Clinical and neurological findings of severe vitamin B12 deficiency in infancy and importance of early diagnosis and treatment.

Abstract:

AIM:Nutritional vitamin B12 deficiency among children in developing countries may lead to a severe clinical status. In this article, the clinical manifestations of vitamin B12 deficiency and the consequences of delay in its diagnosis have been evaluated. METHODS:A total of 41 patients who were hospitalised and treated with the diagnosis of severe vitamin B12 deficiency in the paediatric haematology department of the hospital were enrolled in the trial. The diagnosis of severe vitamin B12 deficiency was based on haematological values, a serum vitamin B12 level of <100 pg/mL and a normal level of folic acid. Mental, neuro-motor and social developments of the enrolled patients were assessed by the same physician using the Ankara Developmental Screening Inventory. RESULTS:The mean age of 25 male and 16 female patients was determined as 12 (6-18 months) months. Almost all of the children had been fed with breast milk and a poor nutritional state was found in all of the mothers. Non-specific findings such as growth retardation (78%), hyperpigmentation of the skin (78%), diarrhoea (63.4%), convulsion (14.6%), weakness, reluctance to eat, vomiting, irritability and tremor were found in all the patients, in addition to hypotonia, motor retardation and pallor. Treatment with vitamin B12 provided recovery in all the patients. The mean age of the patients with full recovery was 11.7 months, while the mean age of patients with partial recovery was 12.9 months. CONCLUSION:As a delay in the diagnosis causes irreversible neurological damage, early diagnosis and treatment is highly important.

authors

Demir N,Koc A,Üstyol L,Peker E,Abuhandan M

doi

10.1111/jpc.12292

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

820-4

issue

10

eissn

1034-4810

issn

1440-1754

journal_volume

49

pub_type

杂志文章
  • Personalised medicine in paediatric oncology: Ethical practice outside the clinical trial framework?

    abstract::Modern paediatric oncology practice has rapidly evolved from a fatal condition at diagnosis in the 1940s to modern survival rates of over 80%. With the advent of the 'omics' era and modern diagnostics platforms, we can now determine many of the molecular driving mechanisms of malignancy. Current molecular diagnostics ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.14325

    authors: Hansford JR

    更新日期:2019-01-01 00:00:00

  • Alternatives to ward admission from the emergency department.

    abstract::There is ever-increasing pressure on hospital resources in general and emergency departments (ED) in particular. At the same time, there is increasing recognition that traditional inpatient ward-based care is not necessary for the majority of children presenting to the ED with acute illness, and that there are patient...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章,评审

    doi:10.1111/jpc.13100

    authors: Bryant PA,Hopper SM

    更新日期:2016-02-01 00:00:00

  • Cows milk consumption in constipation and anal fissure in infants and young children.

    abstract:OBJECTIVE:To examine daily cows milk consumption and duration of breastfeeding in infants and young children with anal fissure and constipation. METHODS:Two groups of 30 consecutive children aged between 4 months and 3 years were evaluated retrospectively. Group I comprised children with chronic constipation and anal ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1046/j.1440-1754.2003.00152.x

    authors: Andiran F,Dayi S,Mete E

    更新日期:2003-07-01 00:00:00

  • Usage and impact of an online education tool for preventing sudden unexpected death in infancy.

    abstract:AIM:This paper describes the usage, impact and reach of an online education tool for preventing sudden infant death. METHODS:A 24-slide presentation was formatted for online access. Content was designed for mainstream audiences to align current knowledge, attitudes and actions for a blitz approach to preventing sudden...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.12128

    authors: Cowan S,Pease A,Bennett S

    更新日期:2013-03-01 00:00:00

  • Familial Cushing's disease with severe weight loss occurring in late childhood.

    abstract::We describe a rare case of familial Cushing's disease occurring in a 7-year-old boy, and 19 years of follow up. Our patient first presented soon after his maternal aunt had been treated for Cushing's disease. The clinical presentation was made complicated by the development of an intercurrent eating disorder resemblin...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.1997.tb00996.x

    authors: Cameron FJ,Warne GL

    更新日期:1997-02-01 00:00:00

  • Idiopathic necrotizing dermatitis: current management.

    abstract:OBJECTIVES:To identify and demonstrate necrotizing dermatitis in infancy; an uncommon, puzzling syndrome, in which anecdotal reporting and personal experience indicates that one third of cases may require skin grafting. Much informed discussion about the pathogenesis of this distressing syndrome centres on the role of ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2005.00531.x

    authors: Lui PC,Petersen D,Kimble RM,Raven RJ,Pearn JH

    更新日期:2005-01-01 00:00:00

  • Neuronal ceroid lipofuscinosis type 2: an Australian case series.

