stroke related to positional and tran...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001136
更新日期:2016-01-01 00:00:00
abstract:STUDY DESIGN:A retrospective review was conducted covering records of patients who underwent spinal surgery after acute spinal cord injury. OBJECTIVE:To study the relation between time of operation and mobilization of patients. SUMMARY OF BACKGROUND DATA:No such report has existed in the literature. METHODS:Reviews ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200110150-00022
更新日期:2001-10-15 00:00:00
abstract::In this study, the authors evaluated the stiffness of motion segments in intact spines in two spine fracture models, and with each of five implant systems used for posterior fixation of thoracolumbar spine fractures. The devices represented a cross-section of types, including those employing sublaminar wires with and ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198805000-00003
更新日期:1988-05-01 00:00:00
abstract:STUDY DESIGN:Cross-sectional cohort study of chronic low back pain (CLBP) patients and matched controls. OBJECTIVE:To explore the interplay between vertebral endplate damage and adjacent paraspinal muscle (PSM) quality, and to test their association in a cohort of patients with CLBP and matched controls. SUMMARY OF B...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003035
更新日期:2019-07-15 00:00:00
abstract:STUDY DESIGN:A retrospective cohort analysis. OBJECTIVE:The aim of this study was to assess whether duration of symptoms (DOS) has an effect on clinical outcomes in patients undergoing lumbar decompression. SUMMARY OF BACKGROUND DATA:The success of surgical interventions for lumbar spinal stenosis varies depending on...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002818
更新日期:2019-03-01 00:00:00
abstract:STUDY DESIGN:A prospective, randomized clinical study comparing beta-tricalcium phosphate (beta-TCP) with autograft bone graft with follow-up of 3 years. OBJECTIVE:To determine the efficacy of beta-TCP as a bone graft substitute combined with local autograft obtained from decompression compared with the use of autolog...
journal_title:Spine
pub_type: 杂志文章,随机对照试验
doi:10.1097/BRS.0b013e3181732a8e
更新日期:2008-05-20 00:00:00
abstract:STUDY DESIGN:Basic science, biologic study. OBJECTIVE:To determine the potential benefits of using resveratrol (RSV) for intervertebral disc (IVD) matrix repair and regeneration. SUMMARY OF BACKGROUND DATA:The phytoestrogen RSV is a natural compound found in various plants including grapes and red wines. RSV has been...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181883883
更新日期:2008-11-15 00:00:00
abstract:STUDY DESIGN:A case report describing chronic recurrent multifocal osteomyelitis (CRMO) with initial presentation limited to spine, successfully treated by anti-TNF-alpha therapy after failure of conventional treatment methods. OBJECTIVE:To describe an unusual manifestation and treatment of a rare disease. SUMMARY OF...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181c09601
更新日期:2010-04-01 00:00:00
abstract::Primary amyloidosis of bone is a rare disease process. When amyloid lesions do occur in bone, they are often associated with myeloma or other plasma cell dyscrasias. Because of its rarity and its protean clinical and radiographic picture adequate biopsy tissue for histopathologic studies is essential for accurate diag...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198505000-00002
更新日期:1985-05-01 00:00:00
abstract:STUDY DESIGN:A retrospective review of 10 consecutive patients with a noninflammatory retro-odontoid pseudotumor. OBJECTIVE:To examine the radiographic characteristics in patients with a retro-odontoid pseudotumor and to evaluate the efficacy of posterior fusion. SUMMARY OF BACKGROUND DATA:A retro-odontoid pseudotumo...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31818acd27
更新日期:2009-02-01 00:00:00
abstract::Spinal cord evoked potentials were recorded from spinous processes of the lumbar, thoracic, and cervical levels of the spinal column of normal cats in response to direct stimulation of the sciatic nerve and subcutaneous stimulation of the posterior tibial nerve. The typical primary response was altered by changes in l...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-197911000-00007
