Dysbiosis signature of fecal microbiota in colorectal cancer patients.

Abstract:

:The human gut microbiota is a complex system that is essential to the health of the host. Increasing evidence suggests that the gut microbiota may play an important role in the pathogenesis of colorectal cancer (CRC). In this study, we used pyrosequencing of the 16S rRNA gene V3 region to characterize the fecal microbiota of 19 patients with CRC and 20 healthy control subjects. The results revealed striking differences in fecal microbial population patterns between these two groups. Partial least-squares discriminant analysis showed that 17 phylotypes closely related to Bacteroides were enriched in the gut microbiota of CRC patients, whereas nine operational taxonomic units, represented by the butyrate-producing genera Faecalibacterium and Roseburia, were significantly less abundant. A positive correlation was observed between the abundance of Bacteroides species and CRC disease status (R = 0.462, P = 0.046 < 0.5). In addition, 16 genera were significantly more abundant in CRC samples than in controls, including potentially pathogenic Fusobacterium and Campylobacter species at genus level. The dysbiosis of fecal microbiota, characterized by the enrichment of potential pathogens and the decrease in butyrate-producing members, may therefore represent a specific microbial signature of CRC. A greater understanding of the dynamics of the fecal microbiota may assist in the development of novel fecal microbiome-related diagnostic tools for CRC.

journal_name

Microb Ecol

journal_title

Microbial ecology

authors

Wu N,Yang X,Zhang R,Li J,Xiao X,Hu Y,Chen Y,Yang F,Lu N,Wang Z,Luan C,Liu Y,Wang B,Xiang C,Wang Y,Zhao F,Gao GF,Wang S,Li L,Zhang H,Zhu B

doi

10.1007/s00248-013-0245-9

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

462-70

issue

2

eissn

0095-3628

issn

1432-184X

journal_volume

66

pub_type

杂志文章
  • Trichoderma harzianum Rifai 1295-22 mediates growth promotion of crack willow (Salix fragilis) saplings in both clean and metal-contaminated soil.

    abstract::We investigated if the plant growth promoting fungus Trichoderma harzianum Rifai 1295-22 (also known as "T22") could be used to enhance the establishment and growth of crack willow (Salix fragilis) in a soil containing no organic or metal pollutants and in a metal-contaminated soil by comparing this fungus with nonino...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-006-9203-0

    authors: Adams P,De-Leij FA,Lynch JM

    更新日期:2007-08-01 00:00:00

  • Simultaneous growth on citrate reduces the effects of iron limitation during toluene degradation in Pseudomonas.

    abstract::Rhizoremediation has been suggested as an attractive bioremediation strategy for the effective breakdown of pollutants in soil. The presence of plant root exudates such as organic acids, sugars, and amino acids that may serve as carbon sources or biosynthetic building blocks and the limited bioavailability of iron may...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-002-2023-y

    authors: Dinkla IJ,Janssen DB

    更新日期:2003-01-01 00:00:00

  • Sequence analyses of type IV pili from Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus.

    abstract::Bacterial surface structures called pili have been studied extensively for their role as possible colonization factors. Most sequenced Vibrio genomes predict a variety of pili genes in these organisms, including several types of type IV pili. In particular, the mannose-sensitive hemagglutinin (MSHA) and the PilA pili,...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-012-0021-2

    authors: Aagesen AM,Häse CC

    更新日期:2012-08-01 00:00:00

  • Molecular, biochemical, and physiological approaches for understanding the ecology of denitrification.

    abstract::One of the major challenges in microbial ecology for the future is to establish links between structural and functional biodiversity. This is particularly difficult when one is interested in a phylogenetically diversified function such as denitrification. The data banks are very rich in functional gene sequences (nirS...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-004-0256-7

    authors: Goregues CM,Michotey VD,Bonin PC

    更新日期:2005-02-01 00:00:00

  • Variability in fermentation patterns of sugar-utilizing bacteria isolated from anaerobic, intertidal sediments.

    abstract::Three dominant types of sugar-fermenting bacteria were isolated from the anaerobic, intertidal sediments of the Eems-Dollard estuary by applying techniques involving anaerobic agar shake tubes. One of the isolated types was tentatively identified as aStreptococcus species, the other two asBacteroides species. All type...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02010484

    authors: Laanbroek HJ,Blok JP,Steenhuis L

    更新日期:1985-06-01 00:00:00

  • Ectoparasite Activity During Incubation Increases Microbial Growth on Avian Eggs.

