Abstract:
BACKGROUND:Hepatitis B virus (HBV) is an important infectious agent that causes widespread concern because billions of people are infected by at least 8 different HBV genotypes worldwide. However, reconstruction of the phylogenetic relationship between HBV genotypes is difficult. Specifically, the phylogenetic relationships among genotypes A, B, and C are not clear from previous studies because of the confounding effects of genotype recombination. In order to clarify the evolutionary relationships, a rigorous approach is required that can effectively explore genetic sequences with recombination. RESULT:In the present study, phylogenetic relationship of the HBV genotypes was reconstructed using a consensus phylogeny of phylogenetic trees of HBV genome segments. Reliability of the reconstructed phylogeny was extensively evaluated in agreements of local phylogenies of genome segments.The reconstructed phylogenetic tree revealed that HBV genotypes B and C had a closer phylogenetic relationship than genotypes A and B or A and C. Evaluations showed the consensus method was capable to reconstruct reliable phylogenetic relationship in the presence of recombinants. CONCLUSION:The consensus method implemented in this study provides an alternative approach for reconstructing reliable phylogenetic relationships for viruses with possible genetic recombination. Our approach revealed the phylogenetic relationships of genotypes A, B, and C of HBV.
journal_name
BMC Evol Bioljournal_title
BMC evolutionary biologyauthors
Jiang Y,Wang M,Zheng H,Wang WR,Jin L,He Ydoi
10.1186/1471-2148-13-120subject
Has Abstractpub_date
2013-06-11 00:00:00pages
120issn
1471-2148pii
1471-2148-13-120journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Cetacean brain size expansion is an enigmatic event in mammalian evolution, yet its genetic basis remains poorly explored. Here, all exons of the seven primary microcephaly (MCPH) genes that play key roles in size regulation during brain development were investigated in representative cetacean lineages. RES...
journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2017-08-29 00:00:00
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journal_title:BMC evolutionary biology
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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journal_title:BMC evolutionary biology
pub_type: 杂志文章
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更新日期:2017-02-06 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-02-20 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
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更新日期:2009-02-19 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-14 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-04-26 00:00:00
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更新日期:2017-06-05 00:00:00
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pub_type: 杂志文章
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