Arabidopsis plants perform arithmetic division to prevent starvation at night.

abstract：:Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibits in vitro the growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western micr...

journal_title：eLife

authors： Di Rienzi SC,Jacobson J,Kennedy EA,Bell ME,Shi Q,Waters JL,Lawrence P,Brenna JT,Britton RA,Walter J,Ley RE

更新日期：2018-03-27 00:00:00

abstract：:Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...

journal_title：eLife

authors： Dijkstra N,Mostert P,Lange FP,Bosch S,van Gerven MA

更新日期：2018-05-29 00:00:00

abstract：:To restore vision for the blind, several prosthetic approaches have been explored that convey raw images to the brain. So far, these schemes all suffer from a lack of bandwidth. An alternate approach would restore vision at the cognitive level, bypassing the need to convey sensory data. A wearable computer captures vi...

journal_title：eLife

authors： Liu Y,Stiles NR,Meister M

更新日期：2018-11-27 00:00:00

abstract：:The roles of long non-coding RNAs (lncRNAs) in regulating cancer and stem cells are being increasingly appreciated. Its diverse mechanisms provide the regulatory network with a bigger repertoire to increase complexity. Here we report a novel LncRNA, Lnc34a, that is enriched in colon cancer stem cells (CCSCs) and initi...

journal_title：eLife

authors： Wang L,Bu P,Ai Y,Srinivasan T,Chen HJ,Xiang K,Lipkin SM,Shen X

更新日期：2016-04-14 00:00:00

abstract：:Using a common analysis pipeline to compare data from three major lineages of complex eukaryotes reveals that transcription seems to evolve at a common rate. ...

journal_title：eLife

authors： Odom DT

更新日期：2016-02-11 00:00:00

abstract：:We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR directly interacts with CHK2 and ionizing radiation (IR) increases this int...

journal_title：eLife

authors： Ta HQ,Dworak N,Ivey ML,Roller DG,Gioeli D

更新日期：2020-06-24 00:00:00

abstract：:Minor and major spliceosomes control splicing of distinct intron types and are thought to act largely independent of one another. SR proteins are essential splicing regulators mostly connected to the major spliceosome. Here, we show that Srsf10 expression is controlled through an autoregulated minor intron, tightly co...

journal_title：eLife

authors： Meinke S,Goldammer G,Weber AI,Tarabykin V,Neumann A,Preussner M,Heyd F

更新日期：2020-04-27 00:00:00

abstract：:We present the development and in vivo application of a feedback-based tracking microscope to follow individual mitochondria in sensory neurons of zebrafish larvae with nanometer precision and millisecond temporal resolution. By combining various technical improvements, we tracked individual mitochondria with unpreced...

journal_title：eLife

authors： Wehnekamp F,Plucińska G,Thong R,Misgeld T,Lamb DC

更新日期：2019-06-10 00:00:00

abstract：:Centering and decentering of cellular components is essential for internal organization of cells and their ability to perform basic cellular functions such as division and motility. How cells achieve proper localization of their organelles is still not well-understood, especially in large cells such as oocytes. Here, ...

journal_title：eLife

authors： Ierushalmi N,Malik-Garbi M,Manhart A,Abu Shah E,Goode BL,Mogilner A,Keren K

更新日期：2020-04-21 00:00:00

abstract：:Whether neurons encode information through their spike rates, their activity times or both is an ongoing debate in systems neuroscience. Here, we tested whether humans can discriminate between a pair of temporal odor mixtures (TOMs) composed of the same two components delivered in rapid succession in either one tempor...

journal_title：eLife

authors： Perl O,Nahum N,Belelovsky K,Haddad R

更新日期：2020-02-07 00:00:00

abstract：:Being exposed to cannabinoids in the womb has different consequences for male and female rats. ...

journal_title：eLife

authors： Musardo S,Bellone C

更新日期：2018-09-28 00:00:00

abstract：:Engaging with vocal sounds is critical for children's social-emotional learning, and children with autism spectrum disorder (ASD) often 'tune out' voices in their environment. Little is known regarding the neurobiological basis of voice processing and its link to social impairments in ASD. Here, we perform the first c...

