Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery.

abstract：:The levels of alpha 1-proteinase inhibitor (alpha 1-antitrypsin) in keratoconus, normal human, and other diseased corneas were examined. Using an immunoperoxidase technique, the presence of this inhibitor was demonstrated in the epithelium, stroma and endothelium of all corneal sections. Compared with normal human con...

journal_title：Experimental eye research

authors： Sawaguchi S,Twining SS,Yue BY,Wilson PM,Sugar J,Chan SK

更新日期：1990-05-01 00:00:00

abstract：:Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Although intravitreal injection of anti-VEGF antibodies and VEGF Trap have significant clinical benefits, the complications of intravitreal injection, drug resistance and patient compliance still need to be concerned. In th...

journal_title：Experimental eye research

authors： Wei X,Zhang T,Yao Y,Zeng S,Li M,Xiang H,Zhao C,Cao G,Li M,Wan R,Yang P,Yang J

更新日期：2018-03-01 00:00:00

abstract：:We investigated the pharmacological actions of hydrogen sulfide (H(2)S) using sodium hydrosulfide (NaHS) and sodium sulfide (Na(2)S) as donors on isolated porcine irides in the presence of tone induced by muscarinic receptor stimulation. Furthermore, we also investigated the mechanism of action of H(2)S in this smooth...

journal_title：Experimental eye research

authors： Monjok EM,Kulkarni KH,Kouamou G,McKoy M,Opere CA,Bongmba ON,Njie YF,Ohia SE

更新日期：2008-12-01 00:00:00

abstract：:The purpose of this study was to evaluate the composition of ghost vessels and the newly identified intravitreal structures type 1 and 2 (IVS-1 and 2) observed in the rabbit vitreous body. Rabbit eyes (n = 10, 0.5- approximately 36 months of age) were fixed and embedded in plastic. Post-embedding immuno transmission e...

journal_title：Experimental eye research

authors： Los LI,van Luyn MJ,Eggli PS,Dijk F,Nieuwenhuis P

更新日期：2000-08-01 00:00:00

abstract：:Fatty Liver Shionogi (FLS) mice have been shown to develop a hereditary disorder characterized by localized retinochoroidal defects of the ventral fundus very similar to human typical ocular coloboma without microphthalmia. The objective of this study was to determine when and how the failure of the optic fissure clos...

journal_title：Experimental eye research

authors： Tsuji N,Kita K,Ozaki K,Narama I,Matsuura T

更新日期：2012-01-01 00:00:00

abstract：:SV40 human corneal epithelial cell (HCEC) populations are readily used as a substitute for primary corneal epithelial cells that are difficult to maintain in vitro. To initiate cell-cycle experiments with the SV40-HCEC cells, two separate methods of cell synchronization were compared including serum starvation and ste...

journal_title：Experimental eye research

authors： Liliensiek SJ,Schell K,Howard E,Nealey P,Murphy CJ

更新日期：2006-07-01 00:00:00

abstract：:The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microa...

journal_title：Experimental eye research

authors： Stowell C,Burgoyne CF,Tamm ER,Ethier CR,Lasker\/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

更新日期：2017-04-01 00:00:00

abstract：:The trabecular meshwork is considered a smooth muscle like tissue contributing to aqueous outflow regulation and thus to regulation of intraocular pressure. An elevation in intraocular pressure is one of the greatest risk factors for most forms of glaucoma. We assume that contraction of trabecular meshwork reduces aqu...

journal_title：Experimental eye research

authors： Rosenthal R,Choritz L,Schlott S,Bechrakis NE,Jaroszewski J,Wiederholt M,Thieme H

更新日期：2005-06-01 00:00:00

abstract：:The autonomic innervation in the anterior chamber (AC) structures might play an efferent role in neural intraocular pressure (IOP) regulation, the center of which is thought to be located in the hypothalamus. In this study, we identified the efferent pathway from the hypothalamus to the autonomic innervation in the AC...

journal_title：Experimental eye research

authors： Yang F,Zhu X,Liu X,Ma L,Zhang Z,Pei L,Wang H,Xu F,Liu H

更新日期：2021-01-01 00:00:00

abstract：:Analysis of bovine interphotoreceptor matrix and conditioned medium from human Y-79 retinoblastoma cells by gelatin SDS-PAGE zymography reveals abundant activity of a 72-kDa M(r) gelatinase. The 72-kDa gelatinase from either source is inhibited by EDTA but not aprotinin or NEM, indicating that it is a metalloproteinas...