更新日期:1979-11-01 00:00:00
abstract:STUDY DESIGN:A case is reported in which a 45-year-old man developed cauda equina syndrome caused by enlargement of an L4-L5 juxtafacet cyst diagnosed 4 months earlier. OBJECTIVES:To highlight the short interval that can elapse between the discovery of a juxtafacet cyst and its remarkable progression. SUMMARY OF BACK...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-200206010-00022
更新日期:2002-06-01 00:00:00
abstract::Rectus abdominis muscles of young healthy female volunteers were studied to determine both the maximum strength in isometric flexion and the relation between the surface electromyogram (RMS EMG) and torque. Both the upper and lower portions of the abdominal muscle were studied during graded increase and decrease of to...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-198908000-00015
更新日期:1989-08-01 00:00:00
abstract:STUDY DESIGN:Immunoblotting study to evaluate aggrecan degradation patterns in rat intervertebral discs (IVDs) subjected to mechanical overload. OBJECTIVE:To evaluate the effects of in vivo dynamic compression overloading on aggrecan degradation products associated with matrix metalloproteinase (MMP) and aggrecanase a...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181cec247
更新日期:2011-02-01 00:00:00
abstract:STUDY DESIGN:A retrospective study that involved a total of 82 adult deformity patients who underwent spinal fusion surgery with instrumentation of 6 or more levels. OBJECTIVE:The purpose of this study is to assess the efficacy and safety of aprotinin in reducing blood loss in adult spinal deformity patients. SUMMARY...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e31817b87c4
更新日期:2008-07-15 00:00:00
abstract:STUDY DESIGN:Retrospective comparative cohort study. OBJECTIVE:Assess the incidence, risk factors, and outcomes of recurrent proximal junctional kyphosis (r-PJK) in PJK revision patients. SUMMARY OF BACKGROUND DATA:Several studies have identified the incidence and risk factors for PJK after primary surgery. However, ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000003202
更新日期:2020-01-01 00:00:00
abstract:STUDY DESIGN:A study of the histologic changes of the intervertebral discs (IVDs) in biglycan (Bgn)-deficient mice. OBJECTIVE:In this study, we investigate whether the absence of Bgn accelerates the degenerative process in mouse intervertebral disc (IVD). SUMMARY OF BACKGROUND DATA:Proteoglycans and collagen fibrils ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0b013e3181b7c7ec
更新日期:2009-12-01 00:00:00
abstract:STUDY DESIGN:Retrospective cohort study. OBJECTIVE:The aims of this study were to (1) compare patient and procedure-specific characteristics among those who had short versus long hospital stays and (2) identify independent risk factors that may correlate with extended length of hospital stay (LOS) in patients with ado...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000002919
更新日期:2019-05-15 00:00:00
abstract:STUDY DESIGN:Fabrication and characterization of a regenerative intervertebral disc (IVD) cartilaginous endplate (CEP) based on tissue culturing on biomimetic scaffolds. OBJECTIVE:To fabricate a regenerative CEP to support nutrients and metabolites exchange between IVD and the milieu interior. SUMMARY OF BACKGROUND D...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/BRS.0000000000001791
更新日期:2017-03-01 00:00:00
abstract:STUDY DESIGN:Open design cross-sectional questionnaire. OBJECTIVES:The aims of this study are to determine the frequency of low back pains in the younger population and the factors that have an influence on this frequency. SUMMARY OF BACKGROUND DATA:Low back pain is one of the most important social problems that caus...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/01.brs.0000131432.72531.96
更新日期:2004-07-15 00:00:00
abstract:STUDY DESIGN:A review of 60 surgical cases for correction of scoliosis, during which neuromotor evoked potentials and somatosensory evoked potentials were monitored. OBJECTIVES:To determine the validity and reliability of intraoperative neuromotor evoked potential monitoring in cases of scoliosis, where damage to the ...
journal_title:Spine
pub_type: 杂志文章
doi:10.1097/00007632-199910010-00012
更新日期:1999-10-01 00:00:00