journal_title：eLife

authors： Abrams DA,Padmanabhan A,Chen T,Odriozola P,Baker AE,Kochalka J,Phillips JM,Menon V

更新日期：2019-02-26 00:00:00

abstract：:It is now clear that microglia and macrophages are present in brain tumors, but whether or how they affect initiation and development of tumors is not known. Exploiting the advantages of the zebrafish (Danio rerio) model, we showed that macrophages and microglia respond immediately upon oncogene activation in the brai...

journal_title：eLife

authors： Chia K,Mazzolini J,Mione M,Sieger D

更新日期：2018-02-21 00:00:00

abstract：:Neural computations underlying cognitive functions require calibration of the strength of excitatory and inhibitory synaptic connections and are associated with modulation of gamma frequency oscillations in network activity. However, principles relating gamma oscillations, synaptic strength and circuit computations ar...

journal_title：eLife

authors： Solanka L,van Rossum MC,Nolan MF

更新日期：2015-07-06 00:00:00

abstract：:Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR) pathways. Like mice lacking primary UPR components, hepatic Lrh-1-null m...

journal_title：eLife

authors： Mamrosh JL,Lee JM,Wagner M,Stambrook PJ,Whitby RJ,Sifers RN,Wu SP,Tsai MJ,Demayo FJ,Moore DD

更新日期：2014-04-15 00:00:00

abstract：:How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type Caenorhabditis elegans zygotes, symmetry breaking during anterior-posterior axis specification is guided by centrosomes, resulting in anterior-directed cortical flows and a single posterior PAR-2 domain. We unco...

journal_title：eLife

authors： Klinkert K,Levernier N,Gross P,Gentili C,von Tobel L,Pierron M,Busso C,Herrman S,Grill SW,Kruse K,Gönczy P

更新日期：2019-02-26 00:00:00

abstract：:Variation in the presence or absence of transposable elements (TEs) is a major source of genetic variation between individuals. Here, we identified 23,095 TE presence/absence variants between 216 Arabidopsis accessions. Most TE variants were rare, and we find these rare variants associated with local extremes of gene ...

journal_title：eLife

authors： Stuart T,Eichten SR,Cahn J,Karpievitch YV,Borevitz JO,Lister R

更新日期：2016-12-02 00:00:00

abstract：:Mapping polyclonal serum responses is critical to rational vaccine design. However, most high-resolution mapping approaches involve isolating and characterizing individual antibodies, which incompletely defines the polyclonal response. Here we use two complementary approaches to directly map the specificities of the n...

journal_title：eLife

authors： Dingens AS,Pratap P,Malone KD,Hilton SK,Ketas T,Cottrell CA,Overbaugh JM,Moore JP,Klasse PJ,Ward AB,Bloom JD

更新日期：2021-01-13 00:00:00

abstract：:Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment and action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells, is well ...

journal_title：eLife

authors： Cornford JH,Mercier MS,Leite M,Magloire V,Häusser M,Kullmann DM

更新日期：2019-10-28 00:00:00

abstract：:The germ line provides the cellular link between generations of multicellular organisms, its cells entering the meiotic cell cycle only once each generation. However, the mechanisms governing this initiation of meiosis remain poorly understood. Here, we examined cells undergoing meiotic initiation in mice, and we foun...

journal_title：eLife

authors： Kojima ML,de Rooij DG,Page DC

更新日期：2019-02-27 00:00:00

abstract：:Non-segmented negative-strand RNA viruses, such as measles, ebola and Newcastle disease viruses (NDV), encapsidate viral genomic RNAs into helical nucleocapsids, which serve as the template for viral replication and transcription. Here, the clam-shaped nucleocapsid structure, where the NDV viral genome is sequestered,...

journal_title：eLife

authors： Song X,Shan H,Zhu Y,Hu S,Xue L,Chen Y,Ding W,Niu T,Gu J,Ouyang S,Shen QT,Liu ZJ

