Does platelet-rich plasma enhance microfracture treatment for chronic focal chondral defects? An in-vivo study performed in a rat model.

Abstract:

OBJECTIVE:The purpose of the present study was to compare the effectiveness of platelet-rich plasma (PRP) + microfracture and microfracture treatments in the healing of chronic focal chondral defects. METHODS:The study included 57 adult male Sprague-Dawley rats. Forty-two rats were divided into three groups of 14 rats with a chondral defect (control, microfracture only, PRP+microfracture). The remaining 15 rats were used to produce the PRP preparation. The rats were then euthanatized at 3 and 6 weeks after treatment and examined. Histological analysis using the modified Pineda scoring system and immunohistochemical staining for Type 2 collagen were performed. RESULTS:At both time intervals, control group histological scores (Week 3: 8.8±1.2, Week 6: 8.5±0.7) were higher than microfracture (Week 3: 6.8±1.0, Week 6: 7.1±0.6) and PRP+microfracture (Week 3: 6.4±1.3, Week 6: 5.7±1.2) scores (p<0.05). The microfracture group score was higher at Week 6 than the PRP+microfracture group (p<0.05). The degree of Type 2 collagen staining was higher at Week 6 in the PRP+microfracture group and was unique in showing staining at the cell membrane. CONCLUSION:The addition of PRP application to microfracture treatment appears to enhance cartilage healing in chronic focal chondral defects.

authors

Hapa O,Çakici H,Yüksel HY,Fırat T,Kükner A,Aygün H

doi

10.3944/aott.2013.2928

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

201-7

issue

3

eissn

1017-995X

issn

2589-1294

journal_volume

47

pub_type

杂志文章
  • Positional alterations of the Kambin's triangle and foraminal areas in the lumbosacral region.

    abstract:OBJECTIVE:The aim of this anatomical study was to compare the effects of the prone and lateral decubitus positions in endoscopic disc surgery on the Kambin's triangle (KT) and neural foramina zones in the lumbosacral region. METHODS:The study included 32 healthy volunteers (16 females and 16 males). Bilateral KT areas...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.14.0233

    authors: Botanlıoğlu H,Aydıngöz Ö,Kantarcı F,Kaynak G,Güven MF,Ertan S

    更新日期:2015-01-01 00:00:00

  • Comparison of tunnel expansion and isometric muscle strength after ACL reconstruction with single- or dual-bundle hamstring allograft: a prospective, randomized study.

    abstract:OBJECTIVE:The aim of this study was to compare tunnel expansion and isokinetic muscle strength after single- and dual-bundle reconstruction of the anterior cruciate ligament (ACL). METHODS:This study included 34 patients who underwent ACL reconstruction in our clinic between November 2007 and March 2008. Eighteen pati...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章,随机对照试验

    doi:10.3944/aott.2012.2749

    authors: Beyaz S,Özkoç G,Akpınar S,Demir Ş,Adam M,Tuncay IC

    更新日期:2012-01-01 00:00:00

  • [Treatment results of pseudarthrosis of the humeral shaft by open reduction and internal fixation with dynamic compression plating].

    abstract:OBJECTIVES:We evaluated the results of open reduction and internal fixation with the use of dynamic compression plating in patients with pseudarthrosis of the humeral shaft. METHODS:Eighteen patients (12 males, 6 females; mean age 41 years; range 22 to 68 years) with aseptic pseudarthrosis of the humeral shaft were tr...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Oztürkmen Y,Karamehmetoğlu M,Caniklioğlu M,Ozlük AV

    更新日期:2004-01-01 00:00:00

  • [Lengthening of the phalanges by callus distraction in traumatic amputations of the fingers].

    abstract:OBJECTIVES:We evaluated the results of lengthening of the phalanges by callus distraction in traumatic amputations of the fingers. METHODS:We treated traumatic amputations of 16 fingers of 13 male patients (mean age 27.7 years; range 12 to 43 years) by callotasis of the phalanges. Callus distraction was performed with...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Parmaksizoğlu F,Beyzadeoğlu T

    更新日期:2004-01-01 00:00:00

  • Anterior tibial artery pseudoaneurysm due to interlocking bolt of tibial nail: A case report and review.

    abstract::Vascular injuries associated with the tibial nailing have been reported in few case reports. We here report a unique case of anterior tibial artery (ATA) pseudoaneurysm caused by the second proximal coronal interlocking bolt. We found that the position of interlocking bolts on the nail brings them very close to the an...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.1016/j.aott.2015.01.001

    authors: Gahlot N,Kanojia RK

    更新日期:2017-01-01 00:00:00

  • [Simultaneous existence of unicameral bone cysts involving the femur and ischium].

