Complications after 90Y microsphere radioembolization for unresectable hepatic tumors: An evaluation of 112 patients.

Abstract:

PURPOSE:The aim of this study was to estimate the incidence of complications after (90)Y microsphere radioembolization for unresectable hepatic tumors and evaluate risk factors for late complications. METHODS AND MATERIALS:A cohort of 112 consecutive patients from two institutions underwent (90)Y microsphere radioembolization for unresectable hepatic tumors. Complications were graded according to the Common Terminology Criteria for Adverse Events, version 3.0. Symptoms secondary to postradioembolization syndrome occurring within 30 days were recorded as early complications, and all other complications were considered late complications. RESULTS:Seventy-eight patients (70%) experienced postradioembolization syndrome, including fatigue, abdominal pain, nausea, vomiting, anorexia, or fever. Three patients (3%) experienced a Grade 3 early complication; no Grade 4 or 5 early toxicity occurred. Two patients (2%) experienced clinically significant liver dysfunction; 13 patients (12%), 27 patients (24%), and 9 patients (8%) had an elevation of bilirubin, aspartate aminotransferase, and alanine aminotransferase, respectively. Eleven patients (10%) experienced gastrointestinal ulceration, including two Grade 3 complications and one Grade 4 complication. Cholecystitis occurred in 7 patients (6%), including two Grade 3 complications. Grade 2 pancreatitis occurred in 1 patient (1%). No radiation pneumonitis was observed. The cumulative incidence of late Grade 3 or 4 complications at 12 months after radioembolization was 8%. No Grade 5 toxicity occurred. CONCLUSIONS:(90)Y microsphere radioembolization is a well-tolerated treatment for unresectable hepatic tumors with a low risk of Grade 3 or higher early or late toxicity.

journal_name

Brachytherapy

journal_title

Brachytherapy

authors

Peterson JL,Vallow LA,Johnson DW,Heckman MG,Diehl NN,Smith AA,Tzou KS,Paz-Fumagalli R,Kim S,Ko SJ,Daugherty LC,Kim GP,Brown N,Mori KW,Buskirk SJ

doi

10.1016/j.brachy.2013.05.008

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

573-9

issue

6

eissn

1538-4721

issn

1873-1449

pii

S1538-4721(13)00296-1

journal_volume

12

pub_type

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