当前位置： SCI文献检索 > BRAIN & DEVELOPMENT期刊下所有文献 > Towards early diagnosis and treatment to save children from catastrophic epilepsy -- focus on epilepsy surgery.

Towards early diagnosis and treatment to save children from catastrophic epilepsy -- focus on epilepsy surgery.

Abstract：

OBJECTIVE:To analyze and to discuss whether by paying attention to the many recent advancements in the field of pediatric epilepsy surgery catastrophic childhood epilepsies caused by definitive or suspected structural lesions can be prevented more often these days in comparison to the past. METHODS:Based on data from the literature and supplemented by the authors own experience, risks for children suffering from structural focal epilepsies that the epilepsy becomes catastrophic and ways how such evolutions can possibly be prevented are discussed for the different lesion-types separately - in the order of their frequency as they are seen at pediatric epilepsy surgery centers. Special emphasis is put on data regarding attempts to prevent permanent severe mental retardations. RESULTS:There are common factors predisposing to catastrophic courses in all structural focal epilepsies, such as early onset and a longer duration of epilepsy (with respect to cognitive outcome not with respect to seizure outcome), but there are also differences. Moreover the better perspectives now in comparison to the past for children with conditions like MRI-negative focal epilepsies, subtle focal cortical dysplasias, epilepsies post hypoxic-ischemic events, tuberous sclerosis etc. are not well recognized yet. While there is agreement that "early" (and successful) surgery is essential in many instances to prevent permanent mental retardations there is insufficient data regarding the issue that "early surgery "might not be early enough under certain circumstances and there is also only little data regarding variables which would allow to keep calm when a child is presenting with early onset difficult to control seizures. One of the biggest changes seen over the last decade is the fact that children with very severe epilepsies, who have unilateral lesions, but "generalized" seizures and/or "generalized" EEGs, are not excluded anymore from considerations for epilepsy surgery. Even children with bilateral lesions can be surgical candidates. CONCLUSION:The gradually widening spectrum of indications for epilepsy surgery in children is resulting in an increasing number of preventions of catastrophic epilepsies. Insufficient data regarding timing of surgery in order to prevent permanent mental retardations are calling for prospective multi-center studies.

journal_name

Brain Dev

journal_title

Brain & development

authors

Holthausen H,Pieper T,Kudernatsch M

doi

10.1016/j.braindev.2013.05.003

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

730-41

issue

8

eissn

0387-7604

issn

1872-7131

pii

S0387-7604(13)00166-6

journal_volume

35

pub_type

杂志文章,评审

相关文献

BRAIN & DEVELOPMENT文献大全
  • Long-term effectiveness and side effects of acetazolamide as an adjunct to other anticonvulsants in the treatment of refractory epilepsies.

    abstract：:The long-term effectiveness of acetazolamide (AZA) and its side effects, especially the formation of renal calculi, were investigated in a prospective study when AZA was used as an adjunct to other antiepileptic drugs in the treatment of refractory epilepsies. The subjects comprised 37 patients aged from 1 to 17 years...

    journal_title：Brain & development

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0387-7604(02)00003-7

    authors： Katayama F,Miura H,Takanashi S

    更新日期：2002-04-01 00:00:00

  • A novel PLP1 frameshift mutation causing a milder form of Pelizaeus-Merzbacher disease.

    abstract：BACKGROUND:Pelizaeus-Merzbacher disease (PMD), a hypomyelinating leukodystrophy, and the related but less severe allelic spastic paraplegia 2 (SPG2) are caused by mutations in the proteolipid protein 1 (PLP1) gene. Magnetic resonance imaging (MRI) is pivotal for diagnosing these disorders. The severity of PMD/SPG2 vari...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2014.06.011

    authors： Shiihara T,Watanabe M,Moriyama K,Uematsu M,Sameshima K

    更新日期：2015-04-01 00:00:00

  • Benign convulsions with mild gastroenteritis: a report of 10 recent cases detailing clinical varieties.

