Abstract:
OBJECTIVE:The purpose of the present study was to compare the effectiveness of platelet-rich plasma (PRP) + microfracture and microfracture treatments in the healing of chronic focal chondral defects. METHODS:The study included 57 adult male Sprague-Dawley rats. Forty-two rats were divided into three groups of 14 rats with a chondral defect (control, microfracture only, PRP+microfracture). The remaining 15 rats were used to produce the PRP preparation. The rats were then euthanatized at 3 and 6 weeks after treatment and examined. Histological analysis using the modified Pineda scoring system and immunohistochemical staining for Type 2 collagen were performed. RESULTS:At both time intervals, control group histological scores (Week 3: 8.8±1.2, Week 6: 8.5±0.7) were higher than microfracture (Week 3: 6.8±1.0, Week 6: 7.1±0.6) and PRP+microfracture (Week 3: 6.4±1.3, Week 6: 5.7±1.2) scores (p<0.05). The microfracture group score was higher at Week 6 than the PRP+microfracture group (p<0.05). The degree of Type 2 collagen staining was higher at Week 6 in the PRP+microfracture group and was unique in showing staining at the cell membrane. CONCLUSION:The addition of PRP application to microfracture treatment appears to enhance cartilage healing in chronic focal chondral defects.
journal_name
Acta Orthop Traumatol Turcjournal_title
Acta orthopaedica et traumatologica turcicaauthors
Hapa O,Çakici H,Yüksel HY,Fırat T,Kükner A,Aygün Hdoi
10.3944/aott.2013.2928subject
Has Abstractpub_date
2013-01-01 00:00:00pages
201-7issue
3eissn
1017-995Xissn
2589-1294journal_volume
47pub_type
杂志文章abstract:OBJECTIVE:The aim of this anatomical study was to compare the effects of the prone and lateral decubitus positions in endoscopic disc surgery on the Kambin's triangle (KT) and neural foramina zones in the lumbosacral region. METHODS:The study included 32 healthy volunteers (16 females and 16 males). Bilateral KT areas...
journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.14.0233
更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:We evaluated the results of open reduction and internal fixation with the use of dynamic compression plating in patients with pseudarthrosis of the humeral shaft. METHODS:Eighteen patients (12 males, 6 females; mean age 41 years; range 22 to 68 years) with aseptic pseudarthrosis of the humeral shaft were tr...
journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::Vascular injuries associated with the tibial nailing have been reported in few case reports. We here report a unique case of anterior tibial artery (ATA) pseudoaneurysm caused by the second proximal coronal interlocking bolt. We found that the position of interlocking bolts on the nail brings them very close to the an...
journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.1016/j.aott.2015.01.001
更新日期:2017-01-01 00:00:00
abstract::We report a 30-year-old male patient with two unicameral bone cysts (UBC) simultaneously located in the proximal third of the right femur and ipsilateral ischium ramus, respectively. Fine needle biopsies were attempted for both lesions. Biopsy of the femoral lesion under local anesthesia was unsuccessful, so an open b...
journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2009.185
更新日期:2009-03-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2009.007
更新日期:2009-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/aott.2012.2592
更新日期:2012-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.15.0140
更新日期:2016-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2011.2468
更新日期:2011-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.1016/j.aott.2017.09.011
更新日期:2017-12-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.14.0340
更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.14.0034
更新日期:2016-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type:
doi:10.5152/j.aott.2020.02.278
更新日期:2020-03-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.aott.2019.05.003
更新日期:2019-09-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:10.3944/aott.2008.310
更新日期:2008-11-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.14.0309
更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.1016/j.aott.2017.10.004
更新日期:2017-12-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.1016/j.aott.2019.08.002
更新日期:2019-11-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/aott.2008.166
更新日期:2008-05-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.3944/AOTT.2015.14.0450
更新日期:2015-01-01 00:00:00
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journal_title:Acta orthopaedica et traumatologica turcica
pub_type: 杂志文章
doi:10.5152/j.aott.2020.03.243
更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
doi:10.3944/AOTT.2009.400
更新日期:2009-11-01 00:00:00