Abstract:
BACKGROUND:Recent trials on rectal cancer have demonstrated significant improvements in local recurrence without improvements in overall survival. The aim of this paper was to define the influence of local recurrence on survival in a prospective series of patients who underwent R0 or R1 resections for rectal cancer. METHODS:Patients presenting with rectal cancer from 1996 to 2012 were prospectively audited. The study included patients who underwent an R0 or R1 resection. Local recurrence was defined as cancer regrowth detected in the pelvis regardless of whether or not new metastases were found elsewhere. Kaplan-Meier curves, smoothed hazard functions and Cox models using both time since diagnosis and age as the time scale were used to define the influence of local recurrence on overall survival. RESULTS:The study involved 483 patients, of mean age 66 years (standard deviation = 13) and a median follow-up of 5.2 years. The results at 5 years were overall survival 71% (95% confidence interval (CI) 66-75), local recurrence 7% (95% CI 5-10) and distant recurrence 18% (95% CI 14-22). Patients diagnosed with local recurrence died faster than patients diagnosed with either distant recurrence or no recurrence, and this was particularly obvious for younger patients (local hazard ratio (HR) 54, 95% CI 12-253 and distant HR19, 95% CI 4-80). Local recurrence that developed early following surgery also had worse survival outcomes. CONCLUSIONS:Within this cohort of rectal cancer patients, the early development of local recurrence was the single most important indicator of a reduced survival, and carried a worse prognosis than the development of distant metastases alone.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Platell C,Spilsbury Kdoi
10.1111/ans.12214subject
Has Abstractpub_date
2014-01-01 00:00:00pages
85-90issue
1-2eissn
1445-1433issn
1445-2197journal_volume
84pub_type
临床试验,杂志文章abstract:BACKGROUND:Previous studies have shown that children with isolated linear skull fractures have excellent clinical outcomes and low risk of surgery. We wish to identify other injury patterns within the spectrum of paediatric mild head injury, which need only conservative management. Children with low risk of evolving ne...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.14175
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS:Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40%) hepatectomy by measurement of liver weight. Hepa...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-2197.2007.04360.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:This study aimed to explore the effects of early antiplatelet therapy (APT) for portal vein thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy with gastro-oesophageal devascularization. METHODS:We retrospectively analysed 139 patients who underwent splenectomy with gastro-oeso...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.14395
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Laparoscopic common bile duct exploration (LCBDE) is increasingly being used to treat choledocholithiasis. However, few studies have examined the treatment of recurrent common bile duct stones (CBDS) in patients with a history of prior biliary surgery. The current research aimed to compare the outcomes of la...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.16529
更新日期:2020-12-28 00:00:00
abstract::Recent advances in understanding of the biology of appendicitis are reviewed. Immunological aspects are discussed in the setting of a changing microbiome. Implications for practice are summarized. ...
journal_title:ANZ journal of surgery
pub_type: 杂志文章,评审
doi:10.1111/ans.16018
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Despite conflicting data regarding oncological outcomes, studies demonstrate that complete mesocolic excision (CME) and central vascular ligation (CVL) for right-sided colon cancer removes significantly more tissue and yields higher lymph node counts when compared to conventional resection. This study aims t...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.16224
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and make up 1-2% of all gastrointestinal malignancies. Traditionally, the treatment of choice for primary disease is surgical resection; however, no single surgeon or institution gets extensive expo...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.12429
更新日期:2016-03-01 00:00:00
abstract::Acute colonic pseudo-obstruction (ACPO) and chronic intestinal pseudo-obstruction (CIPO) are distinct clinical entities in which patients present similarly with symptoms of a mechanical obstruction without an occlusive lesion. Unfortunately, they also share the issues related to a delay in diagnosis, including inappro...
journal_title:ANZ journal of surgery
pub_type: 杂志文章,评审
doi:10.1111/ans.13148
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to assess the value of fine-needle aspiration cytology (FNAC) as a preoperative evaluation for parotid tumours. METHODS:Prospectively collected data on 77 patients, collected on a parotid database, were retrospectively analysed. Preoperative investigations were carried out and cyto...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-2197.2008.04651.x
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:To examine the common presentations and management of acute epiglottitis in adults. METHOD:Retrospective clinical study of 17 consecutive adult patients who presented to the Royal Melbourne Hospital between January 1988 and December 2000 was undertaken. RESULTS:The mean patient age was 47 years (range 20-8...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1445-1433.2001.02265.x
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Haemorrhagic complication occurs in 5-16% of patients following pancreaticoduodenectomy (PD). We report an analysis of patients with post-PD bleed, to identify predictors of bleed, predictors of survival following bleed and the management of post-PD bleed. METHODS:Two hundred and eighteen patients with peri...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-1433.2004.03212.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Quad bikes are a prominent cause of morbidity and mortality in Australia in both agriculture and recreation. This study describes the clinical and epidemiological characteristics of quad bike injuries at the Royal Darwin Hospital (RDH). METHODS:A retrospective review of the RDH Trauma Registry for all quad ...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.15631
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Anastomotic leakage following colorectal resection and anastomosis has been proposed as a colorectal surgical indicator. Leak rates after elective surgery vary and tend to be higher as anastomoses become lower. The present study audits leak rates and outcomes of patients undergoing colorectal surgery, under ...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1440-1622.2001.02189.x
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Sore throat is not an uncommon complaint following general anaesthesia (GA) with endotracheal intubation. It has been a source of considerable discomfort particularly in those patients who had thyroid surgery. Driven by the increased number of patients with post-intubation sore throat following thyroid surge...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1445-1433.2001.02230.x
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Oncology literature is increasingly recognizing prevalence of second primary cancers including several longitudinal studies showing an increased risk of colorectal cancer following a prostate cancer diagnosis. A retrospective study was conducted to examine the relationship between prior prostate cancer diagn...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.12136
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:The present paper examines the local recurrence rate following surgical treatment for carcinoma of the lower rectum with principally blunt dissection directed at tumour-specific mesorectal excision (including total mesorectal excision when appropriate). METHODS:During the period April 1987-December 1999, 12...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-1433.2004.03136.x
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Bisphosphonates (BPs) are widely used for the treatment of osteoporosis. Oversuppression of bone turnover with BPs may paradoxically limit the reserve capacity of bone to heal. The aim of this review was to study the predisposition of some patients to delayed/non-union of upper limb fractures associated with...
