Abstract：
:Prostate cancer is widely observed to be biologically heterogeneous. Its heterogeneity is manifested histologically as multifocal prostate cancer, which is observed more frequently than unifocal prostate cancer. The clinical and prognostic significance of either focal cancer type is not fully established. To investigate prostate cancer heterogeneity, the genetic profiles of multifocal and unifocal prostate cancers were compared. Here, we report observations deduced from tumor-tumor comparison of copy number alteration data of both focal categories. Forty-one fresh frozen prostate cancer foci from 14 multifocal prostate cancers and eight unifocal prostate cancers were subjected to copy number variation analysis with the Affymetrix SNP 6.0 microarray tool. With the investigated cases, tumors obtained from a single prostate exhibited different genetic profiles of variable degrees. Further comparison identified no distinct genetic pattern or signatures specific to multifocal or unifocal prostate cancer. Our findings suggest that samples obtained from multiple sites of a single unifocal prostate cancer show as much genetic heterogeneity and variability as separate tumors obtained from a single multifocal prostate cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Ibeawuchi C,Schmidt H,Voss R,Titze U,Abbas M,Neumann J,Eltze E,Hoogland AM,Jenster G,Brandt B,Semjonow Adoi
10.3390/ijms140611816subject
Has Abstractpub_date
2013-06-03 00:00:00pages
11816-29issue
6issn
1422-0067pii
ijms140611816journal_volume
14pub_type
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