    abstract:AIM:Late infantile neuronal ceroid lipofuscinosis type 2 (CLN2) disease is a rare neurodegenerative disorder presenting in children aged 2-4 years with seizures and loss of motor and language skills, followed by blindness and death in late childhood. Initial presenting features are similar to a range of common epilepsi...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.14890

    authors: Johnson AM,Mandelstam S,Andrews I,Boysen K,Yaplito-Lee J,Fietz M,Nagarajan L,Rodriguez-Casero V,Ryan MM,Smith N,Scheffer IE,Ellaway C

    更新日期:2020-08-01 00:00:00

  • Cardiac cirrhosis and hepatocellular carcinoma in a 13-year-old treated with doxorubicin microbead transarterial chemoembolization.

    abstract::Increasing numbers of children are surviving into adulthood following surgery to correct or palliate congenital heart disease. This surgery can occasionally result in long-standing elevated right heart pressures and chronic hepatic venous congestion leading to cardiac cirrhosis. We report the first paediatric case of ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2010.01932.x

    authors: Rosenbaum J,Vrazas J,Lane GK,Hardikar W

    更新日期:2012-03-01 00:00:00

  • The role of appetite-regulating hormones: Ghrelin and leptin in the nutritional status of children with neurogenic bladder due to myelomeningocele.

    abstract:AIM:We wanted to investigate serum levels of ghrelin and leptin - appetite-regulating hormones - and their correlation with the nutritional status of children with neurogenic bladder (NB) due to myelomeningocele (MMC) in comparison to healthy individuals. METHODS:This prospective analysis was conducted on 67 children ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.14314

    authors: Bagińska JO,Liszewska A,Wasilewska A,Korzeniecka-Kozerska A

    更新日期:2019-08-01 00:00:00

  • Skin exposure during conventional phototherapy in preterm infants: A randomized controlled trial.

    abstract:OBJECTIVE:To assess the effect of reduced skin exposure in preterm infants receiving overhead phototherapy treatment on total serum bilirubin (TSB). METHODS:Randomized controlled trial. Preterm infants (>1500 g birthweight and < or = 36 weeks gestation) were randomized to being nursed either partially clothed with onl...

    journal_title:Journal of paediatrics and child health

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1440-1754.2004.00362.x

    authors: Pritchard MA,Beller EM,Norton B

    更新日期:2004-05-01 00:00:00

  • Severe spontaneous intracranial hypotension and Marfan syndrome in an adolescent.

    abstract::We describe a 14-year-old girl with Marfan syndrome who presented with severe postural headache. Dural ectasia was demonstrated radiologically. Cerebrospinal fluid (CSF) pressure was immeasurable on formal measurement. Radionucleide cisternography failed to demonstrate a CSF leak. We consider that the underlying fibri...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2005.00541.x

    authors: Milledge JT,Ades LC,Cooper MG,Jaumees A,Onikul E

    更新日期:2005-01-01 00:00:00

  • Diagnostic accuracy of paediatric echocardiograms interpreted by individuals other than paediatric cardiologists.

    abstract:OBJECTIVE:To assess the diagnostic error rate among echocardiograms undertaken by individuals other than paediatric cardiologists in our referral area. METHODOLOGY:External group: The charts and echocardiographic results of all patients who had undergone outside echocardiograms between January 1996 and December 1999 w...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1046/j.1440-1754.2001.00695.x

    authors: Ward CJ,Purdie J

    更新日期:2001-08-01 00:00:00

  • Benign paroxysmal torticollis of infancy: An underdiagnosed condition.

    abstract::Benign paroxysmal torticollis is probably an under-diagnosed condition of infancy. It is a self-limiting disorder characterised by periods of unusual, sustained posture of the head and neck, during which the head tilts to one side. Episodes are often accompanied by marked autonomic features, irritability, ataxia, apat...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.12841

    authors: Hadjipanayis A,Efstathiou E,Neubauer D

    更新日期:2015-07-01 00:00:00

  • Chemoprophylaxis of neonatal fungal infections in very low birthweight infants: efficacy and safety of fluconazole and nystatin.

