Abstract：
:We report for the first time the lack of therapeutic effects after the switch from a brand formulation of allopurinol to a generic one. A 56-year-old man, with a 5 years history of well-treated gout arthropathy with allopurinol (Zyloric(®) 300 mg/die), developed acute gout arthropathy after the switch from the brand formulation of allopurinol to a generic one. Clinical evaluation and laboratory findings confirmed the diagnosis of acute gout arthropathy. Generic formulation of the drug was dismissed and Zyloric(®) was administered with an improvement of both clinical symptoms and laboratory findings. In conclusion, even if generic formulations are considered to have the same effects in comparison to the brand one, more data are necessaries in order to well define their effectiveness and rationale use.
journal_name
J Forensic Leg Medjournal_title
Journal of forensic and legal medicineauthors
De Vuono A,Scicchitano F,Palleria C,Russo E,De Sarro G,Gallelli Ldoi
10.1016/j.jflm.2013.02.007subject
Has Abstractpub_date
2013-07-01 00:00:00pages
540-2issue
5eissn
1752-928Xissn
1878-7487pii
S1752-928X(13)00026-7journal_volume
20pub_type
杂志文章abstract：:Intimate partner violence (IPV) is an important cause of women's health and socio-familial severe problems, the most extreme being the victims' homicide. This is the first nationwide Portuguese autopsy-based and judicial-proven study about female intimate partner homicide. At least 62 women over 15 years old were kill...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2013.09.015
更新日期：2013-11-01 00:00:00
abstract：:Assessment of suspected cardiac injuries in a trauma setting is a challenging and time-critical matter, with clinical and imaging findings having complementary roles in the formation of an accurate diagnosis. In this article, we review the supporting literature for the pathophysiology, classification and evaluation of...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.jflm.2017.08.013
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Determining the prevalence and characteristics of female-perpetrated child sexual abuse (CSA) is fraught with difficultly. There is a historical lack of empirical research and a discrepancy between the number of cases that reach the attention of the authorities and its suspected prevalence in society. It is ...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2020.102112
更新日期：2021-01-07 00:00:00
abstract：:Paternity disputes and other forms of kinship testing are routinely resolved using short tandem repeat (STR) DNA loci. Sibship determination is encountered in instances where the DNA profiles of two individuals are compared to determine if they are siblings. If either parent is available for testing then the situation...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2007.12.018
更新日期：2008-07-01 00:00:00
abstract：:We report a fatal case of streptococcal and meningococcal meningitis in a previously healthy 2-year-old child, a simultaneous co-infection of both pathogens that is poorly reported in the reviewed literature. The lack of a clinical diagnosis in addition to the medico-legal aspects arising from possible professional li...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2013.04.004
更新日期：2013-08-01 00:00:00
abstract：INTRODUCTION:Disability following traumatic spine injury often requires assessment for judicial reasons. OBJECTIVE:To determine the optimum time to carry out a medico-legal evaluation. METHODS:Retrospective study (1995-2000) of patients with traumatic spine injury with a follow-up of five years. The American Spinal I...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2007.06.003
更新日期：2008-01-01 00:00:00
abstract：:A fatality of an 83-year-old female experiencing acute circulatory failure as a result of a type II odontoid fracture is compared with the case of an 86-year-old female who died from delayed cardiopulmonary complications due to a lower cervical spine injury. Falls on the forehead from minor height can cause odontoid f...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2019.101883
更新日期：2020-01-01 00:00:00
abstract：:A death certificate is an official document in which the medical practitioner primarily records the cause of death sequence, the time interval between the onset of the cause of death and death, and personal details of the deceased. Errors in death certificate documentation are not uncommon. We aim to review the common...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.jflm.2019.101864
更新日期：2019-11-01 00:00:00
abstract：:The identification of commingled mutilated remains is a challenge to forensic experts and hence, a need of studies on estimation of stature from various body parts in different population groups. Such studies can help in narrowing down the pool of possible victim matches in cases of identification from dismembered rem...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2011.12.036
更新日期：2012-07-01 00:00:00
abstract：:To understand the causes and patterns of shark attacks on humans, accurate identification of the shark species involved is necessary. Often, the only reliable evidence for this comes from the characteristics of the wounds exhibited by the victim. The present case report is intended as a reappraisal of the Luengoni, 20...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2015.04.011
更新日期：2015-07-01 00:00:00
abstract：:Therapeutic artefacts are a challenge for forensic pathologists for correct interpretation at autopsy. A 23-year-old female was found unconscious at home and immediately admitted to an emergency of a tertiary care hospital where resuscitative measures were taken. However, she died after 4 h of hospitalization. The inj...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2020.102050
更新日期：2020-10-01 00:00:00
abstract：:Suicide is an important health hazard worldwide. Hanging is one of the preferred means of committing suicide in India. The current research is aimed to describe the victimologic profile and find the gender differences in suicidal hanging in Manipal, South India. A 10-year retrospective review of medicolegal autopsy re...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2008.05.004
更新日期：2008-11-01 00:00:00
abstract：:Air weapons whether rifles or pistols are, potentially, lethal weapons. The UK legislation is complex and yet little known to the public. Hunting with air weapons and the laws controlling those animals that are permitted to be shot with air weapons is even more labyrinthine due to the legal power limitations on the po...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2009.11.003
更新日期：2010-04-01 00:00:00
abstract：:Although Marfan syndrome has a range of characteristic morphological features involving the ocular, cardiovascular and musculoskeletal systems, the phenotype is variable. In addition, mutations have been identified in the gene encoding for fibrillin-1 and also in the transforming growth factor-beta receptor 2 (TGF-bet...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2007.07.010