    abstract：:To better define the characteristic clinical features of benign convulsions with mild gastroenteritis, recently recognized as a new entity in Japan, we reviewed all the 10 patients we have seen from 1992 to 1994. The clinical features have been previously reported in the literature to be afebrile generalized tonic-clo...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(95)00074-l

    authors： Komori H,Wada M,Eto M,Oki H,Aida K,Fujimoto T

    更新日期：1995-09-01 00:00:00

  • Electroencephalographic features of epileptic drop attacks and absence seizures: a case study.

    abstract：:A study of epileptic drop attacks (EDA) by simultaneous video-polygraphic recordings was carried out in one epileptic patient with myoclonic astatic seizures (Doose syndrome). EDA was shown to correspond to a burst of generalized bilaterally synchronous spike and wave complexes (GBSSW) at 3 Hz. Absence seizures were a...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(93)90070-o

    authors： Oguni H,Imaizumi Y,Uehara T,Oguni M,Fukuyama Y

    更新日期：1993-05-01 00:00:00

  • Alexander disease with mild dorsal brainstem atrophy and infantile spasms.

    abstract：:We present the case of a Japanese male infant with Alexander disease who developed infantile spasms at 8 months of age. The patient had a cluster of partial seizures at 4 months of age. He presented with mild general hypotonia and developmental delay. Macrocephaly was not observed. Brain magnetic resonance imaging (MR...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2012.06.009

    authors： Torisu H,Yoshikawa Y,Yamaguchi-Takada Y,Yano T,Sanefuji M,Ishizaki Y,Sawaishi Y,Hara T

    更新日期：2013-05-01 00:00:00

  • Pharmacokinetics of zonisamide in perinatal period.

    abstract：:Zonisamide is widely used for intractable epilepsy and the effects of this drug on fetuses and neonates through the mother taking it for epilepsy need to be clarified. We measured the zonisamide concentration in plasma and breast milk using high-performance liquid chromatography to investigate the transfer of zonisami...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(01)00407-7

    authors： Kawada K,Itoh S,Kusaka T,Isobe K,Ishii M

    更新日期：2002-03-01 00:00:00

  • Cerebrospinal fluid apolipoprotein E levels in subacute sclerosing panencephalitis.

    abstract：:Neurofibrillary tangles (NFTs) have been shown in 20% of subacute sclerosing panencephalitis (SSPE) cases. NFTs contain paired helical filaments formed by hyperphosphorylated tau. The intraneuronal tau metabolism and the rate of formation of paired helical filaments can be regulated by interactions between tau and iso...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2011.07.001

    authors： Yüksel D,Ichiyama T,Yilmaz D,Anlar B

    更新日期：2012-04-01 00:00:00

  • Lennox-Gastaut syndrome after a further attenuated live measles vaccination.

    abstract：:We reported a 2-year-old boy with Lennox-Gastaut syndrome, of which the cause could be an adverse effect of further attenuated live (FL) measles vaccine. The pre- and peri-natal histories of the patient were uneventful, except that he was one of monozygotic twins. He had developed normally until 24 months of life, whe...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(99)00076-5

    authors： Ishikawa T,Ogino C,Chang S

    更新日期：1999-12-01 00:00:00

  • The evolution of electroencephalographic features in lissencephaly syndrome.

    abstract：:The electroencephalographic features and their evolutional changes with age were described in three cases of lissencephaly syndrome diagnosed by CT scan. The case with more severe lissencephaly displayed very similar EEG findings. In early or middle infancy when infantile spasms began, EEG showed very high amplitude (...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(79)80042-x

    authors： Hakamada S,Watanabe K,Hara K,Miyazaki S

    更新日期：1979-01-01 00:00:00

  • Influence of ACTH therapy on overnight sleep polygrams in infantile spasms.

    abstract：:Overnight sleep polygrams were recorded before and during therapy in nine patients with infantile spasms. Results showed that ACTH therapy increased the waking time and decreased rapid eye movement sleep. Thus it caused sleep disturbance in patients with infantile spasms. During ACTH therapy the number of rapid eye mo...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(81)80006-x

    authors： Hashimoto T,Hiura K,Suzue J,Nokawa T,Fukuda K,Endo S,Tayama M,Tamura Y,Miyao M

