Abstract：
:Based on molecularly imprinted photonic hydrogels (MIPHs) that combined the colloidal-crystal with molecular imprinting technique, a novel label-free colorimetric chemosensor for convenient and fast efficient detection of atropine with high sensitivity and specificity was developed. Due to the special inverse opal arrays with a thin polymer wall in which the imprinted nanocavities of atropine moleculars distributed, the proposed MIPHs designed as water-compatible exhibited high sensitive (as low as 1 pg/mL), rapid responsive (less than 30 s) and specific detection of atropine in complex matrix. The unique three-dimensional, highly-ordered photonic hydrogels would be obviously swelling in response to the specific atropine molecular recognition process and the response would be directly transferred into visually perceptible optical signal (change in color) that could be detected by the naked eye through Bragg diffractive shifts of ordered macroporous arrays. With a broad concentration range varying from 1 pg/mL to 1 μg/mL of atropine, the distinct color changes of MIPHs almost covered the whole visible-light wavelength range from blue to red for semi-quantitative analysis. The smart chemosensor was successfully employed to determine the trace level atropine in human urine samples, providing a fast and effective alternative for semi-quantitative detection of atropine for clinical analysis and forensic investigations.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Meng L,Meng P,Tang B,Zhang Q,Wang Ydoi
10.1016/j.forsciint.2013.04.008subject
Has Abstractpub_date
2013-09-10 00:00:00pages
6-12issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(13)00229-6journal_volume
231pub_type
杂志文章abstract：:Since it is established that human chorionic gonadotropin (hCG) affects testosterone production and release in the human body, the use of this hormone as a performance enhancing drug has been prohibited by the World Anti-Doping Agency. Nowadays, the only validated biomarker of a hCG doping is its direct quantification...
journal_title：Forensic science international
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pub_type： 杂志文章
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2017.12.002
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journal_title：Forensic science international
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pub_type： 杂志文章,多中心研究
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.05.020
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pub_type： 杂志文章,评审
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journal_title：Forensic science international
pub_type： 杂志文章
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.03.014
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2018.09.030
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pub_type： 杂志文章
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更新日期：2012-06-10 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(98)00102-9
更新日期：1998-08-12 00:00:00
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journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.01.034
更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.forsciint.2005.01.001
更新日期：2006-01-27 00:00:00
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更新日期：2000-01-10 00:00:00
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journal_title：Forensic science international
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doi：10.1016/j.forsciint.2004.09.077
更新日期：2005-01-29 00:00:00
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更新日期：2016-07-01 00:00:00
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更新日期：1998-11-09 00:00:00
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