Expression of T-cell Immunoglobulin- and Mucin-domain-containing Molecule-3 on Lymphocytes from Henoch-Schoenlein Purpura Patients.

Abstract:

OBJECTIVE:To investigate T-cell immunoglobulin domain and mucin domain-containing molecule-3 (Tim-3) and its ligand galectin-9 mRNA expression in peripheral blood mononuclear cells (PBMCs) from Henoch-Schoenlein Purpura (HSP) patients. METHODS:Quantitative real-time reverse transcription-polymerase chain reaction (PCR) was used to examine the mRNA expression of Tim-3 and its ligand galectin-9 in PBMCs from HSP patients. ELISA methods were used to examine the levels of serum IFN-γ and immunoglobulin A1 (IgA1). The Spearman rank test was used for correlation analysis between Tim-3, galectin-9 mRNA expression and serum IFN-γ and IgA1 levels, respectively. FINDINGS:The results showed that Tim-3 and galectin-9 mRNA expression was obviously higher in patients, which was closely correlated with serum IFN-γ and IgA1, respectively. CONCLUSION:The results suggested that Tim-3/Tim-3L may be related to the pathogenesis of HSP.

journal_name

Iran J Pediatr

authors

Yuan LP,Bo Y,Ling L,Bo H

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

345-8

issue

3

eissn

2008-2142

issn

2008-2150

journal_volume

23

pub_type

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