    更新日期：1981-01-01 00:00:00

  • MR imaging, diffusion-weighted imaging and MR spectroscopy findings in acute rapidly progressive subacute sclerosing panencephalitis.

    abstract：:We are presenting two cases with subacute sclerosing panencephalitis of acute and rapid form, which were initially diagnosed as acute viral encephalitis. We obtained both diffusion-weighted imaging and magnetic resonance spectroscopy, whose findings suggested the presence of acute inflammatory and metabolic changes wi...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.09.013

    authors： Oguz KK,Celebi A,Anlar B

    更新日期：2007-06-01 00:00:00

  • Founder mutation causes classical Fukuyama congenital muscular dystrophy (FCMD) in Chinese patients.

    abstract：PURPOSE:Fukuyama congenital muscular dystrophy (FCMD) is a congenital muscular dystrophy rarely reported outside Japan. Here, we report three patients with Fukuyama congenital muscular dystrophy (FCMD) in China who shared a similar clinical phenotype and 3-kb insertion in the FKTN 3' untranslated region. METHODS:Immun...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2015.02.010

    authors： Yang H,Kobayashi K,Wang S,Jiao H,Xiao J,Toda T,Wu X,Xiong H

    更新日期：2015-10-01 00:00:00

  • Cerebellar primary germ-cell tumor in a young boy.

    abstract：:Germ cell tumors originating in the posterior fossa are very rare. Described herein is a case of primary germ cell tumor (yolk sac tumor) found in the cerebellar vermis. A 5-year-old boy who complained of headache was admitted. CT and MRI revealed a tumor with diffuse enhancement by contrast medium in the right cerebe...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(94)90128-7

    authors： Nakase H,Ohnishi H,Touho H,Karasawa J,Tsunoda S

    更新日期：1994-09-01 00:00:00

  • Clonazepam monotherapy for epilepsy in childhood.

    abstract：:Sixty patients (age-range one month to 14 years) with other types of epilepsy than infantile spasms were treated with clonazepam. Disappearance of seizures and normalization of abnormal EEG with disappearance of seizures were recognized in 77% and 50%, respectively. Seizures disappeared in 71% of the patients with gen...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：

    authors： Ishikawa A,Sakuma N,Nagashima T,Kohsaka S,Kajii N

    更新日期：1985-01-01 00:00:00

  • Recent advances in the biochemistry and genetics of sphingolipidoses.

    abstract：:Sphingolipidoses are a subgroup of lysosomal storage diseases. They are defined as disorders caused by a genetic defect in catabolism of sphingosine-containing lipids. Catabolism of these lipids involves enzymes and activator proteins. After the discovery of lysosomes by de Duve and the demonstration of the first defe...

    journal_title：Brain & development

    pub_type： 杂志文章,评审

    doi：10.1016/j.braindev.2004.01.005

    authors： Ozkara HA

    更新日期：2004-12-01 00:00:00

  • Idiopathic hypereosinophilic syndrome complicated by central sinovenous thrombosis.

    abstract：:Idiopathic hypereosinophilic syndrome (IHES) is a rare disorder affecting cardiac, pulmonary and nervous systems with peripheral neuropathy, encephalopathy and cerebral thromboembolism. We report a 7-year-old boy with IHES who developed central sinovenous thrombosis and cerebral hemorrhage. Although he had hypereosino...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2006.08.004

    authors： Sakuta R,Tomita Y,Ohashi M,Nagai T,Murakami N

    更新日期：2007-04-01 00:00:00

  • Association between Tourette syndrome and comorbidities in Japan.