    abstract::While direct detrimental effects of parasites on hosts are relatively well documented, other more subtle but potentially important effects of parasitism are yet unexplored. Biological activity of ectoparasites, apart from skin injuries and blood-feeding, often results in blood remains, or parasite faeces that accumula...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-017-1140-6

    authors: Tomás G,Martín-Gálvez D,Ruiz-Castellano C,Ruiz-Rodríguez M,Peralta-Sánchez JM,Martín-Vivaldi M,Soler JJ

    更新日期:2018-08-01 00:00:00

  • Comamonadaceae OTU as a Remnant of an Ancient Microbial Community in Sulfidic Waters.

    abstract::Intraterrestrial waters harbor microbial communities being extensively studied to understand microbial processes underlying subsurface ecosystem functioning. This paper provides the results of an investigation on the microbiomes of unique, subsurface sulfidic waters associated with Upper Jurassic, Cretaceous, and Mioc...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-018-1270-5

    authors: Deja-Sikora E,Gołębiewski M,Kalwasińska A,Krawiec A,Kosobucki P,Walczak M

    更新日期:2019-07-01 00:00:00

  • Bacterial regeneration of ammonium and phosphate as affected by the carbon:nitrogen:phosphorus ratio of organic substrates.

    abstract::The effect of carbon∶nitrogen∶phosphorus (C∶N∶P) ratio of organic substrates on the regeneration of ammonium and phosphate was investigated by growing natural assemblages of freshwater bacteria in mineral media supplemented with the simple organic C, N, and P sources (glucose, asparagine, and sodium glycerophosphate, ...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02017167

    authors: Tezuka Y

    更新日期:1990-05-01 00:00:00

  • Repression of Proteases and Hsp90 Chaperone Expression Induced by an Antiretroviral in Virulent Environmental Strains of Cryptococcus neoformans.

    abstract::This study evaluated the effect of the antiretroviral ritonavir on protease secretion in different strains of Cryptococcus neoformans isolated from the environment and investigated the expression of heat shock protein (Hsp90), classically described virulence factors in other yeast in the presence of the same antiretro...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-016-0900-z

    authors: Serafin CF,Paris AP,Paula CR,Simão RC,Gandra RF

    更新日期:2017-04-01 00:00:00

  • Laboratory-induced endolithic growth in calcarenites: biodeteriorating potential assessment.

    abstract::This study is aimed to assess the formation of photosynthetic biofilms on and within different natural stone materials, and to analyse their biogeophysical and biogeochemical deterioration potential. This was performed by means of artificial colonisation under laboratory conditions during 3 months. Monitoring of micro...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-010-9666-x

    authors: Miller AZ,Rogerio-Candelera MA,Laiz L,Wierzchos J,Ascaso C,Sequeira Braga MA,Hernández-Mariné M,Maurício A,Dionísio A,Macedo MF,Saiz-Jimenez C

    更新日期:2010-07-01 00:00:00

  • Molecular detection of murine herpesvirus 68 in ticks feeding on free-living reptiles.

    abstract::The MHV-68 (designed as Murid herpesvirus 4 (MuHV 4) strain 68) isolated from two rodents, Myodes glareolus and Apodemus flavicollis, is considered as a natural pathogen of free-living murid rodents. Recently, the detection of MHV antibodies in the blood of animals living in the same biotope as MHV-infected mice has s...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-011-9907-7

    authors: Ficová M,Betáková T,Pančík P,Václav R,Prokop P,Halásová Z,Kúdelová M

    更新日期:2011-11-01 00:00:00

  • A Comparison of the Survival of Intraperiplasmic and Attack Phase Bdellovibrios with Reduced Oxygen

    abstract::The ability of intraperiplasmic and attack phase bdellovibrios to survive and/or grow under anoxic and microaerobic conditions was examined. Both halotolerant and nonhalotolerant bdellovibrio strains were examined. In all instances, the bdellovibrio strains were unable to grow under anoxic conditions, but were able to...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF00170105

    authors: Schoeffield AJ,Williams HN,Turng B,Fackler WA Jr

    更新日期:1996-07-01 00:00:00

  • Unlocking the Genomic Taxonomy of the Prochlorococcus Collective.

    abstract::Prochlorococcus is the most abundant photosynthetic prokaryote on our planet. The extensive ecological literature on the Prochlorococcus collective (PC) is based on the assumption that it comprises one single genus comprising the species Prochlorococcus marinus, containing itself a collective of ecotypes. Ecologists a...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-020-01526-5

    authors: Tschoeke D,Salazar VW,Vidal L,Campeão M,Swings J,Thompson F,Thompson C

    更新日期:2020-10-01 00:00:00

  • Decomposition and fungi of needle litter from slow- and fast-growing Norway spruce (Picea abies) clones.