journal_title：Experimental eye research

authors： Jones BE,Moshyedi P,Gallo S,Tombran-Tink J,Arand G,Reid DA,Thompson EW,Chader GJ,Waldbillig RJ

更新日期：1994-09-01 00:00:00

abstract：:Epithelial cells in explants from rat lenses differentiate into fibre cells when cultured with retina conditioned medium (RCM). This differentiation is characterised by cell elongation, the accumulation of alpha-crystallin and the onset of synthesis of the fibre specific beta- and gamma-crystallins. To determine the e...

journal_title：Experimental eye research

authors： Richardson NA,McAvoy JW

更新日期：1988-02-01 00:00:00

abstract：:Utilizing cultured lenses from normal and homozygous glutathione peroxidase (GSHPx-1) knockout mice and inhibitors for GSSG Reductase (GSSG Red), 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and catalase (Cat), 3-aminotriazole (3-AT), the ability to degrade H2O2 was examined at two H2O2 concentrations, 300 microM and 80...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Yang Y,Ho YS

更新日期：1997-03-01 00:00:00

abstract：:Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways involved in their effects are currently unknown. To understand the role o...

journal_title：Experimental eye research

authors： Rangasamy S,Monickaraj F,Legendre C,Cabrera AP,Llaci L,Bilagody C,McGuire P,Das A

更新日期：2020-06-01 00:00:00

abstract：:In order to study acute retinal toxicity of intravitreal triamcinolone acetonide (TA) at high doses in an animal model, thirty New Zealand albino rabbits were injected with intravitreal TA. The animals were divided in five groups: Group 1 received an intravitreal injection of 0.1 mL balanced salt solution; Group 2, 0....

journal_title：Experimental eye research

authors： Ruiz-Moreno JM,Montero JA,Bayon A,Rueda J,Vidal M

更新日期：2007-02-01 00:00:00

abstract：:Conjunctival impression cytology samples from patients with meibomian gland dysfunction (MGD), dry eye (DE), and healthy subjects (CT) were collected for determination of the degree of squamous metaplasia (SM) by PAS-hematoxylin staining and for comparative proteomic analyses by 2D-DIGE. The protein spots with discrim...

journal_title：Experimental eye research

authors： Soria J,Acera A,Durán JA,Boto-de-Los-Bueis A,Del-Hierro-Zarzuelo A,González N,Reigada R,Suárez T

更新日期：2018-02-01 00:00:00

abstract：:Retinoblastoma (RB) is a common malignant intraocular tumor primarily affecting children. Multidrug resistance (MDR) proteins (P-gp and MRPs) mediated chemoresistance have been considered as a major cause of treatment failure in treatment of RB. Ocular cells have shown good tolerability against moxifloxacin (MFX). Hen...

journal_title：Experimental eye research

authors： Barot M,Gokulgandhi MR,Pal D,Mitra AK

更新日期：2014-01-01 00:00:00

abstract：:A prior study found that inhibition of nitric oxide synthase with L-NAME causes a large, rapid decrease in IOP in anesthetized rabbits. In this follow-up study we sought to determine if this hypotensive effect was due to decreased aqueous production, possibly caused by ciliary vasoconstriction. Two protocols were perf...

journal_title：Experimental eye research

authors： Kiel JW,Reitsamer HA,Walker JS,Kiel FW

更新日期：2001-09-01 00:00:00

abstract：:The results reported here clearly document changes in the properties and the organization of fiber-cell membrane lipids that occur with age, based on electron paramagnetic resonance (EPR) analysis of lens membranes of clear lenses from donors of age groups from 0 to 20, 21 to 40, and 61 to 80 years. The physical prope...

journal_title：Experimental eye research

authors： Raguz M,Mainali L,O'Brien WJ,Subczynski WK

更新日期：2015-03-01 00:00:00

abstract：:A simple culture method that was recently developed in our laboratory was applied to the chick iris tissues to characterize neural stem/progenitor-like cells. Iris tissue is a non-neuronal tissue and does not contain any neuronal cells. In the present study we isolated iris tissues from chick embryos just prior to hat...

journal_title：Experimental eye research

authors： Matsushita T,Fujihara A,Royall L,Kagiwada S,Kosaka M,Araki M

更新日期：2014-06-01 00:00:00

abstract：:This study tests the hypothesis that choroidal myogenic autoregulation participates in the intraocular pressure (IOP) response to mean arterial pressure (MAP) by minimizing arterial-pressure-dependent changes in choroidal blood volume. To test this hypothesis, the IOP response to MAP was quantified before and after im...