    abstract：:The purpose of this study was (1) to document cases of Tourette syndrome (TS) with comorbidities such as obsessive-compulsive symptoms (OCS) and hyperkinetic disorder (HD), and (2) to examine differences in clinical characteristics between TS patients with OCS and HD and those without these comorbidities. The subjects...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.01.005

    authors： Kano Y,Ohta M,Nagai Y,Scahill L

    更新日期：2010-03-01 00:00:00

  • The test of variables of attention (TOVA) is useful in the diagnosis of Japanese male children with attention deficit hyperactivity disorder.

    abstract：:The purpose of this study was to evaluate the ability of the test of variables of attention (TOVA) to distinguish between 6- to 12-year-old Japanese male children with attention deficit hyperactivity disorder (ADHD group; n=17) meeting DSM-IV and ICD-10 criteria, and age-matched, normal Japanese male controls (control...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00168-6

    authors： Wada N,Yamashita Y,Matsuishi T,Ohtani Y,Kato H

    更新日期：2000-09-01 00:00:00

  • Thiamine-deficient encephalopathy due to excessive intake of isotonic drink or overstrict diet therapy in Japanese children.

    abstract：AIM:To report on two children with encephalopathy caused by dietary thiamine deficiency due to newly developing nutritional problems in contemporary Japan. SUBJECTS:A 1-year-old boy who had consumed 1l of isotonic drinks per day for 4 months after an episode of diarrhea, and presented with ocular movement disorder, dy...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2009.08.004

    authors： Saeki K,Saito Y,Komaki H,Sakakibra T,Nakagawa E,Sugai K,Sakuma H,Sasaki M,Honda T,Hayashi H,Katori N,Miyahara Y

    更新日期：2010-08-01 00:00:00

  • A neuropathological study of early onset Cockayne syndrome with chromosomal anomaly 47XXX.

    abstract：:We present the clinical and neuropathological findings in a female patient with early onset Cockayne syndrome and a chromosomal anomaly (47XXX). The girl was the only child of healthy, unrelated parents. She was born with a birth weight of 1,930 gm. She had progeroid facial features with bilateral cataracts. A diagnos...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(12)80282-8

    authors： Hayashi M,Hayakawa K,Suzuki F,Sugita K,Satoh J,Morimatsu Y

    更新日期：1992-01-01 00:00:00

  • Neurodegeneration in hereditary nucleotide repair disorders.

    abstract：:Both xeroderma pigmentosum group A (XPA) and Cockayne syndrome (CS) are rare autosomal disorders, have a genetic defect in the step of nucleotide repair, and involve various neurological abnormalities caused by progressive neurodegeneration. We performed comprehensive neuropathological analysis of five cases of XPA an...

    journal_title：Brain & development

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0387-7604(99)00033-9

    authors： Itoh M,Hayashi M,Shioda K,Minagawa M,Isa F,Tamagawa K,Morimatsu Y,Oda M

    更新日期：1999-07-01 00:00:00

  • Clinical variation within sibships in Fukuyama-type congenital muscular dystrophy.

    abstract：:A family in which three siblings were affected with severe cerebral malformations in association with ocular anomalies and muscle disease is reported. One sibling was diagnosed as having Fukuyama type congenital muscular dystrophy (FCMD) because he showed severe hypotonia with dystrophic findings on a muscle biopsy in...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(12)80154-9

    authors： Yoshioka M,Kuroki S,Nigami H,Kawai T,Nakamura H

    更新日期：1992-09-01 00:00:00

  • Use of amplitude-integrated electroencephalography (aEEG) and near infrared spectroscopy findings in neonates with asphyxia during selective head cooling.

    abstract：BACKGROUND:Amplitude-integrated electroencephalogram (aEEG) at <6 h is the best single outcome predictor in term infants with perinatal asphyxia at normothermia. Hypothermia treatment has changed the cutoff values for outcome prediction by using time at onset of normal trace and SWC. Cerebral hemodynamics and oxygenati...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2011.06.005

    authors： Gucuyener K,Beken S,Ergenekon E,Soysal S,Hirfanoglu I,Turan O,Unal S,Altuntas N,Kazanci E,Kulali F,Koc E,Turkyilmaz C,Onal E,Atalay Y