    abstract::We report a 30-year-old male patient with two unicameral bone cysts (UBC) simultaneously located in the proximal third of the right femur and ipsilateral ischium ramus, respectively. Fine needle biopsies were attempted for both lesions. Biopsy of the femoral lesion under local anesthesia was unsuccessful, so an open b...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2009.185

    authors: Makris V,Papavasiliou KA,Bobos M,Hytiroglou P,Kirkos JM,Kapetanos GA

    更新日期:2009-03-01 00:00:00

  • [Treatment of trimalleolar fractures. Is osteosynthesis needed in posterior malleolar fractures measuring less than 25% of the joint surface?].

    abstract:OBJECTIVES:We evaluated the effect of posterior malleolar fractures, which measured less than 25% of the joint surface, on the results of ankle fractures. METHODS:The study included 44 patients (21 females, 23 males; mean age 44 years; range 17 to 76 years) who underwent surgical treatment for Weber types B or C ankle...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Katiöz H,Bombaci H,Görgeç M

    更新日期:2003-01-01 00:00:00

  • [External rotation osteotomy of the humerus for the treatment of shoulder problems secondary to obstetric brachial plexus palsy].

    abstract:OBJECTIVES:We evaluated the results of external rotation osteotomy of the humerus for the treatment of shoulder problems secondary to obstetric brachial plexus palsy. METHODS:Forty children (24 boys, 16 girls; mean age 7.5 years; range 23 months to 14.8 years) underwent external rotation osteotomy of the humerus. Invo...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Akinci M,Ay S,Kamiloğlu S,Erçetin O

    更新日期:2005-01-01 00:00:00

  • [Treatment of adult tibial diaphysis fractures with reamed and locked intramedullary nailing].

    abstract:OBJECTIVES:We evaluated the results of reamed and locked intramedullary nailing for tibial diaphysis fractures. METHODS:The study included 73 patients (68 males, 5 females; mean age 31 years; range 17 to 68 years) who were treated with reamed and locked intramedullary nailing for tibial diaphysis fractures. There were...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2009.007

    authors: Burç H,Dursun M,Orhun H,Gürkan V,Bayhan I

    更新日期:2009-01-01 00:00:00

  • Minimally invasive plate osteosynthesis (MIPO) in diaphyseal humerus and proximal humerus fractures.

    abstract:OBJECTIVE:Our aim was to evaluate the results of minimally invasive plate osteosynthesis (MIPO) using locking plates in diaphyseal humerus and proximal humerus fractures. METHODS:Nine patients who underwent open reduction and MIPO for the treatment of diaphyseal and proximal humerus fractures between June 2006 and Oct...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/aott.2012.2592

    authors: Aksu N,Karaca S,Kara AN,Işiklar ZU

    更新日期:2012-01-01 00:00:00

  • Prognostic factors in sensory recovery after digital nerve repair.

    abstract:OBJECTIVE:The prognostic factors that affect sensory nerve recovery after digital nerve repair are variable because of nonhomogeneous data, subjective tests, and different assessment/scoring methods. The aim of this study was to evaluate the success of sensory nerve recovery after digital nerve repair and to investigat...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.15.0140

    authors: Bulut T,Akgün U,Çıtlak A,Aslan C,Şener U,Şener M

    更新日期:2016-01-01 00:00:00

  • Is plating of mid-shaft clavicular fractures possible with a conventional straight 3.5 millimeter locking compression plate?

    abstract:OBJECTIVES:Current literature describes improved clinical outcomes and a minor rate of pseudoarthrosis following operatively treated clavicular fractures. We investigated the feasibility of using a standard 3.5 mm AO locking compression plate (LCP) of adequate length for the stabilisation of mid-shaft fractures of the ...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2011.2468

    authors: Grechenig W,Heidari N,Leitgoeb O,Prager W,Pichler W,Weinberg AM

    更新日期:2011-01-01 00:00:00

  • Atypically localized glomus tumor causing anterior interosseous nerve syndrome: A case report.

    abstract::This article presents a 48-year-old male patient who presented with pain in the left forearm and weakness and clumsiness in the left hand of 6 months' duration. Flexor motor strength loss of the thumb and the index finger was present and neurophysiologic tests showed findings compatible with axonal injury in the anter...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.1016/j.aott.2017.09.011

    authors: Akman YE,Yalcinkaya M,Arikan Y,Kabukcuoglu Y

    更新日期:2017-12-01 00:00:00

  • Surgical management of bone metastases from urological malignancies: an analysis of 70 cases.