    abstract::The fungal species involved in the decomposition of needle litter and their response to intraspecific genetic variation of trees are poorly known. First, we compared the needle decomposition and fungal decomposers underneath eight different Norway spruce clones in situ. This experiment revealed 60-70% loss of needle m...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-007-9326-y

    authors: Korkama-Rajala T,Müller MM,Pennanen T

    更新日期:2008-07-01 00:00:00

  • Bacterial growth on dissolved organic carbon from a blackwater river.

    abstract::Different nominal molecular weight (nMW) fractions of DOC from a southeastern blackwater river were concentrated by ultrafiltration and added to sieved river water to assess each fraction's ability to stimulate bacterial growth. Bacterial growth was measured using change in bacterial biomass from direct counts and usi...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02014960

    authors: Meyer JL,Edwards RT,Risley R

    更新日期:1987-01-01 00:00:00

  • Arbuscular mycorrhizal fungi and rhizospheric bacteria diversity along an altitudinal gradient in South American Puna grassland.

    abstract::Rhizospheric soil samples were taken from Puna native grasses along an altitudinal gradient. Biodiversity of arbuscular mycorrhizal fungi (AMF) and associated bacteria was analyzed considering altitude and grasses photosynthetic pathways (metabolic type C3, C4). Cultivation-dependent approaches were applied to obtain ...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-007-9313-3

    authors: Lugo MA,Ferrero M,Menoyo E,Estévez MC,Siñeriz F,Anton A

    更新日期:2008-05-01 00:00:00

  • Trophic Ecology of the Tropical Pacific Sponge Mycale grandis Inferred from Amino Acid Compound-Specific Isotopic Analyses.

    abstract::Many sponges host abundant and active microbial communities that may play a role in the uptake of dissolved organic matter (DOM) by the sponge holobiont, although the mechanism of DOM uptake and metabolism is uncertain. Bulk and compound-specific isotopic analysis of whole sponge, isolated sponge cells, and isolated s...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-019-01410-x

    authors: Shih JL,Selph KE,Wall CB,Wallsgrove NJ,Lesser MP,Popp BN

    更新日期:2020-02-01 00:00:00

  • Migration of Paraburkholderia terrae BS001 Along Old Fungal Hyphae in Soil at Various pH Levels.

    abstract::The movement of bacterial cells along with fungal hyphae in soil (the mycosphere) has been reported in several previous studies. However, how local soil conditions affect bacterial migration direction in the mycosphere has not been extensively studied. Here, we investigated the influence of two soil parameters, pH and...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-017-1137-1

    authors: Yang P,Oliveira da Rocha Calixto R,van Elsas JD

    更新日期:2018-08-01 00:00:00

  • Biological soil crusts of sand dunes in Cape Cod National Seashore, Massachusetts, USA.

    abstract::Biological soil crusts cover hundreds of hectares of sand dunes at the northern tip of Cape Cod National Seashore (Massachusetts, USA). Although the presence of crusts in this habitat has long been recognized, neither the organisms nor their ecological roles have been described. In this study, we report on the microbi...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-004-0254-9

    authors: Smith SM,Abed RM,Gercia-Pichel F

    更新日期:2004-08-01 00:00:00

  • Influence of phagotrophic processes on the regeneration of nutrients in two-stage continuous culture systems.

    abstract::Regeneration of nutrients in aquatic ecosystems may be affected by autolysis, bacterial degradation, and activities of phagotrophic organisms. To examine the relative importance of these processes, mineralization of carbon, nitrogen, and phosphorus was studied in a two-stage continuous culture system. In the first sta...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02010599

    authors: Güde H

    更新日期:1985-09-01 00:00:00

  • Inoculation effects of Pseudomonas putida, Gluconacetobacter azotocaptans, and Azospirillum lipoferum on corn plant growth under greenhouse conditions.

    abstract::Alcohol production from corn is gaining importance in Ontario, Canada, and elsewhere. A major cost of corn production is the cost of chemical fertilizers and these continue to increase in price. The competitiveness of alcohol with fossil fuels depends on access to low-cost corn that allows growers to earn a sustainabl...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-006-9039-7

    authors: Mehnaz S,Lazarovits G

    更新日期:2006-04-01 00:00:00

  • Diel, seasonal, and depth-related variability of viruses and dissolved DNA in the northern Adriatic Sea.

    abstract::The depth-dependent, seasonal, and diel variability of virus numbers, dissolved DNA (D-DNA), and other microbial parameters was investigated in the northern Adriatic Sea. During periods of water stratification, we found higher virus abundances and virus/bacterium ratios (VBRs) as well as a larger variability of D-DNA ...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF00184511

    authors: Weinbauer MG,Fuks D,Puskaric S,Peduzzi P

    更新日期:1995-07-01 00:00:00

  • Significance and Roles of Proteus spp. Bacteria in Natural Environments.