journal_title：Experimental eye research

authors： Kiel JW

更新日期：1994-05-01 00:00:00

abstract：:Cataract is a multifactorial disease, and a large variety of stressors induce cataracts. Many cataractogenic stressors and endoplasmic reticulum (ER) stressors induce the unfolded protein response (UPR) in various cell types. The UPR is known to produce reactive oxygen species (ROS) prior to the inducement of apoptosi...

journal_title：Experimental eye research

authors： Ikesugi K,Yamamoto R,Mulhern ML,Shinohara T

更新日期：2006-09-01 00:00:00

abstract：:Familial exudative vitreoretinopathy (FEVR) is a disease exhibits a wide range of clinical signs, ranging mild peripheral retinal vascular anomalies to severe retinal detachments. Individuals with mild FEVR are frequently asymptomatic with good visual function and are often undiagnosed. However, little is known about ...

journal_title：Experimental eye research

authors： Chen C,Sun L,Li S,Huang L,Zhang T,Wang Z,Yu B,Ding X

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Absence of collagen VII causes blistering of the skin, eyes and many other tissues. This disease is termed dystrophic epidermolysis bullosa (DEB). Corneal fibrosis occurs in up to 41% and vision loss in up to 64% of patients. Standard treatments are supportive and there is no cure. The hypomorphic mouse mode...

journal_title：Experimental eye research

authors： Chen VM,Shelke R,Nyström A,Laver N,Sampson JF,Zhiyi C,Bhat N,Panjwani N

更新日期：2018-10-01 00:00:00

abstract：:We sequenced selected peptides of alligator rhodopsin that accounted for about half of the total protein. These sequences were confirmed when the total primary structure of alligator rhodopsin was deduced from the cDNA sequence. Differences in the amino-terminal region, compared to that of bovine rhodopsin, account fo...

journal_title：Experimental eye research

authors： Smith WC,Adamus G,Van Der Wel H,Timmers A,Palczewski K,Ulshafer RJ,Hargrave PA,McDowell JH

更新日期：1995-11-01 00:00:00

abstract：:The retinal ganglion cell (RGC)-like RGC-5 line can be differentiated with staurosporine to stop dividing, extend neurites, and increase levels of several ganglion cell markers. This allows study of regulation of neurite development on a single cell basis. However, it is unclear whether the neurites induced by differe...

journal_title：Experimental eye research

authors： Lieven CJ,Millet LE,Hoegger MJ,Levin LA

更新日期：2007-11-01 00:00:00

abstract：:This study sought to pharmacologically characterize bradykinin receptors on SV40-immortalized human trabecular meshwork (HTM3) cells. Phosphoinositide (PI) turnover studies were conducted using [3H]myo-inositol-labeled HTM3 cells and anion exchange chromatography to quantify [3H]inositol phosphates generated in respon...

journal_title：Experimental eye research

authors： Sharif NA,Xu SX

更新日期：1996-12-01 00:00:00

abstract：:A lesion in cGMP metabolism has been hypothesized to cause retinal degeneration in rd mice. Available cloned cDNAs coding for proteins involved in the cGMP cascade have been used to compare the corresponding retinal RNAs in the degenerative (rd/rd) mouse at 8-11 days with those in the 8-11-day-old morphologically norm...

journal_title：Experimental eye research

authors： Bowes C,Farber DB

更新日期：1987-10-01 00:00:00

abstract：:The R49C mutation of alphaA-crystallin (alphaA-R49C) causes hereditary cataracts in humans; patients in a four-generation Caucasian family were found be heterozygous for this autosomal dominant mutation. We previously generated knock-in mouse models of this mutation and found that by 2 months of age, heterozygous muta...

journal_title：Experimental eye research

authors： Andley UP,Reilly MA

更新日期：2010-06-01 00:00:00

abstract：:To assess the ability of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to detect blood retinal barrier (BRB) damage in patients with diabetic macular edema (DME). DCE-MRI with 0.1 mmol Gd-DTPA was used to measure BRB permeability in 10 healthy and visually normal subjects and eight patients with DME, ...

journal_title：Experimental eye research

authors： Trick GL,Liggett J,Levy J,Adamsons I,Edwards P,Desai U,Tofts PS,Berkowitz BA

更新日期：2005-07-01 00:00:00

abstract：:Crystallin-bound non-tryptophan fluorescence and protein cross-linking were studied in chronic galactosemia. Fluorescence (excitation/emission--370/440 nm) was significantly higher in galactosemic rats compared to controls (P less than 0.001). Accumulation of fluorescence was significantly reduced both in water solubl...

journal_title：Experimental eye research

authors： Nagaraj RH,Monnier VM

更新日期：1990-10-01 00:00:00