    abstract:AIM:To review the use of antifungal chemoprophylaxis to prevent neonatal invasive fungal infections (IFI) in very low birthweight infants (VLBW <1500 g). METHOD:Systematic review of randomised controlled trials. RESULTS:Nine trials were identified (2029 infants), with six comparing fluconazole with placebo/no treatme...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1440-1754.2012.02543.x

    authors: Blyth CC,Barzi F,Hale K,Isaacs D

    更新日期:2012-09-01 00:00:00

  • Intussusception in the Northern Territory: the incidence is low in Aboriginal and Torres Strait Islander children.

    abstract:AIM:To describe the epidemiology, immunisation status and management of children with intussusception in the Northern Territory (NT), 1993-2003. METHODS:Intussusception data were obtained from all NT hospitals using the International Classification of Diseases (ICD 9/10) codes for children under 18 years of age betwee...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2006.00844.x

    authors: Webby RJ,Bines JE,Barnes GL,Tindall H,Krause V,Patel M

    更新日期:2006-05-01 00:00:00

  • Health and well-being of young people who attend secondary school in Aotearoa, New Zealand: what has changed from 2001 to 2007?

    abstract:AIM:To describe the changes in the health and well-being of secondary school students from 2001 to 2007. METHODS:A total of 9107 secondary school students were randomly selected to participate in a comprehensive health and well-being survey using Internet tablets conducted in 2007. Comparisons are made with the first ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2010.01945.x

    authors: Denny SJ,Grant S,Utter J,Robinson EM,Fleming TM,Milfont TL,Crengle S,Clark T,Ameratunga SN,Dixon R,Merry S,Herd R,Watson P

    更新日期:2011-04-01 00:00:00

  • Chronic fatigue syndrome: successful outcome of an intensive inpatient programme.

    abstract:OBJECTIVE:To study the outcome of adolescents with chronic fatigue syndrome (CFS) following an intensive multi-disciplinary inpatient programme. METHODS:A follow-up questionnaire was distributed to all 57 adolescents who had completed the CFS inpatient programme at the Austin and Repatriation Medical Centre. RESULTS:...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1046/j.1440-1754.2002.00786.x

    authors: Lim A,Lubitz L

    更新日期:2002-06-01 00:00:00

  • Unilateral vocal cord paralysis after surgical closure of a patent ductus arteriosus in extremely preterm infants.

    abstract:AIM:Left vocal cord paralysis (LVCP) is variably reported post ligation of patent ductus arteriosus (PDA). Our objective was to determine the incidence of LVCP and identify predictive factors and associated morbidities in preterm infants post PDA ligation. METHODS:This is a retrospective cohort study of infants less t...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.13632

    authors: Pharande P,Karthigeyan S,Walker K,D'Cruz D,Badawi N,Luig M,Winlaw D,Popat H

    更新日期:2017-12-01 00:00:00

  • Regular source of primary care and emergency department use of children in Victoria.

    abstract:AIM:The aim of this paper was to study the prevalence of a regular source of primary care for Victorian children attending one of four emergency departments (EDs) and to determine associated characteristics, including ED use. METHODS:Responses were collected via an electronic survey from parents attending EDs with the...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.13027

    authors: Turbitt E,Freed GL

    更新日期:2016-03-01 00:00:00

  • Assessment and treatment of childhood asthma.

    abstract::In June 1990 a meeting of Paediatric Respiratory Physicians was held near Adelaide. The guidelines for assessing and treating asthma as prepared by the Thoracic Society of Australia and New Zealand for the management of patients with asthma was considered. Although not explicitly stated, these guidelines were designed...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.1991.tb00395.x

    authors: Henry R,Sly P,Godfrey S,Van Asperen P,Staugas R,Le Souef P,Smith G,Robertson I,Robertson C,Phelan P

    更新日期:1991-08-01 00:00:00

  • Milk curd obstruction in premature infants receiving fortified expressed breast milk.

    abstract:AIM:Milk curd obstruction is one of the less common causes of neonatal bowel obstruction. It has been described in premature infants who received high caloric formula feeds. We report presentation, management and outcome of premature neonates who developed milk curd obstruction while being fed fortified expressed breas...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2008.01460.x

    authors: Wagener S,Cartwright D,Bourke C

    更新日期:2009-04-01 00:00:00

  • Supervisory needs of research doctoral students in a university teaching hospital setting.

    abstract:BACKGROUND/HYPOTHESIS:Teaching hospitals affiliated with universities are now common sites for research higher degree supervision. We hypothesised that the hospital environment poses unique challenges to supervision compared with the traditional university research institute setting. AIMS:This study aimed to identify ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2012.02522.x

    authors: Caldwell PH,Oldmeadow W,Jones CA

    更新日期:2012-10-01 00:00:00

  • Conservative post-natal management of antenatally diagnosed congenital pulmonary airway malformations.