    abstract::Proteus spp. bacteria were first described in 1885 by Gustav Hauser, who had revealed their feature of intensive swarming growth. Currently, the genus is divided into Proteus mirabilis, Proteus vulgaris, Proteus penneri, Proteus hauseri, and three unnamed genomospecies 4, 5, and 6 and consists of 80 O-antigenic serogr...

    journal_title:Microbial ecology

    pub_type: 杂志文章,评审

    doi:10.1007/s00248-015-0720-6

    authors: Drzewiecka D

    更新日期:2016-11-01 00:00:00

  • Filterable marine bacteria found in the deep sea: Distribution, taxonomy, and response to starvation.

    abstract::A significant number of viable colony-forming bacteria were recovered from deep-ocean bottom water samples passed through a 0.45μm filter. However, these bacteria small enough to pass through a 0.45μm membrane filter and termed "filterable bacteria" were less abundant in open-ocean surface water and coastal water samp...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02010479

    authors: Tabor PS,Ohwada K,Colwell RR

    更新日期:1981-03-01 00:00:00

  • Molecular Ecology of nifH Genes and Transcripts Along a Chronosequence in Revegetated Areas of the Tengger Desert.

    abstract::The colonization and succession of diazotrophs are essential for the development of organic soil layers in desert. We examined the succession of diazotrophs in the well-established revegetated areas representing a chronosequence of 0 year (control), 22 years (restored artificially since 1981), 57 years (restored artif...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-015-0657-9

    authors: Wang J,Bao JT,Li XR,Liu YB

    更新日期:2016-01-01 00:00:00

  • Do Multi-year Applications of Bacillus thuringiensis subsp. israelensis for Control of Mosquito Larvae Affect the Abundance of B. cereus Group Populations in Riparian Wetland Soils?

    abstract::Bacillus thuringiensis subsp. israelensis (Bti) is a soil-borne bacterium affiliated to the Bacillus cereus group (Bcg) and has been used in biocontrol products against nematoceran larvae for several decades. However, knowledge is limited on whether long-term Bti application can affect the structure of indigenous comm...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-017-1004-0

    authors: Schneider S,Tajrin T,Lundström JO,Hendriksen NB,Melin P,Sundh I

    更新日期:2017-11-01 00:00:00

  • Symbiont-Mediated Host-Parasite Dynamics in a Fungus-Gardening Ant.

    abstract::Group-living can promote the evolution of adaptive strategies to prevent and control disease. Fungus-gardening ants must cope with two sets of pathogens, those that afflict the ants themselves and those of their symbiotic fungal gardens. While much research has demonstrated the impact of specialized fungal pathogens t...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-017-1124-6

    authors: Kellner K,Kardish MR,Seal JN,Linksvayer TA,Mueller UG

    更新日期:2018-08-01 00:00:00

  • Regulation of Hydrolytic Enzyme Activity in Aquatic Microbial Communities Hosted by Carnivorous Pitcher Plants.

    abstract::Carnivorous pitcher plants Sarracenia purpurea host diverse eukaryotic and bacterial communities which aid in insect prey digestion, but little is known about the functional processes mediated by the microbial communities. This study aimed to connect pitcher community diversity with functional nutrient transformation ...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s00248-018-1187-z

    authors: Young EB,Sielicki J,Grothjan JJ

    更新日期:2018-11-01 00:00:00

  • Simultaneous consumption of bacteria and dissolved organic matter byTetrahymena pyriformis.

    abstract::The addition of ciliated protozoa to aquatic microcosms and bench-scale sewage treatment plants increases decomposition rates. This is surprising, inasmuch as protozoa consume bacteria, which are the primary decomposers. One possible mechanism of the increase in decomposition rate is the direct consumption of dissolve...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/BF02011712

    authors: Glaser D

    更新日期:1988-03-01 00:00:00

  • Moving Waves of Bacterial Populations and Total Organic Carbon along Roots of Wheat.

    abstract::> Abstract To determine if spatial variation in soluble carbon sources along the root coincides with different trophic groups of bacteria, copiotrophic and oligotrophic bacteria were enumerated from bulk soil and rhizosphere samples at 2 cm intervals along wheat roots 2, 3, and 4 weeks after planting. There was a mode...

    journal_title:Microbial ecology

    pub_type: 杂志文章

    doi:10.1007/s002489900136

    authors: Semenov AM,van Bruggen AHC,Zelenev VV

    更新日期:1999-02-01 00:00:00