Abstract:
BACKGROUND:Oral treatment in women with breast cancer has been increasingly used. However, a potentially negative side of oral medication is poor patient adherence and/or discontinuation, which reduces the treatment effectiveness, accelerating progression of the disease and reducing the patient survival rate. AIM OF THE REVIEW:To compare the rates of adherence and/or discontinuation and the methodologies used to assess these outcomes. It was conducted an integrative review of original articles published from 2000 to 2012, in which their primary outcome was to quantify medication adherence and/or discontinuation of oral hormonal therapy in patients with hormone receptor positive breast cancer. METHODS:Original studies were searched in the PubMed/MEDLINE, Scopus, Embase and SciELO databases. The Medical Subject Heading was used to define descriptors. The descriptor "breast neoplasms" was used in all combinations. Each of the descriptors "medication adherence" and "patient compliance" were combined with each of the following descriptors "tamoxifen", "aromatase inhibitors", "selective estrogen receptor modulators", or the terms "letrozole", "anastrozole", and "exemestane". RESULTS:Twenty-four original articles were included. Our study showed a wide range of adherence and discontinuation rates, ranging from 45-95.7 and 12-73 %, respectively. Regarding the methodological development of the selected articles, a high prevalence (87.5 %) of prospective and/or retrospective longitudinal studies was found. In addition, there was a high prevalence of studies using a database (70.8 %). Among some of the studies, it was shown that patient adherence to hormonal therapy gradually reduces, while discontinuation increases during the treatment. CONCLUSIONS:It was observed a great diversity among rates of adherence and/or discontinuation of hormonal therapy for breast cancer, which may be due to a lack of methodology standardization. Therefore, adequate and validated methods to ensure reliability of the results and allow comparison in the literature are needed. Furthermore, adherence decreases and discontinuation increases over time, suggesting the need for patient continuous education and a pharmacotherapeutic follow up by health professionals to improve these clinical outcomes.
journal_name
Int J Clin Pharmjournal_title
International journal of clinical pharmacyauthors
Ayres LR,Baldoni Ade O,Borges AP,Pereira LRdoi
10.1007/s11096-013-9833-5subject
Has Abstractpub_date
2014-02-01 00:00:00pages
45-54issue
1eissn
2210-7703issn
2210-7711journal_volume
36pub_type
杂志文章,meta分析,评审abstract:BACKGROUND:Older patients, due to polypharmacy, co-morbidities and often multiple prescribing doctors are particularly susceptible to medication history errors, leading to adverse drug events, patient harm and increased costs. Medication reconciliation at the point of admission to hospital can reduce medication discrep...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1007/s11096-016-0254-0
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:There has been little research which specifically examines medicine use among South Asian (SA) and Middle Eastern (ME) groups, although evidence suggests that medicine-related needs may be poorly met for these groups. OBJECTIVE:To describe medicine-related problems (MRPs) experienced by SA and ME patients f...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0103-6
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abstract::Medications are perceived as health risk factors, because they might cause damage if used improperly. In this context, an adequate assessment of medication use history should be encouraged, especially in transitions of care to avoid unintended medication discrepancies (UMDs). In a case-controlled study, we investigate...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,评审
doi:10.1007/s11096-017-0519-2
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abstract::It is well known that patient adherence to appropriately prescribed medications is essential for treatment efficacy and positive therapeutic outcomes. It is also understood that patients who are prescribed medications do not necessarily take them as prescribed. Indeed, variation in patients' medication-taking is an ag...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-013-9856-y
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abstract::Background The direct oral anticoagulants (DOACs) offer several advantages over warfarin in the management atrial fibrillation, including the provision of fixed dosing without a requirement for regular monitoring. Recently however the subject of DOAC monitoring has been probed after several post-hoc analyses demonstra...
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abstract::Background Gram negative pathogens are increasingly resistant to commonly used first line antibiotics and colistin is in most cases the only medicine available. There is very limited information available comparing the effectiveness and costs of low versus high dose colistin with studies showing efficacy with both dos...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0713-x
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abstract::Background Patients' potential misconceptions and concerns about using opioids are among the primary causes of patient-related barriers that may lead to failure in pain management. These barriers can be eliminated through educational interventions, thus achieving better pain management. Objective The aim of this study...
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abstract:BACKGROUND:No overview of preventive health activities conducted by pharmacists in South Germany has been available until now. Moreover, little about the needs of the public is known with regard to pharmacy-based preventive services. OBJECTIVES:To gain an overview of the preventive health services and campaigns carrie...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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abstract:BACKGROUND:Medication discrepancies may occur at transitions in care and negatively impact patient outcomes. OBJECTIVE:To determine if involving clinical pharmacists in hospital care, medication reconciliation and discharge medication plan communication can reduce medication discrepancies with a prospective, randomize...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
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abstract::Background The efficacy and safety of direct oral anticoagulants is well established in patients with atrial fibrillation. However, data on their use in the oldest old patients (≥ 85 years), who have the highest risk of bleeding, is scarce. Objective The aim of this study was to evaluate the safety of direct oral anti...
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,评审
doi:10.1007/s11096-011-9522-1
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0127-y
更新日期:2015-10-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-015-0085-4
更新日期:2015-06-01 00:00:00
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journal_title:International journal of clinical pharmacy
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更新日期:2012-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
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abstract:BACKGROUND:Replacement therapy in haemophilia plays an important role in the effective management of this rare bleeding disorder and requires a high level of knowledge and practical skills. OBJECTIVE:To evaluate and to compare the knowledge and skills about the medicines and their management among people with haemophi...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,多中心研究
doi:10.1007/s11096-015-0207-z
更新日期:2016-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
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pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
abstract::Background Taking regular medication has been shown to have an impact on the daily lives of patients and their families. Objective To explore the medication-related experiences of patients and their families when a child or young person is prescribed regular medication. Setting A specialist U.K. paediatric hospital. M...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-018-0756-z
更新日期:2019-02-01 00:00:00
abstract::Background There are two fundamental approaches to clinical reasoning, intuitive and analytical. These approaches have yet to be well explored to describe how pharmacists make decisions to determine medication appropriateness. Objective (1) to identify the cognitive actions (i.e., operators) that pharmacists employ wh...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-019-00906-3
更新日期:2019-12-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-012-9708-1
更新日期:2013-02-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-019-00800-y
更新日期:2019-04-01 00:00:00
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journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-017-0561-0
更新日期:2018-02-01 00:00:00
abstract::Background Chronic pain is a prevalent and debilitating condition for many people. Globally it is the greatest contributor to years lived with disability. Management often includes pharmacotherapy and pharmacists are therefore well placed to contribute to chronic pain management. Objective To explore chronic pain mana...
journal_title:International journal of clinical pharmacy
pub_type: 杂志文章
doi:10.1007/s11096-020-01198-8
更新日期:2020-11-27 00:00:00