Early development of anti-natalizumab antibodies in MS patients.

Abstract:

:The purpose of this study is to monitor the development of anti-natalizumab antibodies to evaluate their first appearance in multiple sclerosis patients, since their presence has been associated with a reduction in the efficacy of the treatment and an increase of adverse events. A total of 134 multiple sclerosis patients were included in the trial. Anti-natalizumab antibodies were monthly detected by ELISA up to the first year of treatment and subsequently, a determination was made at 18 months. 15.7% of the patients were positive, being 7.5% transiently positive and 8.2% persistently positive. The first appearance of anti-natalizumab antibodies occurred after the first month of treatment onset in 72% of positive patients; 18% did so after the second month, and 9.7% after the third month. Antibodies were never detected for the first time after the fourth infusion. The development of anti-natalizumab antibodies occurs very early after treatment onset. This observation should be considered when standardizing the follow up of patients treated with this drug in order to minimize the risks and optimize the treatment.

journal_name

J Neurol

journal_title

Journal of neurology

authors

Oliver-Martos B,Órpez-Zafra T,Urbaneja P,Maldonado-Sanchez R,Leyva L,Fernández O

doi

10.1007/s00415-013-6991-2

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

2343-7

issue

9

eissn

0340-5354

issn

1432-1459

journal_volume

260

pub_type

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