Abstract：
:Myelofibrosis (MF), polycythemia vera (PV) and essential thrombocythemia (ET) are three classic BCR ABL fusion gene-negative chronic myeloproliferative neoplasms (MPNs). Though rare, it is important to understand the burden of illness of these disorders for public health planning, healthcare insurers and pharmaceutical manufacturers. Therefore, we have described the incidence of MF and prevalence of MF, ET and PV in the United States between 2008 and 2010 based on data from two large health plans. The incidence of primary MF was about 1 per 100 000 per year and did not vary over the study years. The prevalence of PV (44-57 per 100 000) and ET (38-57 per 100 000) was much higher than that of MF (4-6 per 100 000) or subgroups containing MF (post-PV MF = 0.3-0.7 per 100 000; post-ET MF = 0.5-1.1 per 100 000). Additional research using other national databases and/or study designs is needed to substantiate these findings.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Mehta J,Wang H,Iqbal SU,Mesa Rdoi
10.3109/10428194.2013.813500subject
Has Abstractpub_date
2014-03-01 00:00:00pages
595-600issue
3eissn
1042-8194issn
1029-2403journal_volume
55pub_type
杂志文章abstract：:We report follow-up information on 69 hairy cell leukemia (HCL) patients treated with interferon alfa-2b (IFN) as primary treatment from 1983 to 1986. Follow-up through April, 1993 shows that only 14 patients have expired. Forty-seven of the 61 patients completing the intended 12 or more months of initial IFN treatmen...
journal_title：Leukemia & lymphoma
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-01-01 00:00:00
abstract：:Myasthenia gravis (MG) is an autoimmune neuromuscular junction disease. An association between thymic epithelial neoplasms and MG is well known. However, it is rarely associated with hematologic malignancies. In particular, very few cases of lymphoblastic lymphoma involving the thymus and MG have been reported. Here w...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428190109064612
更新日期：2001-07-01 00:00:00
abstract：:Analysis of different ribonucleotide reductase inhibitors to modulate arabinosylcytosine (ara-C) metabolism suggested that pretreatment with arabinosyl-2-fluoroadenine (F-ara-A) significantly potentiated the rate of ara-CTP (5'-triphosphate of ara-C) accumulation in both quiescent lymphocytes (p = 0.046) and in cyclin...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199309149122
更新日期：1993-01-01 00:00:00
abstract：:Current therapies for the treatment of malignancies are associated with significant limitations to the hematopoietic system since chemotherapy and radiation therapy do not discriminate between normal and malignant cells. Since bone marrow depression occurs at low to midlethal doses of irradiation, approaches to improv...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199409051648
更新日期：1994-03-01 00:00:00
abstract：:We retrospectively studied 87 patients aged from 55 to 69 years old with acute myeloid leukemia (AML) who received decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin (DCAG) or standard dose chemotherapy as induction therapy. Patients receiving DCAG had a similar overall response rate (ORR) (p = ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/10428194.2018.1443328
更新日期：2018-11-01 00:00:00
abstract：:B-cell chronic lymphocytic leukemia (CLL) is characterized by profound immune dysfunction and a marked resistance to apoptosis. Understanding the cellular biology of immune effector cells from CLL patients as well as leukemic target cells is essential to developing immune mediated therapeutic strategies for CLL. In th...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428190009113387
更新日期：2000-11-01 00:00:00
abstract：:An analysis by month of diagnosis was made of 1359 cases of Hodgkins disease (HD) on the Scotland and Newcastle Lymphoma Group (SNLG) registry 1979-1992 to look for evidence of seasonality. A March peak was evident when all cases were analysed (p < 0.01). The histological subtypes nodular sclerosing (NS) and mixed cel...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199509059625
更新日期：1995-07-01 00:00:00