    abstract:OBJECTIVE:The purpose of this study was to evaluate symptomatic bone metastases from urological malignancies and the efficacy of surgical treatment of bone metastases in achieving local tumor control. METHODS:This was a retrospective observational study of patients diagnosed with bone metastases from urological malign...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.14.0340

    authors: Toğral G,Arıkan M,Aktaş E,Öztürk R,Güven O,Eksioğlu F

    更新日期:2015-01-01 00:00:00

  • The effect of simple local resection on pain and scoliotic curve in patients with scoliosis secondary to osteoid osteoma and osteoblastoma in the spine.

    abstract:OBJECTIVE:The aim of this study was assess the results of local resection without instrumentation in patients with scoliosis secondary to spinal osteoid osteoma and osteoblastoma. METHODS:The review of our database revealed 176 cases of osteoid osteomas and 18 of osteoblastomas. Painful scoliosis was seen in 5 out of ...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.14.0034

    authors: Balioğlu MB,Albayrak A,Atıcı Y,Sökücü S,Tacal MT,Kaygusuz MA

    更新日期:2016-01-01 00:00:00

  • Bilateral septic arthritis of the hip caused by nontyphoidal salmonella: A case report.

    abstract::Nontyphoidal salmonella (NTS) infection can lead to gastroenteritis, enteric fever, and bacteremia. However, osteoarticular infections caused by NTS are rarely encountered. We report the case of a 53-year-old male patient with bilateral hip infection caused by NTS. We performed a two-stage reconstruction comprising de...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type:

    doi:10.5152/j.aott.2020.02.278

    authors: Shin YR,Park KS,Cho KJ,Yoon TR

    更新日期:2020-03-01 00:00:00

  • [Rupture of the triceps brachii tendon: a case report].

    abstract::Triceps tendon rupture is a rare condition. A thirty-three year old man presented with a complaint of pain in his left elbow, which occurred when his motorcycle slid and flipped on one side. Physical examination two days after the accident showed swelling and ecchymosis in the elbow. There was a palpable, slightly ten...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Esenyel CZ,Oztürk K,Ortak O,Kara AN

    更新日期:2003-01-01 00:00:00

  • Predatory journal preference in the field of Orthopaedics and Traumatology in Turkey.

    abstract:OBJECTIVE:The aim of this study was to determine the prevalence of predatory journals in Orthopedics and Traumatology and to investigate the relationship of these publications with the regulations of scientific fields made in recent years in Turkey. METHODS:The journals and publishers between the years 2000-2018 were ...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.1016/j.aott.2019.05.003

    authors: Sener M,Davulcu CD,Tahta M,Gunal I

    更新日期:2019-09-01 00:00:00

  • [The "wheel track" technique in lateral meniscus surgery: a technical note].

    abstract::Partial meniscectomy is the most widely used intervention in the arthroscopic treatment of meniscal disorders. Despite improved arthroscopic techniques and instrumentation, surgery of the lateral compartment is still challenging. The "wheel track" technique, first described here, will facilitate partial meniscectomy i...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Aydin AT,Ozcanli H

    更新日期:2006-01-01 00:00:00

  • [Extramembranous transfer of the tibialis posterior tendon for the correction of drop foot deformity].

    abstract:OBJECTIVES:We evaluated the effectiveness of extramembranous transfer of the tibialis posterior (TP) tendon for the treatment of drop foot deformity. METHODS:The study included 13 patients (6 females, 7 males; mean age 30 years; range 10 to 46 years) who underwent 15 tendon transfers for drop foot deformity. Ten patie...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/aott.2008.310

    authors: Kiliç A,Parmaksizoğlu AS,Kabukçuoğlu Y,Bilgili F,Sökücü S

    更新日期:2008-11-01 00:00:00

  • [Surgical treatment of Langerhans cell histiocytosis with bone and soft tissue involvement in pediatric patients].

    abstract:OBJECTIVES:We evaluated pediatric patients who underwent surgery for Langerhans cell histiocytosis with mono- or polyostatic involvement and an extensive soft tissue component and/or a high risk for pathologic fractures. METHODS:The study included 13 children (6 boys, 7 girls; mean age 6 years; range 2 to 11 years) wh...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Eralp L,Ozger H,Ozkan K,Bilsel K,Kebudi R,Ayan I

    更新日期:2006-01-01 00:00:00

  • Arthroscopic treatment of bilateral snapping scapula syndrome: a case report and review of the literature.

    abstract::Snapping scapula syndrome represents a rare entity in shoulder surgery. Clinically, it presents as shoulder pain and loud crepitus during shoulder movement. Moreover, glenohumeral bursitis can cause additional pain. Snapping scapula syndrome is caused by an increased angulation of the superomedial part of the scapula ...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章,评审

    doi:10.3944/AOTT.2015.3241

    authors: Freche S,Juch F,Nusselt T,Delank KS,Hagel A

    更新日期:2015-01-01 00:00:00

  • Is Coonrad-Morrey total elbow arthroplasty a viable option for treatment of distal humeral nonunions in the elderly?