更新日期：2008-05-01 00:00:00
abstract：:When creating a basic biological profile, determining the sex of subadult skeletal remains is always problematic and several methods for sex determination have been proposed over time. The lateral angle of the internal auditory canal has been described as a good sex predictor in adults, and here we test its reliabilit...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2011.01.008
更新日期：2011-04-01 00:00:00
abstract：:Whether levels of fetal hemoglobin (HbF), a possible marker of antecedent hypoxemia, are increased in sudden infant death syndrome (SIDS) compared to controls is unresolved. Our aims are to: (1) Compare percent fetal hemoglobin (%HbF) levels in SIDS and control cases, and (2) compare our findings with those reported i...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2006.11.005
更新日期：2007-11-01 00:00:00
abstract：:A complaint by a customer to a food company claimed that the consumption of a chocolate candy fractured his anterior teeth, due to its hard consistency. Fragments of the fractured teeth and the chocolate candy that supposedly caused it were collected, examined and photographed. Fragments presented caries, large restor...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2012.09.010
更新日期：2013-05-01 00:00:00
abstract：:In the present study an attempt has been made to establish standards for sex determination from the various direct and indirect measurements of the cranium. A total of 100 cranium (50 of either sex) were measured for nine direct measurements pertaining to Mastoid triangle and Opisthion-Bimastoid triangle. These measur...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2012.09.020
更新日期：2013-05-01 00:00:00
abstract：:Although the past few years have seen a significant increase in the use of synthetic cannabinoids, very few fatalities have been reported whereby synthetic cannabinoids have contributed or were solely responsible for the death of an individual. We report a rapid death of an individual following ingestion of 5 F-PB-22 ...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2018.07.012
更新日期：2018-10-01 00:00:00
abstract：:Forensic pathologists can help in the investigation of sudden unexpected deaths in co-operation with the officials responsible for the maintenance of law and order to administer justice. Sudden unexpected deaths form the subject of medicolegal investigation if they occur in apparently healthy individuals, wherein an a...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2010.04.013
更新日期：2010-08-01 00:00:00
abstract：:Healthright International, formerly Doctors of the World-USA, has for the past 15years trained clinicians to perform forensic medical evaluations of torture survivors. As the burden of proof in asylum cases in the United States has increased, so has the scrutinizing of the evidence presented. We present a series of ca...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2009.07.010
更新日期：2010-01-01 00:00:00
abstract：:Necrophilia is a paraphilia whereby the perpetrator gets sexual pleasure in having sex with the dead. Most jurisdictions and nations have laws against this practice. Necrophilia exists in many variations, and some authors have attempted to classify necrophilia. However many related terms such as pseudonecrophilia cont...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2008.12.023
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVES:The aim of this study was to evaluate whether the foramen magnum (FM) dimensions could be used for sex determination using the Cone Beam Computed Tomography (CBCT). METHODS:Two hundred and sixty six CBCT full Field Of View (FOV) scans (111 males and 115 female subjects) of the skull were retrospectively sel...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2016.08.005
更新日期：2016-11-01 00:00:00
abstract：INTRODUCTION:Brainstem haemorrhage is common in cases of head injury when it is associated with space-occupying lesion and increases in the intracranial pressure (duret haemorrhage), in cases of diffuse axonal injury (in dorso-lateral quadrant) and diffuses vascular injury (in the periventricular tissue). However focal...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2011.12.015
更新日期：2012-04-01 00:00:00
abstract：:Alcohol absorption and elimination vary considerably amongst individuals, and are subject to influences from a variety of factors. The effects of alcohol concentration and beverage mixer type on the rate of alcohol absorption, in a controlled environment was studied. 21 subjects (12 male, 9 female) consumed a solution...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2006.12.010
更新日期：2007-10-01 00:00:00
abstract：:Traumatic cataract is due to lens damage when mechanical, irradiative, electrical or chemical agents injury the globe. The appearance of a traumatic cataract is typically short and unilateral with rare spontaneous resolution and often involves other ocular anatomical areas. Medico-legal evaluation of the appearance an...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.jflm.2012.05.002
更新日期：2013-02-01 00:00:00
abstract：:The forensic significance of genital injury following rape and sexual assault has been the subject of considerable academic and research interest, in terms of the contribution it may provide to the body of evidence in criminal proceedings. This essay takes a critical look at such research, in the context of modern und...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章,评审
doi：10.1016/j.jflm.2015.06.007
更新日期：2015-08-01 00:00:00
abstract：:Mummification is a peculiar transformative process consisting of the total drying of the body soft tissues. It is produced, in particular conditions, between 6 and 12 months after death. "Precocious" mummification has been reported in countries where recorded weather conditions are more extreme than in Italy, in a con...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2012.06.013
更新日期：2013-02-01 00:00:00
abstract：:Hanging is one of the most lethal methods of suicide, where survival is an obvious rarity. Those who survive the initial act of hanging mostly suffer from hypoxic ischemic encephalopathy, and show some form of neurological damage. Intracranial haemorrhages are rarely associated with hanging. We report the first case o...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2018.02.019
更新日期：2018-04-01 00:00:00
abstract：:A 5-year-old boy with a chromosome-9 abnormality and multiple external and visceral malformations was found in cardiopulmonary arrest during a regular visit to the hospital; he did not respond to cardiopulmonary resuscitation and died. An odontoid process fracture and calcification and fibrosis of the muscles around t...
journal_title：Journal of forensic and legal medicine
pub_type： 杂志文章
doi：10.1016/j.jflm.2018.11.011
更新日期：2019-02-01 00:00:00