abstract：:Primary effusion lymphoma (PEL) is a recently described rare type of non-Hodgkin's lymphoma occurring almost exclusively in HIV infected people. Human herpesvirus 8 (HHV-8), has been linked with PEL, and a causative relationship has been suggested. In the vast majority of PEL cases Epstein-Barr virus (EBV) has been fo...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428190109058002
更新日期：2001-04-01 00:00:00
abstract：:The observation of binucleated lymphocytes (BNLs) on a peripheral blood smear is essential to the diagnosis of persistent polyclonal B-cell lymphocytosis (PPBL). Only a few case reports have mentioned their presence in other contexts, mainly mature B-cell neoplasms such as chronic lymphocytic leukemia or reactive circ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428194.2013.843680
更新日期：2014-07-01 00:00:00
abstract：:Factors associated with failure of antifungal therapy were examined in 42 cancer patients with fusariosis (1987-1997). Thirty-six patients (86%) had leukemia and 39 (93%) were neutropenic. Disseminated infection was the most common presentation. The majority (83%) received amphotericin B-based therapy. Thirty patients...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/1042819031000149386
更新日期：2004-01-01 00:00:00
abstract：:Infant acute leukemia, known to have a poor outcome with conventional therapy, usually has a molecular rearrangement at chromosome band 11q23. The 11q23 translocation partner is typically at 4q21 in infant ALL, but other 11q23 translocation partners occur in infant ALL and AML. The MLL gene at 11q23, and the AF4 gene ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199709114159
更新日期：1997-04-01 00:00:00
abstract：:Bryostatin, a macrocyclic lactone and protein kinase C (PKC) modulator, has been shown to have differentiation and anti-tumor activity against several leukemia cell lines in vitro. In this study, we demonstrated Bryostatin-induced differentiation in B-cell chronic lymphocytic leukemia (B-CLL) cells, characterized by a...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/10428190310001639470
更新日期：2004-05-01 00:00:00
abstract：:Thrombopoietin (TPO) has been successfully used to stimulate megakaryocyte progenitor proliferation and platelet production both in vitro and in vivo. We and other investigators have found that TPO also stimulates normal marrow colony-forming unit granulocyte-macrophage (CFU-GM) and burst-forming unit-erythroid (BFU-E...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199809057541
更新日期：1998-07-01 00:00:00
abstract：:Hepatitis due to reactivation of hepatitis B virus is an important cause of liver-related morbidity and mortality in hepatitis B surface antigen (HBsAg) positive patients undergoing autologous hematopoeitic cell transplantation. With the recent introduction of sensitive serum HBV DNA quantitation assay, the diagnosis ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.1080/1042819031000083343
更新日期：2003-08-01 00:00:00
abstract：:The highly controlled degradation of proteins via the ubiquitin-proteasome pathway represents a key mechanism for cell regulation and homeostasis. Ubiquitin-dependent proteolysis, carried out in large part by the E3 ubiquitin ligases, is a critical mode of post-translational modification that is important in regulatio...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.1080/10428190410001663635
更新日期：2004-07-01 00:00:00
abstract：:We have studied the effect of dimethyl-sulfoxide(DMSO)-induced granulocytic differentiation on the sensitivity of HL-60 cells to various cytotoxic topoisomerase II inhibitors: (i) undifferentiated HL-60 cells are highly sensitive to etoposide, while differentiated HL-60 cells are 700-1000 fold resistant to etoposide, ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199109068137
更新日期：1991-01-01 00:00:00
abstract：:The aim of the present study was to evaluate the efficacy of the combination of fludarabine 30/mg/m2 + cytarabine 2g/m2 followed by the administration of G-CSF to achieve a complete remission (CR) in patients with relapsed acute lymphoblastic leukemia (ALL). We treated twelve patients in first relapse, overall 10 pati...