    abstract:OBJECTIVE:The purpose of this study was to evaluate the functional and radiological results of semiconstrained Coonrad-Morrey total elbow arthroplasty for distal humeral nonunions in the mid-term period. METHODS:Seven patients were treated with Coonrad-Morrey total elbow arthroplasty for distal humeral nonunion. All p...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.14.0309

    authors: Erşen A,Demirhan M,Atalar AC,Atıcı T,Kapıcıoğlu M

    更新日期:2015-01-01 00:00:00

  • Comparison of ultrasound and dorsal horizon radiographic view for the detection of dorsal screw penetration.

    abstract:OBJECTIVE:The aim of this study was to compare the efficiency of dorsal tangential fluoroscopy and ultrasonography in detecting dorsal screw penetration in distal radius volar locking plate applications. METHODS:Ten cadaveric forearms were operated. The distal four screws were protruded 0, 1 and 2 mm into each of the ...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.1016/j.aott.2017.10.004

    authors: Gurbuz Y,Kucuk L,Gunay H,Ozaksar K,Sugun TS,Bilge O

    更新日期:2017-12-01 00:00:00

  • [Early results of medial opening wedge osteotomy in varus gonarthrosis].

    abstract:OBJECTIVES:We evaluated the efficacy and short-term results of medial opening wedge high tibial osteotomy with the use of a Puddu plate in patients with medial compartment gonarthrosis. METHODS:The study included 15 knees of 12 female patients (mean age 50.6 years; range 45 to 63 years) who were treated with medial op...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:

    authors: Orsel S,Altun M,Bekmezci T,Tonbul M,Yalaman O

    更新日期:2006-01-01 00:00:00

  • Comparison of clavicular hook plate with and without coracoclavicular suture fixation for acute acromioclavicular joint dislocation.

    abstract:OBJECTIVE:The aim of this study was to compare the clinical and radiographic outcomes of clavicular hook plate fixation with and without coracoclavicular (CC) tape augmentation for the treatment of acute unstable AC dislocation. METHODS:We treated 47 patients (31 men and 16 women; mean age: 47 years (range, 21-81)) wi...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.1016/j.aott.2019.08.002

    authors: Chang HM,Hong CK,Su WR,Wang TH,Chang CW,Tai TW

    更新日期:2019-11-01 00:00:00

  • [Childhood injuries, their etiologies, and preventive measures].

    abstract:OBJECTIVES:The purpose of this study was to evaluate social, economical, and cultural factors of childhood injuries and to assess preventive measures. METHODS:The study included 120 children (75 boys, 45 girls; mean age 8.3 years; range 0 to 14 years) who presented to the emergency department due to trauma from Septem...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/aott.2008.166

    authors: Bombaci H,Ulkü K,Adiyeke L,Kara S,Görgeç M

    更新日期:2008-05-01 00:00:00

  • Comparison between knot and Winograd techniques on ingrown nail treatment.

    abstract:OBJECTIVE:The aim of this study was to compare the Winograd and knot techniques based on efficiency, complication rate, surgery time, and amount of local anesthetic required. This study also aimed to determine the etiology of ingrown nails, whether due to involvement of the nail or soft tissue. METHODS:Seventy-five pa...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2015.14.0450

    authors: İnce B,Dadacı M,Bilgen F,Yarar S

    更新日期:2015-01-01 00:00:00

  • Academic productivity and obstacles encountered during residency training: A survey among residents in orthopedics and traumatology programs in Turkey.

    abstract:OBJECTIVE:This study aimed to investigate the academic productivity of and the obstacles encountered by orthopedic residents in Turkey. METHODS:Overall, 220 orthopedic specialists who were registered in the Ministry of Health and had started orthopedic residency between 2009 and 2010 were invited to participate in a s...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.5152/j.aott.2020.03.243

    authors: Demirtaş A,Karadeniz H,Akman YE,Duymuş TM,Çarkcı E,Azboy İ

    更新日期:2020-05-01 00:00:00

  • [Comparison of radiation exposure times in the treatment of pediatric supracondylar humeral fractures with open-closed reduction and internal fixation].

    abstract:OBJECTIVES:We compared open reduction-internal fixation (ORIF) and closed reduction-internal fixation (CRIF) with respect to operation and radiation exposure times in the treatment of displaced supracondylar humeral fractures in children. METHODS:This retrospective study included 124 children (76 boys, 48 girls) who u...

    journal_title:Acta orthopaedica et traumatologica turcica

    pub_type: 杂志文章

    doi:10.3944/AOTT.2009.400

    authors: Esen E,Doğramaci Y,Gültekin S,Görmeli G,Yildirim A,Kanatli U,Bölükbaşi S

    更新日期:2009-11-01 00:00:00