journal_title:ANZ journal of surgery
pub_type: 杂志文章,评审
doi:10.1111/ans.12536
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:In Australia, robotic-assisted radical prostatectomy (RARP) has steadily replaced open and laparoscopic surgery in the management of localized prostate cancer. Given the increased cost of this technology, we aimed to compare the perioperative, pathological, oncological and functional outcomes as well as shor...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.12602
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:This review examines the surgical management of acute superior mesenteric artery (SMA) occlusion and the impact of interventional radiology techniques. METHODS:Eight consecutive patients with SMA occlusion were treated at the Lismore Base Hospital, Lismore, NSW, Australia, from 1996 through to 2001 and of t...
journal_title:ANZ journal of surgery
pub_type: 杂志文章,评审
doi:10.1046/j.1445-2197.2002.02289.x
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Ludwig's angina (LA) is an uncommon and potentially life-threatening condition of the upper aero-digestive tract that often requires the coordinated efforts of the surgical, anesthetic and intensive care teams to optimize management. The purpose of the present study was to investigate the documented clinic...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-2197.2010.05496.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The education and training of tomorrow’s surgeons are predicated upon the involvement of a broad spectrum of surgical educators. Identification of the factors that influence their ongoing participation is crucial for its continuity. METHODS:A study was performed on 695 surgeons identified as having major in...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-2197.2011.05777.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Although various surgical procedures have been described for pilonidal sinus disease, the best surgical technique is still controversial. The aim of this study was to evaluate the short-term results of modified elliptical rotation flap (MERF) for pilonidal sinus disease in terms of post-operative complicatio...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.12818
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Thrombosis of the hepatic artery following orthotopic liver transplantation (OLT) can be a devastating com-plication impacting on recipient outcome. The utility of routine intraoperative flow measurements of the hepatic artery in predicting subsequent hepatic artery thrombosis (HAT) is presented in this st...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1445-2197.2002.02552.x
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:The diagnosis of severe acute respiratory syndrome (SARS) in surgical patients can potentially be missed based on current World Health Organization (WHO) case definitions. METHOD:We report a retrospective case series of 10 surgical inpatients diagnosed with SARS following an outbreak in the surgical wards. ...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-2197.2005.03285.x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The 2009 American Thyroid Association (ATA) three-tiered risk stratification, and its updated version in 2015, provided clearer guidance on the use of radioactive iodine (RAI) ablation in differentiated thyroid cancer (DTC) patients. This study examines the impact of these guidelines on RAI use in our instit...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.15522
更新日期:2019-11-01 00:00:00
abstract::It was the achievement of Andreas Vesalius (1514-1564) to redefine the understanding of human anatomy; and that of Homer was to write the first historical novel. This paper offers a link between the works of these two venturers, by way of an examination of the clinical anatomy of the clavicle. ...
journal_title:ANZ journal of surgery
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1445-2197.2011.05711.x
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:The present retrospective study presents the outcomes of a group of 21 patients with laryngeal obstruction caused by bilateral vocal fold fixation. All of these patients were treated by laser assisted muscle tenotomy and vocal process resection - a modification of the technique described by Michael and Eugen...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1445-2197.2003.02603.x
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Patients with centrally located tumours involving the nipple-areolar complex (NAC) who undergo breast-conserving treatment (BCT) are at high risk for breast deformity and asymmetry. Immediate oncoplastic breast reconstruction (OBR) can have a favourable impact on surgical outcome. METHODS:We retrospectively...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/ans.15078
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:There is evidence that antibiotics can be used as primary treatment for appendicitis, however, delayed surgical treatment might still be associated with perforation. Most patients at risk of perforation have high Alvarado scores. We designed a protocol-based approach to suspected appendicitis, in which the A...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1111/j.1445-1433.2004.02993.x
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:The role of splenectomy remains unclear in patients with gastric cancer who undergo total gastrectomy. The aim of this study was to prospectively evaluate the impact of splenectomy on circulating T-lymphocyte subsets and survival in advanced gastric cancer. METHODS:Analysis of lymphocyte subsets was perform...
journal_title:ANZ journal of surgery
pub_type: 杂志文章
doi:10.1046/j.1445-2197.2002.02429.x
更新日期:2002-06-01 00:00:00