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Clinical pregnancy after uterus transplantation.

Abstract：

OBJECTIVE:To present the first clinical pregnancy after uterus transplantation. DESIGN:Case study. SETTING:Tertiary center. PATIENT(S):A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation. INTERVENTION(S):Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos. MAIN OUTCOME MEASURE(S):Implantation of embryo in an allografted human uterus. RESULT(S):The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization. CONCLUSION(S):We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Erman Akar M,Ozkan O,Aydinuraz B,Dirican K,Cincik M,Mendilcioglu I,Simsek M,Gunseren F,Kocak H,Ciftcioglu A,Gecici O,Ozkan O

doi

10.1016/j.fertnstert.2013.06.027

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1358-63

issue

5

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(13)00727-9

journal_volume

100

pub_type

杂志文章

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