Abstract:
IMPORTANCE:Biofeedback with device-guided lowering of breathing frequency could be an alternate nonpharmacologic treatment option for hypertension. Evidence from trials with high methodologic quality is lacking. OBJECTIVE:To evaluate the effects of device-guided lowering of breathing frequency on blood pressure in patients with type 2 diabetes mellitus and hypertension. DESIGN:Single-center, double-blind, sham-controlled trial. SETTING:A large nonacademic teaching hospital in the Netherlands. PARTICIPANTS:Patients with type 2 diabetes mellitus and hypertension. INTERVENTION:Fifteen-minute sessions with either the device that guides breathing through musical tones to a lower breathing frequency (aiming at <10 breaths/min) or a sham device (music without aiming at lowering of breathing frequency) for an 8-week study period. MAIN OUTCOMES AND MEASURES:Systolic and diastolic blood pressure measured in the physician's office. RESULTS:Forty-eight patients were randomized; 21 patients (88%) in the intervention group and 24 patients (100%) in the control group completed the study. There were no significant changes in systolic and diastolic blood pressure, with a difference in systolic blood pressure of 2.35 mm Hg (95% CI, -6.50 to 11.20) in favor of the control group and a difference in diastolic blood pressure of 2.25 mm Hg (95% CI, -2.16 to 6.67) in favor of the intervention group. Three patients in the intervention group experienced adverse events. CONCLUSIONS AND RELEVANCE:This high methodologic quality study shows no significant effect of device-guided lowering of breathing frequency on office-measured blood pressure in patients with type 2 diabetes. On the basis of this study, together with results from all but one previous trial, device-guided lowering of breathing frequency does not appear to be a viable nonpharmacologic option for hypertension treatment.
journal_name
JAMA Intern Medjournal_title
JAMA internal medicineauthors
Landman GW,Drion I,van Hateren KJ,van Dijk PR,Logtenberg SJ,Lambert J,Groenier KH,Bilo HJ,Kleefstra Ndoi
10.1001/jamainternmed.2013.6883subject
Has Abstractpub_date
2013-07-22 00:00:00pages
1346-50issue
14eissn
2168-6106issn
2168-6114pii
1696186journal_volume
173pub_type
杂志文章,随机对照试验abstract:Importance:A critical bottleneck in clinical genomics is the mismatch between large volumes of results and the availability of knowledgeable professionals to return them. Objective:To test whether a web-based platform is noninferior to a genetic counselor for educating patients about their carrier results from exome s...
journal_title:JAMA internal medicine
pub_type: 杂志文章,随机对照试验
doi:10.1001/jamainternmed.2017.8049
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abstract:Importance:The electronic cigarette (EC) has become popular among smokers who wish to reduce their tobacco use levels or quit smoking, but its effectiveness as a cessation aid is uncertain. Objective:To examine the association of regular EC use with the number of cigarettes smoked per day, smoking cessation among curr...
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abstract:Importance:Lung cancer has become a leading cause of death among people living with human immunodeficiency virus (HIV) (PLWH). Over 40% of PLWH in the United States smoke cigarettes; HIV independently increases the risk of lung cancer. Objective:To project cumulative lung cancer mortality by smoking exposure among PLW...
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更新日期:2013-05-27 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2015-11-01 00:00:00
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更新日期:2016-09-01 00:00:00
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-07-08 00:00:00
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更新日期:2020-05-01 00:00:00
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更新日期:2017-01-01 00:00:00
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更新日期:2014-09-01 00:00:00
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更新日期:2017-03-01 00:00:00