Abstract:
IMPORTANCE:Antihypertensive agents are the most commonly prescribed class of medications in the United States. Evidence regarding the relationship between different types of antihypertensives and breast cancer risk is sparse and inconsistent, and prior studies have lacked the capacity to assess impacts of long-term use. OBJECTIVE:To evaluate associations between use of various classes of antihypertensive medications and risks of invasive ductal and invasive lobular breast cancers among postmenopausal women. DESIGN, SETTING, AND PARTICIPANTS:Population-based case-control study in the 3-county Seattle-Puget Sound metropolitan area. Participants were women aged 55 to 74 years, 880 of them with invasive ductal breast cancer, 1027 with invasive lobular breast cancer, and 856 with no cancer serving as controls. EXPOSURES:Recency and duration of use of antihypertensive medications. MAIN OUTCOMES AND MEASURES:Risks of invasive ductal and invasive lobular breast cancers. RESULTS:Current use of calcium-channel blockers for 10 or more years was associated with higher risks of ductal breast cancer (odds ratio [OR], 2.4; 95% CI, 1.2-4.9) (P= .04 for trend) and lobular breast cancer (OR, 2.6; 95% CI, 1.3-5.3) (P= .01 for trend). This relationship did not vary appreciably by type of calcium-channel blocker used (short-acting vs long-acting, dihydropyridines vs non-dihydropyridines). In contrast, use of diuretics, β-blockers, and angiotensin II antagonists were not associated with risk. CONCLUSIONS AND RELEVANCE:While some studies have suggested a positive association between calcium-channel blocker use and breast cancer risk, this is the first study to observe that long-term current use of calcium-channel blockers in particular are associated with breast cancer risk. Additional research is needed to confirm this finding and to evaluate potential underlying biological mechanisms.
journal_name
JAMA Intern Medjournal_title
JAMA internal medicineauthors
Li CI,Daling JR,Tang MT,Haugen KL,Porter PL,Malone KEdoi
10.1001/jamainternmed.2013.9071subject
Has Abstractpub_date
2013-09-23 00:00:00pages
1629-37issue
17eissn
2168-6106issn
2168-6114pii
1723871journal_volume
173pub_type
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abstract:Importance:Elevated incidence rates of thyroid cancer among World Trade Center (WTC)-exposed individuals may be associated with the identification of asymptomatic cancers during medical surveillance. Objective:To examine the association between WTC exposure and thyroid cancer among Fire Department of the City of New Y...
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doi:10.1001/jamainternmed.2013.8738
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pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2015-04-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2014-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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更新日期:2015-05-01 00:00:00
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更新日期:2021-01-01 00:00:00
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更新日期:2018-07-01 00:00:00
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更新日期:2016-05-01 00:00:00
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更新日期:2017-03-01 00:00:00