更新日期：2019-07-10 00:00:00

abstract：:The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the α subunit of AP2 in the nematode Caenorhabditis elegans. α-adaptin mutants are viable and the remaining μ2/β hemicomplex retains some function. Conversely, in μ2 mutants, the alpha/sigma2 hemicomplex is loca...

journal_title：eLife

authors： Gu M,Liu Q,Watanabe S,Sun L,Hollopeter G,Grant BD,Jorgensen EM

更新日期：2013-03-05 00:00:00

abstract：:Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking. We show that explanted MZs generate tensile convergence forces up to 1....

journal_title：eLife

authors： Shook DR,Kasprowicz EM,Davidson LA,Keller R

更新日期：2018-03-13 00:00:00

abstract：:Mechanistic understanding of eukaryotic ribosome formation requires a detailed structural knowledge of the numerous assembly intermediates, generated along a complex pathway. Here, we present the structure of a late pre-40S particle at 3.6 Å resolution, revealing in molecular detail how assembly factors regulate the t...

journal_title：eLife

authors： Heuer A,Thomson E,Schmidt C,Berninghausen O,Becker T,Hurt E,Beckmann R

更新日期：2017-11-20 00:00:00

abstract：:In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial segment (AIS). Both position and length of the AIS vary across and within neuron types, with activity, development and pathology. What is the impact of AIS geometry on excitability? Direct empirical assessment has proven ...

journal_title：eLife

authors： Goethals S,Brette R

更新日期：2020-03-30 00:00:00

abstract：:hIAPP fibrils are associated with Type-II Diabetes, but the link of hIAPP structure to islet cell death remains elusive. Here we observe that hIAPP fibrils are cytotoxic to cultured pancreatic β-cells, leading us to determine the structure and cytotoxicity of protein segments composing the amyloid spine of hIAPP. Usin...

journal_title：eLife

authors： Krotee P,Rodriguez JA,Sawaya MR,Cascio D,Reyes FE,Shi D,Hattne J,Nannenga BL,Oskarsson ME,Philipp S,Griner S,Jiang L,Glabe CG,Westermark GT,Gonen T,Eisenberg DS

更新日期：2017-01-03 00:00:00

abstract：:The investigation of prosocial behavior is of particular interest from an evolutionary perspective. Comparisons of prosociality across non-human animal species have, however, so far largely focused on primates, and their interpretation is hampered by the diversity of paradigms and procedures used. Here, we present the...

journal_title：eLife

authors： Horn L,Bugnyar T,Griesser M,Hengl M,Izawa EI,Oortwijn T,Rössler C,Scheer C,Schiestl M,Suyama M,Taylor AH,Vanhooland LC,von Bayern AM,Zürcher Y,Massen JJ

更新日期：2020-10-20 00:00:00

abstract：:The vertebral column or spine assembles around the notochord rod which contains a core made of large vacuolated cells. Each vacuolated cell possesses a single fluid-filled vacuole, and loss or fragmentation of these vacuoles in zebrafish leads to spine kinking. Here, we identified a mutation in the kinase gene dstyk tha...

journal_title：eLife

authors： Bagwell J,Norman J,Ellis K,Peskin B,Hwang J,Ge X,Nguyen SV,McMenamin SK,Stainier DY,Bagnat M

更新日期：2020-01-29 00:00:00

abstract：:Synaptic adhesion molecules regulate synapse development and function. However, whether and how presynaptic adhesion molecules regulate postsynaptic NMDAR function remains largely unclear. Presynaptic LAR family receptor tyrosine phosphatases (LAR-RPTPs) regulate synapse development through mechanisms that include tra...

journal_title：eLife

authors： Kim K,Shin W,Kang M,Lee S,Kim D,Kang R,Jung Y,Cho Y,Yang E,Kim H,Bae YC,Kim E

更新日期：2020-03-06 00:00:00

abstract：:Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhanced plasticity. We used long-term photometric recordings in mice to stu...

journal_title：eLife

authors： Matias S,Lottem E,Dugué GP,Mainen ZF

更新日期：2017-03-21 00:00:00