    更新日期：2012-04-01 00:00:00

  • Congenital ocular motor apraxia: clinical and neuroradiological findings, and long-term intellectual prognosis.

    abstract：:The severity of intellectual sequelae and prognosis varies in patients with congenital ocular motor apraxia (COMA). Here, we explored this phenomenon with regard to the accompanying oculomotor signs and gross motor development, as well as the subtentorial structure defects. Ten patients diagnosed with COMA (M:F=4:6, 4...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/j.braindev.2007.01.002

    authors： Kondo A,Saito Y,Floricel F,Maegaki Y,Ohno K

    更新日期：2007-08-01 00:00:00

  • Vertebral artery insufficiency as a possible mechanism for sudden infant death--in vivo evidence does not support findings from postmortem studies.

    abstract：:Recent postmortem studies have suggested that sudden infant death syndrome (SIDS) might involve an underlying, gradual brain stem injury caused by repeated episodes of transiently compromised brain stem circulation. Autopsy studies have also reported that vertebral artery occlusion due to head rotations, such as occur...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(03)00004-4

    authors： Vanhatalo S,Nikolajev K,Kiekara O,Seuri R,Riikonen R

    更新日期：2003-08-01 00:00:00

  • Advances in neonatal neurology.

    abstract：:The recent advances in neonatal neurology which are discussed include i) the improved organization of perinatal medical services, ii) technological advances including ultrasonography, brainstem auditory evoked responses and intracranial pressure monitoring and, iii) new developments in therapeutics. The development of...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(84)80095-9

    authors： Ouvrier RA

    更新日期：1984-01-01 00:00:00

  • Sequential MRI findings in a patient with a germ cell tumor in the basal ganglia.

    abstract：:Serial changes of MRI scanning of an 11-year-old boy with hemiparesis due to a germ cell tumor in the basal ganglia are presented. Initial brain MRI T1-weighted images revealed a subtle mixed signal intensity lesion at left anterior and posterior limbs of the internal capsule. This lesion was not enhanced with Gd-DTPA...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/0387-7604(93)90024-3

    authors： Takano T,Matsui E,Yamano T,Shimada M,Nakasu Y,Handa J

    更新日期：1993-07-01 00:00:00

  • Neopterin, biopterin, and nitric oxide concentrations in the cerebrospinal fluid of children with central nervous system infections.

    abstract：:We measured neopterin, biopterin and nitric oxide (NO) concentrations in the cerebrospinal fluid of pediatric patients with central nervous system (CNS) infectious diseases. The nitric oxide and neopterin concentrations were significantly elevated in encephalitis patients, especially in two cases with serious neurolog...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(02)00217-6

    authors： Azumagawa K,Suzuki S,Tanabe T,Wakamiya E,Kawamura N,Tamai H

    更新日期：2003-04-01 00:00:00

  • Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging.

    abstract：:In the present study, we investigated age-related changes in pteridine levels and enzymatic activity responsible for tetrahydrobiopterin biosynthesis in mouse tissues. Until about 15 weeks after the birth, the remarkable change of tetrahydrobiopterin (BH4) was observed in all tissues tested. Between 20 and 50 weeks af...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(00)00144-3

    authors： Yoshida YI,Eda S,Masada M

    更新日期：2000-09-01 00:00:00

  • Rare combination of Becker muscular dystrophy and Klinefelter's syndrome in one patient.

    abstract：:Becker muscular dystrophy (BMD) was diagnosed in a male patient with Klinefelter's syndrome (47, XXY karyotype). The BMD was confirmed by (i) immunohistological methods and Western blotting, showing decreased quantity of dystrophin in muscle biopsy specimen and (ii) molecular genetic analysis which demonstrated a homo...

    journal_title：Brain & development

    pub_type： 杂志文章

    doi：10.1016/s0387-7604(97)00032-6

    authors： Zeitoun O,Ketelsen UP,Wolff G,Müller CR,Korinthenberg R

    更新日期：1997-07-01 00:00:00