journal_title：Leukemia & lymphoma
pub_type： 临床试验,杂志文章
doi：10.3109/10428199709039047
更新日期：1997-05-01 00:00:00
abstract：:Rituximab is a CD20-targeted monoclonal antibody widely used in the treatment of B-cell lymphoma. Previously, we have shown that Epstein-Barr virus (EBV) latent membrane protein-1 (LMP1) increases chemoresistance in malignant cancer cells. In this study we examined the effects of LMP1 on the response of B-cell lymphom...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428194.2012.659736
更新日期：2012-08-01 00:00:00
abstract：:Hematopoietic progenitors can be expanded ex vivo in the presence of various cytokine combinations. Since normal early progenitor or stem cells persist in the blood and bone marrow of patients with Philadelphia chromosome [Ph]-positive chronic myeloid leukaemia (CML), the selection of normal (Ph-negative) progenitor c...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199809059255
更新日期：1998-12-01 00:00:00
abstract：:The prognostic significance of O6-methylguanine DNA methyltransferase (MGMT) inactivation was evaluated in patients with diffuse large B-cell lymphoma (DLBCL) who received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in addition to rituximab. In this retrospective study, we used the methylation-sp...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428190903312462
更新日期：2009-12-01 00:00:00
abstract：:The expression of the interleukin 2 (IL2) receptor chains was investigated by immunofluorescence and mRNA analysis in typical and variant hairy cell leukemia (HCL) cases. While typical hairy cells express both the alpha and the beta chains, variant HCL express the IL2 receptor beta chain on the surface membrane but no...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：
更新日期：1994-01-01 00:00:00
abstract：:Anamorsin is a cell-death-defying factor, which was originally isolated as a molecule that conferred resistance to apoptosis induced by growth factor starvation. In order to evaluate anamorsin expression levels in malignant lymphoma, we immunostained paraffin-embedded sections with anti-anamorsin monoclonal antibodies...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/10428190701713697
更新日期：2008-01-01 00:00:00
abstract：:Analysis of leukemia-specific and leukemia-associated markers following standard or high-dose treatments is crucial in order to evaluate the efficacy of therapeutic strategies. During the last decade, several techniques have been proposed and used for detecting minimal residual disease (MRD). Each approach is characte...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199509075308
更新日期：1995-01-01 00:00:00
abstract：:Expression of T, sialosyl-T and disialosyl-T antigens on normal blood and bone marrow cells as well as transformed cells was examined using specific monoclonal antibodies and multidimensional flow cytometry. Both anti-sialosyl-T (QSH1) and anti-disialosyl-T (QSH2) monoclonal antibodies aggregated erythrocytes. The ant...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199709039027
更新日期：1997-05-01 00:00:00
abstract：:Primary myelosarcomas, also called leukemia cutis, granulocytic sarcomas or chloromas, are rare extramedullary manifestations of acute myeloid leukemia (AML) which precede bone marrow involvement. Skin infiltration was the most frequent localization associated with a myelomonocytic differentiation. Although first remi...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.1080/10428190290012056
更新日期：2002-03-01 00:00:00
abstract：:We describe here a rare case of malignant lymphoma followed by plasmacytoma in Hashimoto's thyroiditis. The patient developed malignant lymphoma (small, non-cleaved cell, and non Burkitt's type by Working Formulation classification), and remained in remission for 2 years after receiving combination chemotherapy, and t...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/10428199909169627
更新日期：1999-11-01 00:00:00
abstract：:The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice. MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章,评审
doi：10.3109/10428199509051699
更新日期：1995-03-01 00:00:00
abstract：:The incidence of documented infections after autologous peripheral blood progenitor cells transplantation (PBPCT) was retrospectively evaluated in 86 consecutive patients (47 males 39 females; median age 36 years, range, 18-63) treated in our institution; 83 patients had refractory hematological malignancies (40 non-H...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199809050943
更新日期：1998-06-01 00:00:00
abstract：:The MRC has conducted randomised trials in CLL sine 1978: CLL 1 (1978-84), 660 patients; CLL 2 (1984-90), 640 patients; CLL 3 (from June 1990), 90 patients. Centralised morphological diagnosis and membrane marker studies have allowed the exclusion of non-CLL disorders. Some of the treatment questions were repeated in ...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.3109/10428199109103389
更新日期：1991-01-01 00:00:00
abstract：:The proteasome inhibitor carfilzomib is highly effective in the treatment of multiple myeloma. It irreversibly binds the chymotrypsin-like active site in the β5 subunit of the 20S proteasome. Despite impressive response rates when carfilzomib is used in combination with immunomodulatory agents in newly diagnosed multi...
journal_title：Leukemia & lymphoma
pub_type： 杂志文章
doi：10.1080/10428194.2016.1214953
更新日期：2017-03-01 00:00:00