    abstract:AIM:Management of congenital pulmonary airway malformations (CPAM) is controversial, especially for asymptomatic patients. We aim to describe the clinical manifestations and management of CPAM at a tertiary paediatric hospital using a retrospective audit. METHODS:Infants with CPAM were identified on the Fetal Diagnost...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.13727

    authors: Makhijani AV,Wong FY

    更新日期:2018-03-01 00:00:00

  • Factors associated with breastfeeding at discharge and duration of breastfeeding.

    abstract:OBJECTIVE:To identify determinants of the initiation and duration of breastfeeding amongst Australian women. METHODS:A prospective cohort study of 556 women in Perth, Western Australia and 503 women from the Darling Downs area, Queensland, Australia. RESULTS:Breastfeeding at discharge was most strongly associated wit...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1046/j.1440-1754.2001.00646.x

    authors: Scott JA,Landers MC,Hughes RM,Binns CW

    更新日期:2001-06-01 00:00:00

  • Vaginal foreign bodies.

    abstract:OBJECTIVE:To evaluate the clinical features and outcome in girls with a vaginal foreign body. METHODS:Retrospective review of medical records of 35 girls with a vaginal foreign body seen in an outpatient clinic for paediatric and adolescent gynaecology between 1980 and 2000. RESULTS:The ages ranged from 2.6 to 9.2 ye...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/j.1440-1754.2004.00338.x

    authors: Stricker T,Navratil F,Sennhauser FH

    更新日期:2004-04-01 00:00:00

  • Clinical markers of serious illness in young infants: a multicentre follow-up study.

    abstract:OBJECTIVE:To perform a multicentre follow-up study to determine if previously identified markers of serious illness in early infancy were robust and statistically reliable. METHODS:Infants aged 1 week to 26 weeks presenting to the Emergency Departments of the Royal Children's Hospital and two Melbourne metropolitan ho...

    journal_title:Journal of paediatrics and child health

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1440-1754.2000.00483.x

    authors: Hewson P,Poulakis Z,Jarman F,Kerr J,McMaster D,Goodge J,Silk G

    更新日期:2000-06-01 00:00:00

  • Use of complementary and alternative medicine in children: too important to ignore.

    abstract::There is evidence that complementary and alternative medicine (CAM) is commonly being used for Australian children, however, at the same time, many doctors have little interest or understanding of the topic. Just as with mainstream treatments, CAM therapies have significant potential for adverse effects and drug inter...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1046/j.1440-1754.2003.00236.x

    authors: South M,Lim A

    更新日期:2003-11-01 00:00:00

  • Observational study of falls in children from windows and balconies: What has changed?

    abstract:AIM:To describe patterns of injury from window and balcony falls in children presenting to a tertiary paediatric trauma centre in New South Wales. METHODS:A retrospective review of cases of children <15 years who had sustained injuries in a fall from a building, identified from the trauma database between 1998 and 201...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.15240

    authors: Houlton AY,Manglick P,Soundappan SSV,Douglass C,Wicks S,Holland AJA,Cass DT

    更新日期:2020-10-27 00:00:00

  • Facilitating educational experiences in a paediatric handover: A qualitative case study.

    abstract:AIM:Handovers have been established as a valuable educational tool; nevertheless, a paucity of literature exists evaluating contributors to the educational experience. Our study aimed to investigate participants' educational experiences based on a paediatric handover, and the facilitators and barriers towards teaching ...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.14964

    authors: Ooi A,Bradley S,Mukherjee S,Stafford K,Henning MA

    更新日期:2020-09-01 00:00:00

  • Paediatric active enhanced disease surveillance: a new surveillance system for Australia.

    abstract:AIM:The Paediatric Active Enhanced Disease Surveillance (PAEDS) is described. PAEDS is active in four tertiary children's hospitals in four states of Australia and aims to address gaps in surveillance for severe vaccine-preventable diseases and adverse events following immunisation. METHODS:From August 2007 to Decembe...

    journal_title:Journal of paediatrics and child health

    pub_type: 杂志文章

    doi:10.1111/jpc.12282

    authors: Zurynski Y,McIntyre P,Booy R,Elliott EJ,PAEDS Investigators Group.

    更新日期:2013-07-01 00:00:00